URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Wei Hsu

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentBiomedical Genetics in the Center for Oral Biology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionUniversity of Rochester Medical Center
DepartmentCancer Center

 
 Awards And Honors
1989 - 1994Predoctoral Fellowship  | Mount Sinai School of Medicine
1992     Traveling & Research Award  | Mount Sinai School of Medicine
1993     Traveling & Research Award  | Mount Sinai School of Medicine
1995     Postdoctoral Fellowship  | National Kidney Foundation
1997     Research Award  | Northeast Regional Development Biology Conference
2007     Idea Award, Breast Cancer Research Program  | DOD/USAMRMC
2012     Distinguished Alumni Award  | Taipei Fuhsing Private School, Taiwan
 
 Overview
Genetic Regulatory Circuits in Development and Disease
1. Craniofacial Morphogenesis
The primary objective is to investigate the fundamental mechanisms underlying craniofacial skeletogenesis, including development of cranial neural crest, tooth development, palatogenesis and calvarial morphogenesis. We currently focus on the interplay of Wnt, FGF and BMP pathways essential for expansion, cell fate determination and differentiation of the skeletal precursors. By elucidating these genetic regulatory networks, we hope to advance the knowledge base of skeletal deformities.
2. Breast Development and Cancer
The main focus is to elucidate the mechanisms by which Wnt signaling regulates stem/progenitor cells at different phases of breast development and their involvements in malignant transformation. We are particularly interested in the role of these precursor cells during parity-mediated remodeling of the mammary gland. Our current efforts focus on the role of mammary stem cells in development and cancer.
3. Stem Cell Biology
This is an integral part of our projects studying the genetic control of cellular signals and signal transduction mechanisms underlying development of lineage-specific stem cells/progenitors in skeletal, nervous and reproductive systems.
4. Ubiquitin-like Modifiers
A multi-disciplinary approach is used to study the SUMO (small ubiquitin-related modifier) pathway in mammalian development and disease. We are determining the role of SUMO-specific protease 2 in placental insufficiencies, cardiovascular, skeletal and neurological disorders, and cancers.
5. Wnt Production and Signaling
This project deciphers the regulatory mechanism underlying the making of Wnt and its signaling effects in signal-producing and signal-receiving cells. The main focus is to test our hypothesis that the newly identified Gpr177/mouse Wntless is a master regulator for intracellular trafficking of Wnt. We currently investigate the reciprocal regulation of Wnt and Gpr177 in craniofacial, skeletal, skin, tooth and mammary development, as well as the Gpr177-mediated regulation of Wnt in birth defects and cancers.

 
 Selected Publications
List All   |   Timeline
  1. Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J. Gpr177 regulates pulmonary vasculature development. Development. 2013 Sep; 140(17):3589-94.
    View in: PubMed
  2. Maruyama T, Jiang M, Hsu W. Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. J Bone Miner Res. 2013 May; 28(5):1150-9.
    View in: PubMed
  3. Zhu X, Zhao P, Liu Y, Zhang X, Fu J, Ivy Yu HM, Qiu M, Chen Y, Hsu W, Zhang Z. Intra-epithelial requirement of canonical Wnt signaling for tooth morphogenesis. J Biol Chem. 2013 Apr 26; 288(17):12080-9.
    View in: PubMed
  4. Maruyama EO, Yu HM, Jiang M, Fu J, Hsu W. Gpr177 deficiency impairs mammary development and prohibits wnt-induced tumorigenesis. PLoS One. 2013; 8(2):e56644.
    View in: PubMed
  5. McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ. Runx2 Protein Represses Axin2 Expression in Osteoblasts and Is Required for Craniosynostosis in Axin2-deficient Mice. J Biol Chem. 2013 Feb 22; 288(8):5291-302.
    View in: PubMed
  6. Fu J, Hsu W. Epidermal Wnt Controls Hair Follicle Induction by Orchestrating Dynamic Signaling Crosstalk between the Epidermis and Dermis. J Invest Dermatol. 2013 Apr; 133(4):890-8.
    View in: PubMed
  7. Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. Cartilage-specific ß-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. J Bone Miner Res. 2012 Aug; 27(8):1680-94.
    View in: PubMed
  8. Galloway CA, Lee H, Nejjar S, Jhun BS, Yu T, Hsu W, Yoon Y. Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress. Diabetes. 2012 Aug; 61(8):2093-104.
    View in: PubMed
  9. Zhang YG, Wu S, Xia Y, Chen D, Petrof EO, Claud EC, Hsu W, Sun J. Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells. PLoS One. 2012; 7(4):e34942.
    View in: PubMed
  10. Lin C, Fisher AV, Yin Y, Maruyama T, Veith GM, Dhandha M, Huang GJ, Hsu W, Ma L. The inductive role of Wnt-ß-Catenin signaling in the formation of oral apparatus. Dev Biol. 2011 Aug 1; 356(1):40-50.
    View in: PubMed
  11. Fu J, Ivy Yu HM, Maruyama T, Mirando AJ, Hsu W. Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn. 2011 Feb; 240(2):365-71.
    View in: PubMed
  12. Jiang M, Chiu SY, Hsu W. SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ. 2011 Jun; 18(6):1005-15.
    View in: PubMed
  13. Mirando AJ, Maruyama T, Fu J, Yu HM, Hsu W. ß-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis. BMC Dev Biol. 2010; 10:116.
    View in: PubMed
  14. Yu HM, Jin Y, Fu J, Hsu W. Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis. Dev Dyn. 2010 Jul; 239(7):2102-9.
    View in: PubMed
  15. Chiu SY, Maruyama EO, Hsu W. Derivation of mouse trophoblast stem cells from blastocysts. J Vis Exp. 2010; (40).
    View in: PubMed
  16. Maruyama T, Mirando AJ, Deng CX, Hsu W. The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. Sci Signal. 2010; 3(123):ra40.
    View in: PubMed
  17. Hsu W, Mirando AJ, Yu HM. Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev Dyn. 2010 Jan; 239(1):338-45.
    View in: PubMed
  18. Fu J, Jiang M, Mirando AJ, Yu HM, Hsu W. Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18598-603.
    View in: PubMed
  19. Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D. Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. J Cell Sci. 2009 Oct 1; 122(Pt 19):3566-78.
    View in: PubMed
  20. Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9715-20.
    View in: PubMed
  21. Chiu SY, Asai N, Costantini F, Hsu W. SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 2008 Dec 16; 6(12):e310.
    View in: PubMed
  22. Liu B, Yu HM, Huang J, Hsu W. Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis. Neoplasia. 2008 Sep; 10(9):1004-13.
    View in: PubMed
  23. Liu B, Yu HM, Hsu W. Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol. 2007 Jan 1; 301(1):298-308.
    View in: PubMed
  24. Yu HM, Liu B, Chiu SY, Costantini F, Hsu W. Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8615-20.
    View in: PubMed
  25. Yu HM, Jerchow B, Sheu TJ, Liu B, Costantini F, Puzas JE, Birchmeier W, Hsu W. The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development. 2005 Apr; 132(8):1995-2005.
    View in: PubMed
  26. Hsu W, Shakya R, Costantini F. Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J Cell Biol. 2001 Dec 10; 155(6):1055-64.
    View in: PubMed
  27. Julius MA, Schelbert B, Hsu W, Fitzpatrick E, Jho E, Fagotto F, Costantini F, Kitajewski J. Domains of axin and disheveled required for interaction and function in wnt signaling. Biochem Biophys Res Commun. 2000 Oct 5; 276(3):1162-9.
    View in: PubMed
  28. Hsu W, Zeng L, Costantini F. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J Biol Chem. 1999 Feb 5; 274(6):3439-45.
    View in: PubMed
  29. Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell. 1997 Jul 11; 90(1):181-92.
    View in: PubMed
  30. Klampfer L, Lee TH, Hsu W, Vilcek J, Chen-Kiang S. NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. Mol Cell Biol. 1994 Oct; 14(10):6561-9.
    View in: PubMed
  31. Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol Cell Biol. 1994 Jan; 14(1):268-76.
    View in: PubMed
  32. Hsu W, Chen-Kiang S. Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells. Mol Cell Biol. 1993 Apr; 13(4):2515-23.
    View in: PubMed
  33. Chen-Kiang S, Hsu W, Natkunam Y, Zhang X. Nuclear signaling by interleukin-6. Curr Opin Immunol. 1993 Feb; 5(1):124-8.
    View in: PubMed
  34. Spergel JM, Hsu W, Akira S, Thimmappaya B, Kishimoto T, Chen-Kiang S. NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J Virol. 1992 Feb; 66(2):1021-30.
    View in: PubMed

Visualizations


Hsu's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department