Lin Gan
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Ophthalmology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 659
Rochester NY 14642
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| Title | Professor |
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| Institution | University of Rochester, River Campus |
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| Department | Center for Visual Science A&S |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurobiology and Anatomy |
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| 1985 |
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| CUSBEA (China-United States Biochemistry and Molecular Biology Examination and Administration) Program Scholarship | Ministry of Education | | 1999 |
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| 2003 | Rosanne H. Silbermann Fellow | Silbermann Foundation | | 2001 |
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| 2011 | NEI (2 RO1 EY013426), "Function of Math5 in Retinal Development." | NIH/NEI | | 2004 |
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| 2010 | NEI (RO1 EY015551), Brn3b Transcription Factors in Retinal Development | NIH/NEI | | 2008 |
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| 2013 | NIH (RO1 DC008856) Function of LIM-domain Transcriptional Regulators in Inner Ear Development. | NIH/NIDCD | | 2008 |
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| 2013 | NIH RO1 (1R01DC009250), Sensory Organ Formation in the Inner Ear | NIH/NIDCD (Co-PI) | | 2011 |
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| Research to Prevent Blindness Senior Scientific Investigator Award | Research to Prevent Blindness |
The mammalian retina and inner ear are two of the most common places of genetic diseases that cause blindness and deafness due to the degeneration of retinal and inner ear neurons. In order to understand the disease processes, it is very crucial to elucidate the fundamental mechanisms regulating the normal development and maintenance of these neurons at the molecular level. My research is centered on identifying genes required for neuron differentiation and survival, investigating the genetic pathways involved in these processes, and developing therapies for blindness and deafness via gene therapy and stem cell replacement. I am currently investigating the roles of three classes of transcription factors (TFs), the basic helix-loop-helix (bHLH), POU-homeodomain (POU-HD), and LIM-domain TFs, in the formation and maintenance of mouse retina and inner ear. Using homologous recombination in mouse embryonic stem (ES) cells to mutate these TF genes, I have shown that these TFs function in a cascade to regulate the differentiation of neuronal progenitor cells into specific types of neurons and to regulate the maturation and survival of post-differentiation neurons.
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Luo XJ, Huang L, Li M, Gan L. Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia. Schizophr Res. 2013 Feb; 143(2-3):390-2.
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Luo XJ, Li M, Huang L, Nho K, Deng M, Chen Q, Weinberger DR, Vasquez AA, Rijpkema M, Mattay VS, Saykin AJ, Shen L, Fernández G, Franke B, Chen JC, Chen XN, Wang JK, Xiao X, Qi XB, Xiang K, Peng YM, Cao XY, Li Y, Shi XD. The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors. PLoS One. 2012; 7(11):e50375.
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Chatterjee M, Li K, Chen L, Maisano X, Guo Q, Gan L, Li JY. Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes. Development. 2012 Dec; 139(24):4633-43.
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Harder JM, Ding Q, Fernandes KA, Cherry JD, Gan L, Libby RT. BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells. Mol Cell Neurosci. 2012 Aug; 51(1-2):53-9.
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Wu H, Lu Y, Shen C, Patel N, Gan L, Xiong WC, Mei L. Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation. Neuron. 2012 Jul 12; 75(1):94-107.
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Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, Ayrault O, Zindy F, Gan L, Roussel MF, Zuo J. Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by atoh1 ectopic expression. J Neurosci. 2012 May 9; 32(19):6600-10.
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Zhang D, Gan L, Cao Y, Wang Q, Qi L, Guo X. Understanding Charge Transfer at PbS-Decorated Graphene Surfaces toward a Tunable Photosensor. Adv Mater. 2012 May 22; 24(20):2715-20.
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Gan L, Zhang D, Guo X. Electrochemistry: an efficient way to chemically modify individual monolayers of graphene. Small. 2012 May 7; 8(9):1326-30.
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Ding Q, Joshi PS, Xie ZH, Xiang M, Gan L. BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1566-71.
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Ding Q, Gan L. Conditional control of gene expression in the mouse retina. Methods Mol Biol. 2012; 884:3-15.
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Bjerknes M, Khandanpour C, Möröy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martín MG, Cheng H. Origin of the brush cell lineage in the mouse intestinal epithelium. Dev Biol. 2012 Feb 15; 362(2):194-218.
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Yu H, Wang M, Chang H, Lu J, Lu B, Li J, Chen W, Tang R, Gan L, Zhao J, Liu B, Chen J. Prevalence of Antibodies against Enterovirus 71 in Children from Lu'an City in Central China. Jpn J Infect Dis. 2011 Nov; 64(6):528-32.
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Gan L, Schwengberg S, Denecke B. MicroRNA profiling during cardiomyocyte-specific differentiation of murine embryonic stem cells based on two different miRNA array platforms. PLoS One. 2011; 6(10):e25809.
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Feng L, Eisenstat DD, Chiba S, Ishizaki Y, Gan L, Shibasaki K. Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience. 2011 Nov 10; 195:9-20.
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Whitney IE, Raven MA, Ciobanu DC, Poché RA, Ding Q, Elshatory Y, Gan L, Williams RW, Reese BE. Genetic modulation of horizontal cell number in the mouse retina. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9697-702.
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Feng L, Xie ZH, Ding Q, Xie X, Libby RT, Gan L. MATH5 controls the acquisition of multiple retinal cell fates. Mol Brain. 2010; 3:36.
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Berahovich RD, Zabel BA, Penfold ME, Lewén S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010 Nov 1; 185(9):5130-9.
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Cao Y, Wei Z, Liu S, Gan L, Guo X, Xu W, Steigerwald ML, Liu Z, Zhu D. High-performance Langmuir-Blodgett monolayer transistors with high responsivity. Angew Chem Int Ed Engl. 2010 Aug 23; 49(36):6319-23.
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Yang H, Gan J, Xie X, Deng M, Feng L, Chen X, Gao Z, Gan L. Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion. Genesis. 2010 Jun; 48(6):400-6.
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Yang H, Xie X, Deng M, Chen X, Gan L. Generation and characterization of Atoh1-Cre knock-in mouse line. Genesis. 2010 Jun; 48(6):407-13.
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Shen LL, Liu H, Peng J, Gan L, Lu L, Zhang Q, Li L, He F, Jiang Y. Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase. Mol Biol Rep. 2011 Jan; 38(1):553-9.
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Gan L, Guo K, Li Y, Kang X, Sun L, Shu H, Liu Y. Up-regulated expression of stathmin may be associated with hepatocarcinogenesis. Oncol Rep. 2010 Apr; 23(4):1037-43.
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Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N. The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron. 2010 Feb 25; 65(4):503-15.
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Lu L, Liu H, Peng J, Gan L, Shen L, Zhang Q, Li L, Zhang L, Su C, Jiang Y. Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages. Lipids Health Dis. 2010; 9:16.
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Hwang CH, Guo D, Harris MA, Howard O, Mishina Y, Gan L, Harris SE, Wu DK. Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice. Dev Dyn. 2010 Feb; 239(2):505-13.
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Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Köppel T, Jahantigh MN, Lutgens E, Wang S, Olson EN, Schober A, Weber C. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal. 2009 Dec 8; 2(100):ra81.
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Deng M, Pan L, Xie X, Gan L. Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev Biol. 2010 Feb 1; 338(1):38-49.
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Sakagami K, Gan L, Yang XJ. Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. J Neurosci. 2009 May 27; 29(21):6932-44.
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Ding Q, Chen H, Xie X, Libby RT, Tian N, Gan L. BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons. J Neurosci. 2009 Apr 1; 29(13):3992-4003.
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Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L. Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23; 60(2):258-72.
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Pan L, Deng M, Xie X, Gan L. ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development. 2008 Jun; 135(11):1981-90.
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Elshatory Y, Gan L. The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci. 2008 Mar 26; 28(13):3291-7.
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Gan L, Yin ZF, Li M. [Expression of PIAS3 an inhibitor of activated STAT3 protein in human prostate cancer]. Zhonghua Yi Xue Za Zhi. 2008 Feb 5; 88(6):419-21.
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Elshatory Y, Everhart D, Deng M, Xie X, Barlow RB, Gan L. Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J Neurosci. 2007 Nov 14; 27(46):12707-20.
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Elshatory Y, Deng M, Xie X, Gan L. Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. J Comp Neurol. 2007 Jul 1; 503(1):182-97.
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Feng L, Xie X, Joshi PS, Yang Z, Shibasaki K, Chow RL, Gan L. Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Development. 2006 Dec; 133(24):4815-25.
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Yin ZF, Li M, Lai YQ, Yuan YM, Liu G, Chen L, Gan L, Na YQ. [Adriamycin and mitomycin dose-dependently downregulate X-kinked inhibitor of apoptosis protein in human bladder cancer cells]. Zhonghua Yi Xue Za Zhi. 2006 Jul 4; 86(25):1774-7.
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Shibasaki K, Takebayashi H, Ikenaka K, Feng L, Gan L. Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells. Gene Expr Patterns. 2007 Jan; 7(1-2):57-65.
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Nyström HC, Lindblom P, Wickman A, Andersson I, Norlin J, Fäldt J, Lindahl P, Skøtt O, Bjarnegård M, Fitzgerald SM, Caidahl K, Gan LM, Betsholtz C, Bergström G. Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries. Cardiovasc Res. 2006 Aug 1; 71(3):557-65.
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Deng M, Pan L, Xie X, Gan L. Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear. Gene Expr Patterns. 2006 Oct; 6(8):857-63.
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Grönros J, Wikström J, Hägg U, Wandt B, Gan LM. Proximal to middle left coronary artery flow velocity ratio, as assessed using color Doppler echocardiography, predicts coronary artery atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1126-31.
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Xie J, Lü L, Deng M, Weng S, Zhu J, Wu Y, Gan L, Chan SM, He J. Inhibition of reporter gene and Iridovirus-tiger frog virus in fish cell by RNA interference. Virology. 2005 Jul 20; 338(1):43-52.
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Hägg U, Johansson ME, Grönros J, Naylor AS, Jonsdottir IH, Bergström G, Svensson PA, Gan LM. Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential role of heat shock proteins. Physiol Genomics. 2005 Aug 11; 22(3):319-26.
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Pan L, Yang Z, Feng L, Gan L. Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis. Development. 2005 Feb; 132(4):703-12.
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Radde-Gallwitz K, Pan L, Gan L, Lin X, Segil N, Chen P. Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. J Comp Neurol. 2004 Sep 27; 477(4):412-21.
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Yan DH, Wen Y, Su LK, Xia W, Wang SC, Zhang S, Gan L, Lee DF, Spohn B, Frey JA, Hortobagyi GN, Hung MC. A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 2004 Mar 11; 23(10):1896-901.
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Yang Z, Ding K, Pan L, Deng M, Gan L. Math5 determines the competence state of retinal ganglion cell progenitors. Dev Biol. 2003 Dec 1; 264(1):240-54.
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Lu JR, Bassel-Duby R, Hawkins A, Chang P, Valdez R, Wu H, Gan L, Shelton JM, Richardson JA, Olson EN. Control of facial muscle development by MyoR and capsulin. Science. 2002 Dec 20; 298(5602):2378-81.
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Wee R, Castrucci AM, Provencio I, Gan L, Van Gelder RN. Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice. J Neurosci. 2002 Dec 1; 22(23):10427-33.
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Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13498-503.
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Guo Z, Clydesdale G, Cheng J, Kim K, Gan L, McConkey DJ, Ullrich SE, Zhuang Y, Su B. Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol Cell Biol. 2002 Aug; 22(16):5761-8.
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Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan; 129(2):467-77.
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Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA, Beremand PD, Thomas TL, Gan L, Klein WH. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Nucleic Acids Res. 2001 Dec 15; 29(24):4983-93.
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Kim BS, Savinova OV, Reedy MV, Martin J, Lun Y, Gan L, Smith RS, Tomarev SI, John SW, Johnson RL. Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function. Mol Cell Biol. 2001 Nov; 21(22):7707-13.
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Eng SR, Gratwick K, Rhee JM, Fedtsova N, Gan L, Turner EE. Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice. J Neurosci. 2001 Jan 15; 21(2):541-9.
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Wang SW, Kim BS, Ding K, Wang H, Sun D, Johnson RL, Klein WH, Gan L. Requirement for math5 in the development of retinal ganglion cells. Genes Dev. 2001 Jan 1; 15(1):24-9.
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Lu J, Chang P, Richardson JA, Gan L, Weiler H, Olson EN. The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9525-30.
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Wagner DS, Gan L, Klein WH. Identification of a differentially expressed RNA helicase by gene trapping. Biochem Biophys Res Commun. 1999 Sep 7; 262(3):677-84.
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Gan L, Wang SW, Huang Z, Klein WH. POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol. 1999 Jun 15; 210(2):469-80.
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Vivian JL, Gan L, Olson EN, Klein WH. A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Dev Biol. 1999 Apr 1; 208(1):44-55.
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Wagner DS, Gan L, Klein WH. Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: evidence for alternative rRNA production in hematopoietic cells. Biochem Biophys Res Commun. 1998 Sep 29; 250(3):674-81.
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Lin X, Gan L, Klein WH, Wells D. Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):738-43.
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Evrard YA, Lun Y, Aulehla A, Gan L, Johnson RL. lunatic fringe is an essential mediator of somite segmentation and patterning. Nature. 1998 Jul 23; 394(6691):377-81.
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Chen H, Lun Y, Ovchinnikov D, Kokubo H, Oberg KC, Pepicelli CV, Gan L, Lee B, Johnson RL. Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet. 1998 May; 19(1):51-5.
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Xiang M, Gan L, Li D, Chen ZY, Zhou L, O'Malley BW, Klein W, Nathans J. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9445-50.
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Xiang M, Gan L, Li D, Zhou L, Chen ZY, Wagner D, O'Malley BW, Klein W, Nathans J. Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harb Symp Quant Biol. 1997; 62:325-36.
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Xiang M, Gan L, Zhou L, Klein WH, Nathans J. Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11950-5.
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Mao CA, Wikramanayake AH, Gan L, Chuang CK, Summers RG, Klein WH. Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein. Development. 1996 May; 122(5):1489-98.
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Gan L, Xiang M, Zhou L, Wagner DS, Klein WH, Nathans J. POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):3920-5.
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Gan L, Mao CA, Wikramanayake A, Angerer LM, Angerer RC, Klein WH. An orthodenticle-related protein from Strongylocentrotus purpuratus. Dev Biol. 1995 Feb; 167(2):517-28.
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Mao CA, Gan L, Klein WH. Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene. Dev Biol. 1994 Sep; 165(1):229-42.
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Gan L, Klein WH. A positive cis-regulatory element with a bicoid target site lies within the sea urchin Spec2a enhancer. Dev Biol. 1993 May; 157(1):119-32.
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Venuti JM, Gan L, Kozlowski MT, Klein WH. Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo. Mech Dev. 1993 Apr; 41(1):3-14.
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Kozlowski MT, Gan L, Venuti JM, Sawadogo M, Klein WH. Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells. Dev Biol. 1991 Dec; 148(2):625-30.
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Gan L, Wessel GM, Klein WH. Regulatory elements from the related spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene. Dev Biol. 1990 Dec; 142(2):346-59.
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