RESEARCH:
Neurogenesis in the Developing and Adult Mammalian Brain

Brain size and function depend on the generation of the appropriate number of neurons during development and their proper assembly into neural circuits. Our lab is dedicated to the study of neurogenesis (i.e., the generation of new neurons) in the mammalian forebrain. Specifically, we want to know how neurogenesis is controlled during development and why it persists in only a few particular brain regions in adulthood. To address these issues, we are applying molecular, cellular and anatomical techniques to a variety of mammalian models. Knowing the mechanisms that govern neurogenesis can further our understanding of the developmental basis of both the generation of neural diversity across species as well as the pathogenesis of abnormalities in humans. Moreover, continued neuronal production may have implications for plasticity in the adult brain – particularly for enhancing the brain's own capacity for self-repair after neuronal loss due to injury or neurodegenerative disease.

PUBLICATIONS:

Gorelick, P.B., Caplan, L.R., Hier, D.B., Patel, D., Langenberg, P., Pessin, M.S., Biller, J., Kornack, D. (1985). Racial differences in the distribution of posterior circulation occlusive disease. Stroke 16: 785-790
Kornack, D.R., Lu, B., and Black, I.B. (1991). Sexually dimorphic expression of the NGF receptor gene in the developing rat brain. Brain Res. 542: 171-174.
Rakic, P. and Kornack, D.R. (1993) Constraints on neurogenesis in adult primate brain: an evolutionary advantage? Restor. Neurol. 6: 257-266.
Kornack, D.R. and Rakic, P. (1995) Radial and horizontal deployment of clonally related cells in the primate neocortex: relationship to distinct mitotic lineages. Neuron 15: 311-321.
Kornack, D.R. and Rakic, P. (1998) Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proc. Natl. Acad. Sci. USA 95:1242-1246.
Kornack, D.R. and Rakic, P. (1999) Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc. Natl. Acad. Sci. USA 96: 5768-5773.
Kornack, D.R. (2000) Neurogenesis and the evolution of cortical diversity: mode, tempo, and partitioning during development and persistence in adulthood. Brain Behav. Evol. 55: 336-344.
Kornack, D.R. and Rakic, P. (2001a) The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proc. Natl. Acad. Sci. USA 98: 4752-4757.
Kornack, D.R. and Rakic, P. (2001b) Cell proliferation without neurogenesis in adult primate neocortex. Science 294: 2127-2129.
Kornack, D.R. and Giger, R.J. (2005) Probing microtubule +TIPs: regulation of axon branching. Curr. Opin. Neurobiol. 15:58-66

• Kornack DR, Giger RJ. Probing microtubule +TIPs: regulation of axon branching. Curr Opin Neurobiol. 2005 Feb; 15(1):58-66.
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• Kornack DR, Rakic P. Cell proliferation without neurogenesis in adult primate neocortex. Science. 2001 Dec 7; 294(5549):2127-30.
  View in: PubMed
• Kornack DR, Rakic P. The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4752-7.
  View in: PubMed
• Kornack DR. Neurogenesis and the evolution of cortical diversity: mode, tempo, and partitioning during development and persistence in adulthood. Brain Behav Evol. 2000 Jun; 55(6):336-44.
  View in: PubMed
• Kornack DR, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5768-73.
  View in: PubMed
• Kornack DR, Rakic P. Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proc Natl Acad Sci U S A. 1998 Feb 3; 95(3):1242-6.
  View in: PubMed
• Kornack DR, Rakic P. Radial and horizontal deployment of clonally related cells in the primate neocortex: relationship to distinct mitotic lineages. Neuron. 1995 Aug; 15(2):311-21.
  View in: PubMed
• Kornack DR, Lu B, Black IB. Sexually dimorphic expression of the NGF receptor gene in the developing rat brain. Brain Res. 1991 Feb 22; 542(1):171-4.
  View in: PubMed
• Gorelick PB, Caplan LR, Hier DB, Patel D, Langenberg P, Pessin MS, Biller J, Kornack D. Racial differences in the distribution of posterior circulation occlusive disease. Stroke. 1985 Sep-Oct; 16(5):785-90.
  View in: PubMed