Douglas Portman
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Genetics in the Center for Neural Development & Disease |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester NY 14642
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| Title | Associate Professor |
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| Institution | University of Rochester, River Campus |
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| Department | Biology RC |
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Genetic Control of Sex Differences in Neurobiology and Disease
Though the existence of two sexes is a fundamental characteristic of nearly all animal species, the way biological sex brings about sex differences in the brain and behavior is poorly understood. Moreover, susceptibility to a host of human neurological and mental health disorders is strongly influenced by gender, but in most cases the biological bases for these differences remain opaque. Our research uses a simple, experimentally tractable model system--the small soil nematode C. elegans--to shed light on the genetic underpinnings of sex differences in neural development, behavior, and disease susceptibility.
For more information, please visit the lab website at: http://wormweb.urmc.rochester.edu/
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Mowrey WR, Portman DS. Sex differences in behavioral decision-making and the modulation of shared neural circuits. Biol Sex Differ. 2012; 3:8.
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Siehr MS, Koo PK, Sherlekar AL, Bian X, Bunkers MR, Miller RM, Portman DS, Lints R. Multiple doublesex-Related Genes Specify Critical Cell Fates in a C. elegans Male Neural Circuit. PLoS One. 2011; 6(11):e26811.
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Miller RM, Portman DS. The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage. J Neurosci. 2011 Sep 14; 31(37):13281-91.
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Hurd DD, Miller RM, Núñez L, Portman DS. Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegans. Genetics. 2010 Jul; 185(3):883-96.
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Miller RM, Portman DS. A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5. Dis Model Mech. 2010 Jul-Aug; 3(7-8):441-50.
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Mason DA, Rabinowitz JS, Portman DS. dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans. Development. 2008 Aug; 135(14):2373-82.
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Lee K, Portman DS. Neural sex modifies the function of a C. elegans sensory circuit. Curr Biol. 2007 Nov 6; 17(21):1858-63.
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Portman DS. Genetic control of sex differences in C. elegans neurobiology and behavior. Adv Genet. 2007; 59:1-37.
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Portman DS. Profiling C. elegans gene expression with DNA microarrays. WormBook. 2006; 1-11.
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Portman DS, Bohmann D. Toward the computable transcriptome. Mol Cell. 2004 Jun 18; 14(6):693-4.
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Portman DS, Emmons SW. Identification of C. elegans sensory ray genes using whole-genome expression profiling. Dev Biol. 2004 Jun 15; 270(2):499-512.
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Portman DS, Emmons SW. The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage. Development. 2000 Dec; 127(24):5415-26.
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Hassfeld W, Chan EK, Mathison DA, Portman D, Dreyfuss G, Steiner G, Tan EM. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. Nucleic Acids Res. 1998 Jan 15; 26(2):439-45.
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Portman DS, O'Connor JP, Dreyfuss G. YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity. RNA. 1997 May; 3(5):527-37.
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Kamma H, Portman DS, Dreyfuss G. Cell type-specific expression of hnRNP proteins. Exp Cell Res. 1995 Nov; 221(1):187-96.
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Portman DS, Dreyfuss G. RNA annealing activities in HeLa nuclei. EMBO J. 1994 Jan 1; 13(1):213-21.
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Görlach M, Burd CG, Portman DS, Dreyfuss G. The hnRNP proteins. Mol Biol Rep. 1993 Aug; 18(2):73-8.
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