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Alison Elder

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester NY 14642
 
 Awards And Honors
1992     College Chemistry Award, Society for Analytical Chemists of Pittsburgh
1995 - 1996Graduate Student Fellowship, U.S. Environmental Protection Agency
2007     Cornerstone Alumna Award in Environmental Medicine, Chatham University
2009     Young Investigator Award, Inhalation and Respiratory Specialty Section, Society of Toxicology
 
 Overview
Toxicology of Inhaled Ultrafine Particles and Engineered Nanomaterials

Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant exposure, and health status on the response(s) to inhaled UFPs. We are also interested in determining the basis for potential adverse effects of inhaled particles in the cardiovascular and central nervous systems.

This research focus has naturally led to our work with engineered nanomaterials. The research commonalities between UFP and nanomaterials are numerous, including the kinetics of tissue distribution following exposure, mechanisms of response related to oxidative stress, particle-protein interactions, and the physicochemical characteristics of the particles that determine response. Our research aims are met by using a combination of animal and cell culture models as well as detailed particle characterization.

In addition to looking for nanosized particles in tissues via chemical and microscopic means, responses are determined by measuring markers of inflammation and oxidative stress in the lung lining fluid, lung tissue, blood, circulating inflammatory cells, and extrapulmonary tissues (e.g. heart, liver, spleen, kidney, brain regions). We also have specific projects focused on cardiovascular stability and neurodegeneration following exposures to UFPs and nanomaterials.

 
 Selected Publications
List All   |   Timeline
  1. Baisch BL, Corson NM, Wade-Mercer P, Gelein R, Kennell AJ, Oberdörster G, Elder A. Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation. Part Fibre Toxicol. 2014; 11(1):5.
    View in: PubMed
  2. Gordon SC, Butala JH, Carter JM, Elder A, Gordon T, Gray G, Sayre PG, Schulte PA, Tsai CS, West J. Workshop report: Strategies for setting occupational exposure limits for engineered nanomaterials. Regul Toxicol Pharmacol. 2014 Apr; 68(3):305-11.
    View in: PubMed
  3. Mortensen LJ, Jatana S, Gelein R, De Benedetto A, De Mesy Bentley KL, Beck LA, Elder A, Delouise LA. Quantification of quantum dot murine skin penetration with UVR barrier impairment. Nanotoxicology. 2013 Dec; 7:1386-98.
    View in: PubMed
  4. Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G. Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data. Toxicology. 2012 Jul 16; 297(1-3):1-9.
    View in: PubMed
  5. Shi M, Kwon HS, Peng Z, Elder A, Yang H. Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles. ACS Nano. 2012 Mar 27; 6(3):2157-64.
    View in: PubMed
  6. Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G. Validation of an LDH assay for assessing nanoparticle toxicity. Toxicology. 2011 Sep 5; 287(1-3):99-104.
    View in: PubMed
  7. Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdörster G. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ Health A. 2010; 73(5):445-61.
    View in: PubMed
  8. Oberdörster G, Elder A, Rinderknecht A. Nanoparticles and the brain: cause for concern?. J Nanosci Nanotechnol. 2009 Aug; 9(8):4996-5007.
    View in: PubMed
  9. Elder A, Vidyasagar S, DeLouise L. Physicochemical factors that affect metal and metal oxide nanoparticle passage across epithelial barriers. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Jul-Aug; 1(4):434-50.
    View in: PubMed
  10. Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhal Toxicol. 2007 Jan; 19(1):1-12.
    View in: PubMed
  11. Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black. J Occup Environ Med. 2006 Dec; 48(12):1265-78.
    View in: PubMed
  12. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006 Aug; 114(8):1172-8.
    View in: PubMed
  13. Elder A, Oberdörster G. Translocation and effects of ultrafine particles outside of the lung. Clin Occup Environ Med. 2006; 5(4):785-96.
    View in: PubMed
  14. Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci. 2005 Dec; 88(2):614-29.
    View in: PubMed
  15. Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Exp Lung Res. 2005 Jul-Aug; 31(6):527-46.
    View in: PubMed
  16. Silva VM, Corson N, Elder A, Oberdörster G. The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP). Toxicol Sci. 2005 Jun; 85(2):983-9.
    View in: PubMed
  17. Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res. 2004 Jul-Aug; 30(5):369-82.
    View in: PubMed
  18. Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhal Toxicol. 2004 Jun; 16(6-7):461-71.
    View in: PubMed
  19. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol. 2004 Jun; 16(6-7):437-45.
    View in: PubMed
  20. Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Exp Lung Res. 2004 Mar; 30(2):105-20.
    View in: PubMed
  21. Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdörster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong CH. On-road exposure to highway aerosols. 1. Aerosol and gas measurements. Inhal Toxicol. 2004; 16 Suppl 1:31-9.
    View in: PubMed
  22. Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal Toxicol. 2004; 16 Suppl 1:41-53.
    View in: PubMed
  23. Gallagher J, Sams R, Inmon J, Gelein R, Elder A, Oberdörster G, Prahalad AK. Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in rat lung DNA following subchronic inhalation of carbon black. Toxicol Appl Pharmacol. 2003 Aug 1; 190(3):224-31.
    View in: PubMed
  24. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A. 2002 Oct 25; 65(20):1531-43.
    View in: PubMed
  25. Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC. Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst. 2000 Aug; (96):5-74; disc. 75-86.
    View in: PubMed
  26. Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G. Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice. Inhal Toxicol. 2000 Mar; 12(3):225-43.
    View in: PubMed
  27. Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G. Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin. Inhal Toxicol. 2000; 12 Suppl 4:227-46.
    View in: PubMed

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