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Clement L. Ren

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 667
Rochester NY 14642
 
 Awards And Honors
1986     American Liver Foundation Student Research Fellowship  | American Liver Foundation
1992     Children's Hospital Farley Fund Research Award  | Children's Hospital Farley Fund
1992     Marion Merrill Dow Scholar in Allergy Award  | Marion Merrill Dow
1997     Resident Teaching Award  | Department of Pediatrics
1999     Award for Outstanding Teaching  | Class of 1999
2004     AAMC Humanism in Medicine Nominee  | Association of American Medical Colleges
2008 - 2011George Washington Goler Professor of Pediatrics, University of Rochester
2011     Consumers' Research Council of America's Top Pediatricians
 
 Overview
Dr. Ren's research focuses in three areas: (1) the application of novel methods of pulmonary function tests (PFTs) in infants and young children to clinical and translational studies of pediatric respiratory disease, (2) Cystic fibrosis (CF) epidemiology, and (3) multicenter clinical trials. Our areas of disease focus are CF, premature infants, and viral bronchiolitis.

Prematurity and Respiratory Outcomes Program (PROP)
Dr. Ren is the pulmonary PI and the co-chair of the Pulmonary Working Group for PROP. PROP is an NIH funded multicenter program whose aim is to promote collaborative, innovative research to identify mechanisms and associated functional and molecular biomarkers of respiratory disease risk of premature infants ready for discharge from the neonatal intensive care unit (NICU). As part of the PROP, he assist in conducting a longitudinal study of respiratory function in the first year of life utilizing non-invasive respiratory testing (including RIP) and performing infant PFTs using the raised volume rapidthoracoabdominal compression technique.

Cystic Fibrosis
Epidemiologic Study of Cystic Fibrosis (ESCF)
The ESCF was a prospective observational study of CF patients in North America. Data were collected from 1994-2005, and analyses are still ongoing. Using ESCF data, we have studied the effect of inhaled corticosteroid therapy on lung function, the impact of methicillin resistant S. aureus infection on lung function, and the relationship between infant care patterns and outcomes. We recently used ESCF data to demonstrate that wheezing in early childhood is associated with lower lung function in children with CF.

Early Pseudomonas Infection Control Observational Study (EPIC)
EPIC is a longitudinal cohort study of young CF patients whose primary goal is to identify risk factors for the acquisition of Pseudomonas aeruginosa (Pa). Secondary objectives include better definition of outcomes associated with Pa infection and the impact of other organisms on clinical outcomes.

CF Clinical Trials
As a member of the CF Foundation Therapeutics Development Network the Pediatric Pulmonary Division is involved in a number of clinical trials. Further information regarding clinical trials can be found at the Division of Pediatric Pulmonology website: http://www.urmc.rochester.edu/pediatrics/research/subspecialty/pulmonology

Advanced Lung Function Testing
Multiple breath washout (MBW) equipment was recently added to our Pediatric Pulmonary Function Laboratory. MBW is a noninvasive method to assess ventilation inhomogeneity, a feature of many pediatric lung diseases, such as CF. Our group is presently developing pilot projects to apply MBW to the study of CF and preterm lung disease.

 
 Selected Publications
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  1. Kelly A, Ren CL. Is vitamin d deficiency the root of all pulmonary evils? Ann Am Thorac Soc. 2014 Feb; 11(2):220-2.
    View in: PubMed
  2. Rosenfeld M, Allen J, Arets BH, Aurora P, Beydon N, Calogero C, Castile RG, Davis SD, Fuchs S, Gappa M, Gustaffson PM, Hall GL, Jones MH, Kirkby JC, Kraemer R, Lombardi E, Lum S, Mayer OH, Merkus P, Nielsen KG, Oliver C, Oostveen E, Ranganathan S, Ren CL, Robinson PD, Seddon PC, Sly PD, Sockrider MM, Sonnappa S, Stocks J, Subbarao P, Tepper RS, Vilozni D. An official american thoracic society workshop report: optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia, and recurrent wheezing in children less than 6 years of age. Ann Am Thorac Soc. 2013 Apr; 10(2):S1-S11.
    View in: PubMed
  3. Sawicki GS, Ren CL, Konstan MW, Millar SJ, Pasta DJ, Quittner AL. Treatment complexity in cystic fibrosis: Trends over time and associations with site-specific outcomes. J Cyst Fibros. 2013 Sep; 12(5):461-7.
    View in: PubMed
  4. Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet. 2012 Aug; 44(8):886-9.
    View in: PubMed
  5. Rosenfeld M, Ratjen F, Brumback L, Daniel S, Rowbotham R, McNamara S, Johnson R, Kronmal R, Davis SD. Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial. JAMA. 2012 Jun 6; 307(21):2269-77.
    View in: PubMed
  6. Yan R, Ren C, Li J, Maximov AV, Mori WB, Sheng ZM, Tsung FS. Generating energetic electrons through staged acceleration in the two-plasmon-decay instability in inertial confinement fusion. Phys Rev Lett. 2012 Apr 27; 108(17):175002.
    View in: PubMed
  7. Ren CL, Konstan MW, Yegin A, Rasouliyan L, Trzaskoma B, Morgan WJ, Regelmann W. Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis. J Cyst Fibros. 2012 Jul; 11(4):293-9.
    View in: PubMed
  8. McColley SA, Ren CL, Schechter MS, Regelmann WE, Pasta DJ, Konstan MW. Risk factors for onset of persistent respiratory symptoms in children with cystic fibrosis. Pediatr Pulmonol. 2012 Oct; 47(10):966-72.
    View in: PubMed
  9. Kerby GS, Rosenfeld M, Ren CL, Mayer OH, Brumback L, Castile R, Hart MA, Hiatt P, Kloster M, Johnson R, Jones P, Davis SD. Lung function distinguishes preschool children with CF from healthy controls in a multi-center setting. Pediatr Pulmonol. 2012 Jun; 47(6):597-605.
    View in: PubMed
  10. Ren CL, Rosenfeld M, Mayer OH, Davis SD, Kloster M, Castile RG, Hiatt PW, Hart M, Johnson R, Jones P, Brumback LC, Kerby GS. Analysis of the associations between lung function and clinical features in preschool children with cystic fibrosis. Pediatr Pulmonol. 2012 Jun; 47(6):574-81.
    View in: PubMed
  11. Ren CL, Desai H, Platt M, Dixon M. Clinical outcomes in infants with cystic fibrosis transmembrane conductance regulator (CFTR) related metabolic syndrome. Pediatr Pulmonol. 2011 Nov; 46(11):1079-84.
    View in: PubMed
  12. Rosenfeld M, Emerson J, McNamara S, Joubran K, Retsch-Bogart G, Graff GR, Gutierrez HH, Kanga JF, Lahiri T, Noyes B, Ramsey B, Ren CL, Schechter M, Morgan W, Gibson RL. Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort. Pediatr Pulmonol. 2010 Sep; 45(9):934-44.
    View in: PubMed
  13. Yan R, Maximov AV, Ren C, Tsung FS. Growth and saturation of convective modes of the two-plasmon decay instability in inertial confinement fusion. Phys Rev Lett. 2009 Oct 23; 103(17):175002.
    View in: PubMed
  14. Sawicki GS, Rasouliyan L, Ren CL. The impact of MRSA on lung function in patients with cystic fibrosis. Am J Respir Crit Care Med. 2009 Apr 15; 179(8):734-5; author reply 735.
    View in: PubMed
  15. Voter KZ, Ren CL. Diagnosis of cystic fibrosis. Clin Rev Allergy Immunol. 2008 Dec; 35(3):100-6.
    View in: PubMed
  16. Ren CL. Cystic fibrosis: evolution from a fatal disease of infancy with a clear phenotype to a chronic disease of adulthood with diverse manifestations. Clin Rev Allergy Immunol. 2008 Dec; 35(3):97-9.
    View in: PubMed
  17. Sawicki GS, Rasouliyan L, Pasta DJ, Regelmann WE, Wagener JS, Waltz DA, Ren CL. The impact of incident methicillin resistant Staphylococcus aureus detection on pulmonary function in cystic fibrosis. Pediatr Pulmonol. 2008 Nov; 43(11):1117-23.
    View in: PubMed
  18. Ren CL, Pasta DJ, Rasouliyan L, Wagener JS, Konstan MW, Morgan WJ. Relationship between inhaled corticosteroid therapy and rate of lung function decline in children with cystic fibrosis. J Pediatr. 2008 Dec; 153(6):746-51.
    View in: PubMed
  19. VanDevanter DR, Rasouliyan L, Murphy TM, Morgan WJ, Ren CL, Konstan MW, Wagener JS. Trends in the clinical characteristics of the U.S. cystic fibrosis patient population from 1995 to 2005. Pediatr Pulmonol. 2008 Aug; 43(8):739-44.
    View in: PubMed
  20. Farrell PM, Rosenstein BJ, White TB, Accurso FJ, Castellani C, Cutting GR, Durie PR, Legrys VA, Massie J, Parad RB, Rock MJ, Campbell PW. Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report. J Pediatr. 2008 Aug; 153(2):S4-S14.
    View in: PubMed
  21. Ren CL. Assessment and monitoring of cystic fibrosis lung disease in infants and young children. Expert Rev Respir Med. 2008 Jun; 2(3):381-90.
    View in: PubMed
  22. Li G, Yan R, Ren C, Wang TL, Tonge J, Mori WB. Laser channeling in millimeter-scale underdense plasmas of fast-ignition targets. Phys Rev Lett. 2008 Mar 28; 100(12):125002.
    View in: PubMed
  23. Ren CL, Morgan WJ, Konstan MW, Schechter MS, Wagener JS, Fisher KA, Regelmann WE. Presence of methicillin resistant Staphylococcus aureus in respiratory cultures from cystic fibrosis patients is associated with lower lung function. Pediatr Pulmonol. 2007 Jun; 42(6):513-8.
    View in: PubMed
  24. Padman R, McColley SA, Miller DP, Konstan MW, Morgan WJ, Schechter MS, Ren CL, Wagener JS. Infant care patterns at epidemiologic study of cystic fibrosis sites that achieve superior childhood lung function. Pediatrics. 2007 Mar; 119(3):e531-7.
    View in: PubMed
  25. Ren CL. Pulmonary manifestations in deltaF508/R117H. Pediatrics. 2007 Mar; 119(3):647; author reply 647-8.
    View in: PubMed
  26. Ren CL, Brucker JL, Rovitelli AK, Bordeaux KA. Changes in lung function measured by spirometry and the forced oscillation technique in cystic fibrosis patients undergoing treatment for respiratory tract exacerbation. Pediatr Pulmonol. 2006 Apr; 41(4):345-9.
    View in: PubMed
  27. Ren CL. Comment on Sagel et al. Pediatr Pulmonol. 2005 Sep; 40(3):275; author reply 276.
    View in: PubMed
  28. Ang JY, Ray-Mazumder S, Nachman SA, Rongkavilit C, Asmar BI, Ren CL. Use of complementary and alternative medicine by parents of children with HIV infection and asthma and well children. South Med J. 2005 Sep; 98(9):869-75.
    View in: PubMed
  29. Ren CL. Cystic fibrosis gene mutations and chronic rhinosinusitis. J Allergy Clin Immunol. 2005 Aug; 116(2):463.
    View in: PubMed
  30. Ren CL. What is the best way to measure lung function? Chest. 2003 Mar; 123(3):667-8.
    View in: PubMed
  31. Ren CL. Use of modulators of airways inflammation in patients with CF. Clin Rev Allergy Immunol. 2002 Aug; 23(1):29-39.
    View in: PubMed
  32. Talmaciu I, Ren CL, Kolb SM, Hickey E, Panitch HB. Pulmonary function in technology-dependent children 2 years and older with bronchopulmonary dysplasia. Pediatr Pulmonol. 2002 Mar; 33(3):181-8.
    View in: PubMed
  33. Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A. Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. J Allergy Clin Immunol. 2000 Nov; 106(5):973-80.
    View in: PubMed
  34. Loh RK, Jabara HH, Ren CL, Fu SM, Vercelli D, Geha RS. Role of protein tyrosine kinases and phosphatases in isotype switching: crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells. Immunol Lett. 1995 Feb; 45(1-2):99-106.
    View in: PubMed
  35. Ren CL, Fu SM, Geha RS. Protein tyrosine kinase activation and protein kinase C translocation are functional components of CD40 signal transduction in resting human B cells. Immunol Invest. 1994 Nov; 23(6-7):437-48.
    View in: PubMed
  36. Loh RK, Jabara HH, Ren CL, Fu SM, Geha RS. Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE. J Allergy Clin Immunol. 1994 Oct; 94(4):784-92.
    View in: PubMed
  37. Ren CL, Morio T, Fu SM, Geha RS. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. J Exp Med. 1994 Feb 1; 179(2):673-80.
    View in: PubMed
  38. Fernandez-Checa JC, Ren C, Aw TY, Ookhtens M, Kaplowitz N. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1988 Oct; 255(4 Pt 1):G403-8.
    View in: PubMed
  39. Aw TY, Ookhtens M, Ren C, Kaplowitz N. Kinetics of glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1986 Feb; 250(2 Pt 1):G236-43.
    View in: PubMed
  40. Forte TM, Luming Ren C, Nordhausen RW, Nichols AV. Formation of phospholipid-rich HDL: a model for square-packing lipoprotein particles found in interstitial fluid and in abetalipoproteinemic plasma. Biochim Biophys Acta. 1985 May 17; 834(3):386-95.
    View in: PubMed

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