Clement Ren
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 667
Rochester NY 14642
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| 1982 |
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| Associated Western Universities Student Research Internship | Associated Western Universities | | 1986 |
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| American Liver Foundation Student Research Fellowship | American Liver Foundation | | 1992 |
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| Children's Hospital Farley Fund Research Award | Children's Hospital Farley Fund | | 1992 |
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| Marion Merrill Dow Scholar in Allergy Award | Marion Merrill Dow | | 1997 |
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| Resident Teaching Award | Department of Pediatrics | | 1999 |
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| Award for Outstanding Teaching | Class of 1999 | | 2004 |
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| AAMC Humanism in Medicine Nominee | Association of American Medical Colleges | | 2008 |
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| 2011 | George Washington Goler Professor of Pediatrics, University of Rochester |
Description of Research
My research activities are focused in three areas: (1) the application of novel methods of pulmonary function tests (PFTs) in infants and young children to clinical and translational studies of pediatric respiratory disease, (2) Cystic fibrosis (CF) epidemiology, and (3) multicenter clinical trials. Our areas of disease focus are CF, premature infants, and viral bronchiolitis.
We currently are involved in the following PFT projects:
• Lung Function Measures in Young Children with CF (OM0004).
This is a CF Foundation sponsored observational study that compares three different PFT techniques in young children with CF: modified spirometry, respiratory inductive plethysmography (RIP), and forced oscillometry (FO). We completed enrollment and follow-up in 2009 and are currently in the process of data analysis.
• Prematurity and Respiratory Outcomes Program (PROP)
PROP is an NIH funded multicenter program whose aim is to promote collaborative, innovative research to identify mechanisms and associated functional and molecular biomarkers of respiratory disease risk of premature infants ready for discharge from the neonatal intensive care unit (NICU). As part of the PROP, we are conducting a longitudinal study of respiratory function in the first year of life utilizing non-invasive respiratory testing (including RIP) and performing infant PFTs using the raised volume rapidthoracoabdominal compression technique.
• Effect of Albuterol on Tidal Breathing in Viral Bronchiolitis
The goal of this study, which received support from Medimmune and the Strong Children's Research Center, was to use RIP as an objective method to assess the effect of albuterol on respiratory function in infants hospitalized with viral bronchiolitis. Enrollment was completed in 2009, and we are presently in the process of data analysis.
My epidemiologic work has focused on CF and utilizes data from two large observational studies:
• Epidemiologic Study of Cystic Fibrosis (ESCF)
The ESCF was a prospective observational study of CF patients in North America. Data were collected from 1994-2005, and analyses are still ongoing. Using ESCF data, we have studied the effect of inhaled corticosteroid therapy on lung function, the impact of methicillin resistant S. aureus infection on lung function, and the relationship between infant care patterns and outcomes. We are presently studying the relationship between multiply antibiotic resistant Pseudomonas aeruginosa and clinical outcomes in CF.
• Early Pseuomonas Infection Control Observational Study (EPIC)
EPIC is a longitudinal cohort study of young CF patients whose primary goal is to identify risk factors for the acquisition of Pseudomonas aeruginosa (Pa). Secondary objectives include better definition of outcomes associated with Pa infection and the impact of other organisms on clinical outcomes.
We are involved in a number of clinical trials, primarily in CF. Further information regarding clinical trials can be found at the Division of Pediatric Pulmonology website: http://www.urmc.rochester.edu/pediatrics/research/subspecialty/pulmonology_allergy/Pulmonology_Research.pdf
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Yan R, Ren C, Li J, Maximov AV, Mori WB, Sheng ZM, Tsung FS. Generating energetic electrons through staged acceleration in the two-plasmon-decay instability in inertial confinement fusion. Phys Rev Lett. 2012 Apr 27; 108(17):175002.
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Ren CL, Konstan MW, Yegin A, Rasouliyan L, Trzaskoma B, Morgan WJ, Regelmann W. Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis. J Cyst Fibros. 2012 Jul; 11(4):293-9.
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McColley SA, Ren CL, Schechter MS, Regelmann WE, Pasta DJ, Konstan MW. Risk factors for onset of persistent respiratory symptoms in children with cystic fibrosis. Pediatr Pulmonol. 2012 Oct; 47(10):966-72.
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Kerby GS, Rosenfeld M, Ren CL, Mayer OH, Brumback L, Castile R, Hart MA, Hiatt P, Kloster M, Johnson R, Jones P, Davis SD. Lung function distinguishes preschool children with CF from healthy controls in a multi-center setting. Pediatr Pulmonol. 2012 Jun; 47(6):597-605.
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Ren CL, Rosenfeld M, Mayer OH, Davis SD, Kloster M, Castile RG, Hiatt PW, Hart M, Johnson R, Jones P, Brumback LC, Kerby GS. Analysis of the associations between lung function and clinical features in preschool children with Cystic Fibrosis. Pediatr Pulmonol. 2012 Jun; 47(6):574-81.
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Ren CL, Desai H, Platt M, Dixon M. Clinical outcomes in infants with cystic fibrosis transmembrane conductance regulator (CFTR) related metabolic syndrome. Pediatr Pulmonol. 2011 Nov; 46(11):1079-84.
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Rosenfeld M, Emerson J, McNamara S, Joubran K, Retsch-Bogart G, Graff GR, Gutierrez HH, Kanga JF, Lahiri T, Noyes B, Ramsey B, Ren CL, Schechter M, Morgan W, Gibson RL. Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort. Pediatr Pulmonol. 2010 Sep; 45(9):934-44.
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Yan R, Maximov AV, Ren C, Tsung FS. Growth and saturation of convective modes of the two-plasmon decay instability in inertial confinement fusion. Phys Rev Lett. 2009 Oct 23; 103(17):175002.
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Sawicki GS, Rasouliyan L, Ren CL. The impact of MRSA on lung function in patients with cystic fibrosis. Am J Respir Crit Care Med. 2009 Apr 15; 179(8):734-5; author reply 735.
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Voter KZ, Ren CL. Diagnosis of cystic fibrosis. Clin Rev Allergy Immunol. 2008 Dec; 35(3):100-6.
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Ren CL. Cystic fibrosis: evolution from a fatal disease of infancy with a clear phenotype to a chronic disease of adulthood with diverse manifestations. Clin Rev Allergy Immunol. 2008 Dec; 35(3):97-9.
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Sawicki GS, Rasouliyan L, Pasta DJ, Regelmann WE, Wagener JS, Waltz DA, Ren CL. The impact of incident methicillin resistant Staphylococcus aureus detection on pulmonary function in cystic fibrosis. Pediatr Pulmonol. 2008 Nov; 43(11):1117-23.
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Ren CL, Pasta DJ, Rasouliyan L, Wagener JS, Konstan MW, Morgan WJ. Relationship between inhaled corticosteroid therapy and rate of lung function decline in children with cystic fibrosis. J Pediatr. 2008 Dec; 153(6):746-51.
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VanDevanter DR, Rasouliyan L, Murphy TM, Morgan WJ, Ren CL, Konstan MW, Wagener JS. Trends in the clinical characteristics of the U.S. cystic fibrosis patient population from 1995 to 2005. Pediatr Pulmonol. 2008 Aug; 43(8):739-44.
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Ren CL. Assessment and monitoring of cystic fibrosis lung disease in infants and young children. Expert Rev Respir Med. 2008 Jun; 2(3):381-90.
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Li G, Yan R, Ren C, Wang TL, Tonge J, Mori WB. Laser channeling in millimeter-scale underdense plasmas of fast-ignition targets. Phys Rev Lett. 2008 Mar 28; 100(12):125002.
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Ren CL, Morgan WJ, Konstan MW, Schechter MS, Wagener JS, Fisher KA, Regelmann WE. Presence of methicillin resistant Staphylococcus aureus in respiratory cultures from cystic fibrosis patients is associated with lower lung function. Pediatr Pulmonol. 2007 Jun; 42(6):513-8.
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Padman R, McColley SA, Miller DP, Konstan MW, Morgan WJ, Schechter MS, Ren CL, Wagener JS. Infant care patterns at epidemiologic study of cystic fibrosis sites that achieve superior childhood lung function. Pediatrics. 2007 Mar; 119(3):e531-7.
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Ren CL. Pulmonary manifestations in deltaF508/R117H. Pediatrics. 2007 Mar; 119(3):647; author reply 647-8.
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Ren CL, Brucker JL, Rovitelli AK, Bordeaux KA. Changes in lung function measured by spirometry and the forced oscillation technique in cystic fibrosis patients undergoing treatment for respiratory tract exacerbation. Pediatr Pulmonol. 2006 Apr; 41(4):345-9.
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Ren CL. Comment on Sagel et al. Pediatr Pulmonol. 2005 Sep; 40(3):275; author reply 276.
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Ang JY, Ray-Mazumder S, Nachman SA, Rongkavilit C, Asmar BI, Ren CL. Use of complementary and alternative medicine by parents of children with HIV infection and asthma and well children. South Med J. 2005 Sep; 98(9):869-75.
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Ren CL. Cystic fibrosis gene mutations and chronic rhinosinusitis. J Allergy Clin Immunol. 2005 Aug; 116(2):463.
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Ren CL. What is the best way to measure lung function? Chest. 2003 Mar; 123(3):667-8.
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Ren CL. Use of modulators of airways inflammation in patients with CF. Clin Rev Allergy Immunol. 2002 Aug; 23(1):29-39.
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Talmaciu I, Ren CL, Kolb SM, Hickey E, Panitch HB. Pulmonary function in technology-dependent children 2 years and older with bronchopulmonary dysplasia. Pediatr Pulmonol. 2002 Mar; 33(3):181-8.
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Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A. Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. J Allergy Clin Immunol. 2000 Nov; 106(5):973-80.
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Loh RK, Jabara HH, Ren CL, Fu SM, Vercelli D, Geha RS. Role of protein tyrosine kinases and phosphatases in isotype switching: crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells. Immunol Lett. 1995 Feb; 45(1-2):99-106.
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Ren CL, Fu SM, Geha RS. Protein tyrosine kinase activation and protein kinase C translocation are functional components of CD40 signal transduction in resting human B cells. Immunol Invest. 1994 Nov; 23(6-7):437-48.
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Loh RK, Jabara HH, Ren CL, Fu SM, Geha RS. Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE. J Allergy Clin Immunol. 1994 Oct; 94(4):784-92.
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Ren CL, Morio T, Fu SM, Geha RS. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. J Exp Med. 1994 Feb 1; 179(2):673-80.
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Fernandez-Checa JC, Ren C, Aw TY, Ookhtens M, Kaplowitz N. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1988 Oct; 255(4 Pt 1):G403-8.
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Aw TY, Ookhtens M, Ren C, Kaplowitz N. Kinetics of glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1986 Feb; 250(2 Pt 1):G236-43.
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Forte TM, Luming Ren C, Nordhausen RW, Nichols AV. Formation of phospholipid-rich HDL: a model for square-packing lipoprotein particles found in interstitial fluid and in abetalipoproteinemic plasma. Biochim Biophys Acta. 1985 May 17; 834(3):386-95.
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