Thomas Gasiewicz
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Environmental Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester NY 14642
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| Title | Chair |
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| Institution | School of Medicine and Dentistry |
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| Department | Environmental Medicine |
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| 1977 |
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| 1980 | National Institutes of Health Postdoctoral Fellowship Award | | 1987 |
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| 1990 | International Life Sciences Institute Research Foundation Award | | 1989 |
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| 1990 | Visiting Associate Professor, Department of Pharmacology, Stanford University | | 1998 |
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| University of Rochester, School of Medicine, Alumni Award for Excellence in Graduate Education | | 1999 |
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| Best Paper in Toxicology and Applied Pharmacology, 1998 | | 2005 |
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| Paper of the Year, Immunotoxicology Specialty Section, Society of Toxicology, 2005 |
Receptor-mediated Modulation of Gene Expression and Association with Biological and Toxic Responses
While genetics is known to influence the initiation, progression, and outcome of a variety of human diseases including cancer, it is clear that these are also influenced to a great extent by a number of other factors. These include, for example, exposure to chemicals in the environment, diet and aging.
The overall goal of the research in this laboratory is to determine how certain chemicals and substances in the diet influence, in both a positive and negative manner, the processes that influence the progression and outcomes of disease.
By understanding the molecular mechanisms by which these factors act, we will also be providing information that can be used in the design of tools for more effective diagnosis and treatment of these diseases.
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Casado FL, Singh KP, Gasiewicz TA. Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration. Mol Pharmacol. 2011 Oct; 80(4):673-82.
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Singh KP, Garrett RW, Casado FL, Gasiewicz TA. Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions. Stem Cells Dev. 2011 May; 20(5):769-84.
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Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Pröschel M, Opanashuk LA. Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Stem Cells Dev. 2011 Feb; 20(2):313-26.
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Casado FL, Singh KP, Gasiewicz TA. The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases. Blood Cells Mol Dis. 2010 Apr 15; 44(4):199-206.
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Laiosa MD, Mills JH, Lai ZW, Singh KP, Middleton FA, Gasiewicz TA, Silverstone AE. Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation. Mol Pharmacol. 2010 May; 77(5):773-83.
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Henry EC, Welle SL, Gasiewicz TA. TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts. Toxicol Sci. 2010 Mar; 114(1):90-100.
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Gasiewicz TA, Singh KP, Casado FL. The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity. Chem Biol Interact. 2010 Mar 19; 184(1-2):246-51.
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Yin Z, Henry EC, Gasiewicz TA. (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor. Biochemistry. 2009 Jan 20; 48(2):336-45.
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Singh KP, Casado FL, Opanashuk LA, Gasiewicz TA. The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations. Biochem Pharmacol. 2009 Feb 15; 77(4):577-87.
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Singh KP, Wyman A, Casado FL, Garrett RW, Gasiewicz TA. Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells. Carcinogenesis. 2009 Jan; 30(1):11-9.
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Vezina CM, Allgeier SH, Moore RW, Lin TM, Bemis JC, Hardin HA, Gasiewicz TA, Peterson RE. Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate. Toxicol Sci. 2008 Dec; 106(2):488-96.
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Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. J Biol Chem. 2008 Oct 24; 283(43):28944-57.
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Henry EC, Gasiewicz TA. Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor. Arch Biochem Biophys. 2008 Apr 15; 472(2):77-88.
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Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA. 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicol Sci. 2008 May; 103(1):125-36.
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Gasiewicz TA, Henry EC, Collins LL. Expression and activity of aryl hydrocarbon receptors in development and cancer. Crit Rev Eukaryot Gene Expr. 2008; 18(4):279-321.
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Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J Bone Miner Res. 2007 Oct; 22(10):1571-80.
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Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am J Pathol. 2007 Mar; 170(3):855-64.
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Bemis JC, Alejandro NF, Nazarenko DA, Brooks AI, Baggs RB, Gasiewicz TA. TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue. Toxicol Sci. 2007 Jan; 95(1):240-8.
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Garrett RW, Gasiewicz TA. The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin alters the circadian rhythms, quiescence, and expression of clock genes in murine hematopoietic stem and progenitor cells. Mol Pharmacol. 2006 Jun; 69(6):2076-83.
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Kim SH, Henry EC, Kim DK, Kim YH, Shin KJ, Han MS, Lee TG, Kang JK, Gasiewicz TA, Ryu SH, Suh PG. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun; 69(6):1871-8.
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Henry EC, Bemis JC, Henry O, Kende AS, Gasiewicz TA. A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Arch Biochem Biophys. 2006 Jun 1; 450(1):67-77.
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Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65.
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Bemis JC, Nazarenko DA, Gasiewicz TA. Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. Toxicol Sci. 2005 Oct; 87(2):529-36.
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Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005 Sep; 289(3):L391-9.
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Palermo CM, Westlake CA, Gasiewicz TA. Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein. Biochemistry. 2005 Apr 5; 44(13):5041-52.
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Williamson MA, Gasiewicz TA, Opanashuk LA. Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity. Toxicol Sci. 2005 Feb; 83(2):340-8.
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Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 2004 Jun; 25(4):605-16.
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Minsavage GD, Park SK, Gasiewicz TA. The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation. J Biol Chem. 2004 May 14; 279(20):20582-93.
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Laiosa MD, Wyman A, Murante FG, Fiore NC, Staples JE, Gasiewicz TA, Silverstone AE. Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor. J Immunol. 2003 Nov 1; 171(9):4582-91.
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Joiakim A, Mathieu PA, Palermo C, Gasiewicz TA, Reiners JJ. The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. Drug Metab Dispos. 2003 Nov; 31(11):1279-82.
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Zhou J, Gasiewicz TA. 3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism. Arch Biochem Biophys. 2003 Aug 1; 416(1):68-80.
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Palermo CM, Hernando JI, Dertinger SD, Kende AS, Gasiewicz TA. Identification of potential aryl hydrocarbon receptor antagonists in green tea. Chem Res Toxicol. 2003 Jul; 16(7):865-72.
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Minsavage GD, Vorojeikina DP, Gasiewicz TA. Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements. Arch Biochem Biophys. 2003 Apr 1; 412(1):95-105.
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Zhou JG, Henry EC, Palermo CM, Dertinger SD, Gasiewicz TA. Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. Mol Pharmacol. 2003 Apr; 63(4):915-24.
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Henry EC, Gasiewicz TA. Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis. Mol Pharmacol. 2003 Feb; 63(2):392-400.
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Laiosa MD, Lai ZW, Thurmond TS, Fiore NC, DeRossi C, Holdener BC, Gasiewicz TA, Silverstone AE. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicol Sci. 2002 Sep; 69(1):117-24.
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Wyman A, Lavin AL, Wilding GE, Gasiewicz TA. 2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system. Toxicol Appl Pharmacol. 2002 May 1; 180(3):164-77.
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Nazarenko DA, Dertinger SD, Gasiewicz TA. In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice. Toxicol Sci. 2001 Jun; 61(2):256-64.
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Nazarenko DA, Dertinger SD, Gasiewicz TA. Enhanced detection of beta-galactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates. Biotechniques. 2001 Apr; 30(4):776-7, 780-1.
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Dertinger SD, Nazarenko DA, Silverstone AE, Gasiewicz TA. Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. Carcinogenesis. 2001 Jan; 22(1):171-7.
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Thurmond TS, Gasiewicz TA. A single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin produces a time- and dose-dependent alteration in the murine bone marrow B-lymphocyte maturation profile. Toxicol Sci. 2000 Nov; 58(1):88-95.
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Lai ZW, Fiore NC, Hahn PJ, Gasiewicz TA, Silverstone AE. Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture. Toxicol Appl Pharmacol. 2000 Oct 1; 168(1):15-24.
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Park S, Henry EC, Gasiewicz TA. Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation. Arch Biochem Biophys. 2000 Sep 15; 381(2):302-12.
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Dertinger SD, Lantum HB, Silverstone AE, Gasiewicz TA. Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. Biochem Pharmacol. 2000 Jul 15; 60(2):189-96.
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Thurmond TS, Murante FG, Staples JE, Silverstone AE, Korach KS, Gasiewicz TA. Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse. Endocrinology. 2000 Jul; 141(7):2309-18.
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Thurmond TS, Staples JE, Silverstone AE, Gasiewicz TA. The aryl hydrocarbon receptor has a role in the in vivo maturation of murine bone marrow B lymphocytes and their response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 2000 Jun 15; 165(3):227-36.
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Murante FG, Gasiewicz TA. Hemopoietic progenitor cells are sensitive targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J mice. Toxicol Sci. 2000 Apr; 54(2):374-83.
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Dertinger SD, Torous DK, Hall NE, Tometsko CR, Gasiewicz TA. Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry. Mutat Res. 2000 Jan 24; 464(2):195-200.
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Gasiewicz TA, Thurmond TS, Staples JE, Murante FG, Silverstone AE. Use of bone marrow chimeras to identify cell targets in the immune system for the actions of chemicals. Ann N Y Acad Sci. 2000; 919:300-3.
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Yudt MR, Vorojeikina D, Zhong L, Skafar DF, Sasson S, Gasiewicz TA, Notides AC. Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation. Biochemistry. 1999 Oct 26; 38(43):14146-56.
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Staples JE, Gasiewicz TA, Fiore NC, Lubahn DB, Korach KS, Silverstone AE. Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations. J Immunol. 1999 Oct 15; 163(8):4168-74.
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Thurmond TS, Silverstone AE, Baggs RB, Quimby FW, Staples JE, Gasiewicz TA. A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1999 Jul 1; 158(1):33-40.
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Henry EC, Kende AS, Rucci G, Totleben MJ, Willey JJ, Dertinger SD, Pollenz RS, Jones JP, Gasiewicz TA. Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation. Mol Pharmacol. 1999 Apr; 55(4):716-25.
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Dertinger SD, Silverstone AE, Gasiewicz TA. Influence of aromatic hydrocarbon receptor-mediated events on the genotoxicity of cigarette smoke condensate. Carcinogenesis. 1998 Nov; 19(11):2037-42.
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Willey JJ, Stripp BR, Baggs RB, Gasiewicz TA. Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice. Toxicol Appl Pharmacol. 1998 Jul; 151(1):33-44.
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Staples JE, Fiore NC, Frazier DE, Gasiewicz TA, Silverstone AE. Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1998 Jul; 151(1):200-10.
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Staples JE, Murante FG, Fiore NC, Gasiewicz TA, Silverstone AE. Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells. J Immunol. 1998 Apr 15; 160(8):3844-54.
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Lavin AL, Hahn DJ, Gasiewicz TA. Expression of functional aromatic hydrocarbon receptor and aromatic hydrocarbon nuclear translocator proteins in murine bone marrow stromal cells. Arch Biochem Biophys. 1998 Apr 1; 352(1):9-18.
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Lai ZW, Fiore NC, Gasiewicz TA, Silverstone AE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture. Toxicol Appl Pharmacol. 1998 Apr; 149(2):167-77.
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Henry EC, Kent TA, Gasiewicz TA. DNA binding and transcriptional enhancement by purified TCDD.Ah receptor complex. Arch Biochem Biophys. 1997 Mar 15; 339(2):305-14.
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Gasiewicz TA. Dioxins and the Ah receptor: probes to uncover processes in neuroendocrine development. Neurotoxicology. 1997; 18(2):393-413.
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Gasiewicz TA, Kende AS, Rucci G, Whitney B, Willey JJ. Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds. Biochem Pharmacol. 1996 Dec 13; 52(11):1787-803.
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Germolec DR, Henry EC, Maronpot R, Foley JF, Adams NH, Gasiewicz TA, Luster MI. Induction of CYP1A1 and ALDH-3 in lymphoid tissues from Fisher 344 rats exposed to 2,3,7,8-tetrachlorodibenzodioxin (TCDD). Toxicol Appl Pharmacol. 1996 Mar; 137(1):57-66.
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DeVito MJ, Birnbaum LS, Farland WH, Gasiewicz TA. Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals. Environ Health Perspect. 1995 Sep; 103(9):820-31.
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White TE, Rucci G, Liu Z, Gasiewicz TA. Weanling female Sprague-Dawley rats are not sensitive to the antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol. 1995 Aug; 133(2):313-20.
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Mahon MJ, Gasiewicz TA. Ah receptor phosphorylation: localization of phosphorylation sites to the C-terminal half of the protein. Arch Biochem Biophys. 1995 Apr 1; 318(1):166-74.
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Bradfield CA, Gallo MA, Gasiewicz TA, Greenberg RS, Greenlee WF, Margolick J, Mattison DR, Munson P, Neal RA, Okey AB, et al. EPA dioxin reassessment. Science. 1994 Dec 9; 266(5191):1628-9.
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Henry EC, Rucci G, Gasiewicz TA. Purification to homogeneity of the heteromeric DNA-binding form of the aryl hydrocarbon receptor from rat liver. Mol Pharmacol. 1994 Dec; 46(6):1022-7.
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Frazier DE, Silverstone AE, Gasiewicz TA. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced thymic atrophy and lymphocyte stem cell alterations by mechanisms independent of the estrogen receptor. Biochem Pharmacol. 1994 Jun 1; 47(11):2039-48.
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Silverstone AE, Frazier DE, Fiore NC, Soults JA, Gasiewicz TA. Dexamethasone, beta-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets. Toxicol Appl Pharmacol. 1994 Jun; 126(2):248-59.
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Frazier DE, Silverstone AE, Soults JA, Gasiewicz TA. The thymus does not mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin-elicited alterations in bone marrow lymphocyte stem cells. Toxicol Appl Pharmacol. 1994 Feb; 124(2):242-7.
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Silverstone AE, Frazier DE, Gasiewicz TA. Alternate immune system targets for TCDD: lymphocyte stem cells and extrathymic T-cell development. Exp Clin Immunogenet. 1994; 11(2-3):94-101.
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Henry EC, Gasiewicz TA. Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem J. 1993 Aug 15; 294 ( Pt 1):95-101.
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White TE, Gasiewicz TA. The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Biophys Res Commun. 1993 Jun 30; 193(3):956-62.
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Mahon MJ, Gasiewicz TA. Chelatable metal ions are not required for aryl hydrocarbon receptor transformation to a DNA binding form: phenanthrolines are possible competitive antagonists of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys. 1992 Aug 15; 297(1):1-8.
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Henry EC, Hayden KA, Bauman PA, Gasiewicz TA. Ribonuclease inhibits Ah receptor transformation in vitro. Biochem J. 1991 Nov 1; 279 ( Pt 3):689-94.
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Gasiewicz TA, Rucci G. Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor. Mol Pharmacol. 1991 Nov; 40(5):607-12.
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Henry EC, Gasiewicz TA. Inhibition and reconstitution of Ah receptor transformation in vitro: role and partial characterization of a cytosolic factor(s). Arch Biochem Biophys. 1991 Jul; 288(1):149-56.
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Gasiewicz TA, Elferink CJ, Henry EC. Characterization of multiple forms of the Ah receptor: recognition of a dioxin-responsive enhancer involves heteromer formation. Biochemistry. 1991 Mar 19; 30(11):2909-16.
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Hahn ME, Gasiewicz TA. Determination of individual porphyrins in rodent urine using high-performance liquid chromatography following clean-up by anion-exchange chromatography. J Chromatogr. 1991 Feb 15; 563(2):363-8.
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Elferink CJ, Gasiewicz TA, Whitlock JP. Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric. J Biol Chem. 1990 Nov 25; 265(33):20708-12.
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Ryan JJ, Gasiewicz TA, Brown JF. Human body burden of polychlorinated dibenzofurans associated with toxicity based on the yusho and yucheng incidents. Fundam Appl Toxicol. 1990 Nov; 15(4):722-31.
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Fine JS, Gasiewicz TA, Fiore NC, Silverstone AE. Prothymocyte activity is reduced by perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. J Pharmacol Exp Ther. 1990 Oct; 255(1):128-32.
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Fine JS, Silverstone AE, Gasiewicz TA. Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol. 1990 Feb 15; 144(4):1169-76.
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Ackermann MF, Gasiewicz TA, Lamm KR, Germolec DR, Luster MI. Selective inhibition of polymorphonuclear neutrophil activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1989 Dec; 101(3):470-80.
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Henry EC, Rucci G, Gasiewicz TA. Characterization of multiple forms of the Ah receptor: comparison of species and tissues. Biochemistry. 1989 Jul 25; 28(15):6430-40.
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Hahn ME, Goldstein JA, Linko P, Gasiewicz TA. Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist. Arch Biochem Biophys. 1989 Apr; 270(1):344-55.
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Fine JS, Gasiewicz TA, Silverstone AE. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol. 1989 Jan; 35(1):18-25.
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Silbergeld EK, Gasiewicz TA. Dioxins and the Ah receptor. Am J Ind Med. 1989; 16(4):455-74.
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Rucci G, Gasiewicz TA. In vivo kinetics and DNA-binding properties of the Ah receptor in the golden Syrian hamster. Arch Biochem Biophys. 1988 Aug 15; 265(1):197-207.
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Hahn ME, Gasiewicz TA, Linko P, Goldstein JA. The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice. Biochem J. 1988 Aug 15; 254(1):245-54.
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Henry EC, Kester JE, Gasiewicz TA. Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complex. Biochim Biophys Acta. 1988 Mar 17; 964(3):361-76.
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Kester JE, Gasiewicz TA. Influence of proteinase inhibitors and substrates on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-binding capacity of the rat hepatic Ah receptor. Biochim Biophys Acta. 1987 Aug 13; 925(2):109-16.
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Blank JA, Tucker AN, Sweatlock J, Gasiewicz TA, Luster MI. alpha-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression. Mol Pharmacol. 1987 Jul; 32(1):169-72.
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Henry EC, Gasiewicz TA. Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1987 Jun 30; 89(2):165-74.
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Gasiewicz TA, Bauman PA. Heterogeneity of the rat hepatic Ah receptor and evidence for transformation in vitro and in vivo. J Biol Chem. 1987 Feb 15; 262(5):2116-20.
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Kester JE, Gasiewicz TA. Characterization of the in vitro stability of the rat hepatic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Arch Biochem Biophys. 1987 Feb 1; 252(2):606-25.
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Gasiewicz TA, Rucci G, Henry EC, Baggs RB. Changes in hamster hepatic cytochrome P-450, ethoxycoumarin O-deethylase, and reduced NAD(P): menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial dissociation of temporal and dose-response relationships from elicited toxicity. Biochem Pharmacol. 1986 Aug 15; 35(16):2737-42.
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Lu CJ, Redmond D, Baggs RB, Schecter A, Gasiewicz TA. Growth and hepatic composition in the guinea pig after long-term parenteral hyperalimentation. Am J Physiol. 1986 Aug; 251(2 Pt 2):R388-97.
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Henry EC, Gasiewicz TA. Effects of thyroidectomy on the Ah receptor and enzyme inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver. Chem Biol Interact. 1986 Jul-Aug; 59(1):29-42.
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Huang Lu CJ, Baggs RB, Redmond D, Henry EC, Schecter A, Gasiewicz TA. Toxicity and evidence for metabolic alterations in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated guinea pigs fed by total parenteral nutrition. Toxicol Appl Pharmacol. 1986 Jul; 84(3):439-53.
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Linko P, Yeowell HN, Gasiewicz TA, Goldstein JA. Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice. J Biochem Toxicol. 1986 Jun; 1(2):95-107.
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Goldstein JA, Linko P, Hahn ME, Gasiewicz TA, Yeowell HN. Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat. IARC Sci Publ. 1986; (77):519-26.
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Gasiewicz TA, Rucci G. Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species. Mol Pharmacol. 1984 Jul; 26(1):90-8.
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Gasiewicz TA, Rucci G. Examination and rapid analysis of hepatic cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using gel-permeation high performance liquid chromatography. Biochim Biophys Acta. 1984 Mar 22; 798(1):37-45.
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Gasiewicz TA, Ness WC, Rucci G. Ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver, lung, and thymus. Biochem Biophys Res Commun. 1984 Jan 13; 118(1):183-90.
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Gasiewicz TA, Geiger LE, Rucci G, Neal RA. Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice. Drug Metab Dispos. 1983 Sep-Oct; 11(5):397-403.
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Gasiewicz TA, Neal RA. The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using hydroxylapatite. Anal Biochem. 1982 Jul 15; 124(1):1-11.
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Neal RA, Olson JR, Gasiewicz TA, Geiger LE. The toxicokinetics of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian systems. Drug Metab Rev. 1982; 13(3):355-85.
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Swift LL, Gasiewicz TA, Dunn GD, Soulé PD, Neal RA. Characterization of the hyperlipidemia in guinea pigs induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1981 Jul; 59(3):489-99.
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Olson JR, Gasiewicz TA, Neal RA. Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster. Toxicol Appl Pharmacol. 1980 Oct; 56(1):78-85.
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Gasiewicz TA, Holscher MA, Neal RA. The effect of total parenteral nutrition on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Toxicol Appl Pharmacol. 1980 Jul; 54(3):469-88.
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Gasiewicz TA, Neal RA. 2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs. Toxicol Appl Pharmacol. 1979 Nov; 51(2):329-39.
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Neal RA, Beatty PW, Gasiewicz TA. Studies of the mechanisms of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ann N Y Acad Sci. 1979 May 31; 320:204-13.
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Gasiewicz TA, Smith JC. Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitro. Chem Biol Interact. 1978 Nov; 23(2):171-83.
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Gasiewicz TA, Smith JC. Interaction between cadmium and selenium in rat plasma. Environ Health Perspect. 1978 Aug; 25:133-6.
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Gasiewicz TA, Smith JC. The metabolism of selenite by intact rat erythrocytes in vitro. Chem Biol Interact. 1978 Jun; 21(2-3):299-313.
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Gasiewicz TA, Smith JC. Interactions of cadmium and selenium in rat plasma in vivo and in vitro. Biochim Biophys Acta. 1976 Mar 25; 428(1):113-121.
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