Edward Freedman
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurobiology and Anatomy |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
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| Title | Associate Professor |
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| Institution | University of Rochester, River Campus |
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| Department | Center for Visual Science A&S |
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| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Engineering |
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| 1996 |
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| Louis B. Flexner Award for outstanding dissertation research - Institute of Neurological Sciences, | | 1997 |
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| Donald B. Lindsley Prize in Behavioral Neuroscience, (The Grass Foundation/The Society for Neuroscience). | | 1997 |
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| Saul Winegrad, M.D. Award for outstanding dissertation (Neuroscience) - Biomedical Graduate Studies, | | 2001 |
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| Alfred P. Sloan Research Fellow. | | 2002 |
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| NSF CAREER Award |
RESEARCH:
Neural Control of Coordinated Movements.
Maintaining our sense of the world around us and being able to interact with our environment depends in large part on the nervous system's ability to perform a few basic functions. We must be able to gather accurate sensory information about our surroundings, distinguish our movements from the movements of objects in the world, and coordinate our own movements in order to orient, and navigate smoothly through a complex setting. Vision, audition and somatosensation provide information about objects in the world, information about self movement is provided through the vestibular and proprioceptive systems. This wealth of sensory information must be integrated into a unified representation of objects including our own bodies. This neural representation of the environment can then be used to plan and implement behaviors which allow us to manipulate and interact with objects of interest. For example, we might hear or see an object in the periphery, and in order to visually localize and identify the object we need to plan and execute a movement which will re-direct our line of sight. To accomplish this task (which we do more than 125,000 times a day) we need to assess the object's location based on either the visual or auditory inputs. Then we must compute the difference between our current line of sight and the position of the target, incorporate information about the capabilities of the body segments which will contribute to moving the line of sight (e.g. the mobility of the eyes and head given their current positions), and coordinate more than 40 muscles and muscle groups to smoothly look at the target. Although we generally take this type of computationally intensive behavior for granted, even minor failures can cause a drastic reduction in our ability to function adequately in the world.
My approach to understanding these critical brain functions focuses on issues of sensori-motor integration and the neural computations necessary to plan and execute coordinated movements. In particular, using psychophysical and neurophysiological techniques, research in my lab addresses the neural mechanisms which result in the control and coordination of visual orienting behaviors.
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Walton MM, Freedman EG. Gaze shift duration, independent of amplitude, influences the number of spikes in the burst for medium-lead burst neurons in pontine reticular formation. Exp Brain Res. 2011 Oct; 214(2):225-39.
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Quessy S, Quinet J, Freedman EG. The locus of motor activity in the superior colliculus of the rhesus monkey is unaltered during saccadic adaptation. J Neurosci. 2010 Oct 20; 30(42):14235-44.
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Cecala AL, Freedman EG. Head-unrestrained gaze adaptation in the rhesus macaque. J Neurophysiol. 2009 Jan; 101(1):164-83.
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Freedman EG. Coupling between horizontal and vertical components of saccadic eye movements during constant amplitude and direction gaze shifts in the rhesus monkey. J Neurophysiol. 2008 Dec; 100(6):3375-93.
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Freedman EG. Coordination of the eyes and head during visual orienting. Exp Brain Res. 2008 Oct; 190(4):369-87.
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Freedman EG, Cecala AL. Oblique gaze shifts: head movements reveal new aspects of component coupling. Prog Brain Res. 2008; 171:323-30.
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Cecala AL, Freedman EG. Amplitude changes in response to target displacements during human eye-head movements. Vision Res. 2008 Jan; 48(2):149-66.
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Freedman EG. Head-eye interactions during vertical gaze shifts made by rhesus monkeys. Exp Brain Res. 2005 Dec; 167(4):557-70.
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Freedman EG, Quessy S. Electrical stimulation of rhesus monkey nucleus reticularis gigantocellularis. II. Effects on metrics and kinematics of ongoing gaze shifts to visual targets. Exp Brain Res. 2004 Jun; 156(3):357-76.
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Quessy S, Freedman EG. Electrical stimulation of rhesus monkey nucleus reticularis gigantocellularis. I. Characteristics of evoked head movements. Exp Brain Res. 2004 Jun; 156(3):342-56.
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Freedman EG. Interactions between eye and head control signals can account for movement kinematics. Biol Cybern. 2001 Jun; 84(6):453-62.
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Sparks DL, Freedman EG, Chen LL, Gandhi NJ. Cortical and subcortical contributions to coordinated eye and head movements. Vision Res. 2001; 41(25-26):3295-305.
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Freedman EG, Sparks DL. Coordination of the eyes and head: movement kinematics. Exp Brain Res. 2000 Mar; 131(1):22-32.
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Ling L, Fuchs AF, Phillips JO, Freedman EG. Apparent dissociation between saccadic eye movements and the firing patterns of premotor neurons and motoneurons. J Neurophysiol. 1999 Nov; 82(5):2808-11.
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Freedman EG, Sparks DL. Activity of cells in the deeper layers of the superior colliculus of the rhesus monkey: evidence for a gaze displacement command. J Neurophysiol. 1997 Sep; 78(3):1669-90.
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Freedman EG, Sparks DL. Eye-head coordination during head-unrestrained gaze shifts in rhesus monkeys. J Neurophysiol. 1997 May; 77(5):2328-48.
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Stanford TR, Freedman EG, Sparks DL. Site and parameters of microstimulation: evidence for independent effects on the properties of saccades evoked from the primate superior colliculus. J Neurophysiol. 1996 Nov; 76(5):3360-81.
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Freedman EG, Stanford TR, Sparks DL. Combined eye-head gaze shifts produced by electrical stimulation of the superior colliculus in rhesus monkeys. J Neurophysiol. 1996 Aug; 76(2):927-52.
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Fritz G, Spirito A, Yeung A, Klein R, Freedman E. A pictorial visual analog scale for rating severity of childhood asthma episodes. J Asthma. 1994; 31(6):473-8.
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Lent CM, Zundel D, Freedman E, Groome JR. Serotonin in the leech central nervous system: anatomical correlates and behavioral effects. J Comp Physiol A. 1991 Feb; 168(2):191-200.
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Freedman EG, Olyarchuk J, Marchaterre MA, Bass AH. A temporal analysis of testosterone-induced changes in electric organs and electric organ discharges of mormyrid fishes. J Neurobiol. 1989 Oct; 20(7):619-34.
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Simmons JA, Freedman EG, Stevenson SB, Chen L, Wohlgenant TJ. Clutter interference and the integration time of echoes in the echolocating bat, Eptesicus fuscus. J Acoust Soc Am. 1989 Oct; 86(4):1318-32.
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Freedman EG, Ferragamo M, Simmons AM. Masking patterns in the bullfrog (Rana catesbeiana). II: Physiological effects. J Acoust Soc Am. 1988 Dec; 84(6):2081-91.
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Lent CM, Fliegner KH, Freedman E, Dickinson MH. Ingestive behaviour and physiology of the medicinal leech. J Exp Biol. 1988 Jul; 137:513-27.
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Pearce BR, Freedman EG, Dutton GR. Autoreceptors modify the evoked release of [3H]GABA from cerebellar neurons in dissociated cell culture. Eur J Pharmacol. 1982 Aug 27; 82(3-4):131-5.
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