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Edward Freedman

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionUniversity of Rochester, River Campus
DepartmentCenter for Visual Science A&S

 
 Awards And Honors
1996     Louis B. Flexner Award for outstanding dissertation research - Institute of Neurological Sciences,
1997     Donald B. Lindsley Prize in Behavioral Neuroscience, (The Grass Foundation/The Society for Neuroscience).
1997     Saul Winegrad, M.D. Award for outstanding dissertation (Neuroscience) - Biomedical Graduate Studies,
2001     Alfred P. Sloan Research Fellow.
2002     NSF CAREER Award
 
 Overview
Effects of mild traumatic brain injury (sports-related concussion) on eye-head-hand coordination.

Sports-related concussions (mild traumatic brain injuries or mTBI) are estimated to occur between 1.6 and 3.8 million times annually in the United States. The dangers of repeated injuries can be severe, particularly if additional impacts occur before full recovery. Prevention, identification, treatment, rehabilitation, and determination of recovery time-points are largely inadequate due to the paucity of parametric factors that can be easily and reliably measured both in the field and in the clinic. The overarching goal of the proposed study is to identify behavioral markers of mTBI that will ultimately help protect athletes from the dangers of premature return to full activity by tracking and facilitating recovery after injury. To accomplish this, a battery of visual-spatial tasks has been designed that require coordination of the eyes, head and hand and address sensorimotor plasticity, spatial working memory, and visuo-spatial orientation. These particular tasks have been selected because they permit a focused assessment of a variety of critical brain functions. Functions that when disrupted by mTBI can result in disorientation, dysmetria, and dyscoordination and are often symptoms of mild TBI in human subjects as well as in animal models of TBI. Careful analysis of movement kinematics and coordination during eye-head-hand orienting movements, movements to remembered target locations, visual guidance and control of hand trajectories, and tasks that require adaptive plasticity of coordination will yield parameters that pinpoint effects of mTBI, its progression and recovery to an extent that existing clinical exams and tests do not allow.

For more information visit the Lab Website: http://www.urmc.rochester.edu/labs/freedman-lab/

 
 Selected Publications
List All   |   Timeline
  1. Walton MM, Freedman EG. Activity of long-lead burst neurons in pontine reticular formation during head-unrestrained gaze shifts. J Neurophysiol. 2014 Jan; 111(2):300-12.
    View in: PubMed
  2. Walton MM, Freedman EG. Gaze shift duration, independent of amplitude, influences the number of spikes in the burst for medium-lead burst neurons in pontine reticular formation. Exp Brain Res. 2011 Oct; 214(2):225-39.
    View in: PubMed
  3. Quessy S, Quinet J, Freedman EG. The locus of motor activity in the superior colliculus of the rhesus monkey is unaltered during saccadic adaptation. J Neurosci. 2010 Oct 20; 30(42):14235-44.
    View in: PubMed
  4. Cecala AL, Freedman EG. Head-unrestrained gaze adaptation in the rhesus macaque. J Neurophysiol. 2009 Jan; 101(1):164-83.
    View in: PubMed
  5. Freedman EG. Coupling between horizontal and vertical components of saccadic eye movements during constant amplitude and direction gaze shifts in the rhesus monkey. J Neurophysiol. 2008 Dec; 100(6):3375-93.
    View in: PubMed
  6. Freedman EG. Coordination of the eyes and head during visual orienting. Exp Brain Res. 2008 Oct; 190(4):369-87.
    View in: PubMed
  7. Freedman EG, Cecala AL. Oblique gaze shifts: head movements reveal new aspects of component coupling. Prog Brain Res. 2008; 171:323-30.
    View in: PubMed
  8. Cecala AL, Freedman EG. Amplitude changes in response to target displacements during human eye-head movements. Vision Res. 2008 Jan; 48(2):149-66.
    View in: PubMed
  9. Freedman EG. Head-eye interactions during vertical gaze shifts made by rhesus monkeys. Exp Brain Res. 2005 Dec; 167(4):557-70.
    View in: PubMed
  10. Freedman EG, Quessy S. Electrical stimulation of rhesus monkey nucleus reticularis gigantocellularis. II. Effects on metrics and kinematics of ongoing gaze shifts to visual targets. Exp Brain Res. 2004 Jun; 156(3):357-76.
    View in: PubMed
  11. Quessy S, Freedman EG. Electrical stimulation of rhesus monkey nucleus reticularis gigantocellularis. I. Characteristics of evoked head movements. Exp Brain Res. 2004 Jun; 156(3):342-56.
    View in: PubMed
  12. Freedman EG. Interactions between eye and head control signals can account for movement kinematics. Biol Cybern. 2001 Jun; 84(6):453-62.
    View in: PubMed
  13. Sparks DL, Freedman EG, Chen LL, Gandhi NJ. Cortical and subcortical contributions to coordinated eye and head movements. Vision Res. 2001; 41(25-26):3295-305.
    View in: PubMed
  14. Freedman EG, Sparks DL. Coordination of the eyes and head: movement kinematics. Exp Brain Res. 2000 Mar; 131(1):22-32.
    View in: PubMed
  15. Ling L, Fuchs AF, Phillips JO, Freedman EG. Apparent dissociation between saccadic eye movements and the firing patterns of premotor neurons and motoneurons. J Neurophysiol. 1999 Nov; 82(5):2808-11.
    View in: PubMed
  16. Freedman EG, Sparks DL. Activity of cells in the deeper layers of the superior colliculus of the rhesus monkey: evidence for a gaze displacement command. J Neurophysiol. 1997 Sep; 78(3):1669-90.
    View in: PubMed
  17. Freedman EG, Sparks DL. Eye-head coordination during head-unrestrained gaze shifts in rhesus monkeys. J Neurophysiol. 1997 May; 77(5):2328-48.
    View in: PubMed
  18. Stanford TR, Freedman EG, Sparks DL. Site and parameters of microstimulation: evidence for independent effects on the properties of saccades evoked from the primate superior colliculus. J Neurophysiol. 1996 Nov; 76(5):3360-81.
    View in: PubMed
  19. Freedman EG, Stanford TR, Sparks DL. Combined eye-head gaze shifts produced by electrical stimulation of the superior colliculus in rhesus monkeys. J Neurophysiol. 1996 Aug; 76(2):927-52.
    View in: PubMed
  20. Fritz G, Spirito A, Yeung A, Klein R, Freedman E. A pictorial visual analog scale for rating severity of childhood asthma episodes. J Asthma. 1994; 31(6):473-8.
    View in: PubMed
  21. Lent CM, Zundel D, Freedman E, Groome JR. Serotonin in the leech central nervous system: anatomical correlates and behavioral effects. J Comp Physiol A. 1991 Feb; 168(2):191-200.
    View in: PubMed
  22. Freedman EG, Olyarchuk J, Marchaterre MA, Bass AH. A temporal analysis of testosterone-induced changes in electric organs and electric organ discharges of mormyrid fishes. J Neurobiol. 1989 Oct; 20(7):619-34.
    View in: PubMed
  23. Simmons JA, Freedman EG, Stevenson SB, Chen L, Wohlgenant TJ. Clutter interference and the integration time of echoes in the echolocating bat, Eptesicus fuscus. J Acoust Soc Am. 1989 Oct; 86(4):1318-32.
    View in: PubMed
  24. Freedman EG, Ferragamo M, Simmons AM. Masking patterns in the bullfrog (Rana catesbeiana). II: Physiological effects. J Acoust Soc Am. 1988 Dec; 84(6):2081-91.
    View in: PubMed
  25. Lent CM, Fliegner KH, Freedman E, Dickinson MH. Ingestive behaviour and physiology of the medicinal leech. J Exp Biol. 1988 Jul; 137:513-27.
    View in: PubMed
  26. Pearce BR, Freedman EG, Dutton GR. Autoreceptors modify the evoked release of [3H]GABA from cerebellar neurons in dissociated cell culture. Eur J Pharmacol. 1982 Aug 27; 82(3-4):131-5.
    View in: PubMed

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