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Mark Sullivan

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 695
Rochester NY 14642
 
 Awards And Honors
1975 - 1976Wisconsin Alumni Research Foundation Fellowship  | University of Wisconsin
1976 - 1979NIH Predoctoral Fellowship  | University of Wisconsin
1990     C.E.K. Mees Award for Excellence in Scientific Research and Reporting  | Eastman Kodak Company
 
 Overview
The ability to rapidly isolate human antibodies using phage display has opened up new approaches to understanding protein function. Research in my laboratory is focused on the manipulation of immunoglobulin molecules to develop novel reagents for characterization of protein expression and structure. We are using phage antibody technology in several areas of proteomics research to develop improved reagents for protein characterization as well as novel inhibitors of protein function that will aid in defining the roles of the many new proteins discovered through genomic sequencing. Major efforts are aimed at dissecting the saliva proteome and developing panels of antibodies for incorporation into new diagnostic platforms using protein microarrays. A second initiative is to derive antibodies useful for solving the structure of proteins by X-ray crystallography. Additional studies focus on the therapeutic potential of single-chain antibodies to reduce protein aggregation and misfolding, a process that characterizes a variety of neurodegenerative diseases.

 
 Selected Publications
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  1. Sullivan MA, Brooks LR, Weidenborner P, Domm W, Mattiacio J, Xu Q, Tiberio M, Wentworth T, Kobie J, Bryk P, Zheng B, Murphy M, Sanz I, Dewhurst S. Anti-idiotypic monobodies derived from a fibronectin scaffold. Biochemistry. 2013 Mar 12; 52(10):1802-13.
    View in: PubMed
  2. Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99.
    View in: PubMed
  3. Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe J. Phosphorylation of Protein Inhibitor of Activated STAT1 (PIAS1) by MAPK-Activated Protein Kinase-2 Inhibits Endothelial Inflammation via Increasing Both PIAS1 Transrepression and SUMO E3 Ligase Activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9.
    View in: PubMed
  4. Boonanantanasarn K, Gill AL, Yap Y, Jayaprakash V, Sullivan MA, Gill SR. Enterococcus faecalis enhances cell proliferation through hydrogen peroxide-mediated epidermal growth factor receptor activation. Infect Immun. 2012 Oct; 80(10):3545-58.
    View in: PubMed
  5. Sullivan MA, Wentworth T, Kobie JJ, Sanz I. Anti-idiotypic monobodies for immune response profiling. Methods. 2012 Sep; 58(1):62-8.
    View in: PubMed
  6. Pershad K, Sullivan MA, Kay BK. Drop-out phagemid vector for switching from phage displayed affinity reagents to expression formats. Anal Biochem. 2011 May 15; 412(2):210-6.
    View in: PubMed
  7. Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Mol Ther. 2010 Aug; 18(8):1471-81.
    View in: PubMed
  8. Laforce-Nesbitt SS, Sullivan MA, Hoyer LL, Bliss JM. Inhibition of Candida albicans adhesion by recombinant human antibody single-chain variable fragment specific for Als3p. FEMS Immunol Med Microbiol. 2008 Nov; 54(2):195-202.
    View in: PubMed
  9. Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 2008 May; 7(5):1994-2006.
    View in: PubMed
  10. Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Mol Ther. 2008 Mar; 16(3):481-6.
    View in: PubMed
  11. Maguire-Zeiss KA, Wang CI, Yehling E, Sullivan MA, Short DW, Su X, Gouzer G, Henricksen LA, Wuertzer CA, Federoff HJ. Identification of human alpha-synuclein specific single chain antibodies. Biochem Biophys Res Commun. 2006 Nov 3; 349(4):1198-205.
    View in: PubMed
  12. Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK. The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Mol Biol Cell. 2005 Sep; 16(9):4202-13.
    View in: PubMed
  13. Shea C, Bloedorn L, Sullivan MA. Rapid isolation of single-chain antibodies for structural genomics. J Struct Funct Genomics. 2005; 6(2-3):171-5.
    View in: PubMed
  14. Bliss JM, Sullivan MA, Malone J, Haidaris CG. Differentiation of Candida albicans and Candida dubliniensis by using recombinant human antibody single-chain variable fragments specific for hyphae. J Clin Microbiol. 2003 Mar; 41(3):1152-60.
    View in: PubMed
  15. Irby LR, Norland JE, Westfall JA, Sullivan MA. Evaluation of a forage allocation model for Theodore Roosevelt National Park. J Environ Manage. 2002 Feb; 64(2):153-69.
    View in: PubMed
  16. Haidaris CG, Malone J, Sherrill LA, Bliss JM, Gaspari AA, Insel RA, Sullivan MA. Recombinant human antibody single chain variable fragments reactive with Candida albicans surface antigens. J Immunol Methods. 2001 Nov 1; 257(1-2):185-202.
    View in: PubMed
  17. Murali R, Helmer-Citterich M, Sharkey DJ, Scalice ER, Daiss JL, Sullivan MA, Krishna Murthy HM. Structural studies on an inhibitory antibody against Thermus aquaticus DNA polymerase suggest mode of inhibition. Protein Eng. 1998 Feb; 11(2):79-86.
    View in: PubMed
  18. Malone J, Sullivan MA. Analysis of antibody selection by phage display utilizing anti-phenobarbital antibodies. J Mol Recognit. 1996 Sep-Dec; 9(5-6):738-45.
    View in: PubMed
  19. Tibbetts RS, Kim IY, Olson CL, Barthel LM, Sullivan MA, Winquist AG, Miller SD, Engman DM. Molecular cloning and characterization of the 78-kilodalton glucose-regulated protein of Trypanosoma cruzi. Infect Immun. 1994 Jun; 62(6):2499-507.
    View in: PubMed
  20. Nadeau K, Sullivan MA, Bradley M, Engman DM, Walsh CT. 83-kilodalton heat shock proteins of trypanosomes are potent peptide-stimulated ATPases. Protein Sci. 1992 Aug; 1(8):970-9.
    View in: PubMed
  21. Vasanthakumar G, Davis RL, Sullivan MA, Donahue JP. Cloning and expression in Escherichia coli of a hypoxanthine-guanine phosphoribosyltransferase-encoding cDNA from Plasmodium falciparum. Gene. 1990 Jul 2; 91(1):63-9.
    View in: PubMed
  22. Vasanthakumar G, Davis RL, Sullivan MA, Donahue JP. Nucleotide sequence of cDNA clone for hypoxanthine-guanine phosphoribosyltransferase from Plasmodium falciparum. Nucleic Acids Res. 1989 Oct 25; 17(20):8382.
    View in: PubMed
  23. Sullivan MA, Bock RM. Isolation and characterization of antisuppressor mutations in Escherichia coli. J Bacteriol. 1985 Jan; 161(1):377-84.
    View in: PubMed
  24. Sullivan MA, Cannon JF, Webb FH, Bock RM. Antisuppressor mutation in Escherichia coli defective in biosynthesis of 5-methylaminomethyl-2-thiouridine. J Bacteriol. 1985 Jan; 161(1):368-76.
    View in: PubMed
  25. Sullivan MA, Yasbin RE, Young FE. New shuttle vectors for Bacillus subtilis and Escherichia coli which allow rapid detection of inserted fragments. Gene. 1984 Jul-Aug; 29(1-2):21-6.
    View in: PubMed

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