Kathleen McGrath
| Title | Research Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester NY 14642
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| Title | Research Assistant Professor |
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| Institution | University of Rochester Medical Center |
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| Department | Center for Pediatric Biomedical Research |
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Dr. McGrath's research interests are:
1) Red Blood Cell transcriptome and development (Erythroid progenitor cells)
2) Blood development in the murine embryo
3) Developmental Biology
4) Molecular Biology.
Her research interest is based on a fundamental curiosity about how cells decide which fate to adopt as embryos develop. Simplistically, this involves a dynamic interplay between the potential each cell has and the signals that it receives that narrow that potential into specific fates. As part of Jim Palis' research group, she applies that paradigm to the development of the blood system in the mouse embryo.
Recently, Dr. McGrath has focused on the initial appearance of the linked fates of blood and vascular systems in the embryo and roles of signaling systems active at the time and place of these initial fate choices (e.g. Notch, BMP and Wnt signaling systems). She has also begun to examine the genetic control of later steps in the maturation of specific lineages within the blood system in the embryo versus the adult utilizing cell sorting technologies.
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Peslak SA, Wenger J, Bemis JC, Kingsley PD, Koniski AD, McGrath KE, Palis J. EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress. Blood. 2012 Sep 20; 120(12):2501-11.
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Sturgeon CM, Chicha L, Ditadi A, Zhou Q, McGrath KE, Palis J, Hammond SM, Wang S, Olson EN, Keller G. Primitive Erythropoiesis Is Regulated by miR-126 via Nonhematopoietic Vcam-1(+) Cells. Dev Cell. 2012 Jul 17; 23(1):45-57.
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McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. A transient definitive erythroid lineage with unique regulation of the ß-globin locus in the mammalian embryo. Blood. 2011 Apr 28; 117(17):4600-8.
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Fromm G, Cadiz-Rivera B, de Vries C, Getman M, McGrath KE, Kingsley PD, Fields J, Fiering S, Bulger M. An embryonic stage-specific enhancer within the murine ß-globin locus mediates domain-wide histone hyperacetylation. Blood. 2011 May 12; 117(19):5207-14.
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Peslak SA, Wenger J, Bemis JC, Kingsley PD, Frame JM, Koniski AD, Chen Y, Williams JP, McGrath KE, Dertinger SD, Palis J. Sublethal radiation injury uncovers a functional transition during erythroid maturation. Exp Hematol. 2011 Apr; 39(4):434-45.
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England SJ, McGrath KE, Frame JM, Palis J. Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood. 2011 Mar 3; 117(9):2708-17.
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Berahovich RD, Zabel BA, Penfold ME, Lewén S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010 Nov 1; 185(9):5130-9.
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Palis J, Malik J, McGrath KE, Kingsley PD. Primitive erythropoiesis in the mammalian embryo. Int J Dev Biol. 2010; 54(6-7):1011-8.
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McGrath KE, Bushnell TP, Palis J. Multispectral imaging of hematopoietic cells: where flow meets morphology. J Immunol Methods. 2008 Jul 31; 336(2):91-7.
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Tober J, McGrath KE, Palis J. Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb. Blood. 2008 Mar 1; 111(5):2636-9.
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McGrath K, Palis J. Ontogeny of erythropoiesis in the mammalian embryo. Curr Top Dev Biol. 2008; 82:1-22.
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McGrath KE, Kingsley PD, Koniski AD, Porter RL, Bushnell TP, Palis J. Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus. Blood. 2008 Feb 15; 111(4):2409-17.
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Lux CT, Yoshimoto M, McGrath K, Conway SJ, Palis J, Yoder MC. All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood. 2008 Apr 1; 111(7):3435-8.
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Tober J, Koniski A, McGrath KE, Vemishetti R, Emerson R, de Mesy-Bentley KK, Waugh R, Palis J. The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood. 2007 Feb 15; 109(4):1433-41.
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Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J. "Maturational" globin switching in primary primitive erythroid cells. Blood. 2006 Feb 15; 107(4):1665-72.
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McGrath KE, Palis J. Hematopoiesis in the yolk sac: more than meets the eye. Exp Hematol. 2005 Sep; 33(9):1021-8.
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Reynolds SD, Giangreco A, Hong KU, McGrath KE, Ortiz LA, Stripp BR. Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1256-65.
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Ji RP, Phoon CK, Aristizábal O, McGrath KE, Palis J, Turnbull DH. Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper. Circ Res. 2003 Feb 7; 92(2):133-5.
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McGrath KE, Koniski AD, Malik J, Palis J. Circulation is established in a stepwise pattern in the mammalian embryo. Blood. 2003 Mar 1; 101(5):1669-76.
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Keith Ho HC, McGrath KE, Brodbeck KC, Palis J, Schick BP. Serglycin proteoglycan synthesis in the murine uterine decidua and early embryo. Biol Reprod. 2001 Jun; 64(6):1667-76.
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Kingsley PD, McGrath KE, Maltby KM, Koniski AD, Ramchandran R, Palis J. Subtractive hybridization reveals tissue-specific expression of ahnak during embryonic development. Dev Growth Differ. 2001 Apr; 43(2):133-43.
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McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis J. Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol. 1999 Sep 15; 213(2):442-56.
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McGrath KE, Seidler FJ, Slotkin TA. Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. Brain Res Dev Brain Res. 1997 Dec 19; 104(1-2):209-13.
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McGrath KE, Palis J. Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation. Mol Reprod Dev. 1997 Oct; 48(2):145-53.
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McGrath KE, Smothers JF, Dadd CA, Madireddi MT, Gorovsky MA, Allis CD. An abundant nucleolar phosphoprotein is associated with ribosomal DNA in Tetrahymena macronuclei. Mol Biol Cell. 1997 Jan; 8(1):97-108.
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Palis J, McGrath KE, Kingsley PD. Initiation of hematopoiesis and vasculogenesis in murine yolk sac explants. Blood. 1995 Jul 1; 86(1):156-63.
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McGrath KE, Yu SM, Heruth DP, Kelly AA, Gorovsky MA. Regulation and evolution of the single alpha-tubulin gene of the ciliate Tetrahymena thermophila. Cell Motil Cytoskeleton. 1994; 27(3):272-83.
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Gaertig J, Thatcher TH, McGrath KE, Callahan RC, Gorovsky MA. Perspectives on tubulin isotype function and evolution based on the observation that Tetrahymena thermophila microtubules contain a single alpha- and beta-tubulin. Cell Motil Cytoskeleton. 1993; 25(3):243-53.
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