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John Cullen

TitleResearch Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentSurgery
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box SURG
Rochester NY 14642
 
 Awards And Honors
1997     Travel Award  | British Pharmacological Society
1998     Travel Award  | International Society for Heart Research
2002     New Investigator Award  | American Heart Association: ATVB Council
2002     Merit Award for Young Investigators  | American Heart Association: ATVB Council
2008     Enoch Gordis Research Recognition Award Finalist  | Research Society on Alcoholism
2011     Board President, American Heart Association, Rochester Division, New York
2012     Distinguished Leadership Award  | American Heart Association
 
 Overview
Dr. Cullen received his Bachelor of Science with Honors in Pharmacology from the University of Edinburgh, Scotland, followed by a PhD in Cardiovascular Pharmacology from the Queen's University of Belfast, Ireland. His postdoctoral training was completed in the Department of Surgery at the University of Rochester Medical Center from 1999-2002. Currently, he is a Research Associate Professor in the Department of Surgery, Basic and Translational Research Division. His research interests focus on the effects of patterns on alcohol consumption on the development of atherosclerosis and on monocyte activation in relation to sepsis, MODS and mortality after surgery, injury or infection.

 
 Selected Publications
List All   |   Timeline
  1. Redmond EM, Hamm K, Cullen JP, Hatch E, Cahill PA, Morrow D. Inhibition of patched-1 prevents injury-induced neointimal hyperplasia. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1960-4.
    View in: PubMed
  2. Liu W, Redmond EM, Morrow D, Cullen JP. Differential effects of daily-moderate versus weekend-binge alcohol consumption on atherosclerotic plaque development in mice. Atherosclerosis. 2011 Dec; 219(2):448-54.
    View in: PubMed
  3. Guha S, Cullen JP, Morrow D, Colombo A, Lally C, Walls D, Redmond EM, Cahill PA. Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival. Basic Res Cardiol. 2011 Sep; 106(5):773-85.
    View in: PubMed
  4. Nickels MW, Cullen JP, Demme RA, Vetter M, Boulay R, Betts R, McKee M, Orloff M, Bozorgzadeh A. A psychosocial evaluation process for living liver donors: the University of Rochester model. Int J Psychiatry Med. 2011; 41(4):295-308.
    View in: PubMed
  5. Morrow D, Cullen JP, Liu W, Cahill PA, Redmond EM. Alcohol inhibits smooth muscle cell proliferation via regulation of the Notch signaling pathway. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2597-603.
    View in: PubMed
  6. Horgan S, Mintz Y, Jacobsen GR, Sandler BJ, Cullen JP, Spivack A, Easter DW, Chock A, Savu MK, Ramamoorthy S, Bosia J, Agarwal S, Lukacz E, Whitcomb E, Savides T, Talamini MA. Video. Magnetic retraction for NOTES transvaginal cholecystectomy. Surg Endosc. 2010 Sep; 24(9):2322.
    View in: PubMed
  7. Horgan S, Mintz Y, Jacobsen GR, Sandler BJ, Cullen JP, Spivack A, Easter DW, Chock A, Savu MK, Ramamoorthy S, Bosia J, Agarwal S, Lukacz E, Whitcomb E, Savides T, Talamini MA. Video. NOTES: transvaginal cholecystectomy with assisting articulating instruments. Surg Endosc. 2009 Aug; 23(8):1900.
    View in: PubMed
  8. Morrow D, Cullen JP, Liu W, Guha S, Sweeney C, Birney YA, Collins N, Walls D, Redmond EM, Cahill PA. Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1112-8.
    View in: PubMed
  9. Horgan S, Cullen JP, Talamini MA, Mintz Y, Ferreres A, Jacobsen GR, Sandler B, Bosia J, Savides T, Easter DW, Savu MK, Ramamoorthy SL, Whitcomb E, Agarwal S, Lukacz E, Dominguez G, Ferraina P. Natural orifice surgery: initial clinical experience. Surg Endosc. 2009 Jul; 23(7):1512-8.
    View in: PubMed
  10. Redmond EM, Morrow D, Kundimi S, Miller-Graziano CL, Cullen JP. Acetaldehyde stimulates monocyte adhesion in a P-selectin- and TNFalpha-dependent manner. Atherosclerosis. 2009 Jun; 204(2):372-80.
    View in: PubMed
  11. Morrow D, Cullen JP, Cahill PA, Redmond EM. Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway. Cardiovasc Res. 2008 Jul 15; 79(2):313-21.
    View in: PubMed
  12. Doherty LS, Cullen JP, Nolan P, McNicholas WT. The human genioglossus response to negative airway pressure: stimulus timing and route of delivery. Exp Physiol. 2008 Feb; 93(2):288-95.
    View in: PubMed
  13. Cullen JP, Morrow D, Jin Y, von Offenberg Sweeney N, Sitzmann JV, Cahill PA, Redmond EM. Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes. Atherosclerosis. 2007 Nov; 195(1):e125-33.
    View in: PubMed
  14. Morrow D, Cullen JP, Cahill PA, Redmond EM. Cyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1289-96.
    View in: PubMed
  15. Cullen JP, Morrow D, Jin Y, Curley B, Robinson A, Sitzmann JV, Cahill PA, Redmond EM. Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion. J Vasc Res. 2007; 44(1):75-84.
    View in: PubMed
  16. Cullen JP, Sayeed S, Kim Y, Theodorakis NG, Sitzmann JV, Cahill PA, Redmond EM. Ethanol inhibits pulse pressure-induced vascular smooth muscle cell migration by differentially modulating plasminogen activator inhibitor type 1, matrix metalloproteinase-2 and -9. Thromb Haemost. 2005 Sep; 94(3):639-45.
    View in: PubMed
  17. Cullen JP, Sayeed S, Jin Y, Theodorakis NG, Sitzmann JV, Cahill PA, Redmond EM. Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1669-75.
    View in: PubMed
  18. von Offenberg Sweeney N, Cummins PM, Birney YA, Cullen JP, Redmond EM, Cahill PA. Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity. Cardiovasc Res. 2004 Sep 1; 63(4):625-34.
    View in: PubMed
  19. Cullen JP, Nicholl SM, Sayeed S, Sitzmann JV, Okada SS, Cahill PA, Redmond EM. Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration. Thromb Res. 2004; 114(1):57-65.
    View in: PubMed
  20. Cullen JP, Sayeed S, Sawai RS, Theodorakis NG, Cahill PA, Sitzmann JV, Redmond EM. Pulsatile flow-induced angiogenesis: role of G(i) subunits. Arterioscler Thromb Vasc Biol. 2002 Oct 1; 22(10):1610-6.
    View in: PubMed
  21. Sayeed S, Cullen JP, Coppage M, Sitzmann JV, Redmond EM. Ethanol differentially modulates the expression and activity of cell cycle regulatory proteins in rat aortic smooth muscle cells. Eur J Pharmacol. 2002 Jun 12; 445(3):163-70.
    View in: PubMed
  22. Cullen JP, Bell D, Kelso EJ, McDermott BJ. Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy. Eur J Pharmacol. 2001 Apr 13; 417(3):157-68.
    View in: PubMed
  23. Redmond EM, Cullen JP, Cahill PA, Sitzmann JV, Stefansson S, Lawrence DA, Okada SS. Endothelial cells inhibit flow-induced smooth muscle cell migration: role of plasminogen activator inhibitor-1. Circulation. 2001 Jan 30; 103(4):597-603.
    View in: PubMed
  24. Drummond GB, Cullen JP. Detection of inspiratory resistive loads after anaesthesia for minor surgery. Br J Anaesth. 1997 Mar; 78(3):308-10.
    View in: PubMed

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