Mark Noble
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Genetics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester NY 14642
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurobiology and Anatomy |
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| 1977 |
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| 1978 | National Science Foundation Postdoctoral fellowship | | 1978 |
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| 1980 | National Institutes of Health postdoctoral fellowship | | 1979 |
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| Woods Hole Neurobiology Course Fellow | | 1988 |
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| The Jean Monnet Prize of the European Neurological Society (with Damian Wren and Guus Wolswijk) |
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Noble M, Mayer-Pröschel M, Davies JE, Davies SJ, Pröschel C. Cell therapies for the central nervous system: how do we identify the best candidates? Curr Opin Neurol. 2011 Dec; 24(6):570-6.
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Noble M, Davies JE, Mayer-Pröschel M, Pröschel C, Davies SJ. Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury. Neurotherapeutics. 2011 Oct; 8(4):677-93.
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Bollen KA, Noble MD. Structural equation models and the quantification of behavior. Proc Natl Acad Sci U S A. 2011 Sep 13; 108 Suppl 3:15639-46.
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Noble M, Pröschel C, Mayer-Pröschel M. Oxidative-reductionist approaches to stem and progenitor cell function. Cell Stem Cell. 2011 Jan 7; 8(1):1-2.
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Hyrien O, Dietrich J, Noble M. Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors. Cancer Res. 2010 Dec 15; 70(24):10051-9.
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Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble MD, Beattie MS, Bresnahan JC. Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats. Exp Neurol. 2011 Jan; 227(1):159-71.
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Chen R, Hyrien O, Noble M, Mayer-Pröschel M. A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process. Biostatistics. 2011 Jan; 12(1):173-91.
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Hyrien O, Chen R, Mayer-Pröschel M, Noble M. Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications. Biometrics. 2010 Jun; 66(2):567-77.
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Davies JE, Pröschel C, Zhang N, Noble M, Mayer-Pröschel M, Davies SJ. Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. J Biol. 2008; 7(7):24.
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Han R, Yang YM, Dietrich J, Luebke A, Mayer-Pröschel M, Noble M. Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system. J Biol. 2008; 7(4):12.
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Li Z, Dong T, Pröschel C, Noble M. Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS Biol. 2007 Feb; 5(2):e35.
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Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med. 2006 Sep 21; 355(12):1253-61.
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Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data. Theor Biol Med Model. 2006; 3:21.
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Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ. Astrocytes derived from glial-restricted precursors promote spinal cord repair. J Biol. 2006; 5(3):7.
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Noble M. Implications for CNS repair of redox modulation of cell survival, division and differentiation. Curr Alzheimer Res. 2006 Feb; 3(1):37-47.
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Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol. 2006; 5(7):22.
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Noble M. Ethics in the trenches: a multifaceted analysis of the stem cell debate. Stem Cell Rev. 2005 Dec; 1(4):345-76.
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Noble M, Mayer-Pröschel M, Pröschel C. Redox regulation of precursor cell function: insights and paradoxes. Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1456-67.
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Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. A stochastic model to analyze clonal data on multi-type cell populations. Biometrics. 2005 Mar; 61(1):199-207.
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Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M, Torres C, Pröschel C. EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy. Nat Med. 2005 Mar; 11(3):277-83.
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Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture. Math Biosci. 2005 Feb; 193(2):255-74.
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Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC. Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration. Exp Neurol. 2004 Dec; 190(2):289-310.
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Noble M, Dietrich J. The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity. Trends Neurosci. 2004 Mar; 27(3):148-54.
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Noble M. The possible role of myelin destruction as a precipitating event in Alzheimer's disease. Neurobiol Aging. 2004 Jan; 25(1):25-31.
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Noble M, Pröschel C, Mayer-Pröschel M. Getting a GR(i)P on oligodendrocyte development. Dev Biol. 2004 Jan 1; 265(1):33-52.
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Biran R, Noble MD, Tresco PA. Directed nerve outgrowth is enhanced by engineered glial substrates. Exp Neurol. 2003 Nov; 184(1):141-52.
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Noble M, Smith J, Power J, Mayer-Pröschel M. Redox state as a central modulator of precursor cell function. Ann N Y Acad Sci. 2003 Jun; 991:251-71.
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Noble M, Arhin A, Gass D, Mayer-Pröschel M. The cortical ancestry of oligodendrocytes: common principles and novel features. Dev Neurosci. 2003 Mar-Aug; 25(2-4):217-33.
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Dietrich J, Noble M, Mayer-Proschel M. Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells. Glia. 2002 Oct; 40(1):65-77.
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Power J, Mayer-Pröschel M, Smith J, Noble M. Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions. Dev Biol. 2002 May 15; 245(2):362-75.
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Noble M, Dietrich J. Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damage. Trends Neurosci. 2002 Feb; 25(2):103-7.
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Gregori N, Pröschel C, Noble M, Mayer-Pröschel M. The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function. J Neurosci. 2002 Jan 1; 22(1):248-56.
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Biran R, Webb K, Noble MD, Tresco PA. Surfactant-immobilized fibronectin enhances bioactivity and regulates sensory neurite outgrowth. J Biomed Mater Res. 2001 Apr; 55(1):1-12.
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Mayer-Pröschel M, Morath D, Noble M. Are hypothyroidism and iron deficiency precursor cell diseases? Dev Neurosci. 2001; 23(4-5):277-86.
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Noble M. Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage? Proc Natl Acad Sci U S A. 2000 Nov 7; 97(23):12393-5.
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Smith J, Ladi E, Mayer-Proschel M, Noble M. Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10032-7.
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Tresco PA, Biran R, Noble MD. Cellular transplants as sources for therapeutic agents. Adv Drug Deliv Rev. 2000 Aug 20; 42(1-2):3-27.
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Biran R, Noble MD, Tresco PA. Characterization of cortical astrocytes on materials of differing surface chemistry. J Biomed Mater Res. 1999 Aug; 46(2):150-9.
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Yakovlev AY, Boucher K, Mayer-Proschel M, Noble M. Quantitative insight into proliferation and differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14164-7.
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Rao MS, Noble M, Mayer-Pröschel M. A tripotential glial precursor cell is present in the developing spinal cord. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3996-4001.
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Sinden JD, Rashid-Doubell F, Kershaw TR, Nelson A, Chadwick A, Jat PS, Noble MD, Hodges H, Gray JA. Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus. Neuroscience. 1997 Dec; 81(3):599-608.
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Ibarrola N, Mayer-Pröschel M, Rodriguez-Peña A, Noble M. Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro. Dev Biol. 1996 Nov 25; 180(1):1-21.
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Bhakoo KK, Williams SR, Florian CL, Land H, Noble MD. Immortalization and transformation are associated with specific alterations in choline metabolism. Cancer Res. 1996 Oct 15; 56(20):4630-5.
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Florian CL, Williams SR, Bhakoo KK, Noble MD. Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography. Neurochem Res. 1996 Sep; 21(9):1065-74.
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Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT. LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. Cell. 1996 Jul 12; 86(1):59-69.
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Bhakoo KK, Williams IT, Williams SR, Gadian DG, Noble MD. Proton nuclear magnetic resonance spectroscopy of primary cells derived from nervous tissue. J Neurochem. 1996 Mar; 66(3):1254-63.
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Ehler E, Jat PS, Noble MD, Citi S, Draeger A. Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties. Circulation. 1995 Dec 1; 92(11):3289-96.
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Pröschel C, Blouin MJ, Gutowski NJ, Ludwig R, Noble M. Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro. Oncogene. 1995 Oct 5; 11(7):1271-81.
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Florian CL, Preece NE, Bhakoo KK, Williams SR, Noble MD. Cell type-specific fingerprinting of meningioma and meningeal cells by proton nuclear magnetic resonance spectroscopy. Cancer Res. 1995 Jan 15; 55(2):420-7.
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Woolf AS, Kolatsi-Joannou M, Hardman P, Andermarcher E, Moorby C, Fine LG, Jat PS, Noble MD, Gherardi E. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol. 1995 Jan; 128(1-2):171-84.
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Mayer M, Noble M. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16):7496-500.
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Morgan JE, Beauchamp JR, Pagel CN, Peckham M, Ataliotis P, Jat PS, Noble MD, Farmer K, Partridge TA. Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: a model system for the derivation of tissue-specific and mutation-specific cell lines. Dev Biol. 1994 Apr; 162(2):486-98.
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Bögler O, Noble M. Measurement of time in oligodendrocyte-type-2 astrocyte (O-2A) progenitors is a cellular process distinct from differentiation or division. Dev Biol. 1994 Apr; 162(2):525-38.
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Mayer M, Bhakoo K, Noble M. Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro. Development. 1994 Jan; 120(1):143-53.
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Groves AK, Entwistle A, Jat PS, Noble M. The characterization of astrocyte cell lines that display properties of glial scar tissue. Dev Biol. 1993 Sep; 159(1):87-104.
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Chambers TJ, Owens JM, Hattersley G, Jat PS, Noble MD. Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5578-82.
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Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M. Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells. Nature. 1993 Apr 1; 362(6419):453-5.
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Whitehead RH, VanEeden PE, Noble MD, Ataliotis P, Jat PS. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):587-91.
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Wolswijk G, Noble M. Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells. J Cell Biol. 1992 Aug; 118(4):889-900.
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Venter DJ, Stratton MR, Noble MD. Molecular genetic study showing that the IN/157 'oligodendroglioma' cell line has been contaminated by rhabdomyosarcoma (RD) cells. Neuropathol Appl Neurobiol. 1992 Apr; 18(2):159-69.
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Wren D, Wolswijk G, Noble M. In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells. J Cell Biol. 1992 Jan; 116(1):167-76.
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Jat PS, Noble MD, Ataliotis P, Tanaka Y, Yannoutsos N, Larsen L, Kioussis D. Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5096-100.
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Venter DJ, Bevan KL, Ludwig RL, Riley TE, Jat PS, Thomas DG, Noble MD. Retinoblastoma gene deletions in human glioblastomas. Oncogene. 1991 Mar; 6(3):445-8.
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Bögler O, Wren D, Barnett SC, Land H, Noble M. Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6368-72.
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Wolswijk G, Noble M. Identification of an adult-specific glial progenitor cell. Development. 1989 Feb; 105(2):387-400.
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Raff MC, Lillien LE, Richardson WD, Burne JF, Noble MD. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature. 1988 Jun 9; 333(6173):562-5.
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Noble M, Murray K, Stroobant P, Waterfield MD, Riddle P. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. Nature. 1988 Jun 9; 333(6173):560-2.
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Kennedy PG, Watkins BA, Thomas DG, Noble MD. Antigenic expression by cells derived from human gliomas does not correlate with morphological classification. Neuropathol Appl Neurobiol. 1987 Sep-Oct; 13(5):327-47.
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Small RK, Riddle P, Noble M. Evidence for migration of oligodendrocyte--type-2 astrocyte progenitor cells into the developing rat optic nerve. Nature. 1987 Jul 9-15; 328(6126):155-7.
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Noble M, Murray K. Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell. EMBO J. 1984 Oct; 3(10):2243-7.
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Raff MC, Miller RH, Noble M. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature. 1983 Jun 2-8; 303(5916):390-6.
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Bartlett PF, Noble MD, Pruss RM, Raff MC, Rattray S, Williams CA. Rat neural antigen-2 (RAN-2): a cell surface antigen on astrocytes, ependymal cells, Müller cells and lepto-meninges defined by a monoclonal antibody. Brain Res. 1981 Jan 12; 204(2):339-51.
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