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Catherine Ovitt

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentBiomedical Genetics in the Center for Oral Biology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester NY 14642
 
 Overview
Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.

 
 Selected Publications
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  1. Arany S, Benoit DS, Dewhurst S, Ovitt CE. Nanoparticle-mediated Gene Silencing Confers Radioprotection to Salivary Glands In Vivo. Mol Ther. 2013 Jun; 21(6):1182-94.
    View in: PubMed
  2. Arany S, Xu Q, Hernady E, Benoit DS, Dewhurst S, Ovitt CE. Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. J Cell Biochem. 2012 Jun; 113(6):1955-65.
    View in: PubMed
  3. Rugel-Stahl A, Elliott ME, Ovitt CE. Ascl3 marks adult progenitor cells of the mouse salivary gland. Stem Cell Res. 2012 May; 8(3):379-87.
    View in: PubMed
  4. Lan Y, Liu H, Ovitt CE, Jiang R. Generation of Osr1 conditional mutant mice. Genesis. 2011 May; 49(5):419-22.
    View in: PubMed
  5. Arany S, Catalán MA, Roztocil E, Ovitt CE. Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration. Dev Biol. 2011 May 15; 353(2):186-93.
    View in: PubMed
  6. Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol. 2010 Oct; 30(20):4797-807.
    View in: PubMed
  7. Gao Y, Lan Y, Ovitt CE, Jiang R. Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development. Dev Biol. 2009 Apr 15; 328(2):200-9.
    View in: PubMed
  8. Bullard T, Koek L, Roztocil E, Kingsley PD, Mirels L, Ovitt CE. Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands. Dev Biol. 2008 Aug 1; 320(1):72-8.
    View in: PubMed
  9. Lan Y, Wang Q, Ovitt CE, Jiang R. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis. 2007 Oct; 45(10):618-24.
    View in: PubMed
  10. Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 2007 Aug; 45(8):482-6.
    View in: PubMed
  11. Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE. Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells. Am J Physiol Regul Integr Comp Physiol. 2007 Jun; 292(6):R2380-90.
    View in: PubMed
  12. Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE. Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12; 279(46):47681-7.
    View in: PubMed
  13. Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004 Jul; 131(13):3207-16.
    View in: PubMed
  14. Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC, Treier M. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development. 2004 Feb; 131(4):933-42.
    View in: PubMed
  15. Ronfani L, Ferraguti M, Croci L, Ovitt CE, Schöler HR, Consalez GG, Bianchi ME. Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development. 2001 Apr; 128(8):1265-73.
    View in: PubMed
  16. Ovitt CE, Schöler HR. The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod. 1998 Nov; 4(11):1021-31.
    View in: PubMed
  17. De Felice M, Ovitt C, Biffali E, Rodriguez-Mallon A, Arra C, Anastassiadis K, Macchia PE, Mattei MG, Mariano A, Schöler H, Macchia V, Di Lauro R. A mouse model for hereditary thyroid dysgenesis and cleft palate. Nat Genet. 1998 Aug; 19(4):395-8.
    View in: PubMed
  18. Brehm A, Ovitt CE, Schöler HR. Oct-4: more than just a POUerful marker of the mammalian germline? APMIS. 1998 Jan; 106(1):114-24; discussion 124-6.
    View in: PubMed
  19. Bertocchini F, Ovitt CE, Conti A, Barone V, Schöler HR, Bottinelli R, Reggiani C, Sorrentino V. Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 1997 Dec 1; 16(23):6956-63.
    View in: PubMed
  20. Yeom YI, Fuhrmann G, Ovitt CE, Brehm A, Ohbo K, Gross M, Hübner K, Schöler HR. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development. 1996 Mar; 122(3):881-94.
    View in: PubMed
  21. Ludwig T, Munier-Lehmann H, Bauer U, Hollinshead M, Ovitt C, Lobel P, Hoflack B. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts. EMBO J. 1994 Aug 1; 13(15):3430-7.
    View in: PubMed
  22. Ludwig T, Ovitt CE, Bauer U, Hollinshead M, Remmler J, Lobel P, Rüther U, Hoflack B. Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes. EMBO J. 1993 Dec 15; 12(13):5225-35.
    View in: PubMed
  23. Wang ZQ, Ovitt C, Grigoriadis AE, Möhle-Steinlein U, Rüther U, Wagner EF. Bone and haematopoietic defects in mice lacking c-fos. Nature. 1992 Dec 24-31; 360(6406):741-5.
    View in: PubMed
  24. Ovitt CE, Rüther U. The proto-oncogene c-fos: structure, expression, and functional aspects. Oxf Surv Eukaryot Genes. 1989; 6:33-51.
    View in: PubMed
  25. Seetharam S, Ovitt C, Strauss AW, Rubin D, Alpers DH. Fat feeding stimulates only one of the two mRNAs encoding rat intestinal membranous and secreted alkaline phosphatase. Biochem Biophys Res Commun. 1987 May 29; 145(1):363-8.
    View in: PubMed
  26. Ovitt CE, Strauss AW, Alpers DH, Chou JY, Boime I. Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3781-5.
    View in: PubMed
  27. Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. J Biol Chem. 1983 Oct 10; 258(19):11492-9.
    View in: PubMed
  28. Ordahl CP, Tilghman SM, Ovitt C, Fornwald J, Largen MT. Structure and developmental expression of the chick alpha-actin gene. Nucleic Acids Res. 1980 Nov 11; 8(21):4989-5005.
    View in: PubMed
  29. Ordahl CP, Kioussis D, Tilghman SM, Ovitt CE, Fornwald J. Molecular cloning of developmentally regulated, low-abundance mRNA sequences from embryonic muscle. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):4519-23.
    View in: PubMed

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