|Institution||School of Medicine and Dentistry|
|Department||Medicine in the Aab Cardiovascular Research Institute|
|Address||Aab Cardiovascular Research Institute|
211 Bailey Road
West Henrietta NY 14586
|Institution||University of Rochester Medical Center|
|Department||Aab Cardiovascular Research Institute|
||Helen S. Page Memorial Ph.D.|
||Post-Doctoral National Research Service, Smooth Muscle Cell Differentiation | National Institutes of Health|
||Manitowoc Heart-A-Rama Research for Life | American Heart Association (AHA)|
||2007||Established Investigator Award
American Heart Association|
||Who's Who in Medicine and Healthcare|
Research in the Miano Lab is focused on the expression regulation and biology of several genes cloned from vascular smooth muscle cells (SMC).
The genes include serum response factor (SRF) and its coactivator, myocardin (MYOCD), which together represent a powerful transcriptional master-switch for the SMC contractile phenotype; a direct target of this transcriptional switch called SMC calponin (CNN1); a tumor suppressor gene, AKAP12, comprising three independent transcription units including one, AKAP12(alpha), that is a direct target of SRF and another, AKAP12(beta), that is massively induced by anti-cancer drugs called retinoids; and a newly defined SMC-restricted gene called leiomodin 1 (LMOD1). The lab is also studying the role of microRNAs in the regulation of SMC differentiation. Our ideas and efforts span the spectrum from computer to DNA to cells to whole animals. We intend to elucidate the transcriptional and post-transcriptional regulation of these genes and/or their functions during normal or pathological processes involving, but not limited to, the cardiovascular system. For example, the transcriptional program of SMC differentiation is under study to gain insight into basic processes underlying vascular development as well as cancer, Alzheimer's disease, and vascular occlusive disease. Tools in genetics, genomics, bioinformatics, and molecular biology are utilized to characterize regulatory elements called CArG boxes that bind the SRF-Myocardin master switch. Recent efforts are underway to fully elucidate the Human CArGome (all functional CArG boxes in the genome) and functionally variants (SNPs) in and around CArG boxes (CArG-SNPs) that may alter programs of gene expression associated with disease.
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