|Title||Research Assistant Professor|
|Institution||School of Medicine and Dentistry|
|Department||Microbiology and Immunology|
|Address||University of Rochester Medical Center|
School of Medicine and Dentistry
601 Elmwood Ave, Box 695
Rochester NY 14642
||1976||Wisconsin Alumni Research Foundation Fellowship | University of Wisconsin|
||1979||NIH Predoctoral Fellowship | University of Wisconsin|
||C.E.K. Mees Award for Excellence in Scientific Research and Reporting | Eastman Kodak Company|
The ability to rapidly isolate human antibodies using phage display has opened up new approaches to understanding protein function. Research in my laboratory is focused on the manipulation of immunoglobulin molecules to develop novel reagents for characterization of protein expression and structure. We are using phage antibody technology in several areas of proteomics research to develop improved reagents for protein characterization as well as novel inhibitors of protein function that will aid in defining the roles of the many new proteins discovered through genomic sequencing. Major efforts are aimed at dissecting the saliva proteome and developing panels of antibodies for incorporation into new diagnostic platforms using protein microarrays. A second initiative is to derive antibodies useful for solving the structure of proteins by X-ray crystallography. Additional studies focus on the therapeutic potential of single-chain antibodies to reduce protein aggregation and misfolding, a process that characterizes a variety of neurodegenerative diseases.
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