Catherine Ovitt
| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Genetics in the Center for Oral Biology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester NY 14642
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Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.
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Arany S, Xu Q, Hernady E, Benoit DS, Dewhurst S, Ovitt CE. Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. J Cell Biochem. 2012 Jun; 113(6):1955-65.
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Rugel-Stahl A, Elliott ME, Ovitt CE. Ascl3 marks adult progenitor cells of the mouse salivary gland. Stem Cell Res. 2012 May; 8(3):379-87.
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Lan Y, Liu H, Ovitt CE, Jiang R. Generation of Osr1 conditional mutant mice. Genesis. 2011 May; 49(5):419-22.
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Arany S, Catalán MA, Roztocil E, Ovitt CE. Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration. Dev Biol. 2011 May 15; 353(2):186-93.
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Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol. 2010 Oct; 30(20):4797-807.
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Gao Y, Lan Y, Ovitt CE, Jiang R. Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development. Dev Biol. 2009 Apr 15; 328(2):200-9.
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Bullard T, Koek L, Roztocil E, Kingsley PD, Mirels L, Ovitt CE. Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands. Dev Biol. 2008 Aug 1; 320(1):72-8.
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Lan Y, Wang Q, Ovitt CE, Jiang R. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis. 2007 Oct; 45(10):618-24.
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Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 2007 Aug; 45(8):482-6.
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Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE. Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells. Am J Physiol Regul Integr Comp Physiol. 2007 Jun; 292(6):R2380-90.
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Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE. Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12; 279(46):47681-7.
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Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004 Jul; 131(13):3207-16.
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Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC, Treier M. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development. 2004 Feb; 131(4):933-42.
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Ronfani L, Ferraguti M, Croci L, Ovitt CE, Schöler HR, Consalez GG, Bianchi ME. Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development. 2001 Apr; 128(8):1265-73.
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Ovitt CE, Schöler HR. The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod. 1998 Nov; 4(11):1021-31.
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De Felice M, Ovitt C, Biffali E, Rodriguez-Mallon A, Arra C, Anastassiadis K, Macchia PE, Mattei MG, Mariano A, Schöler H, Macchia V, Di Lauro R. A mouse model for hereditary thyroid dysgenesis and cleft palate. Nat Genet. 1998 Aug; 19(4):395-8.
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Brehm A, Ovitt CE, Schöler HR. Oct-4: more than just a POUerful marker of the mammalian germline? APMIS. 1998 Jan; 106(1):114-24; discussion 124-6.
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Bertocchini F, Ovitt CE, Conti A, Barone V, Schöler HR, Bottinelli R, Reggiani C, Sorrentino V. Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 1997 Dec 1; 16(23):6956-63.
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Yeom YI, Fuhrmann G, Ovitt CE, Brehm A, Ohbo K, Gross M, Hübner K, Schöler HR. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development. 1996 Mar; 122(3):881-94.
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Ludwig T, Munier-Lehmann H, Bauer U, Hollinshead M, Ovitt C, Lobel P, Hoflack B. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts. EMBO J. 1994 Aug 1; 13(15):3430-7.
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Ludwig T, Ovitt CE, Bauer U, Hollinshead M, Remmler J, Lobel P, Rüther U, Hoflack B. Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes. EMBO J. 1993 Dec 15; 12(13):5225-35.
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Wang ZQ, Ovitt C, Grigoriadis AE, Möhle-Steinlein U, Rüther U, Wagner EF. Bone and haematopoietic defects in mice lacking c-fos. Nature. 1992 Dec 24-31; 360(6406):741-5.
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Ovitt CE, Rüther U. The proto-oncogene c-fos: structure, expression, and functional aspects. Oxf Surv Eukaryot Genes. 1989; 6:33-51.
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Seetharam S, Ovitt C, Strauss AW, Rubin D, Alpers DH. Fat feeding stimulates only one of the two mRNAs encoding rat intestinal membranous and secreted alkaline phosphatase. Biochem Biophys Res Commun. 1987 May 29; 145(1):363-8.
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Ovitt CE, Strauss AW, Alpers DH, Chou JY, Boime I. Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3781-5.
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Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. J Biol Chem. 1983 Oct 10; 258(19):11492-9.
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Ordahl CP, Tilghman SM, Ovitt C, Fornwald J, Largen MT. Structure and developmental expression of the chick alpha-actin gene. Nucleic Acids Res. 1980 Nov 11; 8(21):4989-5005.
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Ordahl CP, Kioussis D, Tilghman SM, Ovitt CE, Fornwald J. Molecular cloning of developmentally regulated, low-abundance mRNA sequences from embryonic muscle. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):4519-23.
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