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William Maniscalco

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester NY 14642
 
 Awards And Honors
1980 - 1982Buswell Faculty Research Award  | University of Rochester School of Medicine
 
 Overview
Dr. Maniscalco's research interests are:
1) Bronchopulmonary Dysplasia
2) Angiogenesis
3) Lung Development.

His laboratory research focuses on injury to the developing lung and the cellular response that is essential to repair the injured alveolus. Oxygen injury to the lungs is a common clinical problem that can result from therapeutic use of oxygen.

Their primary focus is on the development of the microvasculature and the effects of oxidant injury. The factors that regulate development of the pulmonary microvasculature are not known but likely involve vascular endothelial growth factor (VEGF) and its receptors. VEGF is a peptide growth factor that is specifically mitogenic for endothelial cells. It may be a major angiogenic growth factor in several situations, such as lung development and recovery lung injury, in which neovascularization is active. They have determined that alveolar type II cells express VEGF in animals during the recovery phase of lung injury.

Their current studies seek to determine which cells express VEGF in developing lung, the impact of hyperoxic injury on lung vascular development, and the regulation of type II cell VEGF expression in vitro. They are also determining endothelial expression of the major VEGF receptors in lung during development and after oxygen injury. They use standard molecular and protein methods, such as Northern hybridization, in situ hybridization, immunocytochemistry and Western blotting.

 
 Selected Publications
List All   |   Timeline
  1. Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ. Murine mechanical ventilation stimulates alveolar epithelial cell proliferation. Exp Lung Res. 2010 Aug; 36(6):331-41.
    View in: PubMed
  2. McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):492-500.
    View in: PubMed
  3. Pierce RA, Joyce B, Officer S, Heintz C, Moore C, McCurnin D, Johnston C, Maniscalco W. Retinoids increase lung elastin expression but fail to alter morphology or angiogenesis genes in premature ventilated baboons. Pediatr Res. 2007 Jun; 61(6):703-9.
    View in: PubMed
  4. Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM. Pathogenesis of bronchopulmonary dysplasia. Semin Perinatol. 2006 Aug; 30(4):171-8.
    View in: PubMed
  5. Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1101-11.
    View in: PubMed
  6. Maniscalco WM, Watkins RH, Roper JM, Staversky R, O'Reilly MA. Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression. Pediatr Res. 2005 Sep; 58(3):549-56.
    View in: PubMed
  7. Roper JM, Mazzatti DJ, Watkins RH, Maniscalco WM, Keng PC, O'Reilly MA. In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2004 May; 286(5):L1045-54.
    View in: PubMed
  8. D'Angio CT, Maniscalco WM. Bronchopulmonary dysplasia in preterm infants: pathophysiology and management strategies. Paediatr Drugs. 2004; 6(5):303-30.
    View in: PubMed
  9. O'Reilly MA, Watkins RH, Staversky RJ, Maniscalco WM. Induced p21Cip1 in premature baboons with CLD: implications for alveolar hypoplasia. Am J Physiol Lung Cell Mol Physiol. 2003 Oct; 285(4):L964-71.
    View in: PubMed
  10. Maniscalco WM, Watkins RH, O'Reilly MA, Shea CP. Increased epithelial cell proliferation in very premature baboons with chronic lung disease. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L991-L1001.
    View in: PubMed
  11. Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am J Pathol. 2002 Oct; 161(4):1383-93.
    View in: PubMed
  12. Stevens TP, Chess PR, McConnochie KM, Sinkin RA, Guillet R, Maniscalco WM, Fisher SG. Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenation. Pediatrics. 2002 Sep; 110(3):590-6.
    View in: PubMed
  13. D'Angio CT, Maniscalco WM. The role of vascular growth factors in hyperoxia-induced injury to the developing lung. Front Biosci. 2002 Jul 1; 7:d1609-23.
    View in: PubMed
  14. Maniscalco WM, Watkins RH, Pryhuber GS, Bhatt A, Shea C, Huyck H. Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L811-23.
    View in: PubMed
  15. Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM. Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 1):1971-80.
    View in: PubMed
  16. Winkler CA, Kittelberger AM, Watkins RH, Maniscalco WM, Schwartz GJ. Maturation of carbonic anhydrase IV expression in rabbit kidney. Am J Physiol Renal Physiol. 2001 May; 280(5):F895-903.
    View in: PubMed
  17. O'Reilly MA, Staversky RJ, Huyck HL, Watkins RH, LoMonaco MB, D'Angio CT, Baggs RB, Maniscalco WM, Pryhuber GS. Bcl-2 family gene expression during severe hyperoxia induced lung injury. Lab Invest. 2000 Dec; 80(12):1845-54.
    View in: PubMed
  18. Bhatt AJ, Amin SB, Chess PR, Watkins RH, Maniscalco WM. Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung. Pediatr Res. 2000 May; 47(5):606-13.
    View in: PubMed
  19. Sinkin RA, Dweck HS, Horgan MJ, Gallaher KJ, Cox C, Maniscalco WM, Chess PR, D'Angio CT, Guillet R, Kendig JW, Ryan RM, Phelps DL. Early dexamethasone-attempting to prevent chronic lung disease. Pediatrics. 2000 Mar; 105(3 Pt 1):542-8.
    View in: PubMed
  20. O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM, Keng PC. p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2000 Mar; 278(3):L552-9.
    View in: PubMed
  21. Stevens TP, Sinkin RA, Hall CB, Maniscalco WM, McConnochie KM. Respiratory syncytial virus and premature infants born at 32 weeks' gestation or earlier: hospitalization and economic implications of prophylaxis. Arch Pediatr Adolesc Med. 2000 Jan; 154(1):55-61.
    View in: PubMed
  22. D'Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basavegowda K, Sinkin RA. Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone. Biol Neonate. 1999 Nov; 76(5):266-73.
    View in: PubMed
  23. Watkins RH, D'Angio CT, Ryan RM, Patel A, Maniscalco WM. Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury. Am J Physiol. 1999 May; 276(5 Pt 1):L858-67.
    View in: PubMed
  24. O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM. Accumulation of p21(Cip1/WAF1) during hyperoxic lung injury in mice. Am J Respir Cell Mol Biol. 1998 Nov; 19(5):777-85.
    View in: PubMed
  25. Kendig JW, Ryan RM, Sinkin RA, Maniscalco WM, Notter RH, Guillet R, Cox C, Dweck HS, Horgan MJ, Reubens LJ, Risemberg H, Phelps DL. Comparison of two strategies for surfactant prophylaxis in very premature infants: a multicenter randomized trial. Pediatrics. 1998 Jun; 101(6):1006-12.
    View in: PubMed
  26. Maniscalco WM, Watkins RH, Chess PR, Sinkin RA, Horowitz S, Toia L. Cell-specific expression of fibronectin and EIIIA and EIIIB splice variants after oxygen injury. Am J Physiol. 1998 Apr; 274(4 Pt 1):L599-609.
    View in: PubMed
  27. Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM. Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung. Am J Respir Cell Mol Biol. 1997 May; 16(5):557-67.
    View in: PubMed
  28. Veness-Meehan KA, Moats-Staats BM, Maniscalco WM, Watkins RH, Stiles AD. Changes in decorin expression with hyperoxic injury to developing rat lung. Pediatr Res. 1997 Apr; 41(4 Pt 1):464-72.
    View in: PubMed
  29. Maniscalco WM, Watkins RH, Campbell MH. Expression of fibronectin mRNA splice variants by rabbit lung in vivo and by alveolar type II cells in vitro. Am J Physiol. 1996 Dec; 271(6 Pt 1):L972-80.
    View in: PubMed
  30. Hudak ML, Farrell EE, Rosenberg AA, Jung AL, Auten RL, Durand DJ, Horgan MJ, Buckwald S, Belcastro MR, Donohue PK, Carrion V, Maniscalco WW, Balsan MJ, Torres BA, Miller RR, Jansen RD, Graeber JE, Laskay KM, Matteson EJ, Egan EA, Brody AS, Martin DJ, Riddlesberger MM, Montgomery P. A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome. J Pediatr. 1996 Mar; 128(3):396-406.
    View in: PubMed
  31. Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH. Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury. Am J Respir Cell Mol Biol. 1995 Oct; 13(4):377-86.
    View in: PubMed
  32. D'Angio CT, Maniscalco WM, Pichichero ME. Immunologic response of extremely premature infants to tetanus, Haemophilus influenzae, and polio immunizations. Pediatrics. 1995 Jul; 96(1 Pt 1):18-22.
    View in: PubMed
  33. Roberts WA, Maniscalco WM, Cohen AR, Litman RS, Chhibber A. The use of capnography for recognition of esophageal intubation in the neonatal intensive care unit. Pediatr Pulmonol. 1995 May; 19(5):262-8.
    View in: PubMed
  34. Roberts WA, Maniscalco WM. A novel cause of error in capnographic confirmation of intubation in the neonatal intensive care unit. Pediatrics. 1995 Jan; 95(1):140-2.
    View in: PubMed
  35. Maniscalco WM, Sinkin RA, Watkins RH, Campbell MH. Transforming growth factor-beta 1 modulates type II cell fibronectin and surfactant protein C expression. Am J Physiol. 1994 Nov; 267(5 Pt 1):L569-77.
    View in: PubMed
  36. Maniscalco WM, Campbell MH. Transforming growth factor-beta induces a chondroitin sulfate/dermatan sulfate proteoglycan in alveolar type II cells. Am J Physiol. 1994 Jun; 266(6 Pt 1):L672-80.
    View in: PubMed
  37. Piedboeuf B, Maniscalco W, Hall S, Campbell M, Watkins R, Horowitz S. In vivo and in vitro expression of metallothionein in injured type II alveolar epithelial cells. Chest. 1994 Mar; 105(3 Suppl):78S.
    View in: PubMed
  38. Spafford PS, Kendig JW, Maniscalco WM. Use of natural surfactants to prevent and treat respiratory distress syndrome. Semin Perinatol. 1993 Aug; 17(4):285-94.
    View in: PubMed
  39. Fisher DJ, Christy C, Spafford P, Maniscalco WM, Hardy DJ, Graman PS. Neonatal Trichosporon beigelii infection: report of a cluster of cases in a neonatal intensive care unit. Pediatr Infect Dis J. 1993 Feb; 12(2):149-55.
    View in: PubMed
  40. Maniscalco WM, Campbell MH. Alveolar type II cells synthesize hydrophobic cell-associated proteoglycans with multiple core proteins. Am J Physiol. 1992 Sep; 263(3 Pt 1):L348-56.
    View in: PubMed
  41. Coleman RT, Sherer DM, Maniscalco WM. Prevention of neonatal group B streptococcal infections: advances in maternal vaccine development. Obstet Gynecol. 1992 Aug; 80(2):301-9.
    View in: PubMed
  42. Kendig JW, Notter RH, Cox C, Reubens LJ, Davis JM, Maniscalco WM, Sinkin RA, Bartoletti A, Dweck HS, Horgan MJ, et al. A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks' gestation. N Engl J Med. 1991 Mar 28; 324(13):865-71.
    View in: PubMed
  43. Maniscalco WM, Stremmel W, Heeney-Campbell M. Uptake of palmitic acid by rabbit alveolar type II cells. Am J Physiol. 1990 Oct; 259(4 Pt 1):L206-12.
    View in: PubMed
  44. Brown MR, Thunberg BJ, Golub L, Maniscalco WM, Cox C, Shapiro DL. Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant. J Pediatr Gastroenterol Nutr. 1989 Jul; 9(1):21-7.
    View in: PubMed
  45. Maniscalco WM, Finkelstein JN, Parkhurst AB. Effects of exogenous fatty acids and inhibition of de novo fatty acid synthesis on disaturated phosphatidylcholine production by fetal lung cells and adult type II cells. Exp Lung Res. 1989 May; 15(3):473-89.
    View in: PubMed
  46. Maniscalco WM, Kendig JW, Shapiro DL. Surfactant replacement therapy: impact on hospital charges for premature infants with respiratory distress syndrome. Pediatrics. 1989 Jan; 83(1):1-6.
    View in: PubMed
  47. Kendig JW, Notter RH, Cox C, Aschner JL, Benn S, Bernstein RM, Hendricks-Munoz K, Maniscalco WM, Metlay LA, Phelps DL, et al. Surfactant replacement therapy at birth: final analysis of a clinical trial and comparisons with similar trials. Pediatrics. 1988 Nov; 82(5):756-62.
    View in: PubMed
  48. Aschner JL, Punsalang A, Maniscalco WM, Menegus MA. Percutaneous central venous catheter colonization with Malassezia furfur: incidence and clinical significance. Pediatrics. 1987 Oct; 80(4):535-9.
    View in: PubMed
  49. Jacobs AJ, Maniscalco WM, Finkelstein JN. Effects of methylmercuric chloride, cycloheximide, and colchicine on the reaggregation of dissociated mouse cerebellar cells. Toxicol Appl Pharmacol. 1986 Dec; 86(3):362-71.
    View in: PubMed
  50. Shapiro DL, Livingston JN, Maniscalco WM, Finkelstein JN. Insulin receptors and insulin effects on type II alveolar epithelial cells. Biochim Biophys Acta. 1986 Feb 21; 885(2):216-20.
    View in: PubMed
  51. Jacobs AJ, Maniscalco WM, Parkhurst AB, Finkelstein JN. In vivo and in vitro demonstration of reduced myelin synthesis following early postnatal exposure to ionizing radiation in the rat. Radiat Res. 1986 Jan; 105(1):97-104.
    View in: PubMed
  52. Maniscalco WM, Finkelstein JN, Parkhurst AB. Dexamethasone increases de novo fatty acid synthesis in fetal rabbit lung explants. Pediatr Res. 1985 Dec; 19(12):1272-7.
    View in: PubMed
  53. Schwartz JL, Maniscalco WM, Lane AT, Currao WJ. Twin transfusion syndrome causing cutaneous erythropoiesis. Pediatrics. 1984 Oct; 74(4):527-9.
    View in: PubMed
  54. Clarke TA, Maniscalco WM, Taylor-Brown S, Roghmann KJ, Shapiro DL, Hannon-Johnson C. Job satisfaction and stress among neonatologists. Pediatrics. 1984 Jul; 74(1):52-7.
    View in: PubMed
  55. Finkelstein JN, Maniscalco WM, Shapiro DL. Properties of freshly isolated type II alveolar epithelial cells. Biochim Biophys Acta. 1983 Jun 2; 762(3):398-404.
    View in: PubMed
  56. Clarke TA, Maniscalco WM, Emmens RW. Necrotizing enterocolitis in premature infants transferred back to community hospitals. Am J Dis Child. 1983 Jun; 137(6):563-5.
    View in: PubMed
  57. Maniscalco WM, Finkelstein JN, Parkhurst AB. De novo fatty acid synthesis by freshly isolated alveolar type II epithelial cells. Biochim Biophys Acta. 1983 May 16; 751(3):462-9.
    View in: PubMed
  58. Maniscalco WM, Shapiro DL. Effects of dexamethasone on beta-adrenergic receptors in fetal lung explants. Pediatr Res. 1983 Apr; 17(4):274-7.
    View in: PubMed
  59. Maniscalco WM, Clarke TA. Factors influencing neonatal autopsy rate. Am J Dis Child. 1982 Sep; 136(9):781-4.
    View in: PubMed
  60. Maniscalco WM, Finkelstein JN, Parkhurst AB. De novo fatty acid synthesis in developing rat lung. Biochim Biophys Acta. 1982 Apr 15; 711(1):49-58.
    View in: PubMed
  61. Gross I, Smith GJ, Wilson CM, Maniscalco WM, Ingleson LD, Brehier A, Rooney SA. The influence of hormones on the biochemical development of fetal rat lung in organ culture. II. Insulin. Pediatr Res. 1980 Jun; 14(6):834-8.
    View in: PubMed
  62. Maniscalco WM, Wilson CM, Gross I. Influence of aminophylline and cyclic AMP on glycogen metabolism in fetal rat lung in organ culture. Pediatr Res. 1979 Dec; 13(12):1319-22.
    View in: PubMed
  63. Rooney SA, Gobran LI, Marino PA, Maniscalco WM, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochim Biophys Acta. 1979 Jan 29; 572(1):64-76.
    View in: PubMed
  64. Maniscalco WM, Wilson CM, Gross I, Gobran L, Rooney SA, Warshaw JB. Development of glycogen and phospholipid metabolism in fetal and newborn rat lung. Biochim Biophys Acta. 1978 Sep 28; 530(3):333-46.
    View in: PubMed
  65. Gross I, Smith GJ, Maniscalco WM, Czajka MR, Wilson CM, Rooney SA. An organ culture model for study of biochemical development of fetal rat lung. J Appl Physiol. 1978 Sep; 45(3):355-62.
    View in: PubMed

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