URMC Research Network - Bradford Berk

Find People

Bradford Berk

Title	Professor
Institution	School of Medicine and Dentistry
Department	Medicine
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 706 Rochester NY 14642

Other Positions


Title	Senior Vice Pres for Health Sciences
Institution	University of Rochester Medical Center
Department	Office of VP for Health Sciences
Title	CEO, University of Rochester Medical Center
Institution	University of Rochester Medical Center
Department	Office of VP for Health Sciences

Title	Professor
Institution	School of Medicine and Dentistry
Department	Pathology and Laboratory Medicine

Title	Professor
Institution	School of Medicine and Dentistry
Department	Pharmacology and Physiology

Awards And Honors

1973			National Science Foundation Undergraduate Research Program (Molecular Biology) \| California Institute of Technology
1974			Woods Hole Oceanographic Institution Fellowship (Microbiology) \| Woods Hole Oceanographic Institute
1975			Phi Beta Kappa, John Albree Jr. Class of 1981 Memorial Fund Award for History \| John Woodruff Simpson Postgraduate Scholarship in Medicine
1975	-	1981	Medical Scientist Training Program (Pharmacology) \| University of Rochester
1981			Robert Kates Memorial Prize in Research, Doran J. Stephens Prize in Medicine \| Alpha Omega Alpha
1985			Young Investigator's Award \| American College of Cardiology
1986			Katz Prize Finalist \| American Heart Association
1992			Marion Young Scholar Award \| American Society for Hypertension
1995			Pfizer Visiting Professor of Cardiovascular Disease \| Wayne State University School of Medicine
1999			Borun Visiting Professor in Cardiology \| UCLA Medical Center
1999			Annual Pulsifer Lecture, Guest Speaker \| Rochester Academy of Medicine
2002			Theo Tsagaris Memorial Lecture \| University of Utah
2002			Indiana Vascular Society/ICVBM Conference \| University of Indiana
2002			Pfizer Visiting Professor \| University of Iowa
2003			Russell Ross Memorial Lectureship in Vascular Biology \| Council for Arteriosclerosis, Thrombosis, Vascular Biology
2004	-	2005	Vice-chair \| Vascular Cell Biology Gordon Conference

Overview

Dr. Berk's laboratory is known for studying signal transduction mechanisms in the vasculature, focusing specifically on defining the mechanisms by which cells in the vascular wall respond to hemodynamic and hormonal stimuli. The four major research areas ongoing in the laboratory include 1) Mechanisms by which blood vessels sense changes in blood flow using protein kinases as targets for signal events. Using cultured endothelial cells and animal models of altered blood flow two projects are underway. The first project investigates the mechanisms by which flow activates the Big MAP kinase (or ERK5) and inhibits inflammation and atherosclerosis. In the second project, the redox-dependent mechanisms that maintain an antioxidant environment are being studied using the apoptosis signal kinase-1 (ASK1) and thioredoxin as targets. The goal of these projects is to identify signal transduction events that confer atheroprotection in the setting of steady laminar flow as opposed to the pro-atherosclerotic effects of disturbed and turbulent flow. 2) The cellular mechanisms that cause hypertension are being investigated by analysis of the role of the renin angiotensin system and the kinases that regulate intracellular sodium. The regulation of smooth muscle cell growth by angiotensin II is focused on the activation of intracellular kinases and phosphatases by the angiotensin II receptor. 3) The mechanisms by which changes in cellular redox state alter blood vessel function are being studied to provide insight into the ways that reactive oxygen species regulate vessel function. Specifically the role of the chaperone molecule cyclophilin A as a mediator of vascular pathology is being studied with several different transgenic models. 4) A genetic model of vascular remodeling in the mouse has been established. A carotid flow reduction model has been characterized and is being used to identify genes responsible for impaired flow-dependent remodeling by positional cloning in inbred strains of mice.

Selected Publications

Smolock EM, Machleder DE, Korshunov VA, Berk BC. Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery. Arterioscler Thromb Vasc Biol. 2013 May; 33(5):1014-9.

View in: PubMed
Pang J, Xu X, Wang X, Majumder S, Wang J, Korshunov VA, Berk BC. G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration. Arterioscler Thromb Vasc Biol. 2013 May; 33(5):999-1005.

View in: PubMed
Park SY, Shi X, Pang J, Yan C, Berk BC. Thioredoxin-Interacting Protein Mediates Sustained VEGFR2 Signaling in Endothelial Cells Required for Angiogenesis. Arterioscler Thromb Vasc Biol. 2013 Apr; 33(4):737-43.

View in: PubMed
Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk BC. Ribosomal Protein L17, RpL17, is an Inhibitor of Vascular Smooth Muscle Growth and Carotid Intima Formation. Circulation. 2012 Nov 13; 126(20):2418-27.

View in: PubMed
Kim GY, Nigro P, Fujiwara K, Abe J, Berk BC. p62 Binding to Protein Kinase C ? Regulates Tumor Necrosis Factor a-Induced Apoptotic Pathway in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2012 Dec; 32(12):2974-80.

View in: PubMed
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012 May 24; 485(7399):512-6.

View in: PubMed
Spindel ON, Yan C, Berk BC. Thioredoxin-Interacting Protein Mediates Nuclear-to-Plasma Membrane Communication: Role in Vascular Endothelial Growth Factor 2 Signaling. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1264-70.

View in: PubMed
Wang XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC. Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing kruppel-like factor 2. Circ Res. 2012 Feb 17; 110(4):560-8.

View in: PubMed
Spindel ON, Berk BC. Redox redux: protecting the ischemic myocardium. J Clin Invest. 2012 Jan 3; 122(1):30-2.

View in: PubMed
Spindel ON, World C, Berk BC. Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms. Antioxid Redox Signal. 2012 Mar 15; 16(6):587-96.

View in: PubMed
Pang J, Xu X, Getman MR, Shi X, Belmonte SL, Michaloski H, Mohan A, Blaxall BC, Berk BC. G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart. J Mol Cell Cardiol. 2011 Nov; 51(5):769-76.

View in: PubMed
World C, Spindel ON, Berk BC. Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-a: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1890-7.

View in: PubMed
Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J. PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. J Cell Biol. 2011 May 30; 193(5):867-84.

View in: PubMed
Shi X, Yan C, Nadtochiy SM, Abe J, Brookes PS, Berk BC. p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury. J Mol Cell Cardiol. 2011 Aug; 51(2):272-5.

View in: PubMed
Satoh K, Berk BC, Shimokawa H. Vascular-derived reactive oxygen species for homeostasis and diseases. Nitric Oxide. 2011 Aug 1; 25(2):211-5.

View in: PubMed
Nigro P, Abe J, Berk BC. Flow shear stress and atherosclerosis: a matter of site specificity. Antioxid Redox Signal. 2011 Sep 1; 15(5):1405-14.

View in: PubMed
Satoh K, Nigro P, Zeidan A, Soe NN, Jaffré F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC. Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1116-23.

View in: PubMed
Nigro P, Satoh K, O'Dell MR, Soe NN, Cui Z, Mohan A, Abe J, Alexis JD, Sparks JD, Berk BC. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med. 2011 Jan 17; 208(1):53-66.

View in: PubMed
Menon P, Yin G, Smolock EM, Zuscik MJ, Yan C, Berk BC. GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass. J Cell Physiol. 2010 Nov; 225(3):777-85.

View in: PubMed
Satoh K, Shimokawa H, Berk BC. Cyclophilin A: promising new target in cardiovascular therapy. Circ J. 2010 Nov; 74(11):2249-56.

View in: PubMed
Wang J, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC. Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1976-82.

View in: PubMed
Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC. PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood. 2010 Sep 16; 116(11):1971-9.

View in: PubMed
Cavet ME, Smolock EM, Menon P, Konishi A, Korshunov VA, Berk BC. Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension. 2010 Jul; 56(1):105-11.

View in: PubMed
Jeon KI, Xu X, Aizawa T, Lim JH, Jono H, Kwon DS, Abe J, Berk BC, Li JD, Yan C. Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9795-800.

View in: PubMed
Satoh K, Nigro P, Berk BC. Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A. Antioxid Redox Signal. 2010 Mar 1; 12(5):675-82.

View in: PubMed
Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 4; 1317:218-26.

View in: PubMed
Zhang N, Cai W, Yin G, Nagel DJ, Berk BC. GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions. Cell Biol Int. 2010 Jan; 34(1):41-7.

View in: PubMed
Massett MP, Fan R, Berk BC. Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice. Physiol Genomics. 2009 Dec 30; 40(1):15-22.

View in: PubMed
Xie S, Lee YF, Kim E, Chen LM, Ni J, Fang LY, Liu S, Lin SJ, Abe J, Berk B, Ho FM, Chang C. TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13353-8.

View in: PubMed
Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, Mohan A, Yan C, Abe J, Illig KA, Berk BC. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med. 2009 Jun; 15(6):649-56.

View in: PubMed
Pan S, World CJ, Kovacs CJ, Berk BC. Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):895-901.

View in: PubMed
Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC. G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation. 2009 Mar 24; 119(11):1524-32.

View in: PubMed
Ibrahim J, Berk BC. Flow-mediated vascular remodeling in hypertension: relation to hemodyamics. Stroke. 2009 Feb; 40(2):582-90.

View in: PubMed
Alexis JD, Wang N, Che W, Lerner-Marmarosh N, Sahni A, Korshunov VA, Zou Y, Ding B, Yan C, Berk BC, Abe J. Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells. Circ Res. 2009 Jan 2; 104(1):69-78.

View in: PubMed
Wang J, Taba Y, Pang J, Yin G, Yan C, Berk BC. GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):202-8.

View in: PubMed
Korshunov VA, Berk BC. Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):47-53.

View in: PubMed
Plekhanova O, Berk BC, Bashtrykov P, Brooks AI, Tkachuk V, Parfyonova Y. Oligonucleotide microarrays reveal regulated genes related to inward arterial remodeling induced by urokinase plasminogen activator. J Vasc Res. 2009; 46(3):177-87.

View in: PubMed
Satoh K, Matoba T, Suzuki J, O'Dell MR, Nigro P, Cui Z, Mohan A, Pan S, Li L, Jin ZG, Yan C, Abe J, Berk BC. Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation. 2008 Jun 17; 117(24):3088-98.

View in: PubMed
Cavet ME, Pang J, Yin G, Berk BC. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J. 2008 Oct; 22(10):3607-16.

View in: PubMed
Korshunov VA, Berk BC. Smooth muscle apoptosis and vascular remodeling. Curr Opin Hematol. 2008 May; 15(3):250-4.

View in: PubMed
Li L, Tatake RJ, Natarajan K, Taba Y, Garin G, Tai C, Leung E, Surapisitchat J, Yoshizumi M, Yan C, Abe J, Berk BC. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23; 370(1):159-63.

View in: PubMed
Berk BC. Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells. Circulation. 2008 Feb 26; 117(8):1082-9.

View in: PubMed
Pang J, Yan C, Natarajan K, Cavet ME, Massett MP, Yin G, Berk BC. GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):892-8.

View in: PubMed
Cavet ME, Smolock EM, Ozturk OH, World C, Pang J, Konishi A, Berk BC. Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):886-91.

View in: PubMed
Mathews MT, Berk BC. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):711-7.

View in: PubMed
Reinhart-King CA, Fujiwara K, Berk BC. Physiologic stress-mediated signaling in the endothelium. Methods Enzymol. 2008; 443:25-44.

View in: PubMed
Satoh K, Berk BC. Circulating smooth muscle progenitor cells: novel players in plaque stability. Cardiovasc Res. 2008 Feb 1; 77(3):445-7.

View in: PubMed
Korshunov VA, Daul M, Massett MP, Berk BC. Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension. Hypertension. 2007 Dec; 50(6):1057-62.

View in: PubMed
Chen C, Korshunov VA, Massett MP, Yan C, Berk BC. Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways. J Vasc Res. 2007; 44(6):504-12.

View in: PubMed
Korshunov VA, Schwartz SM, Berk BC. Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1722-8.

View in: PubMed
Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC. Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing. Circ Res. 2007 Jul 6; 101(1):97-105.

View in: PubMed
Wang J, Pan S, Berk BC. Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1283-8.

View in: PubMed
Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest. 2007 Mar; 117(3):568-75.

View in: PubMed
Berk BC. Novel approaches to treat oxidative stress and cardiovascular diseases. Trans Am Clin Climatol Assoc. 2007; 118:209-14.

View in: PubMed
Pan S, Berk BC. Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway. Circ Res. 2007 Feb 2; 100(2):213-9.

View in: PubMed
Garin G, Berk BC. Flow-mediated signaling modulates endothelial cell phenotype. Endothelium. 2006 Nov-Dec; 13(6):375-84.

View in: PubMed
World CJ, Yamawaki H, Berk BC. Thioredoxin in the cardiovascular system. J Mol Med (Berl). 2006 Dec; 84(12):997-1003.

View in: PubMed
Barker TA, Massett MP, Korshunov VA, Mohan AM, Kennedy AJ, Berk BC. Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade. Hypertension. 2006 Nov; 48(5):942-9.

View in: PubMed
Miano JM, Berk BC. HDAC7 supports vascular integrity. Nat Med. 2006 Sep; 12(9):997-8.

View in: PubMed
Plekhanova OS, Men'shikov MY, Bashtrykov PP, Berk BC, Tkachuk VA, Parfenova EV. Urokinase induces ROS production in vascular smooth muscle cells. Bull Exp Biol Med. 2006 Sep; 142(3):304-7.

View in: PubMed
Menshikov M, Torosyan N, Elizarova E, Plakida K, Vorotnikov A, Parfyonova Y, Stepanova V, Bobik A, Berk B, Tkachuk V. Urokinase induces matrix metalloproteinase-9/gelatinase B expression in THP-1 monocytes via ERK1/2 and cytosolic phospholipase A2 activation and eicosanoid production. J Vasc Res. 2006; 43(5):482-90.

View in: PubMed
Maekawa N, Abe J, Shishido T, Itoh S, Ding B, Sharma VK, Sheu SS, Blaxall BC, Berk BC. Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation. 2006 May 30; 113(21):2516-23.

View in: PubMed
World CJ, Garin G, Berk B. Vascular shear stress and activation of inflammatory genes. Curr Atheroscler Rep. 2006 May; 8(3):240-4.

View in: PubMed
Korshunov VA, Mohan AM, Georger MA, Berk BC. Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling. Circ Res. 2006 Jun 9; 98(11):1446-52.

View in: PubMed
Hoefen RJ, Berk BC. The multifunctional GIT family of proteins. J Cell Sci. 2006 Apr 15; 119(Pt 8):1469-75.

View in: PubMed
Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J. Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation. 2006 Apr 11; 113(14):1787-98.

View in: PubMed
Suzuki J, Jin ZG, Meoli DF, Matoba T, Berk BC. Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circ Res. 2006 Mar 31; 98(6):811-7.

View in: PubMed
Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C. Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Circ Res. 2006 Mar 31; 98(6):777-84.

View in: PubMed
Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, Tkachuk V, Berk BC. Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):801-7.

View in: PubMed
Berk BC, Korshunov VA. Genetic determinants of vascular remodelling. Can J Cardiol. 2006 Feb; 22 Suppl B:6B-11B.

View in: PubMed
Ibrahim J, Berk BC, Hughes AD. Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Hypertens. 2006 Jan; 28(1):57-72.

View in: PubMed
Natarajan K, Berk BC. Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases. Methods Mol Biol. 2006; 332:51-77.

View in: PubMed
Velarde G, Berk BC. Role of hypertension in the metabolic syndrome: who is affected? Curr Hypertens Rep. 2005 Dec; 7(6):418-26.

View in: PubMed
Korshunov VA, Nikonenko TA, Tkachuk VA, Brooks A, Berk BC. Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening. Arterioscler Thromb Vasc Biol. 2006 Feb; 26(2):295-300.

View in: PubMed
Shen WL, Gao PJ, Che ZQ, Ji KD, Yin M, Yan C, Berk BC, Zhu DL. NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation. Biochem Biophys Res Commun. 2006 Jan 6; 339(1):337-43.

View in: PubMed
Garin G, Mathews M, Berk BC. Tissue-resident bone marrow-derived progenitor cells: key players in hypoxia-induced angiogenesis. Circ Res. 2005 Nov 11; 97(10):955-7.

View in: PubMed
Berk B. The International Society on Thrombosis and Haemostasis--XXth Annual Congress. IDrugs. 2005 Nov; 8(11):904-6.

View in: PubMed
Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14771-6.

View in: PubMed
Watanabe T, Suzuki J, Yamawaki H, Sharma VK, Sheu SS, Berk BC. Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179. Circulation. 2005 Sep 20; 112(12):1798-805.

View in: PubMed
Giles TD, Berk BC, Black HR, Cohn JN, Kostis JB, Izzo JL, Weber MA. Expanding the definition and classification of hypertension. J Clin Hypertens (Greenwich). 2005 Sep; 7(9):505-12.

View in: PubMed
Tai LK, Zheng Q, Pan S, Jin ZG, Berk BC. Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2. J Biol Chem. 2005 Aug 19; 280(33):29620-4.

View in: PubMed
Yin G, Zheng Q, Yan C, Berk BC. GIT1 is a scaffold for ERK1/2 activation in focal adhesions. J Biol Chem. 2005 Jul 29; 280(30):27705-12.

View in: PubMed
Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC. BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha. Circ Res. 2005 Jun 10; 96(11):1145-51.

View in: PubMed
Ding B, Abe J, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Circulation. 2005 May 17; 111(19):2469-76.

View in: PubMed
Blaxall BC, Miano JM, Berk BC. Angiotensin II: a devious activator of mineralocorticoid receptor-dependent gene expression. Circ Res. 2005 Apr 1; 96(6):610-1.

View in: PubMed
Yamawaki H, Berk BC. Thioredoxin: a multifunctional antioxidant enzyme in kidney, heart and vessels. Curr Opin Nephrol Hypertens. 2005 Mar; 14(2):149-53.

View in: PubMed
Yamawaki H, Pan S, Lee RT, Berk BC. Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. J Clin Invest. 2005 Mar; 115(3):733-8.

View in: PubMed
Jin ZG, Wong C, Wu J, Berk BC. Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. J Biol Chem. 2005 Apr 1; 280(13):12305-9.

View in: PubMed
Watanabe T, Barker TA, Berk BC. Angiotensin II and the endothelium: diverse signals and effects. Hypertension. 2005 Feb; 45(2):163-9.

View in: PubMed
Massett MP, Berk BC. Strain-dependent differences in responses to exercise training in inbred and hybrid mice. Am J Physiol Regul Integr Comp Physiol. 2005 Apr; 288(4):R1006-13.

View in: PubMed
Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C. Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. J Mol Cell Cardiol. 2005 Jan; 38(1):175-84.

View in: PubMed
Berk BC, Bisognano JD. VALUE in hypertension treatment. Curr Hypertens Rep. 2004 Dec; 6(6):411-3.

View in: PubMed
Jin ZG, Berk BC. Role of secreted oxidative stress-induced factors (SOXFs) in the pathogenesis of atherosclerosis. Arch Mal Coeur Vaiss. 2004 Dec; 97(12):1256-9.

View in: PubMed
Narins CR, Lin DA, Burton PB, Jin ZG, Berk BC. Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarction. Am J Cardiol. 2004 Nov 15; 94(10):1285-7.

View in: PubMed
Korshunov VA, Solomatina MA, Plekhanova OS, Parfyonova YV, Tkachuk VA, Berk BC. Plasminogen activator expression correlates with genetic differences in vascular remodeling. J Vasc Res. 2004 Nov-Dec; 41(6):481-90.

View in: PubMed
Akaike M, Che W, Marmarosh NL, Ohta S, Osawa M, Ding B, Berk BC, Yan C, Abe J. The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in endothelial cells. Mol Cell Biol. 2004 Oct; 24(19):8691-704.

View in: PubMed
Melaragno MG, Cavet ME, Yan C, Tai LK, Jin ZG, Haendeler J, Berk BC. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. J Mol Cell Cardiol. 2004 Oct; 37(4):881-7.

View in: PubMed
Lungu AO, Jin ZG, Yamawaki H, Tanimoto T, Wong C, Berk BC. Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae. J Biol Chem. 2004 Nov 19; 279(47):48794-800.

View in: PubMed
Korshunov VA, Berk BC. Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined. Circulation. 2004 Jul 13; 110(2):220-6.

View in: PubMed
Parfyonova Y, Plekhanova O, Solomatina M, Naumov V, Bobik A, Berk B, Tkachuk V. Contrasting effects of urokinase and tissue-type plasminogen activators on neointima formation and vessel remodelling after arterial injury. J Vasc Res. 2004 May-Jun; 41(3):268-76.

View in: PubMed
Jin ZG, Lungu AO, Xie L, Wang M, Wong C, Berk BC. Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler Thromb Vasc Biol. 2004 Jul; 24(7):1186-91.

View in: PubMed
Jin ZG, Berk BC. SOXF: redox mediators of vascular smooth muscle cell growth. Heart. 2004 May; 90(5):488-90.

View in: PubMed
Konishi A, Aizawa T, Mohan A, Korshunov VA, Berk BC. Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells. J Biol Chem. 2004 Jul 2; 279(27):28766-70.

View in: PubMed
Osawa M, Itoh S, Ohta S, Huang Q, Berk BC, Marmarosh NL, Che W, Ding B, Yan C, Abe J. ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation. J Biol Chem. 2004 Jul 9; 279(28):29691-9.

View in: PubMed
Natarajan K, Yin G, Berk BC. Scaffolds direct Src-specific signaling in response to angiotensin II: new roles for Cas and GIT1. Mol Pharmacol. 2004 Apr; 65(4):822-5.

View in: PubMed
Tanimoto T, Lungu AO, Berk BC. Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res. 2004 Apr 30; 94(8):1050-8.

View in: PubMed
van Nieuw Amerongen GP, Natarajan K, Yin G, Hoefen RJ, Osawa M, Haendeler J, Ridley AJ, Fujiwara K, van Hinsbergh VW, Berk BC. GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. Circ Res. 2004 Apr 30; 94(8):1041-9.

View in: PubMed
Korshunov VA, Massett MP, Carey RM, Berk BC. Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling. J Vasc Res. 2004 Mar-Apr; 41(2):148-56.

View in: PubMed
Yin G, Haendeler J, Yan C, Berk BC. GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor. Mol Cell Biol. 2004 Jan; 24(2):875-85.

View in: PubMed
Zheng Q, Yin G, Yan C, Cavet M, Berk BC. 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function. J Biol Chem. 2004 Mar 5; 279(10):8787-91.

View in: PubMed
Pi X, Yan C, Berk BC. Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ Res. 2004 Feb 20; 94(3):362-9.

View in: PubMed
Yamawaki H, Haendeler J, Berk BC. Thioredoxin: a key regulator of cardiovascular homeostasis. Circ Res. 2003 Nov 28; 93(11):1029-33.

View in: PubMed
Korshunov VA, Berk BC. Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening. Arterioscler Thromb Vasc Biol. 2003 Dec; 23(12):2185-91.

View in: PubMed
Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC. GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor. J Biol Chem. 2003 Dec 12; 278(50):49936-44.

View in: PubMed
Yamawaki H, Lehoux S, Berk BC. Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo. Circulation. 2003 Sep 30; 108(13):1619-25.

View in: PubMed
Lerner-Marmarosh N, Yoshizumi M, Che W, Surapisitchat J, Kawakatsu H, Akaike M, Ding B, Huang Q, Yan C, Berk BC, Abe J. Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation. Arterioscler Thromb Vasc Biol. 2003 Oct 1; 23(10):1775-81.

View in: PubMed
Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C. Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells. Circ Res. 2003 Sep 5; 93(5):406-13.

View in: PubMed
Jin ZG, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC. Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase. Circ Res. 2003 Aug 22; 93(4):354-63.

View in: PubMed
Konishi A, Berk BC. Epidermal growth factor receptor transactivation is regulated by glucose in vascular smooth muscle cells. J Biol Chem. 2003 Sep 12; 278(37):35049-56.

View in: PubMed
Yin G, Yan C, Berk BC. Angiotensin II signaling pathways mediated by tyrosine kinases. Int J Biochem Cell Biol. 2003 Jun; 35(6):780-3.

View in: PubMed
Berk BC. Angiotensin type 2 receptor (AT2R): a challenging twin. Sci STKE. 2003 May 6; 2003(181):PE16.

View in: PubMed
Ibrahim J, Miyashiro JK, Berk BC. Shear stress is differentially regulated among inbred rat strains. Circ Res. 2003 May 16; 92(9):1001-9.

View in: PubMed
Ogata Y, Takahashi M, Ueno S, Takeuchi K, Okada T, Mano H, Ookawara S, Ozawa K, Berk BC, Ikeda U, Shimada K, Kobayashi E. Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro. Hypertension. 2003 May; 41(5):1156-63.

View in: PubMed
Cavet ME, Lehoux S, Berk BC. 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity. J Biol Chem. 2003 May 16; 278(20):18376-83.

View in: PubMed
Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T. Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases. J Pharmacol Sci. 2003 Mar; 91(3):172-6.

View in: PubMed
Yan C, Kim D, Aizawa T, Berk BC. Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator. Arterioscler Thromb Vasc Biol. 2003 Jan 1; 23(1):26-36.

View in: PubMed
Tai LK, Okuda M, Abe J, Yan C, Berk BC. Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway. Arterioscler Thromb Vasc Biol. 2002 Nov 1; 22(11):1790-6.

View in: PubMed
Hojo Y, Saito Y, Tanimoto T, Hoefen RJ, Baines CP, Yamamoto K, Haendeler J, Asmis R, Berk BC. Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. Circ Res. 2002 Oct 18; 91(8):712-8.

View in: PubMed
Haendeler J, Hoffmann J, Tischler V, Berk BC, Zeiher AM, Dimmeler S. Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. Nat Cell Biol. 2002 Oct; 4(10):743-9.

View in: PubMed
Tanimoto T, Jin ZG, Berk BC. Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J Biol Chem. 2002 Nov 8; 277(45):42997-3001.

View in: PubMed
Abe J, Berk BC. Hypoxia and HIF-1alpha stability: another stress-sensing mechanism for Shc. Circ Res. 2002 Jul 12; 91(1):4-6.

View in: PubMed
Pi X, Yan C, Kim D, Chen J, Berk BC. Differential expression of genes from nitrate-tolerant rat aorta. J Vasc Res. 2002 Jul-Aug; 39(4):304-10.

View in: PubMed
Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J. Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. Circ Res. 2002 Jun 14; 90(11):1222-30.

View in: PubMed
Frame MD, Fox RJ, Kim D, Mohan A, Berk BC, Yan C. Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2377-85.

View in: PubMed
Huang Q, Lerner-Marmarosh N, Che W, Ohta S, Osawa M, Yoshizumi M, Glassman M, Yan C, Berk BC, Abe J. The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation. J Biol Chem. 2002 Aug 9; 277(32):29330-41.

View in: PubMed
Hoefen RJ, Berk BC. The role of MAP kinases in endothelial activation. Vascul Pharmacol. 2002 May; 38(5):271-3.

View in: PubMed
Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC. Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem. 2002 Jun 28; 277(26):23216-22.

View in: PubMed
Saito Y, Berk BC. Angiotensin II-mediated signal transduction pathways. Curr Hypertens Rep. 2002 Apr; 4(2):167-71.

View in: PubMed
Takeishi Y, Huang Q, Abe J, Che W, Lee JD, Kawakatsu H, Hoit BD, Berk BC, Walsh RA. Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy. Cardiovasc Res. 2002 Jan; 53(1):131-7.

View in: PubMed
Abe JI, Che W, Yoshizumi M, Huang Q, Glassman M, Ohta S, Wu Y, Arlinghaus R, Berk BC. Bcr in vascular smooth muscle cells involvement of Ras and Raf-1 activation by Bcr. Ann N Y Acad Sci. 2001 Dec; 947:341-3.

View in: PubMed
Berk BC, Abe JI, Min W, Surapisitchat J, Yan C. Endothelial atheroprotective and anti-inflammatory mechanisms. Ann N Y Acad Sci. 2001 Dec; 947:93-109; discussion 109-11.

View in: PubMed
Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C. Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation. 2001 Nov 6; 104(19):2338-43.

View in: PubMed
Takeishi Y, Huang Q, Wang T, Glassman M, Yoshizumi M, Baines CP, Lee JD, Kawakatsu H, Che W, Lerner-Marmarosh N, Zhang C, Yan C, Ohta S, Walsh RA, Berk BC, Abe J. Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning. J Mol Cell Cardiol. 2001 Nov; 33(11):1989-2005.

View in: PubMed
Saito Y, Haendeler J, Hojo Y, Yamamoto K, Berk BC. Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Mol Cell Biol. 2001 Oct; 21(19):6387-94.

View in: PubMed
Che W, Abe J, Yoshizumi M, Huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, Lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC. p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells. Circulation. 2001 Sep 18; 104(12):1399-406.

View in: PubMed
Takeishi Y, Huang Q, Abe J, Glassman M, Che W, Lee JD, Kawakatsu H, Lawrence EG, Hoit BD, Berk BC, Walsh RA. Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch. J Mol Cell Cardiol. 2001 Sep; 33(9):1637-48.

View in: PubMed
Berk BC. Vascular smooth muscle growth: autocrine growth mechanisms. Physiol Rev. 2001 Jul; 81(3):999-1030.

View in: PubMed
Surapisitchat J, Hoefen RJ, Pi X, Yoshizumi M, Yan C, Berk BC. Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6476-81.

View in: PubMed
Miano JM, Berk BC. Retinoids: new insight into smooth muscle cell growth inhibition. Arterioscler Thromb Vasc Biol. 2001 May; 21(5):724-6.

View in: PubMed
Liu Y, Yin G, Surapisitchat J, Berk BC, Min W. Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3. J Clin Invest. 2001 Apr; 107(7):917-23.

View in: PubMed
Chen K, Vita JA, Berk BC, Keaney JF. c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. J Biol Chem. 2001 May 11; 276(19):16045-50.

View in: PubMed
Lehoux S. 14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange. J Biol Chem. 2001 May 11; 276(19):15794-800.

View in: PubMed
Yan C, Luo H, Lee JD, Abe J, Berk BC. Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains. J Biol Chem. 2001 Apr 6; 276(14):10870-8.

View in: PubMed
Saito Y, Berk BC. Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors. J Mol Cell Cardiol. 2001 Jan; 33(1):3-7.

View in: PubMed
Haendeler J, Berk BC. Angiotensin II mediated signal transduction. Important role of tyrosine kinases. Regul Pept. 2000 Nov 24; 95(1-3):1-7.

View in: PubMed
Ou H, Haendeler J, Aebly MR, Kelly LA, Cholewa BC, Koike G, Kwitek-Black A, Jacob HJ, Berk BC, Miano JM. Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. Circ Res. 2000 Nov 10; 87(10):881-7.

View in: PubMed
Jin ZG, Melaragno MG, Liao DF, Yan C, Haendeler J, Suh YA, Lambeth JD, Berk BC. Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ Res. 2000 Oct 27; 87(9):789-96.

View in: PubMed
Miano JM, Berk BC. Retinoids: versatile biological response modifiers of vascular smooth muscle phenotype. Circ Res. 2000 Sep 1; 87(5):355-62.

View in: PubMed
Berk BC, Haendeler J, Sottile J. Angiotensin II, atherosclerosis, and aortic aneurysms. J Clin Invest. 2000 Jun; 105(11):1525-6.

View in: PubMed
Heeneman S, Haendeler J, Saito Y, Ishida M, Berk BC. Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein Shc. J Biol Chem. 2000 May 26; 275(21):15926-32.

View in: PubMed
Yoshizumi M, Abe J, Haendeler J, Huang Q, Berk BC. Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species. J Biol Chem. 2000 Apr 21; 275(16):11706-12.

View in: PubMed
Haendeler J, Ishida M, Hunyady L, Berk BC. The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways. Circ Res. 2000 Apr 14; 86(7):729-36.

View in: PubMed
Abe J, Baines CP, Berk BC. Role of mitogen-activated protein kinases in ischemia and reperfusion injury : the good and the bad. Circ Res. 2000 Mar 31; 86(6):607-9.

View in: PubMed
Abe J, Okuda M, Huang Q, Yoshizumi M, Berk BC. Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras. J Biol Chem. 2000 Jan 21; 275(3):1739-48.

View in: PubMed
Liao DF, Jin ZG, Baas AS, Daum G, Gygi SP, Aebersold R, Berk BC. Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J Biol Chem. 2000 Jan 7; 275(1):189-96.

View in: PubMed
Takeishi Y, Abe J, Lee JD, Kawakatsu H, Walsh RA, Berk BC. Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts. Circ Res. 1999 Dec 3-17; 85(12):1164-72.

View in: PubMed
Melaragno MG, Fridell YW, Berk BC. The Gas6/Axl system: a novel regulator of vascular cell function. Trends Cardiovasc Med. 1999 Nov; 9(8):250-3.

View in: PubMed
Gallis B, Corthals GL, Goodlett DR, Ueba H, Kim F, Presnell SR, Figeys D, Harrison DG, Berk BC, Aebersold R, Corson MA. Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J Biol Chem. 1999 Oct 15; 274(42):30101-8.

View in: PubMed
Miano JM, Berk BC. NAB2: a transcriptional brake for activated gene expression in the vessel wall? Am J Pathol. 1999 Oct; 155(4):1009-12.

View in: PubMed
Okuda M, Takahashi M, Suero J, Murry CE, Traub O, Kawakatsu H, Berk BC. Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation. J Biol Chem. 1999 Sep 17; 274(38):26803-9.

View in: PubMed
Berk BC. Redox signals that regulate the vascular response to injury. Thromb Haemost. 1999 Aug; 82(2):810-7.

View in: PubMed
Abe J, Berk BC. Fyn and JAK2 mediate Ras activation by reactive oxygen species. J Biol Chem. 1999 Jul 23; 274(30):21003-10.

View in: PubMed
Traub O, Ishida T, Ishida M, Tupper JC, Berk BC. Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel. J Biol Chem. 1999 Jul 16; 274(29):20144-50.

View in: PubMed
Takahashi E, Abe J, Gallis B, Aebersold R, Spring DJ, Krebs EG, Berk BC. p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1. J Biol Chem. 1999 Jul 16; 274(29):20206-14.

View in: PubMed
Peterson TE, Poppa V, Ueba H, Wu A, Yan C, Berk BC. Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Circ Res. 1999 Jul 9; 85(1):29-37.

View in: PubMed
Delehanty JM, Ling FS, Berk BC. If I had an acute coronary syndrome... Lancet. 1999 Jun; 353 Suppl 2:SII24-6.

View in: PubMed
Ishida T, Ishida M, Suero J, Takahashi M, Berk BC. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. J Clin Invest. 1999 Mar; 103(6):789-97.

View in: PubMed
Berk BC. Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases. J Am Soc Nephrol. 1999 Jan; 10 Suppl 11:S62-8.

View in: PubMed
Yan C, Takahashi M, Okuda M, Lee JD, Berk BC. Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium. J Biol Chem. 1999 Jan 1; 274(1):143-50.

View in: PubMed
Takahashi E, Berk BC. MAP kinases and vascular smooth muscle function. Acta Physiol Scand. 1998 Dec; 164(4):611-21.

View in: PubMed
Kusuhara M, Takahashi E, Peterson TE, Abe J, Ishida M, Han J, Ulevitch R, Berk BC. p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2. Circ Res. 1998 Oct 19; 83(8):824-31.

View in: PubMed
Melaragno MG, Wuthrich DA, Poppa V, Gill D, Lindner V, Berk BC, Corson MA. Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats. Circ Res. 1998 Oct 5; 83(7):697-704.

View in: PubMed
Poppa V, Miyashiro JK, Corson MA, Berk BC. Endothelial NO synthase is increased in regenerating endothelium after denuding injury of the rat aorta. Arterioscler Thromb Vasc Biol. 1998 Aug; 18(8):1312-21.

View in: PubMed
Schmitz U, Ishida T, Ishida M, Surapisitchat J, Hasham MI, Pelech S, Berk BC. Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK. Circ Res. 1998 Jun 29; 82(12):1272-8.

View in: PubMed
Traub O, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol. 1998 May; 18(5):677-85.

View in: PubMed
Abe J, Berk BC. Reactive oxygen species as mediators of signal transduction in cardiovascular disease. Trends Cardiovasc Med. 1998 Feb; 8(2):59-64.

View in: PubMed
Ishida M, Ishida T, Thomas SM, Berk BC. Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells. Circ Res. 1998 Jan 9-23; 82(1):7-12.

View in: PubMed
Traub O, Monia BP, Dean NM, Berk BC. PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells. J Biol Chem. 1997 Dec 12; 272(50):31251-7.

View in: PubMed
Nunes GL, Robinson K, Kalynych A, King SB, Sgoutas DS, Berk BC. Vitamins C and E inhibit O2- production in the pig coronary artery. Circulation. 1997 Nov 18; 96(10):3593-601.

View in: PubMed
Schmitz U, Ishida M, Berk BC. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins. Characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells. Circ Res. 1997 Oct; 81(4):550-7.

View in: PubMed
Schmitz U, Berk BC. Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways. Trends Endocrinol Metab. 1997 Sep; 8(7):261-6.

View in: PubMed
Miyashiro JK, Poppa V, Berk BC. Flow-induced vascular remodeling in the rat carotid artery diminishes with age. Circ Res. 1997 Sep; 81(3):311-9.

View in: PubMed
Mondy JS, Lindner V, Miyashiro JK, Berk BC, Dean RH, Geary RL. Platelet-derived growth factor ligand and receptor expression in response to altered blood flow in vivo. Circ Res. 1997 Sep; 81(3):320-7.

View in: PubMed
Abe J, Takahashi M, Ishida M, Lee JD, Berk BC. c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1. J Biol Chem. 1997 Aug 15; 272(33):20389-94.

View in: PubMed
Takahashi E, Abe J, Berk BC. Angiotensin II stimulates p90rsk in vascular smooth muscle cells. A potential Na(+)-H+ exchanger kinase. Circ Res. 1997 Aug; 81(2):268-73.

View in: PubMed
Phan VN, Kusuhara M, Lucchesi PA, Berk BC. A 90-kD Na(+)-H+ exchanger kinase has increased activity in spontaneously hypertensive rat vascular smooth muscle cells. Hypertension. 1997 Jun; 29(6):1265-72.

View in: PubMed
Ishida M, Berk BC. Angiotensin II signal transduction in vascular smooth muscle cells: role of tyrosine kinases. Keio J Med. 1997 Jun; 46(2):61-8.

View in: PubMed
Berk BC, Corson MA. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res. 1997 May; 80(5):607-16.

View in: PubMed
Takahashi M, Ishida T, Traub O, Corson MA, Berk BC. Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress. J Vasc Res. 1997 May-Jun; 34(3):212-9.

View in: PubMed
Wiesner TF, Berk BC, Nerem RM. A mathematical model of the cytosolic-free calcium response in endothelial cells to fluid shear stress. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3726-31.

View in: PubMed
Ishida T, Takahashi M, Corson MA, Berk BC. Fluid shear stress-mediated signal transduction: how do endothelial cells transduce mechanical force into biological responses? Ann N Y Acad Sci. 1997 Apr 15; 811:12-23; discussion 23-4.

View in: PubMed
Liao DF, Monia B, Dean N, Berk BC. Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J Biol Chem. 1997 Mar 7; 272(10):6146-50.

View in: PubMed
Kusuhara M, Chait A, Cader A, Berk BC. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol. 1997 Jan; 17(1):141-8.

View in: PubMed
Takahashi M, Berk BC. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase. J Clin Invest. 1996 Dec 1; 98(11):2623-31.

View in: PubMed
Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res. 1996 Nov; 79(5):984-91.

View in: PubMed
Liao DF, Duff JL, Daum G, Pelech SL, Berk BC. Angiotensin II stimulates MAP kinase kinase kinase activity in vascular smooth muscle cells, Role of Raf. Circ Res. 1996 Nov; 79(5):1007-14.

View in: PubMed
Helmlinger G, Berk BC, Nerem RM. Pulsatile and steady flow-induced calcium oscillations in single cultured endothelial cells. J Vasc Res. 1996 Sep-Oct; 33(5):360-9.

View in: PubMed
Ishida T, Peterson TE, Kovach NL, Berk BC. MAP kinase activation by flow in endothelial cells. Role of beta 1 integrins and tyrosine kinases. Circ Res. 1996 Aug; 79(2):310-6.

View in: PubMed
Abe J, Kusuhara M, Ulevitch RJ, Berk BC, Lee JD. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem. 1996 Jul 12; 271(28):16586-90.

View in: PubMed
Vatner SF, Berk BC, Leinwand LA, Libby P, Schwartz K, Strauss HC. A second term for the editors. Status and goals for the review process. Circ Res. 1996 Jul; 79(1):1-3.

View in: PubMed
Lucchesi PA, Bell JM, Willis LS, Byron KL, Corson MA, Berk BC. Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype. Circ Res. 1996 Jun; 78(6):962-70.

View in: PubMed
Wiesner TF, Berk BC, Nerem RM. A mathematical model of cytosolic calcium dynamics in human umbilical vein endothelial cells. Am J Physiol. 1996 May; 270(5 Pt 1):C1556-69.

View in: PubMed
Berk BC, Corson MA, Peterson TE, Tseng H. Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: a hypothesis for calcium-dependent and calcium-independent events activated by flow. J Biomech. 1995 Dec; 28(12):1439-50.

View in: PubMed
Ishida M, Marrero MB, Schieffer B, Ishida T, Bernstein KE, Berk BC. Angiotensin II activates pp60c-src in vascular smooth muscle cells. Circ Res. 1995 Dec; 77(6):1053-9.

View in: PubMed
Tseng H, Peterson TE, Berk BC. Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Circ Res. 1995 Nov; 77(5):869-78.

View in: PubMed
Marrero MB, Schieffer B, Paxton WG, Duff JL, Berk BC, Bernstein KE. The role of tyrosine phosphorylation in angiotensin II-mediated intracellular signalling. Cardiovasc Res. 1995 Oct; 30(4):530-6.

View in: PubMed
Duff JL, Marrero MB, Paxton WG, Schieffer B, Bernstein KE, Berk BC. Angiotensin II signal transduction and the mitogen-activated protein kinase pathway. Cardiovasc Res. 1995 Oct; 30(4):511-7.

View in: PubMed
Helmlinger G, Berk BC, Nerem RM. Calcium responses of endothelial cell monolayers subjected to pulsatile and steady laminar flow differ. Am J Physiol. 1995 Aug; 269(2 Pt 1):C367-75.

View in: PubMed
Baas AS, Berk BC. Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells. Circ Res. 1995 Jul; 77(1):29-36.

View in: PubMed
Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature. 1995 May 18; 375(6528):247-50.

View in: PubMed
Duff JL, Monia BP, Berk BC. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. Effect of actinomycin D and antisense oligonucleotides. J Biol Chem. 1995 Mar 31; 270(13):7161-6.

View in: PubMed
Fishel RS, Eisenberg S, Shai SY, Redden RA, Bernstein KE, Berk BC. Glucocorticoids induce angiotensin-converting enzyme expression in vascular smooth muscle. Hypertension. 1995 Mar; 25(3):343-9.

View in: PubMed
Lucchesi PA, Berk BC. Regulation of sodium-hydrogen exchange in vascular smooth muscle. Cardiovasc Res. 1995 Feb; 29(2):172-7.

View in: PubMed
Nunes GL, Sgoutas DS, Redden RA, Sigman SR, Gravanis MB, King SB, Berk BC. Combination of vitamins C and E alters the response to coronary balloon injury in the pig. Arterioscler Thromb Vasc Biol. 1995 Jan; 15(1):156-65.

View in: PubMed
Fishel RS, Thourani V, Eisenberg SJ, Shai SY, Corson MA, Nabel EG, Bernstein KE, Berk BC. Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury. J Clin Invest. 1995 Jan; 95(1):377-87.

View in: PubMed
Duff JL, Berk BC. Angiotensin II-mediated signal transduction events in vascular smooth muscle cells: kinases and phosphatases. Blood Press Suppl. 1995; 2:55-60.

View in: PubMed
Berk BC, Harris K. Restenosis after percutaneous transluminal coronary angioplasty: new therapeutic insights from pathogenic mechanisms. Adv Intern Med. 1995; 40:445-501.

View in: PubMed
Lucchesi PA, DeRoux N, Berk BC. Na(+)-H+ exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats. Hypertension. 1994 Dec; 24(6):734-8.

View in: PubMed
Paxton WG, Marrero MB, Klein JD, Delafontaine P, Berk BC, Bernstein KE. The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases. Biochem Biophys Res Commun. 1994 Apr 15; 200(1):260-7.

View in: PubMed
Marrero MB, Paxton WG, Duff JL, Berk BC, Bernstein KE. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells. J Biol Chem. 1994 Apr 8; 269(14):10935-9.

View in: PubMed
Duff JL, Marrero MB, Paxton WG, Charles CH, Lau LF, Bernstein KE, Berk BC. Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells. J Biol Chem. 1993 Dec 15; 268(35):26037-40.

View in: PubMed
Bernstein KE, Berk BC. The biology of angiotensin II receptors. Am J Kidney Dis. 1993 Nov; 22(5):745-54.

View in: PubMed
Schneider JE, Berk BC, Gravanis MB, Santoian EC, Cipolla GD, Tarazona N, Lassegue B, King SB. Probucol decreases neointimal formation in a swine model of coronary artery balloon injury. A possible role for antioxidants in restenosis. Circulation. 1993 Aug; 88(2):628-37.

View in: PubMed
Mitsuka M, Nagae M, Berk BC. Na(+)-H+ exchange inhibitors decrease neointimal formation after rat carotid injury. Effects on smooth muscle cell migration and proliferation. Circ Res. 1993 Aug; 73(2):269-75.

View in: PubMed
Mitsumata M, Fishel RS, Nerem RM, Alexander RW, Berk BC. Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells. Am J Physiol. 1993 Jul; 265(1 Pt 2):H3-8.

View in: PubMed
Rao GN, Sardet C, Pouysségur J, Berk BC. Phosphorylation of Na(+)-H+ antiporter is not stimulated by phorbol ester and acidification in granulocytic HL-60 cells. Am J Physiol. 1993 May; 264(5 Pt 1):C1278-84.

View in: PubMed
Rao GN, Lasségue B, Griendling KK, Alexander RW, Berk BC. Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C. Nucleic Acids Res. 1993 Mar 11; 21(5):1259-63.

View in: PubMed
Corson MA, Berk BC. Growth factors and the vessel wall. Heart Dis Stroke. 1993 Mar-Apr; 2(2):166-70.

View in: PubMed
Berk BC, Rao GN. Angiotensin II-induced vascular smooth muscle cell hypertrophy: PDGF A-chain mediates the increase in cell size. J Cell Physiol. 1993 Feb; 154(2):368-80.

View in: PubMed
Rothman A, Kulik TJ, Taubman MB, Berk BC, Smith CW, Nadal-Ginard B. Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures. Circulation. 1992 Dec; 86(6):1977-86.

View in: PubMed
Duff JL, Berk BC, Corson MA. Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun. 1992 Oct 15; 188(1):257-64.

View in: PubMed
Krug LM, Berk BC. Na+, K(+)-adenosine triphosphatase regulation in hypertrophied vascular smooth muscle cells. Hypertension. 1992 Aug; 20(2):144-50.

View in: PubMed
Shai SY, Fishel RS, Martin BM, Berk BC, Bernstein KE. Bovine angiotensin converting enzyme cDNA cloning and regulation. Increased expression during endothelial cell growth arrest. Circ Res. 1992 Jun; 70(6):1274-81.

View in: PubMed
Geiger RV, Berk BC, Alexander RW, Nerem RM. Flow-induced calcium transients in single endothelial cells: spatial and temporal analysis. Am J Physiol. 1992 Jun; 262(6 Pt 1):C1411-7.

View in: PubMed
Rao GN, Sardet C, Pouysségur J, Berk BC. Na+/H+ antiporter gene expression increases during retinoic acid-induced granulocytic differentiation of HL60 cells. J Cell Physiol. 1992 May; 151(2):361-6.

View in: PubMed
Tseng H, Berk BC. The Na/K/2Cl cotransporter is increased in hypertrophied vascular smooth muscle cells. J Biol Chem. 1992 Apr 25; 267(12):8161-7.

View in: PubMed
Rao GN, Berk BC. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res. 1992 Mar; 70(3):593-9.

View in: PubMed
Corson MA, Alexander RW, Berk BC. 5-HT2 receptor mRNA is overexpressed in cultured rat aortic smooth muscle cells relative to normal aorta. Am J Physiol. 1992 Feb; 262(2 Pt 1):C309-15.

View in: PubMed
Taubman MB, Rollins BJ, Poon M, Marmur J, Green RS, Berk BC, Nadal-Ginard B. JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells. Circ Res. 1992 Feb; 70(2):314-25.

View in: PubMed
Rao GN, de Roux N, Sardet C, Pouysségur J, Berk BC. Na+/H+ antiporter gene expression during monocytic differentiation of HL60 cells. J Biol Chem. 1991 Jul 25; 266(21):13485-8.

View in: PubMed
Berk BC. The microcirculation in coronary ischemia. Are native anticoagulant mechanisms a path to new therapies? Circulation. 1991 Jul; 84(1):439-41.

View in: PubMed
Rao GN, Corson MA, Berk BC. Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression. J Biol Chem. 1991 May 5; 266(13):8604-8.

View in: PubMed
Berk BC, Gordon JB, Alexander RW. Pharmacologic roles of heparin and glucocorticoids to prevent restenosis after coronary angioplasty. J Am Coll Cardiol. 1991 May; 17(6 Suppl B):111B-117B.

View in: PubMed
Liu MW, Berk BC. Restenosis following coronary balloon angioplasty Role of smooth muscle cell proliferation. Trends Cardiovasc Med. 1991 Apr; 1(3):107-11.

View in: PubMed
Berk BC, Taubman MB, Griendling KK, Cragoe EJ, Fenton JW, Brock TA. Thrombin-stimulated events in cultured vascular smooth-muscle cells. Biochem J. 1991 Mar 15; 274 ( Pt 3):799-805.

View in: PubMed
Mitsuka M, Berk BC. Long-term regulation of Na(+)-H+ exchange in vascular smooth muscle cells: role of protein kinase C. Am J Physiol. 1991 Mar; 260(3 Pt 1):C562-9.

View in: PubMed
Rao GN, Sardet C, Pouysségur J, Berk BC. Differential regulation of Na+/H+ antiporter gene expression in vascular smooth muscle cells by hypertrophic and hyperplastic stimuli. J Biol Chem. 1990 Nov 15; 265(32):19393-6.

View in: PubMed
Berk BC, Elder E, Mitsuka M. Hypertrophy and hyperplasia cause differing effects on vascular smooth muscle cell Na+/H+ exchange and intracellular pH. J Biol Chem. 1990 Nov 15; 265(32):19632-7.

View in: PubMed
Berk BC, Taubman MB, Cragoe EJ, Fenton JW, Griendling KK. Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways. J Biol Chem. 1990 Oct 5; 265(28):17334-40.

View in: PubMed
Berk BC, Weintraub WS, Alexander RW. Elevation of C-reactive protein in "active" coronary artery disease. Am J Cardiol. 1990 Jan 15; 65(3):168-72.

View in: PubMed
Griendling KK, Tsuda T, Berk BC, Alexander RW. Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms. Am J Hypertens. 1989 Aug; 2(8):659-65.

View in: PubMed
Berk BC, Vekshtein V, Gordon HM, Tsuda T. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension. 1989 Apr; 13(4):305-14.

View in: PubMed
Berk BC, Vallega G, Muslin AJ, Gordon HM, Canessa M, Alexander RW. Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange. J Clin Invest. 1989 Mar; 83(3):822-9.

View in: PubMed
Berk BC, Alexander RW. Vasoactive effects of growth factors. Biochem Pharmacol. 1989 Jan 15; 38(2):219-25.

View in: PubMed
Taubman MB, Berk BC, Izumo S, Tsuda T, Alexander RW, Nadal-Ginard B. Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation. J Biol Chem. 1989 Jan 5; 264(1):526-30.

View in: PubMed
Griendling KK, Tsuda T, Berk BC, Alexander RW. Angiotensin II stimulation of vascular smooth muscle. J Cardiovasc Pharmacol. 1989; 14 Suppl 6:S27-33.

View in: PubMed
Berk BC, Vallega G, Griendling KK, Gordon JB, Cragoe EJ, Canessa M, Alexander RW. Effects of glucocorticoids on Na+/H+ exchange and growth in cultured vascular smooth muscle cells. J Cell Physiol. 1988 Dec; 137(3):391-401.

View in: PubMed
Griendling KK, Berk BC, Alexander RW. Evidence that Na+/H+ exchange regulates angiotensin II-stimulated diacylglycerol accumulation in vascular smooth muscle cells. J Biol Chem. 1988 Aug 5; 263(22):10620-4.

View in: PubMed
Vallega GA, Canessa ML, Berk BC, Brock TA, Alexander RW. Vascular smooth muscle Na+-H+ exchanger kinetics and its activation by angiotensin II. Am J Physiol. 1988 Jun; 254(6 Pt 1):C751-8.

View in: PubMed
Nabel EG, Berk BC, Brock TA, Smith TW. Na+-Ca2+ exchange in cultured vascular smooth muscle cells. Circ Res. 1988 Mar; 62(3):486-93.

View in: PubMed
Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW. Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth muscle cells. Clin Exp Pharmacol Physiol. 1988 Feb; 15(2):105-12.

View in: PubMed
Berk BC, Canessa M, Vallega G, Alexander RW. Agonist-mediated changes in intracellular pH: role in vascular smooth muscle cell function. J Cardiovasc Pharmacol. 1988; 12 Suppl 5:S104-14.

View in: PubMed
Danthuluri NR, Berk BC, Brock TA, Cragoe EJ, Deth RC. Protein kinase C-mediated intracellular alkalinization in rat and rabbit aortic smooth muscle cells. Eur J Pharmacol. 1987 Sep 23; 141(3):503-6.

View in: PubMed
Griendling KK, Berk BC, Ganz P, Gimbrone MA, Alexander RW. Angiotensin II stimulation of vascular smooth muscle phosphoinositide metabolism. State of the art lecture. Hypertension. 1987 Jun; 9(6 Pt 2):III181-5.

View in: PubMed
Berk BC, Aronow MS, Brock TA, Cragoe E, Gimbrone MA, Alexander RW. Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways. J Biol Chem. 1987 Apr 15; 262(11):5057-64.

View in: PubMed
Berk BC, Brock TA, Gimbrone MA, Alexander RW. Early agonist-mediated ionic events in cultured vascular smooth muscle cells. Calcium mobilization is associated with intracellular acidification. J Biol Chem. 1987 Apr 15; 262(11):5065-72.

View in: PubMed
Berk BC, Alexander RW, Brock TA, Gimbrone MA, Webb RC. Vasoconstriction: a new activity for platelet-derived growth factor. Science. 1986 Apr 4; 232(4746):87-90.

View in: PubMed
Berk BC, Brock TA, Webb RC, Taubman MB, Atkinson WJ, Gimbrone MA, Alexander RW. Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction. J Clin Invest. 1985 Mar; 75(3):1083-6.

View in: PubMed
Berk BC, Hinkle PM. Purification of a stimulator of microtubule assembly from bovine thyroid. J Biol Chem. 1981 Nov 25; 256(22):11859-65.

View in: PubMed
Berk BC, Hinkle PM. Thyroid and brain microtubules: a comparison. J Biol Chem. 1980 Apr 10; 255(7):3186-93.

View in: PubMed