Marc Halterman
| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurology |
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| Address | Rochester General Hospital
1425 Portland Avenue
Department of Neurology
Rochester NY 14621
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| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| 1994 |
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| Gilbert B. Forbes Prize in Pediatric Research | | 1998 |
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| NIH Individual Pre-doctoral Combined MD PhD Fellowship | National instititues of Health | | 2001 |
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| Alpha Omega Alpha | | 2002 |
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| Doctor of Medicine with Distinction in Research | University of Rochester SMD | | 2007 |
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| Henry C. Buswell Fellowship Award | Department of Medicine, URMC | | 2008 |
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| K99/R00 Fellowship | NIH/NINDS |
Dr. Halterman's laboratory studies the damage associated with global brain ischemia, with a particular focus on identifying novel therapeutic targets in transcriptional signaling networks. Using a variety of models, they study the effects of hypoxia-ischemia on both the adult nervous system as well as the progenitor cells active within the immature and adult brain. His laboratory is supported by grants from the NIH/NINDS. He also has extensive experience in the field of gene therapy and holds several patents in the areas of gene transfer, drug discovery and medical informatics.
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Rininger A, Wayland A, Prifti V, Halterman MW. Assessment of CA1 injury after global ischemia using supervised 2D analyses of nuclear pyknosis. J Neurosci Methods. 2012 Jun 15; 207(2):181-8.
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Rininger A, Dejesus C, Totten A, Wayland A, Halterman MW. MKP-1 antagonizes C/EBP ß activity and lowers the apoptotic threshold after ischemic injury. Cell Death Differ. 2012 Oct; 19(10):1634-43.
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Qazi A, Halterman MW, Mi Z, Zhang T, Schor NF. Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress. Oxid Med Cell Longev. 2011; 2011:391659.
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Halterman MW. An improved method for the study of apoptosis-related genes using the tet-on system. J Biomol Screen. 2011 Mar; 16(3):332-7.
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Segel GB, Halterman MW, Lichtman MA. The paradox of the neutrophil's role in tissue injury. J Leukoc Biol. 2011 Mar; 89(3):359-72.
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Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. J Biol Chem. 2010 Jul 9; 285(28):21329-40.
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Halterman MW, Giuliano R, Dejesus C, Schor NF. In-tube transfection improves the efficiency of gene transfer in primary neuronal cultures. J Neurosci Methods. 2009 Mar 15; 177(2):348-54.
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Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ. Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Mol Cell Neurosci. 2008 Jun; 38(2):125-37.
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Halterman MW, Vates GE, Riggs G. Teaching NeuroImage: tremor in aqueductal stenosis and response to endoscopic third ventriculostomy. Neurology. 2007 May 8; 68(19):E29-31.
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Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. J Gene Med. 2006 Nov; 8(11):1320-8.
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Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 2004 Feb; 149(1):1-10.
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Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg. 2002 Sep; 236(3):337-42; discussion 342-3.
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Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Mol Ther. 2002 Jun; 5(6):723-30.
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Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff HJ, Fong Y. A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. Mol Ther. 2001 Sep; 4(3):250-6.
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Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y. Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer. Mol Med. 2001 Aug; 7(8):561-8.
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Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 2001 Jul 15; 98(2):287-95.
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Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Ther. 2001 Jan; 8(2):111-20.
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Bennett JJ, Kooby DA, Delman K, McAuliffe P, Halterman MW, Federoff H, Fong Y. Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer. J Mol Med (Berl). 2000; 78(3):166-74.
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Van de Water TR, Staecker H, Halterman MW, Federoff HJ. Gene therapy in the inner ear. Mechanisms and clinical implications. Ann N Y Acad Sci. 1999 Nov 28; 884:345-60.
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Halterman MW, Federoff HJ. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol. 1999 Sep; 159(1):65-72.
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D'Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity. Mol Med. 1999 Sep; 5(9):606-16.
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Halterman MW, Miller CC, Federoff HJ. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. J Neurosci. 1999 Aug 15; 19(16):6818-24.
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Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff HJ, Fong Y. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207). FASEB J. 1999 Aug; 13(11):1325-34.
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Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Hum Gene Ther. 1999 Jul 1; 10(10):1599-606.
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White SM, Renda M, Nam NY, Klimatcheva E, Zhu Y, Fisk J, Halterman M, Rimel BJ, Federoff H, Pandya S, Rosenblatt JD, Planelles V. Lentivirus vectors using human and simian immunodeficiency virus elements. J Virol. 1999 Apr; 73(4):2832-40.
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Brooks AI, Halterman MW, Federoff HJ. Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. Neuroreport. 1999 Feb 5; 10(2):337-44.
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Kutubuddin M, Federoff HJ, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD. Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 1999 Jan 15; 93(2):643-54.
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D'Angelica M, Karpoff H, Halterman M, Ellis J, Klimstra D, Edelstein D, Brownlee M, Federoff H, Fong Y. In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors. Cancer Immunol Immunother. 1999 Jan; 47(5):265-71.
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Carew JF, Federoff H, Halterman M, Kraus DH, Savage H, Sacks PG, Schantz SP, Shah JP, Fong Y. Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. Am J Surg. 1998 Nov; 176(5):404-8.
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Parry S, Holder J, Halterman MW, Weitzman MD, Davis AR, Federoff H, Strauss JF. Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. Am J Pathol. 1998 Jun; 152(6):1521-9.
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Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff HJ. Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector. J Neurosci Methods. 1998 Apr 30; 80(2):137-47.
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Ortega RA, Halterman MW. Concealed illegal drugs: a potential cause of airway obstruction. Anesth Analg. 1993 Jan; 76(1):204.
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Ortega RA, Halterman MW. Is there a role for the Finapres when arterial lines are used? Anesth Analg. 1992 Jun; 74(6):936.
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Chung KW, Dressler JB, Halterman MW, Allison JE. Structural and functional abnormality of ectopic testes in rats. Life Sci. 1984 May 14; 34(20):1953-7.
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