Jonathan Mink
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 631
Rochester NY 14642
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| Title | Professor |
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| Institution | University of Rochester, River Campus |
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| Department | Brain/Cognitive Sciences RC |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurobiology and Anatomy |
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| 1980 |
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| High Honors for Senior Thesis, Wesleyan University | | 1980 |
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| Walkley Prize for Psychology Research, Wesleyan University | | 1987 |
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| O'Leary Prize for Neuroscience Research, Washington University | | 1989 |
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| Irwin Levy Prize in Neurology, Washington University | | 1993 |
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| St. Louis Children's Hospital Housestaff Teaching Award | | 2002 |
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| Elected Member, American Neurological Association | | 2002 |
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| Derek Denny-Brown Neurological Scholar Award, American Neurological Association | | 2002 |
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| Fellow, American Academy of Pediatrics | | 2004 |
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| Fellow | American Academy of Neurology | | 2005 |
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| Neurology Faculty Teaching Award | Department of Neurology, University of Rochester | | 2005 |
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| Best Doctors in America | America's Best Doctors | | 2007 |
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| Who's Who in America | | 2008 |
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| Teacher Recognition Award | American Academy of Neurology | | 2008 |
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| Patient's Choice Award | Patient's Choice | | 2009 |
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| Elected Faculty Member | Alpha Omega Alpha | | 2009 |
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| America's Top Doctors | Castle Connolly Medical Ltd. | | 2011 |
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| Faculty Mentoring Award for Mentoring of Clinical Science Trainees | University of Rochester School of Medicine and Dentistry | | 2011 |
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| Commendation for Third Year Teaching | University of Rochester School of Medicine and Dentistry | | 2011 |
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| Compassionate Doctor Award | Patient's Choice |
My research program focuses on three areas. First is the function of the basal ganglia in normal control of movement and the pathophysiology of basal ganglia disorders characterized by abnormal involuntary movements. The basal ganglia are affected by many disorders beginning in childhood including cerebral palsy, CNS infections, metabolic disorders and other genetic conditions. It is well known that children with diseases involving the basal ganglia have abnormal body postures, slowing of movement, involuntary movements, or a combination of these abnormalities. However, the pathophysiology of these abnormalities is poorly understood. We have hypothesized that the basal ganglia normally act to select desired movement patterns and inhibit competing movements. Deranged basal ganglia output results in unwanted competing motor patterns or difficulty selecting desired motor patterns.
Second, is Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease), a neurodegenerative disease of childhood. Our research has focused on the natural history of the disease and is now pursuing potential disease modifying therapeutics.
Third, is the impact of Tourette Syndrome on children, their families, and the community.
An additional line of research involves the study of children with a degenerative neurological disorder called Batten Disease (aka Neuronal Ceroid Lipofuscinosis). We are investigating the natural history and rate of progression of neurological symptoms in this disorder.
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Guerrini R, Mink JW. Paroxysmal disorders associated with PRRT2 mutations shake up expectations on ion channel genes. Neurology. 2012 Nov 20; 79(21):2086-8.
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Brashear A, Mink JW, Hill DF, Boggs N, McCall WV, Stacy MA, Snively B, Light LS, Sweadner KJ, Ozelius LJ, Morrison L. ATP1A3 mutations in infants: a new rapid-onset dystonia--Parkinsonism phenotype characterized by motor delay and ataxia. Dev Med Child Neurol. 2012 Nov; 54(11):1065-7.
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Schor NF, Mink JW. Robert J. Joynt, MD, PhD: A Tribute. J Child Neurol. 2012 Aug; 27(8):1077-8.
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Singer HS, Gilbert DL, Wolf DS, Mink JW, Kurlan R. Moving from PANDAS to CANS. J Pediatr. 2012 May; 160(5):725-31.
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Cialone J, Adams H, Augustine EF, Marshall FJ, Kwon JM, Newhouse N, Vierhile A, Levy E, Dure LS, Rose KR, Ramirez-Montealegre D, de Blieck EA, Mink JW. Females experience a more severe disease course in batten disease. J Inherit Metab Dis. 2012 May; 35(3):549-55.
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McNaught KS, Mink JW. Advances in understanding and treatment of Tourette syndrome. Nat Rev Neurol. 2011; 7(12):667-76.
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Cialone J, Augustine EF, Newhouse N, Vierhile A, Marshall FJ, Mink JW. Quantitative telemedicine ratings in Batten disease: Implications for rare disease research. Neurology. 2011 Nov 15; 77(20):1808-11.
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Kwon JM, Adams H, Rothberg PG, Augustine EF, Marshall FJ, Deblieck EA, Vierhile A, Beck CA, Newhouse NJ, Cialone J, Levy E, Ramirez-Montealegre D, Dure LS, Rose KR, Mink JW. Quantifying physical decline in juvenile neuronal ceroid lipofuscinosis (Batten disease). Neurology. 2011 Nov 15; 77(20):1801-7.
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Barile JP, Kuperminc GP, Weintraub ES, Mink JW, Thompson WW. Thimerosal exposure in early life and neuropsychological outcomes 7-10 years later. J Pediatr Psychol. 2012 Jan; 37(1):106-18.
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Mink JW. Comment: Affective symptoms associated with subthalamic nucleus dysfunction. Neurology. 2011 Jul 5; 77(1):82.
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Cialone J, Augustine EF, Newhouse N, Adams H, Vierhile A, Marshall FJ, de Blieck EA, Kwon J, Rothberg PG, Mink JW. Parent-reported benefits of flupirtine in juvenile neuronal ceroid lipofuscinosis (Batten disease; CLN3) are not supported by quantitative data. J Inherit Metab Dis. 2011 Oct; 34(5):1075-81.
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Mink JW. Faulty brakes? Inhibitory processes in attention-deficit/hyperactivity disorder. Neurology. 2011 Feb 15; 76(7):592-3.
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Dickson PI, Pariser AR, Groft SC, Ishihara RW, McNeil DE, Tagle D, Griebel DJ, Kaler SG, Mink JW, Shapiro EG, Bjoraker KJ, Krivitzky L, Provenzale JM, Gropman A, Orchard P, Raymond G, Cohen BH, Steiner RD, Goldkind SF, Nelson RM, Kakkis E, Patterson MC. Research challenges in central nervous system manifestations of inborn errors of metabolism. Mol Genet Metab. 2011 Mar; 102(3):326-38.
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Mink J, Kurlan R. Acute postinfectious movement and psychiatric disorders in children and adolescents. J Child Neurol. 2011 Feb; 26(2):214-7.
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Sanger TD, Chen D, Fehlings DL, Hallett M, Lang AE, Mink JW, Singer HS, Alter K, Ben-Pazi H, Butler EE, Chen R, Collins A, Dayanidhi S, Forssberg H, Fowler E, Gilbert DL, Gorman SL, Gormley ME, Jinnah HA, Kornblau B, Krosschell KJ, Lehman RK, MacKinnon C, Malanga CJ, Mesterman R, Michaels MB, Pearson TS, Rose J, Russman BS, Sternad D, Swoboda KJ, Valero-Cuevas F. Definition and classification of hyperkinetic movements in childhood. Mov Disord. 2010 Aug 15; 25(11):1538-49.
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Mink JW, Zinner SH. Movement disorders ii: chorea, dystonia, myoclonus, and tremor. Pediatr Rev. 2010 Jul; 31(7):287-94; quiz 295.
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Zinner SH, Mink JW. Movement disorders I: tics and stereotypies. Pediatr Rev. 2010 Jun; 31(6):223-33.
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Jethwa A, Mink J, Macarthur C, Knights S, Fehlings T, Fehlings D. Development of the Hypertonia Assessment Tool (HAT): a discriminative tool for hypertonia in children. Dev Med Child Neurol. 2010 May; 52(5):e83-7.
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Kaufman CB, Mink JW, Schwalb JM. Bilateral deep brain stimulation for treatment of medically refractory paroxysmal nonkinesigenic dyskinesia. J Neurosurg. 2010 Apr; 112(4):847-50.
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Adams HR, Beck CA, Levy E, Jordan R, Kwon JM, Marshall FJ, Vierhile A, Augustine EF, de Blieck EA, Pearce DA, Mink JW. Genotype does not predict severity of behavioural phenotype in juvenile neuronal ceroid lipofuscinosis (Batten disease). Dev Med Child Neurol. 2010 Jul; 52(7):637-43.
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Mink JW. Is levetiracetam a treatment option for dyskinetic cerebral palsy? Dev Med Child Neurol. 2009 Jun; 51(6):418-9.
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Mink JW. Clinical review of DBS for Tourette Syndrome. Front Biosci (Elite Ed). 2009; 1:72-6.
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Mink JW. Movement disorders. Introduction. Semin Pediatr Neurol. 2009 Jun; 16(2):59.
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Khandwala VJ, Burack MA, Mink JW, Gdowski GT, Gdowski MJ. Measurement of upper limb kinematics and joint angle patterns during deep brain stimulation for parkinson's disease. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:1553-6.
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Karimi M, Golchin N, Tabbal SD, Hershey T, Videen TO, Wu J, Usche JW, Revilla FJ, Hartlein JM, Wernle AR, Mink JW, Perlmutter JS. Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease. Brain. 2008 Oct; 131(Pt 10):2710-9.
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Noseworthy JH, Gross RA, Engel AG, Johnston KC, Knopman DS, Mink JW, Ransohoff RM, Uitti RJ. Translating research into treatments. Neurology. 2008 Jul 22; 71(4):232-3.
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Tabbal SD, Ushe M, Mink JW, Revilla FJ, Wernle AR, Hong M, Karimi M, Perlmutter JS. Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in Parkinson disease. Exp Neurol. 2008 May; 211(1):234-42.
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Mink JW. Paroxysmal dyskinesias. Curr Opin Pediatr. 2007 Dec; 19(6):652-6.
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Tabbal SD, Revilla FJ, Mink JW, Schneider-Gibson P, Wernle AR, de Erausquin GA, Perlmutter JS, Rich KM, Dowling JL. Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's disease. Neurosurgery. 2007 Sep; 61(3 Suppl):119-27; discussion 127-9.
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Adams HR, Kwon J, Marshall FJ, de Blieck EA, Pearce DA, Mink JW. Neuropsychological symptoms of juvenile-onset batten disease: experiences from 2 studies. J Child Neurol. 2007 May; 22(5):621-7.
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Sanger TD, Bastian A, Brunstrom J, Damiano D, Delgado M, Dure L, Gaebler-Spira D, Hoon A, Mink JW, Sherman-Levine S, Welty LJ. Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy. J Child Neurol. 2007 May; 22(5):530-7.
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Landau WM, Mink JW. Is decreased dexterity in Parkinson disease due to apraxia? Neurology. 2007 Jan 9; 68(2):90-1.
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Mink JW, Walkup J, Frey KA, Como P, Cath D, Delong MR, Erenberg G, Jankovic J, Juncos J, Leckman JF, Swerdlow N, Visser-Vandewalle V, Vitek JL. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Mov Disord. 2006 Nov; 21(11):1831-8.
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Qasaymeh MM, Mink JW. New treatments for tic disorders. Curr Treat Options Neurol. 2006 Nov; 8(6):465-73.
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Sanger TD, Chen D, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW. Definition and classification of negative motor signs in childhood. Pediatrics. 2006 Nov; 118(5):2159-67.
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Weiss EM, Hershey T, Karimi M, Racette B, Tabbal SD, Mink JW, Paniello RC, Perlmutter JS. Relative risk of spread of symptoms among the focal onset primary dystonias. Mov Disord. 2006 Aug; 21(8):1175-81.
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Ushe M, Mink JW, Tabbal SD, Hong M, Schneider Gibson P, Rich KM, Lyons KE, Pahwa R, Perlmutter JS. Postural tremor suppression is dependent on thalamic stimulation frequency. Mov Disord. 2006 Aug; 21(8):1290-2.
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Tabbal SD, Mink JW, Antenor JA, Carl JL, Moerlein SM, Perlmutter JS. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced acute transient dystonia in monkeys associated with low striatal dopamine. Neuroscience. 2006 Sep 1; 141(3):1281-7.
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Hershey T, Mink JW. Using functional neuroimaging to study the brain's response to deep brain stimulation. Neurology. 2006 Apr 25; 66(8):1142-3.
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Mink JW. Abnormal circuit function in dystonia. Neurology. 2006 Apr 11; 66(7):959.
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Scahill L, Erenberg G, Berlin CM, Budman C, Coffey BJ, Jankovic J, Kiessling L, King RA, Kurlan R, Lang A, Mink J, Murphy T, Zinner S, Walkup J. Contemporary assessment and pharmacotherapy of Tourette syndrome. NeuroRx. 2006 Apr; 3(2):192-206.
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Adams H, de Blieck EA, Mink JW, Marshall FJ, Kwon J, Dure L, Rothberg PG, Ramirez-Montealegre D, Pearce DA. Standardized assessment of behavior and adaptive living skills in juvenile neuronal ceroid lipofuscinosis. Dev Med Child Neurol. 2006 Apr; 48(4):259-64.
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Albin RL, Mink JW. Recent advances in Tourette syndrome research. Trends Neurosci. 2006 Mar; 29(3):175-82.
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Mink JW. Neurobiology of basal ganglia and Tourette syndrome: basal ganglia circuits and thalamocortical outputs. Adv Neurol. 2006; 99:89-98.
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Perlmutter JS, Mink JW. Deep brain stimulation. Annu Rev Neurosci. 2006; 29:229-57.
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Yang ML, Fullwood E, Goldstein J, Mink JW. Masturbation in infancy and early childhood presenting as a movement disorder: 12 cases and a review of the literature. Pediatrics. 2005 Dec; 116(6):1427-32.
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Kwon JM, Rothberg PG, Leman AR, Weimer JM, Mink JW, Pearce DA. Novel CLN3 mutation predicted to cause complete loss of protein function does not modify the classical JNCL phenotype. Neurosci Lett. 2005 Oct 21; 387(2):111-4.
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Budman C, Coffey B, Dure L, Gilbert D, Juncos J, Kaplan E, King R, Kurlan R, Lowe T, Mack K, Mink J, Schlaggar B, Singer H. Regarding "antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders". Biol Psychiatry. 2005 Dec 1; 58(11):917; author reply 918-9.
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Marshall FJ, de Blieck EA, Mink JW, Dure L, Adams H, Messing S, Rothberg PG, Levy E, McDonough T, DeYoung J, Wang M, Ramirez-Montealegre D, Kwon JM, Pearce DA. A clinical rating scale for Batten disease: reliable and relevant for clinical trials. Neurology. 2005 Jul 26; 65(2):275-9.
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Singer HS, Mink JW, Loiselle CR, Burke KA, Ruchkina I, Morshed S, Parveen S, Leckman JF, Hallett JJ, Lombroso PJ. Microinfusion of antineuronal antibodies into rodent striatum: failure to differentiate between elevated and low titers. J Neuroimmunol. 2005 Jun; 163(1-2):8-14.
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Mink JW, Jenkins ME. Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2004 Nov 23; 63(10):1985-6; author reply 1985-6.
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Ushe M, Mink JW, Revilla FJ, Wernle A, Schneider Gibson P, McGee-Minnich L, Hong M, Rich KM, Lyons KE, Pahwa R, Perlmutter JS. Effect of stimulation frequency on tremor suppression in essential tremor. Mov Disord. 2004 Oct; 19(10):1163-8.
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Perlmutter JS, Mink JW. Dysfunction of dopaminergic pathways in dystonia. Adv Neurol. 2004; 94:163-70.
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Kirsch DB, Mink JW. Psychogenic movement disorders in children. Pediatr Neurol. 2004 Jan; 30(1):1-6.
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Mink JW. The Basal Ganglia and involuntary movements: impaired inhibition of competing motor patterns. Arch Neurol. 2003 Oct; 60(10):1365-8.
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Hershey T, Revilla FJ, Wernle AR, McGee-Minnich L, Antenor JV, Videen TO, Dowling JL, Mink JW, Perlmutter JS. Cortical and subcortical blood flow effects of subthalamic nucleus stimulation in PD. Neurology. 2003 Sep 23; 61(6):816-21.
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Mink JW, Caruso PA, Pomeroy SL. Progressive myoclonus in a child with a deep cerebellar mass. Neurology. 2003 Sep 23; 61(6):829-31.
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Bastian AJ, Kelly VE, Perlmutter JS, Mink JW. Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson's disease. Mov Disord. 2003 Sep; 18(9):1008-17.
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Bastian AJ, Kelly VE, Revilla FJ, Perlmutter JS, Mink JW. Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease. Mov Disord. 2003 Sep; 18(9):1000-7.
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Schlaggar BL, Mink JW. Movement disorders in children. Pediatr Rev. 2003 Feb; 24(2):39-51.
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Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW. Classification and definition of disorders causing hypertonia in childhood. Pediatrics. 2003 Jan; 111(1):e89-97.
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Mink JW, McKinstry RC. Volumetric MRI in autism: can high-tech craniometry provide neurobiological insights? Neurology. 2002 Jul 23; 59(2):158-9.
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Perlmutter JS, Mink JW, Bastian AJ, Zackowski K, Hershey T, Miyawaki E, Koller W, Videen TO. Blood flow responses to deep brain stimulation of thalamus. Neurology. 2002 May 14; 58(9):1388-94.
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Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. 2002 Feb 26; 58(4):527-36.
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Zackowski KM, Bastian AJ, Hakimian S, Mink JW, Perlmutter JS, Koller WC, Thach WT. Thalamic stimulation reduces essential tremor but not the delayed antagonist muscle timing. Neurology. 2002 Feb 12; 58(3):402-10.
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Racette BA, Hartlein JM, Hershey T, Mink JW, Perlmutter JS, Black KJ. Clinical features and comorbidity of mood fluctuations in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2002; 14(4):438-42.
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Mink JW. Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis. Pediatr Neurol. 2001 Sep; 25(3):190-8.
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Mink JW. Basal ganglia motor function in relation to Hallervorden-Spatz syndrome. Pediatr Neurol. 2001 Aug; 25(2):112-7.
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Racette BA, Dowling J, Randle J, Mink JW. Thalamic stimulation for primary writing tremor. J Neurol. 2001 May; 248(5):380-2.
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Racette BA, McGee-Minnich L, Moerlein SM, Mink JW, Videen TO, Perlmutter JS. Welding-related parkinsonism: clinical features, treatment, and pathophysiology. Neurology. 2001 Jan 9; 56(1):8-13.
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Mink JW. Neurobiology of basal ganglia circuits in Tourette syndrome: faulty inhibition of unwanted motor patterns? Adv Neurol. 2001; 85:113-22.
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Black KJ, Mink JW. Response to levodopa challenge in Tourette syndrome. Mov Disord. 2000 Nov; 15(6):1194-8.
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Brunstrom JE, Bastian AJ, Wong M, Mink JW. Motor benefit from levodopa in spastic quadriplegic cerebral palsy. Ann Neurol. 2000 May; 47(5):662-5.
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Racette BA, Rich KM, Randle J, Mink JW. Ipsilateral thalamic stimulation after thalamotomy for essential tremor. A case report. Stereotact Funct Neurosurg. 2000; 75(4):155-9.
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Wenger KK, Musch KL, Mink JW. Impaired reaching and grasping after focal inactivation of globus pallidus pars interna in the monkey. J Neurophysiol. 1999 Nov; 82(5):2049-60.
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Schlaggar BL, Mink JW. A 16-year-old with episodic hemisdystonia. Semin Pediatr Neurol. 1999 Sep; 6(3):210-5.
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Mink JW. The current model of basal ganglia organization under scrutiny. Mov Disord. 1998 Nov; 13(6):981-2.
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Bastian AJ, Mink JW, Kaufman BA, Thach WT. Posterior vermal split syndrome. Ann Neurol. 1998 Oct; 44(4):601-10.
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Jokic R, Klimaszewski A, Mink J, Fitzpatrick MF. Surface tension forces in sleep apnea: the role of a soft tissue lubricant: a randomized double-blind, placebo-controlled trial. Am J Respir Crit Care Med. 1998 May; 157(5 Pt 1):1522-5.
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Mink JW. The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol. 1996 Nov; 50(4):381-425.
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Mink JW, Neil JJ. Masturbation mimicking paroxysmal dystonia or dyskinesia in a young girl. Mov Disord. 1995 Jul; 10(4):518-20.
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Mink JW, Thach WT. Basal ganglia intrinsic circuits and their role in behavior. Curr Opin Neurobiol. 1993 Dec; 3(6):950-7.
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Mink JW, Thach WT. Basal ganglia motor control. II. Late pallidal timing relative to movement onset and inconsistent pallidal coding of movement parameters. J Neurophysiol. 1991 Feb; 65(2):301-29.
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Mink JW, Thach WT. Basal ganglia motor control. I. Nonexclusive relation of pallidal discharge to five movement modes. J Neurophysiol. 1991 Feb; 65(2):273-300.
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Mink JW, Thach WT. Basal ganglia motor control. III. Pallidal ablation: normal reaction time, muscle cocontraction, and slow movement. J Neurophysiol. 1991 Feb; 65(2):330-51.
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Mink JW, Thach WT. Preferential relation of pallidal neurons to ballistic movements. Brain Res. 1987 Aug 11; 417(2):393-8.
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Thach WT, Schieber MH, Mink J, Kane S, Horne M. Cerebellar relation to muscle spindles in hand tracking. Prog Brain Res. 1986; 64:217-24.
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Mink JW, Sinnamon HM, Adams DB. Activity of basal forebrain neurons in the rat during motivated behaviors. Behav Brain Res. 1983 Apr; 8(1):85-108.
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Mink JW, Blumenschine RJ, Adams DB. Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis. Am J Physiol. 1981 Sep; 241(3):R203-12.
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Mink JW, Adams DB. Why offense is reduced when rats are tested in a strange cage. Physiol Behav. 1981 Apr; 26(4):567-73.
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Keesey J, Bein M, Mink J, Sample F, Sarti D, Mulder D, Herrmann C, Peter JB. Detection of thymoma in myasthenia gravis. Neurology. 1980 Mar; 30(3):233-9.
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