Brendan Boyce
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pathology and Laboratory Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics |
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| 1977 |
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| Jean Mackintosh Traveling Research Fellowship (Glasgow, Scotland) | | 1986 |
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| 1987 | Peel International Research Fellowship (London, England) | | 1986 |
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| 1987 | Pathological Society Travel Award (London, England) | | 1986 |
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| 1987 | McCunn Trust Traveling Fellowship (Glasgow, Scotland) | | 1993 |
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| Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Hong Chen (post-doc fellow in my lab) | | 1996 |
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| Young Investigator of Year Award fr Amer. Society for Bone & Mineral Research to Dr. Lianping Xing (post-doc fellow in my lab) | | 1997 |
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| Most Outstanding Abstract of Mtg President's Award fr. Amer. Soc Bone & Min Res Drs L Xing, G Franzoso, U Siebenlist & BF Boyce | | 1998 |
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| Travel Award From American Society for Bone and Mineral Research to Dr. Sheela Rani (post-doctoral fellow in my lab) | | 1999 |
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| Member, Board of Directors International Society of Bone Morphometry | | 1999 |
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| New Investigator Award From Orthopaedic Research Society to Dr. Lianping Xing (post-doctoral fellow in my lab) | | 2000 |
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| Travel Award From American Society for Bone and Mineral Research to Dr. Lianping Xing from my lab | | 2001 |
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| 2007 | Council Member Association of Osteobiology | | 2002 |
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| 2006 | President International Society of Bone Morphometry | | 2003 |
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| 2006 | Secretary/Treasurer, Association of Osteobiology | | 2005 |
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| Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab) | | 2005 |
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| Young Investigator of Year Award from International Society of Bone Morphometry to Dr. Zhenqiang Yao (post-doc fellow in my lab) | | 2007 |
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| Vice Chair, Gordon Research Conference on Bone and Teeth | | 2007 |
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| Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab) | | 2009 |
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| Chair, Gordon Research Conference on Bones and Teeth | | 2010 |
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| Treasurer, United States Biological Stain Commission | | 2010 |
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| Secretary/Treasurer-Elect, American Society for Bone & Mineral Research |
The major focus of research in my lab is study of the regulation of the formation, activation and survival of osteoclasts, the cells that resorb bone. In recent years, many genes have been identified as regulators of these aspects of osteoclast function, and our studies presently are focused on the roles of NF-kappaB and src tyrosine kinase in osteoclasts. My colleague, Dr. Lianping Xing, and I, along with members of the Center for Musculoskeletal Research at the University, are studying the roles of these gene products in the increased bone resorption and decreased bone formation that characterize a number of bone diseases, including postmenopausal osteoporosis, inflammatory joint disease, metastatic bone disease and loosening of joint prostheses. We are also studying the effects of a number of potential drug development compounds developed by ARIAD Pharmaceuticals on bone resorption and bone formation, using a number of models of human bone diseases. NF-kappaB also appears to regulate chondrocyte differentiation, and we are studying its role in endochondral ossification. We acknowledge funding from the National Institutes of Health to support our studies.
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Xing L, Xiu Y, Boyce BF. Osteoclast fusion and regulation by RANKL-dependent and independent factors. World J Orthop. 2012 Dec 18; 3(12):212-22.
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Boyce BF, Rosenberg E, de Papp AE, Duong le T. The osteoclast, bone remodelling and treatment of metabolic bone disease. Eur J Clin Invest. 2012 Dec; 42(12):1332-41.
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Zhao C, Xiu Y, Ashton J, Xing L, Morita Y, Jordan CT, Boyce BF. Noncanonical NF-?B Signaling Regulates Hematopoietic Stem Cell Self-Renewal and Microenvironment Interactions. Stem Cells. 2012 Apr; 30(4):709-18.
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Subik K, Shu L, Wu C, Liang Q, Hicks D, Boyce B, Schiffhauer L, Chen D, Chen C, Tang P, Xing L. The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. Bone. 2012 Apr; 50(4):813-23.
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Zhou Q, Guo R, Wood R, Boyce BF, Liang Q, Wang YJ, Schwarz EM, Xing L. Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice. Arthritis Rheum. 2011 Aug; 63(8):2318-28.
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Bakthavatchalu V, Meka A, Mans JJ, Sathishkumar S, Lopez MC, Bhattacharyya I, Boyce BF, Baker HV, Lamont RJ, Ebersole JL, Kesavalu L. Polymicrobial periodontal pathogen transcriptomes in calvarial bone and soft tissue. Mol Oral Microbiol. 2011 Oct; 26(5):303-20.
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Hicks D, Boyce B. The challenge and importance of standardizing pre-analytical variables in surgical pathology specimens for clinical care and translational research. Biotech Histochem. 2012 Jan; 87(1):14-7.
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Boyce BF. Optimizing the use and applications of special stains: clinical and experimental approaches. Biotech Histochem. 2012 Jan; 87(1):1-2.
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Horvai AE, Boyce BF. Metabolic bone diseases. Semin Diagn Pathol. 2011 Feb; 28(1):13-25.
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Bakthavatchalu V, Meka A, Sathishkumar S, Lopez MC, Bhattacharyya I, Boyce BF, Mans JJ, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L. Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles. Mol Oral Microbiol. 2010 Oct; 25(5):317-30.
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Bakthavatchalu V, Meka A, Sathishkumar S, Lopez MC, Verma RK, Wallet SM, Bhattacharyya I, Boyce BF, Mans JJ, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L. Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles. Mol Oral Microbiol. 2010 Aug; 25(4):260-74.
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Coleman RE, Lipton A, Roodman GD, Guise TA, Boyce BF, Brufsky AM, Clézardin P, Croucher PI, Gralow JR, Hadji P, Holen I, Mundy GR, Smith MR, Suva LJ. Metastasis and bone loss: advancing treatment and prevention. Cancer Treat Rev. 2010 Dec; 36(8):615-20.
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Camacho N, Krakow D, Johnykutty S, Katzman PJ, Pepkowitz S, Vriens J, Nilius B, Boyce BF, Cohn DH. Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia. Am J Med Genet A. 2010 May; 152A(5):1169-77.
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Boyce BF, Yao Z, Xing L. Functions of nuclear factor kappaB in bone. Ann N Y Acad Sci. 2010 Mar; 1192:367-75.
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Meka A, Bakthavatchalu V, Sathishkumar S, Lopez MC, Verma RK, Wallet SM, Bhattacharyya I, Boyce BF, Handfield M, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L. Porphyromonas gingivalis infection-induced tissue and bone transcriptional profiles. Mol Oral Microbiol. 2010 Feb; 25(1):61-74.
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Schwarz EM, Proulx ST, Ritchlin CT, Boyce BF, Xing L. The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis. Adv Exp Med Biol. 2010; 658:1-10.
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Yao Z, Xing L, Boyce BF. NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism. J Clin Invest. 2009 Oct; 119(10):3024-34.
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Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D. Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. J Cell Sci. 2009 Oct 1; 122(Pt 19):3566-78.
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Boyce BF. Stomaching calcium for bone health. Nat Med. 2009 Jun; 15(6):610-2.
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Boyce BF. Sphingosine-1 phosphate: a new player in osteoimmunology. Dev Cell. 2009 Mar; 16(3):323-4.
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Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res. 2009 Feb; 24(2):251-64.
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Boyce BF, Yao Z, Xing L. Osteoclasts have multiple roles in bone in addition to bone resorption. Crit Rev Eukaryot Gene Expr. 2009; 19(3):171-80.
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Coleman RE, Guise TA, Lipton A, Roodman GD, Berenson JR, Body JJ, Boyce BF, Calvi LM, Hadji P, McCloskey EV, Saad F, Smith MR, Suva LJ, Taichman RS, Vessella RL, Weilbaecher KN. Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference. Clin Cancer Res. 2008 Oct 15; 14(20):6387-95.
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Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM. Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging. Arthritis Rheum. 2008 Jul; 58(7):2019-29.
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Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L. Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem. 2008 Aug 22; 283(34):23084-92.
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Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci. 2008 May 1; 121(Pt 9):1455-65.
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Boyce BF, Xing L. Bruton and Tec: new links in osteoimmunology. Cell Metab. 2008 Apr; 7(4):283-5.
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Zhang Q, Guo R, Schwarz EM, Boyce BF, Xing L. TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood. Arthritis Res Ther. 2008; 10(2):R37.
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Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 2008 May 15; 473(2):139-46.
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Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L. VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism. J Biol Chem. 2008 May 9; 283(19):13491-9.
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Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF. Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2. J Bone Miner Res. 2008 Mar; 23(3):314-25.
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Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B. Dimorphic effects of Notch signaling in bone homeostasis. Nat Med. 2008 Mar; 14(3):299-305.
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Yao Z, Xing L, Qin C, Schwarz EM, Boyce BF. Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism. J Biol Chem. 2008 Apr 11; 283(15):9917-24.
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Shakespeare WC, Wang Y, Bohacek R, Keenan T, Sundaramoorthi R, Metcalf C, Dilauro A, Roeloffzen S, Liu S, Saltmarsh J, Paramanathan G, Dalgarno D, Narula S, Pradeepan S, van Schravendijk MR, Keats J, Ram M, Liou S, Adams S, Wardwell S, Bogus J, Iuliucci J, Weigele M, Xing L, Boyce B, Sawyer TK. SAR of carbon-linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity. Chem Biol Drug Des. 2008 Feb; 71(2):97-105.
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Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM. Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. Arthritis Rheum. 2007 Dec; 56(12):4024-37.
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Boyce BF, Yao Z, Zhang Q, Guo R, Lu Y, Schwarz EM, Xing L. New roles for osteoclasts in bone. Ann N Y Acad Sci. 2007 Nov; 1116:245-54.
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Boyce BF, Xing L. The RANKL/RANK/OPG pathway. Curr Osteoporos Rep. 2007 Sep; 5(3):98-104.
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Proulx ST, Kwok E, You Z, Beck CA, Shealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM. MRI and quantification of draining lymph node function in inflammatory arthritis. Ann N Y Acad Sci. 2007 Nov; 1117:106-23.
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Yamashita T, Yao Z, Li F, Zhang Q, Badell IR, Schwarz EM, Takeshita S, Wagner EF, Noda M, Matsuo K, Xing L, Boyce BF. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem. 2007 Jun 22; 282(25):18245-53.
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Saad NE, Briones AJ, Rhodes J, Waldman DL, Boyce B, Davies MG. Pseudoaneurysm of a genicular branch of the popliteal artery and deep venous thrombosis: an unusual presentation of an osteochondroma. J Vasc Interv Radiol. 2007 Apr; 18(4):581-3.
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Zhang Q, Lu Y, Proulx ST, Guo R, Yao Z, Schwarz EM, Boyce BF, Xing L. Increased lymphangiogenesis in joints of mice with inflammatory arthritis. Arthritis Res Ther. 2007; 9(6):R118.
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Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007; 9 Suppl 1:S1.
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Boyce BF, Xing L. Osteoclasts, no longer osteoblast slaves. Nat Med. 2006 Dec; 12(12):1356-8.
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Morello R, Bertin TK, Chen Y, Hicks J, Tonachini L, Monticone M, Castagnola P, Rauch F, Glorieux FH, Vranka J, Bächinger HP, Pace JM, Schwarze U, Byers PH, Weis M, Fernandes RJ, Eyre DR, Yao Z, Boyce BF, Lee B. CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell. 2006 Oct 20; 127(2):291-304.
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Boyce BF, Xing L, Yao Z, Yamashita T, Shakespeare WC, Wang Y, Metcalf CA, Sundaramoorthi R, Dalgarno DC, Iuliucci JD, Sawyer TK. SRC inhibitors in metastatic bone disease. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 2):6291s-6295s.
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Lipton A, Berenson JR, Body JJ, Boyce BF, Bruland OS, Carducci MA, Cleeland CS, Clohisy DR, Coleman RE, Cook RJ, Guise TA, Pearse RN, Powles TJ, Rogers MJ, Roodman GD, Smith MR, Suva LJ, Vessella RL, Weilbaecher KN, King L. Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 2):6209s-6212s.
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Boyce BF, Schwarz EM, Xing L. Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease. Curr Opin Rheumatol. 2006 Jul; 18(4):427-32.
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Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. Autoimmunity and bone. Ann N Y Acad Sci. 2006 Apr; 1068:275-83.
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Boyce BF, Xing L, Yao Z, Shakespeare WC, Wang Y, Metcalf CA, Sundaramoorthi R, Dalgarno DC, Iuliucci JD, Sawyer TK. Future anti-catabolic therapeutic targets in bone disease. Ann N Y Acad Sci. 2006 Apr; 1068:447-57.
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Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L. Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression. J Biol Chem. 2006 Apr 28; 281(17):11846-55.
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Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L. Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem. 2006 Feb 17; 281(7):4326-33.
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Boyce BF, Xing L, Chen D. Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling. Cell Metab. 2005 Dec; 2(6):344-5.
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Xing L, Schwarz EM, Boyce BF. Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev. 2005 Dec; 208:19-29.
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Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L. TNF-alpha and pathologic bone resorption. Keio J Med. 2005 Sep; 54(3):127-31.
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Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF, Xing L. Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2. Arthritis Rheum. 2005 Sep; 52(9):2708-18.
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Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. 2005 Jun; 113(6):749-55.
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Xing L, Boyce BF. Regulation of apoptosis in osteoclasts and osteoblastic cells. Biochem Biophys Res Commun. 2005 Mar 18; 328(3):709-20.
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Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med. 2005 Mar; 11(3):291-7.
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Boyce BF, Yamashita T, Yao Z, Zhang Q, Li F, Xing L. Roles for NF-kappaB and c-Fos in osteoclasts. J Bone Miner Metab. 2005; 23 Suppl:11-5.
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Kapur RP, Yao Z, Iida MH, Clarke CM, Doggett B, Xing L, Boyce BF. Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank. J Bone Miner Res. 2004 Oct; 19(10):1689-97.
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Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L. RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. J Bone Miner Res. 2004 Feb; 19(2):207-13.
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Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L. Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum. 2004 Jan; 50(1):265-76.
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Boyce BF, Xing L, Shakespeare W, Wang Y, Dalgarno D, Iuliucci J, Sawyer T. Regulation of bone remodeling and emerging breakthrough drugs for osteoporosis and osteolytic bone metastases. Kidney Int Suppl. 2003 Jun; (85):S2-5.
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Feng JQ, Xing L, Zhang JH, Zhao M, Horn D, Chan J, Boyce BF, Harris SE, Mundy GR, Chen D. NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro. J Biol Chem. 2003 Aug 1; 278(31):29130-5.
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Boyce BF. Bad bones, grey hair, one mutation. Nat Med. 2003 Apr; 9(4):395-6.
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Xing L, Carlson L, Story B, Tai Z, Keng P, Siebenlist U, Boyce BF. Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption. J Bone Miner Res. 2003 Feb; 18(2):260-9.
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Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13498-503.
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Xing L, Bushnell TP, Carlson L, Tai Z, Tondravi M, Siebenlist U, Young F, Boyce BF. NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis. J Bone Miner Res. 2002 Jul; 17(7):1200-10.
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Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res. 2002 Feb; 17(2):192-9.
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Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS. Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8650-5.
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Sawyer T, Boyce B, Dalgarno D, Iuliucci J. Src inhibitors: genomics to therapeutics. Expert Opin Investig Drugs. 2001 Jul; 10(7):1327-44.
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Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res. 2001 Apr; 16(4):660-70.
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Xing L, Venegas AM, Chen A, Garrett-Beal L, Boyce BF, Varmus HE, Schwartzberg PL. Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes Dev. 2001 Jan 15; 15(2):241-53.
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Marzia M, Sims NA, Voit S, Migliaccio S, Taranta A, Bernardini S, Faraggiana T, Yoneda T, Mundy GR, Boyce BF, Baron R, Teti A. Decreased c-Src expression enhances osteoblast differentiation and bone formation. J Cell Biol. 2000 Oct 16; 151(2):311-20.
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Hentunen TA, Choi SJ, Boyce BF, Dallas MR, Dallas SL, Shen-Ong GL, Roodman GD. A murine model of inflammatory bone disease. Bone. 2000 Feb; 26(2):183-8.
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Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999 Dec 3; 286(5446):1946-9.
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Choi SJ, Reddy SV, Devlin RD, Menaa C, Chung H, Boyce BF, Roodman GD. Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption. J Biol Chem. 1999 Sep 24; 274(39):27747-53.
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Boyce BF, Yoneda T, Guise TA. Factors regulating the growth of metastatic cancer in bone. Endocr Relat Cancer. 1999 Sep; 6(3):333-47.
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Boyce BF, Xing L, Franzoso G, Siebenlist U. Required and nonessential functions of nuclear factor-kappa B in bone cells. Bone. 1999 Jul; 25(1):137-9.
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Tiffee JC, Xing L, Nilsson S, Boyce BF. Dental abnormalities associated with failure of tooth eruption in src knockout and op/op mice. Calcif Tissue Int. 1999 Jul; 65(1):53-8.
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Dunstan CR, Boyce R, Boyce BF, Garrett IR, Izbicka E, Burgess WH, Mundy GR. Systemic administration of acidic fibroblast growth factor (FGF-1) prevents bone loss and increases new bone formation in ovariectomized rats. J Bone Miner Res. 1999 Jun; 14(6):953-9.
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Dallas SL, Garrett IR, Oyajobi BO, Dallas MR, Boyce BF, Bauss F, Radl J, Mundy GR. Ibandronate reduces osteolytic lesions but not tumor burden in a murine model of myeloma bone disease. Blood. 1999 Mar 1; 93(5):1697-706.
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Zhao W, Byrne MH, Boyce BF, Krane SM. Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. J Clin Invest. 1999 Feb; 103(4):517-24.
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Boyce BF, Hughes DE, Wright KR, Xing L, Dai A. Recent advances in bone biology provide insight into the pathogenesis of bone diseases. Lab Invest. 1999 Feb; 79(2):83-94.
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Taguchi Y, Yamamoto M, Yamate T, Lin SC, Mocharla H, DeTogni P, Nakayama N, Boyce BF, Abe E, Manolagas SC. Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. Proc Assoc Am Physicians. 1998 Nov-Dec; 110(6):559-74.
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Zubery Y, Dunstan CR, Story BM, Kesavalu L, Ebersole JL, Holt SC, Boyce BF. Bone resorption caused by three periodontal pathogens in vivo in mice is mediated in part by prostaglandin. Infect Immun. 1998 Sep; 66(9):4158-62.
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Hentunen TA, Reddy SV, Boyce BF, Devlin R, Park HR, Chung H, Selander KS, Dallas M, Kurihara N, Galson DL, Goldring SR, Koop BA, Windle JJ, Roodman GD. Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice. J Clin Invest. 1998 Jul 1; 102(1):88-97.
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Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 1997 Dec 15; 11(24):3482-96.
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Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev. 1997 Nov 1; 11(21):2835-44.
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Uy HL, Mundy GR, Boyce BF, Story BM, Dunstan CR, Yin JJ, Roodman GD, Guise TA. Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo. Cancer Res. 1997 Aug 1; 57(15):3194-9.
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Hughes DE, Boyce BF. Apoptosis in bone physiology and disease. Mol Pathol. 1997 Jun; 50(3):132-7.
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Bonewald LF, Flynn M, Qiao M, Dallas MR, Mundy GR, Boyce BF. Mice lacking 5-lipoxygenase have increased cortical bone thickness. Adv Exp Med Biol. 1997; 433:299-302.
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Garcia C, Boyce BF, Gilles J, Dallas M, Qiao M, Mundy GR, Bonewald LF. Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo. J Bone Miner Res. 1996 Nov; 11(11):1619-27.
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Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, Yoneda T, Mundy GR. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest. 1996 Oct 1; 98(7):1544-9.
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Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med. 1996 Oct; 2(10):1132-6.
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Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, Angelopoulou R, Rosen JM, Greenberg NM. Metastatic prostate cancer in a transgenic mouse. Cancer Res. 1996 Sep 15; 56(18):4096-102.
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Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G. Increased bone formation in osteocalcin-deficient mice. Nature. 1996 Aug 1; 382(6590):448-52.
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Alsina M, Boyce B, Devlin RD, Anderson JL, Craig F, Mundy GR, Roodman GD. Development of an in vivo model of human multiple myeloma bone disease. Blood. 1996 Feb 15; 87(4):1495-501.
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Afzal S. Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression and synthetic matrix metalloproteinase-2 inhibitor binding in ovarian carcinomas and tumor cell lines. Lab Invest. 1996 Feb; 74(2):406-21.
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Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res. 1996 Feb; 11(2):150-9.
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Boyce BF, Wright K, Reddy SV, Koop BA, Story B, Devlin R, Leach RJ, Roodman GD, Windle JJ. Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts. Endocrinology. 1995 Dec; 136(12):5751-9.
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Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res. 1995 Oct; 10(10):1478-87.
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Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR, Yoneda T. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res. 1995 Aug 15; 55(16):3551-7.
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Alsina M, Boyce BF, Mundy GR, Roodman GD. An in vivo model of human multiple myeloma bone disease. Stem Cells. 1995 Aug; 13 Suppl 2:48-50.
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Mundy GR, Boyce B, Hughes D, Wright K, Bonewald L, Dallas S, Harris S, Ghosh-Choudhury N, Chen D, Dunstan C, et al. The effects of cytokines and growth factors on osteoblastic cells. Bone. 1995 Aug; 17(2 Suppl):71S-75S.
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Uy HL, Guise TA, De La Mata J, Taylor SD, Story BM, Dallas MR, Boyce BF, Mundy GR, Roodman GD. Effects of parathyroid hormone (PTH)-related protein and PTH on osteoclasts and osteoclast precursors in vivo. Endocrinology. 1995 Aug; 136(8):3207-12.
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Mbalaviele G, Chen H, Boyce BF, Mundy GR, Yoneda T. The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. J Clin Invest. 1995 Jun; 95(6):2757-65.
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Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest. 1995 Jun; 95(6):2886-95.
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de la Mata J, Uy HL, Guise TA, Story B, Boyce BF, Mundy GR, Roodman GD. Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest. 1995 Jun; 95(6):2846-52.
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Yoneda T, Williams P, Rhine C, Boyce BF, Dunstan C, Mundy GR. Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer. Cancer Res. 1995 May 1; 55(9):1989-93.
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Chander SK, Antoniw P, Beeley NR, Boyce B, Crabbe T, Docherty AJ, Leonard J, Mason B, Millar K, Millican AT, et al. An in vivo model for screening peptidomimetic inhibitors of gelatinase A. J Pharm Sci. 1995 Apr; 84(4):404-9.
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Uy HL, Dallas M, Calland JW, Boyce BF, Mundy GR, Roodman GD. Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage. J Bone Miner Res. 1995 Feb; 10(2):295-301.
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Turner A, King DJ, Farnsworth AP, Rhind SK, Pedley RB, Boden J, Boden R, Millican TA, Millar K, Boyce B, et al. Comparative biodistributions of indium-111-labelled macrocycle chimeric B72.3 antibody conjugates in tumour-bearing mice. Br J Cancer. 1994 Jul; 70(1):35-41.
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Boyce BF, Adamson BB, Gallacher SJ, Byars J, Ralston SH, Boyle IT. Mineralisation defects after pamidronate for Paget's disease. Lancet. 1994 May 14; 343(8907):1231-2.
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Yoneda T, Takaoka Y, Boyce BF, Scott L, Mundy GR. Extracts of porcine pancreas prevent progression of hypercalcemia and cachexia and prolong survival in nude mice bearing a human squamous carcinoma. Cancer Res. 1994 May 1; 54(9):2509-13.
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Boyce BF, Adamson BB, Gallacher SJ, Byars J, Ralston SH, Boyle IT. Length of published reports. Lancet. 1994 Jan 29; 343(8892):297.
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Izbicka E, Niewolna M, Yoneda T, Lowe C, Boyce B, Mundy G. pp60 c-src expression and activity in MG-63 osteoblastic cells modulated by PTH but not required for PTH-mediated adenylate cyclase response. J Bone Miner Res. 1994 Jan; 9(1):127-32.
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Adamson BB, Gallacher SJ, Byars J, Ralston SH, Boyle IT, Boyce BF. Mineralisation defects with pamidronate therapy for Paget's disease. Lancet. 1993 Dec 11; 342(8885):1459-60.
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Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P. Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4485-9.
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Boyce BF, Chen H, Soriano P, Mundy GR. Histomorphometric and immunocytochemical studies of src-related osteopetrosis. Bone. 1993 May-Jun; 14(3):335-40.
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Boyce BF, Yoneda T, Lowe C, Soriano P, Mundy GR. Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest. 1992 Oct; 90(4):1622-7.
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Guise TA, Chirgwin JM, Favarato G, Boyce BF, Mundy GR. Chinese hamster ovarian cells transfected with human parathyroid hormone-related protein cDNA cause hypercalcemia in nude mice. Lab Invest. 1992 Oct; 67(4):477-85.
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Nakai M, Mundy GR, Williams PJ, Boyce B, Yoneda T. A synthetic antagonist to laminin inhibits the formation of osteolytic metastases by human melanoma cells in nude mice. Cancer Res. 1992 Oct 1; 52(19):5395-9.
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Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 1992 Jul 3; 257(5066):88-91.
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Yates AJ, Boyce BF, Favarato G, Aufdemorte TB, Marcelli C, Kester MB, Walker R, Langton BC, Bonewald LF, Mundy GR. Expression of human transforming growth factor alpha by Chinese hamster ovarian tumors in nude mice causes hypercalcemia and increased osteoclastic bone resorption. J Bone Miner Res. 1992 Jul; 7(7):847-53.
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Boyce BF, Byars J, McWilliams S, Mocan MZ, Elder HY, Boyle IT, Junor BJ. Histological and electron microprobe studies of mineralisation in aluminium-related osteomalacia. J Clin Pathol. 1992 Jun; 45(6):502-8.
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Mocan MZ, Mocan H, Fell GS, Junor BJ, Boyce BF. Autonomous hyperparathyroidism not associated with increased aluminum absorption. Isr J Med Sci. 1992 Jan; 28(1):24-6.
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Gallacher SJ, Boyce BF, Patel U, Jenkins A, Ralston SH, Boyle IT. Clinical experience with pamidronate in the treatment of Paget's disease of bone. Ann Rheum Dis. 1991 Dec; 50(12):930-3.
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Mundy GR, Roodman GD, Bonewald LF, Oreffo RO, Boyce BF. Assays for bone resorption and bone formation. Methods Enzymol. 1991; 198:502-10.
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Gallacher SJ, Ralston SH, Dryburgh FJ, Logue FC, Allam BF, Boyce BF, Boyle IT. Immobilization-related hypercalcaemia--a possible novel mechanism and response to pamidronate. Postgrad Med J. 1990 Nov; 66(781):918-22.
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Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest. 1990 Mar; 85(3):632-9.
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Boyce BF, Yates AJ, Mundy GR. Bolus injections of recombinant human interleukin-1 cause transient hypocalcemia in normal mice. Endocrinology. 1989 Nov; 125(5):2780-3.
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Boyce BF, Aufdemorte TB, Garrett IR, Yates AJ, Mundy GR. Effects of interleukin-1 on bone turnover in normal mice. Endocrinology. 1989 Sep; 125(3):1142-50.
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Johnson RA, Boyce BF, Mundy GR, Roodman GD. Tumors producing human tumor necrosis factor induced hypercalcemia and osteoclastic bone resorption in nude mice. Endocrinology. 1989 Mar; 124(3):1424-7.
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Ralston SH, Boyce BF, Cowan RA, Gardner MD, Fraser WD, Boyle IT. Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy. J Bone Miner Res. 1989 Feb; 4(1):103-11.
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Sabatini M, Boyce B, Aufdemorte T, Bonewald L, Mundy GR. Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5235-9.
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Yates AJ, Gutierrez GE, Smolens P, Travis PS, Katz MS, Aufdemorte TB, Boyce BF, Hymer TK, Poser JW, Mundy GR. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. J Clin Invest. 1988 Mar; 81(3):932-8.
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Boyce BF. Uses and limitations of bone biopsy in management of metabolic bone disease. Baillieres Clin Endocrinol Metab. 1988 Feb; 2(1):31-57.
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Boyce BF, Mocan MZ, Byars J, Junor BJ. Treatment and histological healing of aluminum-related osteomalacia. Contrib Nephrol. 1988; 64:151-9.
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Maharaj D, Fell GS, Boyce BF, Ng JP, Smith GD, Boulton-Jones JM, Cumming RL, Davidson JF. Aluminium bone disease in patients receiving plasma exchange with contaminated albumin. Br Med J (Clin Res Ed). 1987 Sep 19; 295(6600):693-6.
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Boyce BF, Forgie I. An outbreak of 'slapped cheek' parvovirus infection (erythema infectiosum) in a Scottish street. Scott Med J. 1987 Jun; 32(3):70-1.
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Ralston SH, Boyce BF, Cowan RA, Fogelman I, Smith ML, Jenkins A, Boyle IT. The effect of 1 alpha-hydroxyvitamin D3 on the mineralization defect in disodium etidronate-treated Paget's disease--a double-blind randomized clinical study. J Bone Miner Res. 1987 Feb; 2(1):5-12.
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Boyce BF, Prime SS, Halls D, Johnston E, Critchlow H, MacDonald DG, Junor BJ. Does osteomalacia contribute to development of oral complications of oxalosis? Oral Surg Oral Med Oral Pathol. 1986 Mar; 61(3):272-7.
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Ralston SH, Boyce BF, Cowan RA, Gardner MD, Dryburgh FJ, Boyle IT. Humoral hypercalcaemia of malignancy: metabolic and histomorphometric studies during surgical management of the primary tumour. Q J Med. 1986 Mar; 58(227):325-35.
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Jack AS, Boyce BF, Lee FD. Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. J Clin Pathol. 1986 Jan; 39(1):16-21.
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Ralston SH, Dryburgh FJ, Cowan RA, Boyce BF, Gardner MD, Boyle IT. Hypercalcaemia of malignancy. Lancet. 1985 Apr 13; 1(8433):878.
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McKillop JH, Maharaj D, Boyce BF, Fogelman I. Bone scan appearances following biopsy of bone and bone marrow. Radiology. 1984 Oct; 153(1):241-2.
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Boyce BF, Smith L, Fogelman I, Johnston E, Ralston S, Boyle IT. Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease. Lancet. 1984 Apr 14; 1(8381):821-4.
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Smith ML, Fogelman I, Ralston S, Boyce BF, Boyle IT. Correlation of skeletal uptake of 99mTc-diphosphonate and alkaline phosphatase before and after oral diphosphonate therapy in Paget's disease. Metab Bone Dis Relat Res. 1984; 5(4):167-70.
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Beastall GH, McKellar N, Boyle IT, Joffe SN, Hutchison JS, Boyce BF, Gardner MD, Bell MA, Cowan RA, Fogelman I, Smith L. Pre-operative localisation of parathyroid tumours using neck vein catheterisation and radioimmunoassay for parathyroid hormone: the Glasgow experience. Scott Med J. 1983 Apr; 28(2):146-52.
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Boyce BF, Fell GS, Elder HY, Junor BJ, Elliot HL, Beastall G, Fogelman I, Boyle IT. Hypercalcaemic osteomalacia due to aluminium toxicity. Lancet. 1982 Nov 6; 2(8306):1009-13.
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Boyce BF, Doherty VR, Mortimer G. Hyperplastic parathyroiditis--a new autoimmune disease? J Clin Pathol. 1982 Aug; 35(8):812-4.
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Boyce BF, Smith L, Fogelman I, Ralston S, Boyle IT. Diphosphonates and inhibition of bone mineralisation. Lancet. 1982 Apr 24; 1(8278):964-5.
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Fogelman I, Gray JM, Gardner MD, Beastall GH, McIntosh WB, Allam BF, Boyce BF, Boyle IT, Lawson DH. Do anticonvulsant drugs commonly induce osteomalacia? Scott Med J. 1982 Apr; 27(2):136-42.
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Macfarlane PW, Chen CY, Boyce B, Fraser RS. Scoring technique for diagnosis of ventricular hypertrophy from three orthogonal lead electrocardiogram. Br Heart J. 1981 Apr; 45(4):402-10.
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Boyce BF, Eider HY, Fell SG, Nicholson WA, Smith GD, Dempster DW, Gray CC, Boyle IT. Quantitation and localisation of aluminum in human cancellous bone in renal osteodystrophy. Scan Electron Microsc. 1981; (Pt 3):329-37.
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Boyce BF, Fogelman I, Boyle IT. Pathogenesis of osteoporosis. Lancet. 1980 Mar 22; 1(8169):658.
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Fogelman I, Boyce B, Boyle IT. Rickets in a white adolescent. Postgrad Med J. 1979 Nov; 55(649):808-9.
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Boyle IT, Fogelman I, Beastall GH, Joffe S, Boyce B. 1-Alpha-hydroxy vitamin D3 in primary hyperparathyroidism. Br Med J. 1979 Mar 24; 1(6166):822-3.
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Boyle IT, Fogelman I, Boyce B, Thomson JE, Beastall GH, McIntosh WB, McLennan I. 1alpha-hydroxyvitamin D3 in primary hyperparathyroidism. Clin Endocrinol (Oxf). 1977 Dec; 7 Suppl:215s-222s.
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Fogelman I, McKillop JH, Cowden EA, Fine A, Boyce B, Boyle IT, Greig WR. Bone scan findings in hypervitaminosis D: case report. J Nucl Med. 1977 Dec; 18(12):1205-7.
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Boyle IT, Hodsman ID, Allam BF, Boyce B, McLennan I. 1-alpha-Hydroxyvitamin D3 in the management of primary hyperparathyroidism with bone disease. Calcif Tissue Res. 1977 May; 22 Suppl:415.
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