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Patricia Sime

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester NY 14642
Other Positions
TitleChief
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
DivisionMedicine - Pulmonary Diseases and Critical Care

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine

TitleProfessor
InstitutionUniversity of Rochester Medical Center
DepartmentCancer Center

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology

 
 Selected Publications
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  1. Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y. Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection. J Immunol. 2014 Jun 1; 192(11):5226-35.
    View in: PubMed
  2. Olsen KC, Epa AP, Kulkarni AA, Kottmann RM, McCarthy CE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):737-47.
    View in: PubMed
  3. Jeon KI, Kulkarni A, Woeller CF, Phipps RP, Sime PJ, Hindman HB, Huxlin KR. Inhibitory Effects of PPAR? Ligands on TGF-ß1-Induced Corneal Myofibroblast Transformation. Am J Pathol. 2014 May; 184(5):1429-45.
    View in: PubMed
  4. Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L, Rahman I. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2014 May; 306(9):L816-28.
    View in: PubMed
  5. Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I. Serotonin and Corticosterone Rhythms in Mice Exposed to Cigarette Smoke and in Patients with COPD: Implication for COPD-Associated Neuropathogenesis. PLoS One. 2014; 9(2):e87999.
    View in: PubMed
  6. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22.
    View in: PubMed
  7. Rosas IO, Kottman RM, Sime PJ. New light is shed on the enigmatic origin of the lung myofibroblast. Am J Respir Crit Care Med. 2013 Oct 1; 188(7):765-6.
    View in: PubMed
  8. Huxlin KR, Hindman HB, Jeon KI, Bühren J, Macrae S, Demagistris M, Ciufo D, Sime PJ, Phipps RP. Topical rosiglitazone is an effective anti-scarring agent in the cornea. PLoS One. 2013; 8(8):e70785.
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  9. Kottmann R, Phipps R, Sime P. Reply: from idiopathic pulmonary fibrosis to cystic fibrosis: got lactate? Am J Respir Crit Care Med. 2013 Jul 1; 188(1):111-2.
    View in: PubMed
  10. Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ. The Triterpenoid CDDO-Me Inhibits Bleomycin-Induced Lung Inflammation and Fibrosis. PLoS One. 2013; 8(5):e63798.
    View in: PubMed
  11. Thatcher TH, Hsiao HM, Pinner E, Laudon M, Pollock SJ, Sime PJ, Phipps RP. Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Jul; 305(2):L165-74.
    View in: PubMed
  12. McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP. Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2013 Jun; 304(11):L774-81.
    View in: PubMed
  13. Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJ. A novel anti-inflammatory and pro-resolving role for resolvin d1 in acute cigarette smoke-induced lung inflammation. PLoS One. 2013; 8(3):e58258.
    View in: PubMed
  14. Reddy RC, Rehan VK, Roman J, Sime PJ. PPARs: Regulators and Translational Targets in the Lung. PPAR Res. 2012; 2012:342924.
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  15. Ramon S, Bancos S, Thatcher TH, Murant TI, Moshkani S, Sahler JM, Bottaro A, Sime PJ, Phipps RP. Peroxisome Proliferator-Activated Receptor ? B Cell-Specific-Deficient Mice Have an Impaired Antibody Response. J Immunol. 2012 Nov 15; 189(10):4740-7.
    View in: PubMed
  16. Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T, Salibi R, Honnons S, Jones C, Isern NG, Hu JZ, Nathan SD, Grant G, Phipps RP, Sime PJ. Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-ß. Am J Respir Crit Care Med. 2012 Oct 15; 186(8):740-51.
    View in: PubMed
  17. Kulkarni AA, Woeller CF, Thatcher TH, Ramon S, Phipps RP, Sime PJ. Emerging PPAR?-Independent Role of PPAR? Ligands in Lung Diseases. PPAR Res. 2012; 2012:705352.
    View in: PubMed
  18. Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM, Davies DE. Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2012 May; 46(5):687-94.
    View in: PubMed
  19. Kuriyan AE, Lehmann GM, Kulkarni AA, Woeller CF, Feldon SE, Hindman HB, Sime PJ, Huxlin KR, Phipps RP. Electrophilic PPAR? ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. Exp Eye Res. 2012 Jan; 94(1):136-45.
    View in: PubMed
  20. Rico de Souza A, Zago M, Pollock SJ, Sime PJ, Phipps RP, Baglole CJ. Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis. J Biol Chem. 2011 Dec 16; 286(50):43214-28.
    View in: PubMed
  21. Blumberg N, Sime PJ, Phipps RP. The mystery of transfusion-related acute lung injury. Transfusion. 2011 Oct; 51(10):2054-7.
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  22. Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP. Ocular fibroblast diversity: implications for inflammation and ocular wound healing. Invest Ophthalmol Vis Sci. 2011 Jun; 52(7):4859-65.
    View in: PubMed
  23. Olsen KC, Sapinoro RE, Kottmann RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. Transglutaminase 2 and its role in pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Sep 15; 184(6):699-707.
    View in: PubMed
  24. Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ. Electrophilic PPAR? Ligands Attenuate IL-1ß and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPAR?-Independent Mechanism. PPAR Res. 2011; 2011:318134.
    View in: PubMed
  25. McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP. Lung-targeted overexpression of the NF-?B member RelB inhibits cigarette smoke-induced inflammation. Am J Pathol. 2011 Jul; 179(1):125-33.
    View in: PubMed
  26. Lehmann GM, Xi X, Kulkarni AA, Olsen KC, Pollock SJ, Baglole CJ, Gupta S, Casey AE, Huxlin KR, Sime PJ, Feldon SE, Phipps RP. The aryl hydrocarbon receptor ligand ITE inhibits TGFß1-induced human myofibroblast differentiation. Am J Pathol. 2011 Apr; 178(4):1556-67.
    View in: PubMed
  27. Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ. PPAR-? ligands repress TGFß-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PLoS One. 2011; 6(1):e15909.
    View in: PubMed
  28. Lin X, Sime PJ, Xu H, Williams MA, LaRussa L, Georas SN, Guo J. Yin yang 1 is a novel regulator of pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1689-97.
    View in: PubMed
  29. Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP. A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis. J Biotechnol. 2010 Nov; 150(3):417-27.
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  30. Kottmann RM, Kelly J, Lyda E, Gurell M, Stalica J, Ormsby W, Moon K, Trawick D, Sime PJ. Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients. Thorax. 2011 Sep; 66(9):823.
    View in: PubMed
  31. Manganaris C, Wittlin S, Xu H, Gurell M, Sime P, Kottmann RM. Metastatic papillary thyroid carcinoma and severe airflow obstruction. Chest. 2010 Sep; 138(3):738-42.
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  32. Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. 2010 May 10; 400(2):224-32.
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  33. Blumberg N, Sime PJ, Phipps RP. Leukoreduction of blood transfusions--there is such a thing as a free lunch. Crit Care Med. 2010 Feb; 38(2):720-1.
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  34. Hindman HB, Swanton JN, Phipps RP, Sime PJ, Huxlin KR. Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):1935-42.
    View in: PubMed
  35. Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ. Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L912-9.
    View in: PubMed
  36. Kottmann RM, Hogan CM, Phipps RP, Sime PJ. Determinants of initiation and progression of idiopathic pulmonary fibrosis. Respirology. 2009 Sep; 14(7):917-33.
    View in: PubMed
  37. Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ. Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. Am J Respir Cell Mol Biol. 2009 Dec; 41(6):722-30.
    View in: PubMed
  38. Gurell MN, Kottmann RM, Xu H, Sime PJ. Exogenous lipoid pneumonia: an unexpected complication of substance abuse. Ann Intern Med. 2008 Sep 2; 149(5):364-5.
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  39. Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. J Biol Chem. 2008 Oct 24; 283(43):28944-57.
    View in: PubMed
  40. Baglole CJ, Sime PJ, Phipps RP. Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L624-36.
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  41. Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. Am J Respir Cell Mol Biol. 2009 Feb; 40(2):147-58.
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  42. Thatcher TH, Benson RP, Phipps RP, Sime PJ. High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. Am J Physiol Lung Cell Mol Physiol. 2008 Sep; 295(3):L412-21.
    View in: PubMed
  43. Hart CM, Roman J, Reddy R, Sime PJ. PPARgamma: a novel molecular target in lung disease. J Investig Med. 2008 Feb; 56(2):515-7.
    View in: PubMed
  44. Sime PJ. The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis. J Investig Med. 2008 Feb; 56(2):534-8.
    View in: PubMed
  45. Bernard MP, Bancos S, Sime PJ, Phipps RP. Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Curr Pharm Des. 2008; 14(21):2051-60.
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  46. Hu JZ, Rommereim DN, Minard KR, Woodstock A, Harrer BJ, Wind RA, Phipps RP, Sime PJ. Metabolomics in lung inflammation:a high-resolution (1)h NMR study of mice exposedto silica dust. Toxicol Mech Methods. 2008; 18(5):385-98.
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  47. Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP. Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies. PPAR Res. 2008; 2008:834612.
    View in: PubMed
  48. Gauldie J, Bonniaud P, Sime P, Ask K, Kolb M. TGF-beta, Smad3 and the process of progressive fibrosis. Biochem Soc Trans. 2007 Aug; 35(Pt 4):661-4.
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  49. Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am J Pathol. 2007 Mar; 170(3):855-64.
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  50. O'Reilly KM, Mclaughlin AM, Beckett WS, Sime PJ. Asbestos-related lung disease. Am Fam Physician. 2007 Mar 1; 75(5):683-8.
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  51. Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. The Role of PPARs in Lung Fibrosis. PPAR Res. 2007; 2007:71323.
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  52. Shah AP, Xu H, Sime PJ, Trawick DR. Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome. Eur Respir J. 2006 Dec; 28(6):1276-9.
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  53. Viscardi RM, Atamas SP, Luzina IG, Hasday JD, He JR, Sime PJ, Coalson JJ, Yoder BA. Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung. Pediatr Res. 2006 Aug; 60(2):141-6.
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  54. Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res. 2006 May; 32(5):181-99.
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  55. Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol. 2006 Jul; 291(1):L19-29.
    View in: PubMed
  56. Baglole CJ, Ray DM, Bernstein SH, Feldon SE, Smith TJ, Sime PJ, Phipps RP. More than structural cells, fibroblasts create and orchestrate the tumor microenvironment. Immunol Invest. 2006; 35(3-4):297-325.
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  57. Thatcher TH, Sime PJ, Barth RK. Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire. Exp Lung Res. 2005 Sep; 31(7):685-700.
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  58. Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005 Sep; 289(3):L391-9.
    View in: PubMed
  59. Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP. Role of CXCR2 in cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2005 Aug; 289(2):L322-8.
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  60. Vallance BA, Gunawan MI, Hewlett B, Bercik P, Van Kampen C, Galeazzi F, Sime PJ, Gauldie J, Collins SM. TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G116-28.
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  61. Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1146-53.
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  62. O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1010-6.
    View in: PubMed
  63. Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, Phipps RP. Isolation and phenotypic characterization of lung fibroblasts. Methods Mol Med. 2005; 117:115-27.
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  64. Pociask DA, Sime PJ, Brody AR. Asbestos-derived reactive oxygen species activate TGF-beta1. Lab Invest. 2004 Aug; 84(8):1013-23.
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  65. Turner CK, Blieden TM, Smith TJ, Feldon SE, Foster DC, Sime PJ, Phipps RP. A novel ELISpot method for adherent cells. J Immunol Methods. 2004 Aug; 291(1-2):63-70.
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  66. Westergren-Thorsson G, Sime P, Jordana M, Gauldie J, Särnstrand B, Malmström A. Lung fibroblast clones from normal and fibrotic subjects differ in hyaluronan and decorin production and rate of proliferation. Int J Biochem Cell Biol. 2004 Aug; 36(8):1573-84.
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  67. Martey CA, Pollock SJ, Turner CK, O'Reilly KM, Baglole CJ, Phipps RP, Sime PJ. Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L981-91.
    View in: PubMed
  68. O'Reilly KM, Boscia JA, Kaplan KL, Sime PJ. A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis. Eur Respir J. 2004 Jun; 23(6):954-6.
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  69. Kaufman J, Sime PJ, Phipps RP. Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis. J Immunol. 2004 Feb 1; 172(3):1862-71.
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  70. Warshamana GS, Pociask DA, Sime P, Schwartz DA, Brody AR. Susceptibility to asbestos-induced and transforming growth factor-beta1-induced fibroproliferative lung disease in two strains of mice. Am J Respir Cell Mol Biol. 2002 Dec; 27(6):705-13.
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  71. Kolb M, Bonniaud P, Galt T, Sime PJ, Kelly MM, Margetts PJ, Gauldie J. Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains. Am J Respir Cell Mol Biol. 2002 Aug; 27(2):141-50.
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  72. Warshamana GS, Pociask DA, Fisher KJ, Liu JY, Sime PJ, Brody AR. Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice. Int J Exp Pathol. 2002 Aug; 83(4):183-201.
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  73. Gauldie J, Kolb M, Sime PJ. A new direction in the pathogenesis of idiopathic pulmonary fibrosis? Respir Res. 2002; 3:1.
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  74. Liu JY, Sime PJ, Wu T, Warshamana GS, Pociask D, Tsai SY, Brody AR. Transforming growth factor-beta(1) overexpression in tumor necrosis factor-alpha receptor knockout mice induces fibroproliferative lung disease. Am J Respir Cell Mol Biol. 2001 Jul; 25(1):3-7.
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  75. Sime PJ, O'Reilly KM. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol. 2001 Jun; 99(3):308-19.
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  76. Kolb M, Margetts PJ, Sime PJ, Gauldie J. Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1327-34.
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  77. Kolb M, Margetts PJ, Galt T, Sime PJ, Xing Z, Schmidt M, Gauldie J. Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):770-7.
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  78. Bakker AC, van de Loo FA, van Beuningen HM, Sime P, van Lent PL, van der Kraan PM, Richards CD, van den Berg WB. Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. Osteoarthritis Cartilage. 2001 Feb; 9(2):128-36.
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  79. Zhao J, Sime PJ, Bringas P, Tefft JD, Buckley S, Bu D, Gauldie J, Warburton D. Spatial-specific TGF-beta1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung. Eur J Cell Biol. 1999 Oct; 78(10):715-25.
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  80. Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D. Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis. Am J Physiol. 1999 Aug; 277(2 Pt 1):L412-22.
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  81. Lee WC, Wan YH, Li W, Fu F, Sime PJ, Gauldie J, Thomson AW, Fung JJ, Lu L, Qian S. Enhancement of dendritic cell tolerogenicity by genetic modification using adenoviral vectors encoding cDNA for TGF beta 1. Transplant Proc. 1999 Feb-Mar; 31(1-2):1195.
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  82. Gauldie J, Sime PJ, Xing Z, Marr B, Tremblay GM. Transforming growth factor-beta gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis. Curr Top Pathol. 1999; 93:35-45.
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  83. Stämpfli MR, Ritz SA, Neigh GS, Sime PJ, Lei XF, Xing Z, Croitoru K, Jordana M. Adenoviral infection inhibits allergic airways inflammation in mice. Clin Exp Allergy. 1998 Dec; 28(12):1581-90.
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  84. Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J. Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol. 1998 Sep; 153(3):825-32.
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  85. Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D. Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA. Mech Dev. 1998 Mar; 72(1-2):89-100.
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  86. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest. 1997 Aug 15; 100(4):768-76.
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  87. Sime PJ, Xing Z, Foley R, Graham FL, Gauldie J. Transient gene transfer and expression in the lung. Chest. 1997 Jun; 111(6 Suppl):89S-94S.
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  88. Sime PJ, Sarnstrand B, Xing Z, Graham F, Fisher L, Gauldie J. Adenovirus-mediated gene transfer of the proteoglycan biglycan induces fibroblastic responses in the lung. Chest. 1997 Jun; 111(6 Suppl):137S.
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  89. Xing Z, Tremblay GM, Sime PJ, Gauldie J. Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation. Am J Pathol. 1997 Jan; 150(1):59-66.
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  90. Gauldie J, Graham F, Xing Z, Braciak T, Foley R, Sime PJ. Adenovirus-vector-mediated cytokine gene transfer to lung tissue. Ann N Y Acad Sci. 1996 Oct 31; 796:235-44.
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  91. Xing Z, Braciak T, Ohkawara Y, Sallenave JM, Foley R, Sime PJ, Jordana M, Graham FL, Gauldie J. Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation. J Leukoc Biol. 1996 Apr; 59(4):481-8.
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  92. Kingshott RN, Sime PJ, Engleman HM, Douglas NJ. Self assessment of daytime sleepiness: patient versus partner. Thorax. 1995 Sep; 50(9):994-5.
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  93. Jordana M, Särnstrand B, Sime PJ, Ramis I. Immune-inflammatory functions of fibroblasts. Eur Respir J. 1994 Dec; 7(12):2212-22.
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  94. Sime PJ, Chilvers ER, Leitch AG. Miliary tuberculosis in Edinburgh--a comparison between 1984-1992 and 1954-1967. Respir Med. 1994 Sep; 88(8):609-11.
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  95. Rubilar M, Sime PJ, Moudgil H, Chilvers ER, Leitch AG. Time to extend 'the timetable of tuberculosis'? Respir Med. 1994 Aug; 88(7):481-2.
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  96. Priestley GC, Aldridge RD, Sime PJ, Wilson D. Skin fibroblast activity in pretibial myxoedema and the effect of octreotide (Sandostatin) in vitro. Br J Dermatol. 1994 Jul; 131(1):52-6.
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  97. Böllert FG, Sime PJ, MacNee W, Crompton GK. Pulmonary Mycobacterium malmoense and aspergillus infection: a fatal combination? Thorax. 1994 May; 49(5):521-2.
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  98. Matusiewicz SP, Williamson IJ, Sime PJ, Brown PH, Wenham PR, Crompton GK, Greening AP. Plasma lactate dehydrogenase: a marker of disease activity in cryptogenic fibrosing alveolitis and extrinsic allergic alveolitis? Eur Respir J. 1993 Oct; 6(9):1282-6.
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  99. Sime PJ, Gordon A, Hooper ML, Bell JE. Differentiation in medulloblastomas and other primitive neuroectodermal tumours. Br J Neurosurg. 1989; 3(1):89-100.
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