K. Hartmut Land
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Genetics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester NY 14642
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| Title | Chairman |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Genetics |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biochemistry and Biophysics |
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| 1982 |
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| 1985 | Postdoctoral Fellow of the Deutsche Forschungsgemeinschaft | | 1996 |
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| Elected Member of the European Molecular Biology Organization (EMBO) | | 2003 |
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| Selected ISI highly cited Investigator (http://isihighlycited.com/) | placed among the 250 most highly cited investigators in |
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McMurray HR, Sampson ER, Compitello G, Kinsey C, Newman L, Smith B, Chen SR, Klebanov L, Salzman P, Yakovlev A, Land H. Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. Nature. 2008 Jun 19; 453(7198):1112-6.
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Xia M, Land H. Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility. Nat Struct Mol Biol. 2007 Mar; 14(3):215-23.
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Deleu L, Shellard S, Alevizopoulos K, Amati B, Land H. Recruitment of TRRAP required for oncogenic transformation by E1A. Oncogene. 2001 Dec 13; 20(57):8270-5.
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Roper E, Weinberg W, Watt FM, Land H. p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes. EMBO Rep. 2001 Feb; 2(2):145-50.
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Perez-Roger I, Kim SH, Griffiths B, Sewing A, Land H. Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1). EMBO J. 1999 Oct 1; 18(19):5310-20.
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Sewing A, Wiseman B, Lloyd AC, Land H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol. 1997 Sep; 17(9):5588-97.
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Pérez-Roger I, Solomon DL, Sewing A, Land H. Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes. Oncogene. 1997 May 22; 14(20):2373-81.
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Lloyd AC, Obermüller F, Staddon S, Barth CF, McMahon M, Land H. Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev. 1997 Mar 1; 11(5):663-77.
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Bhakoo KK, Williams SR, Florian CL, Land H, Noble MD. Immortalization and transformation are associated with specific alterations in choline metabolism. Cancer Res. 1996 Oct 15; 56(20):4630-5.
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Solomon DL, Philipp A, Land H, Eilers M. Expression of cyclin D1 mRNA is not upregulated by Myc in rat fibroblasts. Oncogene. 1995 Nov 2; 11(9):1893-7.
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Land H. Transformation of primary rat embryo cells. Methods Enzymol. 1995; 254:37-41.
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Amati B, Land H. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev. 1994 Feb; 4(1):102-8.
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Amati B, Littlewood TD, Evan GI, Land H. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 1993 Dec 15; 12(13):5083-7.
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Solomon DL, Amati B, Land H. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 1993 Nov 25; 21(23):5372-6.
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Mathew PA, Garni-Wagner BA, Land K, Takashima A, Stoneman E, Bennett M, Kumar V. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15; 151(10):5328-37.
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Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell. 1993 Jan 29; 72(2):233-45.
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Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature. 1992 Oct 1; 359(6394):423-6.
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Littlewood TD, Amati B, Land H, Evan GI. Max and c-Myc/Max DNA-binding activities in cell extracts. Oncogene. 1992 Sep; 7(9):1783-92.
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Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. Induction of apoptosis in fibroblasts by c-myc protein. Cell. 1992 Apr 3; 69(1):119-28.
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Penn LJ, Brooks MW, Laufer EM, Littlewood TD, Morgenstern JP, Evan GI, Lee WM, Land H. Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping. Mol Cell Biol. 1990 Sep; 10(9):4961-6.
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Bögler O, Wren D, Barnett SC, Land H, Noble M. Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6368-72.
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Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 1990 Jun 25; 18(12):3587-96.
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Wiehle RD, Helftenbein G, Land H, Neumann K, Beato M. Establishment of rat endometrial cell lines by retroviral mediated transfer of immortalizing and transforming oncogenes. Oncogene. 1990 Jun; 5(6):787-94.
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Penn LJ, Brooks MW, Laufer EM, Land H. Negative autoregulation of c-myc transcription. EMBO J. 1990 Apr; 9(4):1113-21.
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Morgenstern JP, Land H. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res. 1990 Feb 25; 18(4):1068.
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Penn LJ, Laufer EM, Land H. C-MYC: evidence for multiple regulatory functions. Semin Cancer Biol. 1990 Feb; 1(1):69-80.
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von Deimling A, Aguzzi A, Kleihues P, Land H, Wiestler OD. [Induction of primitive neuroectodermal tumors by oncogene complementation]. Verh Dtsch Ges Pathol. 1990; 74:432-6.
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Noble M, Barnett SC, Bögler O, Land H, Wolswijk G, Wren D. Control of division and differentiation in oligodendrocyte-type-2 astrocyte progenitor cells. Ciba Found Symp. 1990; 150:227-43; discussion 244-9.
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Ridley AJ, Davis JB, Stroobant P, Land H. Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells. J Cell Biol. 1989 Dec; 109(6 Pt 2):3419-24.
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Beddington RS, Morgernstern J, Land H, Hogan A. An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis. Development. 1989 May; 106(1):37-46.
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Compere SJ, Baldacci P, Sharpe AH, Thompson T, Land H, Jaenisch R. The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors. Proc Natl Acad Sci U S A. 1989 Apr; 86(7):2224-8.
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Thompson TC, Southgate J, Kitchener G, Land H. Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ. Cell. 1989 Mar 24; 56(6):917-30.
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Ridley AJ, Paterson HF, Noble M, Land H. Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation. EMBO J. 1988 Jun; 7(6):1635-45.
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Land H, Chen AC, Morgenstern JP, Parada LF, Weinberg RA. Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts. Mol Cell Biol. 1986 Jun; 6(6):1917-25.
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Parada LF, Land H, Chen A, Morganstern J, Weinberg RA. Cooperation between cellular oncogenes in the transformation of primary rat embryo fibroblasts. Prog Med Virol. 1985; 32:115-28.
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Parada LF, Land H, Weinberg RA, Wolf D, Rotter V. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature. 1984 Dec 13-19; 312(5995):649-51.
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Lenoir GM, Land H, Parada LF, Cunningham JM, Weinberg RA. Activated oncogenes in Burkitt's lymphoma. Curr Top Microbiol Immunol. 1984; 113:6-14.
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Land H, Parada LF, Weinberg RA. Cellular oncogenes and multistep carcinogenesis. Science. 1983 Nov 18; 222(4625):771-8.
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Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature. 1983 Aug 18-24; 304(5927):596-602.
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Meier F, Land H. [Use and process evaluation of a self control program in enuresis diurna]. Prax Kinderpsychol Kinderpsychiatr. 1983 Jul; 32(5):181-6.
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Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D, Schütz G. Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA. Nature. 1983 Mar 24-30; 302(5906):342-4.
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Land H, Grez M, Hauser H, Lindenmaier W, Schütz G. Synthesis of ds-cDNA involving addition of dCMP tails to allow cloning of 5'-terminal m RNA sequences. Methods Enzymol. 1983; 100:285-92.
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Land H, Schütz G, Schmale H, Richter D. Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor. Nature. 1982 Jan 28; 295(5847):299-303.
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Grez M, Land H, Giesecke K, Schütz G, Jung A, Sippel AE. Multiple mRNAs are generated from the chicken lysozyme gene. Cell. 1981 Sep; 25(3):743-52.
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Land H, Grez M, Hauser H, Lindenmaier W, Schütz G. 5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency. Nucleic Acids Res. 1981 May 25; 9(10):2251-66.
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Lindenmaier W, Nguyen-Huu MC, Stratmann LM, Blin N, Wurtz T, Hauser HJ, Giesecke K, Land H, Jeep S, Grez M, Sippel AE, Schütz G. The isolation and characterization of the chicken lysozyme and ovomucoid gene. J Steroid Biochem. 1980 Jan; 12:211-8.
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Lindenmaier W, Nguyen-Huu MC, Lurz R, Blin N, Stratmann M, Land H, Jeep S, Sippel AE, Schütz G. Isolation and characterization of the chicken ovomucoid gene. Nucleic Acids Res. 1979 Nov 10; 7(5):1221-32.
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Nguyen-Huu MC, Stratmann M, Groner B, Wurtz T, Land H, Giesecke K, Sippel AE, Schütz G. Chicken lysozyme gene contains several intervening sequences. Proc Natl Acad Sci U S A. 1979 Jan; 76(1):76-80.
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Hofer E, Land H, Sekeris CE, Morris HP. Messenger RNA activities for two liver enzymes, tyrosine aminotransferase and tryptophan oxygenase, in Morris hepatoma 5123C and 9618A and in HTC cells. Correlation with enzyme activities. Eur J Biochem. 1978 Nov 2; 91(1):223-9.
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Sippel AE, Land H, Lindenmaier W, Nguyen-Huu MC, Wurtz T, Timmis KN, Giesecke K, Schütz G. Cloning of chicken lysozyme structural gene sequences synthesized in vitro. Nucleic Acids Res. 1978 Sep; 5(9):3275-94.
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Land H, Hofer E, Sekeris CE. Differential behavior of two dexamethasone induced mRNA activities in HTC cells in response to cordycepin and to withdrawal of hormone. Biochem Biophys Res Commun. 1978 Jul 28; 83(2):607-15.
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Land H, Schäfer KP. In vitro synthesis and stability of RNA in isolated nuclei from bovine lymphocytes. Biochem Biophys Res Commun. 1977 Dec 7; 79(3):947-57.
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