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Brian Blyth

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentEmergency Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 655
Rochester NY 14642
 
 Awards And Honors
      University of Rochester Medical Center Departmental Research Fellow 2002-2003 Department of Emergency Medicine Rochester, NY
1997 - 1998Howard Hughes Medical Institute Fellowship Award
1999     Excellence in Emergency Medicine Award for Graduating Medical Students  | Society for Academic Emergency Medicine
2002     Emergency Medicine Resident Teaching Award  | University of Rochester Medical Center
2003     Army Commendation Medal     | US Army
2004     Emergency Medicine Faculty Teaching Award  | University of Rochester Medical Center
2005     The Course in Scientific Management  | The Burroughs Welcome Fund and Howard Hughes Medical Institute
2006     Army Commendation Medal     | US Army
2008     Army Commendation Medal     | US Army
 
 Overview
The research efforts of the Blyth laboratory focus on traumatic brain injury. The overarching goal of our laboratory is to reduce the morbidity and mortality associated with traumatic brain injury. To accomplish this goal we rely on a translational approach: both clinical and basic studies are used to identify and solve relevant research questions that might lead to improved therapeutics for this disease. Ultimately, promising therapies are tested for efficacy through clinical trials. Laboratory resources include a repository of patient samples collected through a multicenter research network that includes six medical centers located throughout upstate New York with 300,000 patient visits per year. Data and clinical samples collected through this network are housed at a central repository located within the laboratory. Physically, the laboratory consists of state of the art bench research facilities within the Center for Neural Development and Disease at the University of Rochester Medical Center. We utilize patient based studies as well as cell culture and animal models of disease. Several mouse and rat models of traumatic brain injury are utilized. Relevant questions are identified through studies of large numbers of human patients and examined in detail in animal models. Mechanistic insights gleaned through this approach may then allow for novel therapeutics that can then be developed for clinical trials.

 
 Selected Publications
List All   |   Timeline
  1. Kiechle K, Bazarian JJ, Merchant-Borna K, Stoecklein V, Rozen E, Blyth B, Huang JH, Dayawansa S, Kanz K, Biberthaler P. Subject-Specific Increases in Serum S-100B Distinguish Sports-Related Concussion from Sports-Related Exertion. PLoS One. 2014; 9(1):e84977.
    View in: PubMed
  2. Bazarian JJ, Blyth BJ, He H, Mookerjee S, Jones C, Kiechle K, Moynihan R, Wojcik SM, Grant WD, Secreti LM, Triner W, Moscati R, Leinhart A, Ellis GL, Khan J. Classification Accuracy of Serum Apo A-I and S100B for the Diagnosis of Mild Traumatic Brain Injury and Prediction of Abnormal Initial Head Computed Tomography Scan. J Neurotrauma. 2013 Oct 15; 30(20):1747-54.
    View in: PubMed
  3. Bazarian JJ, Zhu T, Blyth B, Borrino A, Zhong J. Subject-specific changes in brain white matter on diffusion tensor imaging after sports-related concussion. Magn Reson Imaging. 2012 Feb; 30(2):171-80.
    View in: PubMed
  4. Blyth BJ, Farahvar A, He H, Nayak A, Yang C, Shaw G, Bazarian JJ. Elevated serum ubiquitin carboxy-terminal hydrolase L1 is associated with abnormal blood-brain barrier function after traumatic brain injury. J Neurotrauma. 2011 Dec; 28(12):2453-62.
    View in: PubMed
  5. Blyth BJ, Bazarian JJ. Traumatic alterations in consciousness: traumatic brain injury. Emerg Med Clin North Am. 2010 Aug; 28(3):571-94.
    View in: PubMed
  6. Bazarian JJ, Blyth B, Mookerjee S, He H, McDermott MP. Sex differences in outcome after mild traumatic brain injury. J Neurotrauma. 2010 Mar; 27(3):527-39.
    View in: PubMed
  7. Blyth BJ, Farhavar A, Gee C, Hawthorn B, He H, Nayak A, Stöcklein V, Bazarian JJ. Validation of serum markers for blood-brain barrier disruption in traumatic brain injury. J Neurotrauma. 2009 Sep; 26(9):1497-1507.
    View in: PubMed
  8. Bazarian JJ, Zhong J, Blyth B, Zhu T, Kavcic V, Peterson D. Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study. J Neurotrauma. 2007 Sep; 24(9):1447-59.
    View in: PubMed
  9. Bazarian JJ, Blyth B, Cimpello L. Bench to bedside: evidence for brain injury after concussion--looking beyond the computed tomography scan. Acad Emerg Med. 2006 Feb; 13(2):199-214.
    View in: PubMed
  10. Bazarian JJ, Beck C, Blyth B, von Ahsen N, Hasselblatt M. Impact of creatine kinase correction on the predictive value of S-100B after mild traumatic brain injury. Restor Neurol Neurosci. 2006; 24(3):163-72.
    View in: PubMed
  11. Babcock-Cimpello L, Blyth B, Bazarian JJ. Decision rules for computed tomographic scans in children after head trauma. Ann Emerg Med. 2004 Jul; 44(1):90-1; author reply 91-2.
    View in: PubMed
  12. Blyth BJ, Hauger RL, Purdy RH, Amico JA. The neurosteroid allopregnanolone modulates oxytocin expression in the hypothalamic paraventricular nucleus. Am J Physiol Regul Integr Comp Physiol. 2000 Mar; 278(3):R684-91.
    View in: PubMed
  13. Blyth BJ, Hollingshead DJ, Amico JA. Time course of induction of oxytocin messenger ribonucleic acid levels in the hypothalamic paraventricular nucleus of ovariectomized rats following gonadal steroid administration. Life Sci. 1997; 60(26):2427-33.
    View in: PubMed
  14. Blyth B. The outcome of severe head injuries. N Z Med J. 1981 Apr 22; 93(682):267-9.
    View in: PubMed

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