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Eileen Redmond

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentSurgery
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box SURG
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology

 
 Awards And Honors
1990     NATO Bursary to attend NATO Advanced Study Institute
1992     American Heart Association Postdoctoral Fellowship
1994 - 2008AHA Arteriosclerosis, Thrombosis and Vascular Biology Council member
1995 - 1998NIH National Research Service Award (NRSA)
1996 - 1998Alcoholic Beverage Medical Research Foundation (ABMRF) Grant-in-Aid Award
2004 - 2008AHA Basic Cardiovascular Sciences Council member
2005 - 2009American Heart Association Grant-in-Aid Award
 
 Overview
The Redmond laboratory's focus is in Vascular Biology, relating particularly to cardiovascular disease including atherosclerosis and restenosis after angioplasty. General areas of interest include (i) cell signaling mechanisms mediating cardiovascular effects of alcohol and red wine constituents, (ii) hemodynamic regulation of vascular endothelial and smooth muscle cell fate and (iii) novel mechanotransduction pathways.

 
 Selected Publications
List All   |   Timeline
  1. Kennedy E, Hakimjavadi R, Greene C, Mooney CJ, Fitzpatrick E, Collins LE, Loscher CE, Guha S, Morrow D, Redmond EM, Cahill PA. Embryonic rat vascular smooth muscle cells revisited - a model for neonatal, neointimal SMC or differentiated vascular stem cells? Vasc Cell. 2014; 6(1):6.
    View in: PubMed
  2. Redmond EM, Liu W, Hamm K, Hatch E, Cahill PA, Morrow D. Perivascular Delivery of Notch 1 siRNA Inhibits Injury-Induced Arterial Remodeling. PLoS One. 2014; 9(1):e84122.
    View in: PubMed
  3. Redmond EM, Hamm K, Cullen JP, Hatch E, Cahill PA, Morrow D. Inhibition of patched-1 prevents injury-induced neointimal hyperplasia. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1960-4.
    View in: PubMed
  4. Cahill PA, Redmond EM. Alcohol and cardiovascular disease--modulation of vascular cell function. Nutrients. 2012 Apr; 4(4):297-318.
    View in: PubMed
  5. Redmond EM, Cahill PA. The NOX-ROS connection: targeting Nox1 control of N-cadherin shedding in vascular smooth muscle cells. Cardiovasc Res. 2012 Mar 1; 93(3):386-7.
    View in: PubMed
  6. Redmond EM, Guha S, Walls D, Cahill PA. Investigational Notch and Hedgehog inhibitors--therapies for cardiovascular disease. Expert Opin Investig Drugs. 2011 Dec; 20(12):1649-64.
    View in: PubMed
  7. Liu W, Redmond EM, Morrow D, Cullen JP. Differential effects of daily-moderate versus weekend-binge alcohol consumption on atherosclerotic plaque development in mice. Atherosclerosis. 2011 Dec; 219(2):448-54.
    View in: PubMed
  8. Walshe TE, Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O'Brien C, Cahill PA. Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of hedgehog and Notch signaling. Invest Ophthalmol Vis Sci. 2011 Jun; 52(7):4472-83.
    View in: PubMed
  9. Guha S, Cullen JP, Morrow D, Colombo A, Lally C, Walls D, Redmond EM, Cahill PA. Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival. Basic Res Cardiol. 2011 Sep; 106(5):773-85.
    View in: PubMed
  10. Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng GS, Jin ZG. Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1016-23.
    View in: PubMed
  11. Banerjee S, Lin CF, Skinner KA, Schiffhauer LM, Peacock J, Hicks DG, Redmond EM, Morrow D, Huston A, Shayne M, Langstein HN, Miller-Graziano CL, Strickland J, O'Donoghue L, De AK. Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression. Cancer Res. 2011 Jan 15; 71(2):318-27.
    View in: PubMed
  12. Morrow D, Cullen JP, Liu W, Cahill PA, Redmond EM. Alcohol inhibits smooth muscle cell proliferation via regulation of the Notch signaling pathway. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2597-603.
    View in: PubMed
  13. Morrow DJ, Avissar NE, Toia L, Redmond EM, Watson TJ, Jones C, Raymond DP, Litle V, Peters JH. Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. Surgery. 2009 Oct; 146(4):714-21; discussion 721-2.
    View in: PubMed
  14. Morrow D, Cullen JP, Liu W, Guha S, Sweeney C, Birney YA, Collins N, Walls D, Redmond EM, Cahill PA. Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1112-8.
    View in: PubMed
  15. Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O'Brien C, Walls D, Redmond EM, Cahill PA. Notch and vascular smooth muscle cell phenotype. Circ Res. 2008 Dec 5; 103(12):1370-82.
    View in: PubMed
  16. Redmond EM, Morrow D, Kundimi S, Miller-Graziano CL, Cullen JP. Acetaldehyde stimulates monocyte adhesion in a P-selectin- and TNFalpha-dependent manner. Atherosclerosis. 2009 Jun; 204(2):372-80.
    View in: PubMed
  17. Morrow D, Cullen JP, Cahill PA, Redmond EM. Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway. Cardiovasc Res. 2008 Jul 15; 79(2):313-21.
    View in: PubMed
  18. Cullen JP, Morrow D, Jin Y, von Offenberg Sweeney N, Sitzmann JV, Cahill PA, Redmond EM. Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes. Atherosclerosis. 2007 Nov; 195(1):e125-33.
    View in: PubMed
  19. Morrow D, Cullen JP, Cahill PA, Redmond EM. Cyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1289-96.
    View in: PubMed
  20. Cullen JP, Morrow D, Jin Y, Curley B, Robinson A, Sitzmann JV, Cahill PA, Redmond EM. Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion. J Vasc Res. 2007; 44(1):75-84.
    View in: PubMed
  21. Cummins PM, von Offenberg Sweeney N, Killeen MT, Birney YA, Redmond EM, Cahill PA. Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H28-42.
    View in: PubMed
  22. Morrow D, Sweeney C, Birney YA, Guha S, Collins N, Cummins PM, Murphy R, Walls D, Redmond EM, Cahill PA. Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C488-96.
    View in: PubMed
  23. Cullen JP, Sayeed S, Kim Y, Theodorakis NG, Sitzmann JV, Cahill PA, Redmond EM. Ethanol inhibits pulse pressure-induced vascular smooth muscle cell migration by differentially modulating plasminogen activator inhibitor type 1, matrix metalloproteinase-2 and -9. Thromb Haemost. 2005 Sep; 94(3):639-45.
    View in: PubMed
  24. Morrow D, Scheller A, Birney YA, Sweeney C, Guha S, Cummins PM, Murphy R, Walls D, Redmond EM, Cahill PA. Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1188-96.
    View in: PubMed
  25. Cullen JP, Sayeed S, Jin Y, Theodorakis NG, Sitzmann JV, Cahill PA, Redmond EM. Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1669-75.
    View in: PubMed
  26. Von Offenberg Sweeney N, Cummins PM, Cotter EJ, Fitzpatrick PA, Birney YA, Redmond EM, Cahill PA. Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation. Biochem Biophys Res Commun. 2005 Apr 8; 329(2):573-82.
    View in: PubMed
  27. Morrow D, Sweeney C, Birney YA, Cummins PM, Walls D, Redmond EM, Cahill PA. Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro. Circ Res. 2005 Mar 18; 96(5):567-75.
    View in: PubMed
  28. Birney YA, Sweeney CH, Cappadona CR, Sitzmann JV, Cummins PM, Redmond EM, Cahill PA. Pulse pressure-induced transmural fluid flux increases bovine aortic smooth muscle cell apoptosis in a mitogen activated protein kinase dependent manner. J Vasc Res. 2004 Jul-Aug; 41(4):364-74.
    View in: PubMed
  29. von Offenberg Sweeney N, Cummins PM, Birney YA, Cullen JP, Redmond EM, Cahill PA. Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity. Cardiovasc Res. 2004 Sep 1; 63(4):625-34.
    View in: PubMed
  30. von Offenberg Sweeney N, Cummins PM, Birney YA, Redmond EM, Cahill PA. Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration. Biochem Biophys Res Commun. 2004 Jul 23; 320(2):325-33.
    View in: PubMed
  31. Sweeney C, Morrow D, Birney YA, Coyle S, Hennessy C, Scheller A, Cummins PM, Walls D, Redmond EM, Cahill PA. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J. 2004 Sep; 18(12):1421-3.
    View in: PubMed
  32. Cullen JP, Nicholl SM, Sayeed S, Sitzmann JV, Okada SS, Cahill PA, Redmond EM. Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration. Thromb Res. 2004; 114(1):57-65.
    View in: PubMed
  33. Birney Y, Redmond EM, Sitzmann JV, Cahill PA. Eicosanoids in cirrhosis and portal hypertension. Prostaglandins Other Lipid Mediat. 2003 Oct; 72(1-2):3-18.
    View in: PubMed
  34. Theodorakis NG, Wang YN, Skill NJ, Metz MA, Cahill PA, Redmond EM, Sitzmann JV. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Gastroenterology. 2003 May; 124(5):1500-8.
    View in: PubMed
  35. Cullen JP, Sayeed S, Sawai RS, Theodorakis NG, Cahill PA, Sitzmann JV, Redmond EM. Pulsatile flow-induced angiogenesis: role of G(i) subunits. Arterioscler Thromb Vasc Biol. 2002 Oct 1; 22(10):1610-6.
    View in: PubMed
  36. Sayeed S, Cullen JP, Coppage M, Sitzmann JV, Redmond EM. Ethanol differentially modulates the expression and activity of cell cycle regulatory proteins in rat aortic smooth muscle cells. Eur J Pharmacol. 2002 Jun 12; 445(3):163-70.
    View in: PubMed
  37. Cahill PA, Redmond EM, Sitzmann JV. Endothelial dysfunction in cirrhosis and portal hypertension. Pharmacol Ther. 2001 Mar; 89(3):273-93.
    View in: PubMed
  38. Redmond EM, Cullen JP, Cahill PA, Sitzmann JV, Stefansson S, Lawrence DA, Okada SS. Endothelial cells inhibit flow-induced smooth muscle cell migration: role of plasminogen activator inhibitor-1. Circulation. 2001 Jan 30; 103(4):597-603.
    View in: PubMed
  39. Redmond EM, Sitzmann JV, Cahill PA. Potential mechanisms for cardiovascular protective effect of ethanol. Acta Pharmacol Sin. 2000 May; 21(5):385-90.
    View in: PubMed
  40. Cappadona C, Redmond EM, Theodorakis NG, McKillop IH, Hendrickson R, Chhabra A, Sitzmann JV, Cahill PA. Phenotype dictates the growth response of vascular smooth muscle cells to pulse pressure in vitro. Exp Cell Res. 1999 Jul 10; 250(1):174-86.
    View in: PubMed
  41. Hendrickson RJ, Okada SS, Cahill PA, Yankah E, Sitzmann JV, Redmond EM. Ethanol inhibits basal and flow-induced vascular smooth muscle cell migration in vitro. J Surg Res. 1999 Jun 1; 84(1):64-70.
    View in: PubMed
  42. Hendrickson RJ, Cahill PA, Sitzmann JV, Redmond EM. Ethanol enhances basal and flow-stimulated nitric oxide synthase activity in vitro by activating an inhibitory guanine nucleotide binding protein. J Pharmacol Exp Ther. 1999 Jun; 289(3):1293-300.
    View in: PubMed
  43. Hendrickson RJ, Cappadona C, Yankah EN, Sitzmann JV, Cahill PA, Redmond EM. Sustained pulsatile flow regulates endothelial nitric oxide synthase and cyclooxygenase expression in co-cultured vascular endothelial and smooth muscle cells. J Mol Cell Cardiol. 1999 Mar; 31(3):619-29.
    View in: PubMed
  44. Redmond EM, Cahill PA, Hirsch M, Wang YN, Sitzmann JV, Okada SS. Effect of pulse pressure on vascular smooth muscle cell migration: the role of urokinase and matrix metalloproteinase. Thromb Haemost. 1999 Feb; 81(2):293-300.
    View in: PubMed
  45. Kouretas PC, Hannan RL, Kapur NK, Hendrickson R, Redmond EM, Myers AK, Kim YD, Cahill PA, Sitzmann JV. Non-anticoagulant heparin increases endothelial nitric oxide synthase activity: role of inhibitory guanine nucleotide proteins. J Mol Cell Cardiol. 1998 Dec; 30(12):2669-82.
    View in: PubMed
  46. Mebazaa A, Wetzel RC, Dodd-o JM, Redmond EM, Shah AM, Maeda K, Maistre G, Lakatta EG, Robotham JL. Potential paracrine role of the pericardium in the regulation of cardiac function. Cardiovasc Res. 1998 Nov; 40(2):332-42.
    View in: PubMed
  47. Cahill PA, Hou MC, Hendrickson R, Wang YN, Zhang S, Redmond EM, Sitzman JV. Increased expression of endothelin receptors in the vasculature of portal hypertensive rats: role in splanchnic hemodynamics. Hepatology. 1998 Aug; 28(2):396-403.
    View in: PubMed
  48. Redmond EM, Cahill PA, Sitzmann JV. Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol. 1998 Jan; 18(1):75-83.
    View in: PubMed
  49. Hou MC, Cahill PA, Zhang S, Wang YN, Hendrickson RJ, Redmond EM, Sitzmann JV. Enhanced cyclooxygenase-1 expression within the superior mesenteric artery of portal hypertensive rats: role in the hyperdynamic circulation. Hepatology. 1998 Jan; 27(1):20-7.
    View in: PubMed
  50. Redmond EM, Cahill PA, Sitzmann JV. Flow-mediated regulation of endothelin receptors in cocultured vascular smooth muscle cells: an endothelium-dependent effect. J Vasc Res. 1997 Nov-Dec; 34(6):425-35.
    View in: PubMed
  51. Hou MC, Cahill PA, Zhang S, Redmond EM, Sitzmann JV. Enhanced G-protein-induced relaxation in portal hypertensive rats: role of nitric oxide. Hepatology. 1997 Jul; 26(1):27-33.
    View in: PubMed
  52. Cahill PA, Redmond EM, Hodges R, Zhang S, Sitzmann JV. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J Hepatol. 1996 Sep; 25(3):370-8.
    View in: PubMed
  53. Redmond EM, Cahill PA, Hodges R, Zhang S, Sitzmann JV. Regulation of endothelin receptors by nitric oxide in cultured rat vascular smooth muscle cells. J Cell Physiol. 1996 Mar; 166(3):469-79.
    View in: PubMed
  54. Cahill PA, Redmond EM, Wu Y, Sitzmann JV. Regulation of atrial natriuretic factor receptors in portal hypertensive rabbits. J Hepatol. 1996 Feb; 24(2):185-93.
    View in: PubMed
  55. Redmond EM, Cahill PA, Sitzmann JV. Perfused transcapillary smooth muscle and endothelial cell co-culture--a novel in vitro model. In Vitro Cell Dev Biol Anim. 1995 Sep; 31(8):601-9.
    View in: PubMed
  56. Cahill PA, Foster C, Redmond EM, Gingalewski C, Wu Y, Sitzmann JV. Enhanced nitric oxide synthase activity in portal hypertensive rabbits. Hepatology. 1995 Aug; 22(2):598-606.
    View in: PubMed
  57. Cahill PA, Redmond EM, Foster C, Sitzmann JV. Nitric oxide regulates angiotensin II receptors in vascular smooth muscle cells. Eur J Pharmacol. 1995 Jan 16; 288(2):219-29.
    View in: PubMed
  58. Redmond EM, Cherian MN, Wetzel RC. 17 beta-Estradiol inhibits flow- and acute hypoxia-induced prostacyclin release from perfused endocardial endothelial cells. Circulation. 1994 Nov; 90(5):2519-24.
    View in: PubMed
  59. Kent A, Redmond EM, Keenan AK. The ANF-C receptor is not linked to adenylyl cyclase inhibition in bovine pulmonary artery endothelial cells. Life Sci. 1992; 51(18):1439-44.
    View in: PubMed

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