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Bin Liu

Title	Research Assistant Professor
Institution	School of Medicine and Dentistry
Department	Medicine in the Aab Cardiovascular Research Institute
Address	Aab Cardiovascular Research Institute 211 Bailey Road West Henrietta NY 14586

Overview

My research is focused on the regulation of mRNA stability of monocyte chemoattractant protein-1 (MCP-1) by PDGF and Angiotensin II (Ang II) in smooth muscle cells (SMC). MCP-1 promotes atherosclerosis and is a mediator of the response to arterial injury. MCP-1 level tracks its mRNA level under physiological or pathological conditions in animal models. MCP-1 mRNA is markedly elevated in response to PDGF-B or Ang II elevation largely due to increase of mRNA stability. Both PDGF-B and Ang II stabilize MCP-1 mRNA through a PKCd-dependent signaling pathway. Our ongoing research is to fully figure out the signaling pathways mediating the mRNA stabilizing effect, to isolate the MCP-1 mRNA stabilizing factor induced by PDGF-B and Ang II, and to reveal the RNases involved in PDGF-b and Ang II induced MCP-1 mRNA stabilization.

Selected Publications

Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. Galactic cosmic radiation leads to cognitive impairment and increased aß plaque accumulation in a mouse model of Alzheimer's disease. PLoS One. 2012; 7(12):e53275.

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Dhawan L, Liu B, Pytlak A, Kulshrestha S, Blaxall BC, Taubman MB. Y-Box Binding Protein 1 and RNase UK114 Mediate Monocyte Chemoattractant Protein 1 mRNA Stability in Vascular Smooth Muscle Cells. Mol Cell Biol. 2012 Sep; 32(18):3768-75.

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Liu B, Dhawan L, Blaxall BC, Taubman MB. Protein kinase Cd mediates MCP-1 mRNA stabilization in vascular smooth muscle cells. Mol Cell Biochem. 2010 Nov; 344(1-2):73-9.

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Dhawan L, Liu B, Blaxall BC, Taubman MB. A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability. J Biol Chem. 2007 Apr 6; 282(14):10146-52.

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Liu B, Poon M, Taubman MB. PDGF-BB enhances monocyte chemoattractant protein-1 mRNA stability in smooth muscle cells by downregulating ribonuclease activity. J Mol Cell Cardiol. 2006 Jul; 41(1):160-9.

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Liu B, Jiang S, Zhang W, Ye F, Wang YH, Wu J, Zhang DY. Novel biodegradable HSAM nanoparticle for drug delivery. Oncol Rep. 2006 Apr; 15(4):957-61.

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Menzies K, Liu B, Kim WJ, Moschella MC, Taubman MB. Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells. Biochem Biophys Res Commun. 2004 May 7; 317(3):801-10.

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Zhang DY, Liu B. Detection of target nucleic acids and proteins by amplification of circularizable probes. Expert Rev Mol Diagn. 2003 Mar; 3(2):237-48.

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Henderson C, Meyers B, Humayun Gultekin S, Liu B, Zhang DY. Intracranial tuberculoma in a liver transplant patient: first reported case and review of the literature. Am J Transplant. 2003 Jan; 3(1):88-93.

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Poon M, Liu B, Taubman MB. Identification of a novel dexamethasone-sensitive RNA-destabilizing region on rat monocyte chemoattractant protein 1 mRNA. Mol Cell Biol. 1999 Oct; 19(10):6471-8.

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