Ollivier Hyrien
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biostatistics and Computational Biology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester NY 14642
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Research Interests-Methodological
Stochastic processes and their biological applications
Asymptotic theory
Mixed effects models
Mixture Models
Computational biology
Functional data
Research Interests-Collaborative
Cell and stem cell biology
Immunology
Cancer research
Flow cytometry
Radiation research
Pharmacokinetics, pharmacodynamics and toxicology
Image analysis
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Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH. Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation. Blood. 2011 Sep 29; 118(13):3591-602.
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Kaspler P, Chen R, Hyrien O, Jelveh S, Bristow RG, Hill RP. Biodosimetry using radiation-induced micronuclei in skin fibroblasts. Int J Radiat Biol. 2011 Aug; 87(8):824-38.
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Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, Chen Y. Impact of radiotherapy on laryngeal cancer survival: A Population-Based Study of 13,808 US Patients. Cancer. 2012 Mar 1; 118(5):1276-87.
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Hyrien O, Dietrich J, Noble M. Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors. Cancer Res. 2010 Dec 15; 70(24):10051-9.
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Chen R, Hyrien O, Noble M, Mayer-Pröschel M. A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process. Biostatistics. 2011 Jan; 12(1):173-91.
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Chen Y, Pandya KJ, Hyrien O, Keng PC, Smudzin T, Anderson J, Qazi R, Smith B, Watson TJ, Feins RH, Johnstone DW. Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2011 Aug 1; 80(5):1358-64.
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Hyrien O, Chen R, Zand MS. An age-dependent branching process model for the analysis of CFSE-labeling experiments. Biol Direct. 2010; 5:41.
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Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, Avlasevich S, Bemis JC, Hyrien O, Palis J, MacGregor JT. Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies. Toxicol Sci. 2010 Jun; 115(2):401-11.
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Kaspler P, Hyrien O, Hill RP. Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiation. Health Phys. 2010 Feb; 98(2):228-33.
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Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, Dertinger SD. Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model. Health Phys. 2010 Feb; 98(2):218-27.
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Bhogal N, Kaspler P, Jalali F, Hyrien O, Chen R, Hill RP, Bristow RG. Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo. Radiat Res. 2010 Jan; 173(1):1-9.
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Phonethepswath S, Franklin D, Torous DK, Bryce SM, Bemis JC, Raja S, Avlasevich S, Weller P, Hyrien O, Palis J, Macgregor JT, Dertinger SD. Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens. Toxicol Sci. 2010 Mar; 114(1):59-70.
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Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH. Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. J Immunol. 2009 Nov 15; 183(10):6157-66.
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Sun H, Dertinger SD, Hyrien O, Wu JH, Chen Y. Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro. Mutat Res. 2009 Nov-Dec; 680(1-2):49-55.
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Henn AD, Rebhahn J, Brown MA, Murphy AJ, Coca MN, Hyrien O, Pellegrin T, Mosmann T, Zand MS. Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division. J Immunol. 2009 Sep 1; 183(5):3177-87.
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Biswas T, Dhakal S, Chen R, Hyrien O, Bernstein S, Friedberg JW, Fisher RI, Liesveld J, Phillips G, Constine LS. Involved field radiation after autologous stem cell transplant for diffuse large B-cell lymphoma in the rituximab era. Int J Radiat Oncol Biol Phys. 2010 May 1; 77(1):79-85.
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Hocdé SA, Hyrien O, Waugh RE. Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM. Biophys J. 2009 Jul 8; 97(1):379-87.
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Hocdé SA, Hyrien O, Waugh RE. Molecular accessibility in relation to cell surface topography and compression against a flat substrate. Biophys J. 2009 Jul 8; 97(1):369-78.
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Hyrien O, Chen R, Mayer-Pröschel M, Noble M. Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications. Biometrics. 2010 Jun; 66(2):567-77.
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Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age. Mutat Res. 2009 Apr 30; 675(1-2):77-80.
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Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ, Bankert RB, Bernstein SH. Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab. Blood. 2009 Apr 16; 113(16):3809-12.
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Khorana AA, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB. Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer. J Thromb Haemost. 2008 Nov; 6(11):1983-5.
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Zhang H, Hyrien O, Pandya KJ, Keng PC, Chen Y. Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization. J Thorac Oncol. 2008 Jun; 3(6):563-8.
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Couderc JP, McNitt S, Hyrien O, Vaglio M, Xia X, Polonsky S, Moss AJ, Zareba W. Improving the detection of subtle I(Kr)-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacin. Drug Saf. 2008; 31(3):249-60.
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Connolly GC, Chen R, Hyrien O, Mantry P, Bozorgzadeh A, Abt P, Khorana AA. Incidence, risk factors and consequences of portal vein and systemic thromboses in hepatocellular carcinoma. Thromb Res. 2008; 122(3):299-306.
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Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry. Mutat Res. 2007 Dec 1; 634(1-2):119-25.
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Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data. Theor Biol Med Model. 2006; 3:21.
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Couderc JP, Vaglio M, Xia X, McNitt S, Hyrien O. Electrocardiographic method for identifying drug-induced repolarization abnormalities associated with a reduction of the rapidly activating delayed rectifier potassium current. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:4010-5.
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Hanin L, Hyrien O, Bedford J, Yakovlev A. A comprehensive stochastic model of irradiated cell populations in culture. J Theor Biol. 2006 Apr 21; 239(4):401-16.
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Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):260-6.
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Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. A stochastic model to analyze clonal data on multi-type cell populations. Biometrics. 2005 Mar; 61(1):199-207.
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Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture. Math Biosci. 2005 Feb; 193(2):255-74.
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Klés V, Hyrien O, Poul JM, Sanders P. Application of pharmacokinetic/pharmacodynamic and stochastic modelling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes. J Appl Toxicol. 2003 Jan-Feb; 23(1):59-70.
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Hyrien O, Klés V, Concordet D, Bonneu M, Laurentie M, Sanders P. Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay. Math Biosci. 2001 Jan; 169(1):27-51.
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Godard T, Fessard V, Huet S, Mourot A, Deslandes E, Pottier D, Hyrien O, Sichel F, Gauduchon P, Poul J. Comparative in vitro and in vivo assessment of genotoxic effects of etoposide and chlorothalonil by the comet assay. Mutat Res. 1999 Jul 21; 444(1):103-16.
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