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Ping Tang

Title	Professor
Institution	School of Medicine and Dentistry
Department	Pathology and Laboratory Medicine
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 626 Rochester NY 14642

Awards And Honors

1986			The First National Conference for outstanding young and middle age basic scientists in Beijing, PR China
1988			A two-year fellowship from Boehringer Ingelheim Foundation of Germany.
1995			Sowell-Huggins award from The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences in Houston.

Overview

Dr. Tang's Ph.D. research at the University of Texas MD Anderson Cancer Center involved tumor necrosis factor signal transduction and protein processing. From 1995-98 she served as a postdoctoral fellow, studying growth inhibition of glioma cells by antisense TGF-alpha. Since her residency at North Shore and her surgical pathology fellowship at Yale, she has focused on early breast carcinogenesis.

At Rochester, Dr. Tang was the recipient of an Empire Clinical Research Investigator Program (ECRIP) award to fund a study of molecular markers that may predict a subgroup of ductal carcinoma in situ (DCIS) with high risk of progression to invasive ductal carcinoma (IDC). DCIS is a heterogeneous group of lesions that accounts over 20% of breast carcinoma diagnosed annually which has a 14-53% chance of progression to IDC over a 10-year period.

She is currently working to identify a group of biomarkers that will predict a subset of breast tumors with a high risk of bone metastasis. She is using immunocytochemistry, a common and relatively inexpensive form of analysis, in the hope that her findings may be easily translated into clinical practice, allowing more aggressive treatment of tumors with greater risk of metastasis.

Selected Publications

Cao CN, Luo JW, Xu GZ, Gao L, Xu ZG, Tang PZ. Management of nasopharyngeal adenoid cystic carcinoma. J Oral Maxillofac Surg. 2013 Apr; 71(4):e203-9.

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Burke K, Tang P, Brown E. Second harmonic generation reveals matrix alterations during breast tumor progression. J Biomed Opt. 2013 Mar; 18(3):031106.

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Burke K, Tang P, Brown E. Second harmonic generation reveals matrix alterations during breast tumor progression. J Biomed Opt. 2013 Mar 1; 18(3):31106.

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Xu GZ, Tang PZ, Luo JW. [Intensify the studies on radiotherapy-based combined treatment of nasopharyngeal carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Mar; 47(3):177-9.

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Zeng Q, Wang XL, Xu ZG, Lü N, Zheng S, Zhao QZ, Tang PZ. [Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in laryngeal squamous cell carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Mar; 47(3):234-40.

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Subik K, Shu L, Wu C, Liang Q, Hicks D, Boyce B, Schiffhauer L, Chen D, Chen C, Tang P, Xing L. The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. Bone. 2012 Apr; 50(4):813-23.

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Liu WS, Xu ZG, Gao L, Tang PZ, Xu GZ, Zhang GF. [Adenoid cystic carcinoma of maxillary sinus: diagnosis, treatment and prognostic factors]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 May; 46(5):402-7.

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Zhang ZX, Li ZJ, Tang PZ, Xu ZG, Zhang ZM, An CM. [Surgical treatment and prognosis analysis on medullary thyroid carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Mar; 46(3):209-13.

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Tang P, Wei B, Yang WJ, Liu YS, Bu H. [Prognostic factors of breast cancer]. Zhonghua Bing Li Xue Za Zhi. 2011 Feb; 40(2):73-6.

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Huang H, Xu ZG, Tang PZ, Liu SY, Wu YH, Wang XL. [Clinical analysis of surgical complications after preoperative concurrent chemoradiotherapy of pyriform sinus cancer]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Feb; 46(2):114-7.

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Tang P, Wang J, Hicks DG, Wang X, Schiffhauer L, McMahon L, Yang Q, Shayne M, Huston A, Skinner KA, Griggs J, Lyman G. A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer. Cancer Invest. 2010 Nov; 28(9):978-82.

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Lin Y, Hatem J, Wang J, Quinn A, Hicks D, Tang P. Tissue microarray-based immunohistochemical study can significantly underestimate the expression of HER2 and progesterone receptor in ductal carcinoma in situ of the breast. Biotech Histochem. 2011 Oct; 86(5):345-50.

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Zhang XM, Cao JZ, Luo JW, Xu GZ, Gao L, Liu SY, Xu ZG, Tang PZ. Nasopharyngeal mucoepidermoid carcinoma: a review of 13 cases. Oral Oncol. 2010 Aug; 46(8):618-21.

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Zhang ZX, Li ZJ, Xu ZG, Tang PZ, Zhang ZM, An CM. [Clinical analysis of 60 cases with maxillary squamous cell carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Jul; 45(7):560-4.

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Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, Tang P. The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines. Breast Cancer (Auckl). 2010; 4:35-41.

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Liu J, Tang PZ, Xu ZG. [Clinical analysis of level V occult metastasis of papillary thyroid carcinoma]. Zhonghua Zhong Liu Za Zhi. 2010 Apr; 32(4):313-5.

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Ni S, Xu ZG, Wang XL, Liu SY, Qi YF, Tang PZ. [Fatal hemorrhage following surgery for head and neck carcinoma]. Zhonghua Zhong Liu Za Zhi. 2010 Jan; 32(1):60-3.

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Biswas T, Tang P, Muhs A, Ling M. Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol. 2009 Dec; 32(6):582-6.

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Wang X, Ni J, Hsu CL, Johnykutty S, Tang P, Ho YS, Lee CH, Yeh S. Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer. Cancer Invest. 2009 Dec; 27(10):971-7.

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Tang PZ, Wang XL. [Overview of the 60-year treatment of head and neck tumors in China]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct; 44(10):805-7.

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Tang P, Skinner KA, Hicks DG. Molecular classification of breast carcinomas by immunohistochemical analysis: are we ready? Diagn Mol Pathol. 2009 Sep; 18(3):125-32.

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Chuang C, Hicks DG, Berenson M, Kulkarni S, Tang P. Benign inclusion of axillary lymph nodes: report of two cases and literature review. Breast J. 2009 Nov-Dec; 15(6):664-5.

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Wei MH, Tang PZ, Xu ZG, Qi YF, Yin YL. [Clinical analysis of 40 cases with sinonasal adenoid cystic carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 May; 44(5):381-4.

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Johnykutty S, Tang P, Zhao H, Hicks DG, Yeh S, Wang X. Dual expression of alpha-tocopherol-associated protein and estrogen receptor in normal/benign human breast luminal cells and the downregulation of alpha-tocopherol-associated protein in estrogen-receptor-positive breast carcinomas. Mod Pathol. 2009 Jun; 22(6):770-5.

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Zeng Q, Tang PZ, Xu ZG, Qi YF, Wu XX, Liu WS. [Malignant minor salivary gland tumors of the larynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan; 44(1):40-3.

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Lester T, Wang J, Bourne P, Yang Q, Fu L, Tang P. Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast. Ann Clin Lab Sci. 2009; 39(1):17-24.

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Tang P, Wei B, Hicks DG, Skinner K, Bu H. [Molecular phenotypes of breast cancer and their clinical application]. Zhonghua Bing Li Xue Za Zhi. 2009 Jan; 38(1):13-7.

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Li ZJ, Li HZ, Liu WS, Xu ZG, Tang PZ. [Clinical analysis of small cell neuroendocrine carcinoma of the head and neck]. Zhonghua Yi Xue Za Zhi. 2008 Dec 16; 88(46):3275-8.

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Quinn AM, Tang P, Yang Q, Bourne PA. Tissue array construction: pitfalls, problems, and progress. Appl Immunohistochem Mol Morphol. 2008 May; 16(3):287-90.

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Tang P, Wang J, Bourne P. Molecular classifications of breast carcinoma with similar terminology and different definitions: are they the same? Hum Pathol. 2008 Apr; 39(4):506-13.

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Han X, Burke RM, Zettel ML, Tang P, Brown EB. Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma. Opt Express. 2008 Feb 4; 16(3):1846-59.

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Hanley K, Wang J, Bourne P, Yang Q, Gao AC, Lyman G, Tang P. Lack of expression of androgen receptor may play a critical role in transformation from in situ to invasive basal subtype of high-grade ductal carcinoma of the breast. Hum Pathol. 2008 Mar; 39(3):386-92.

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Liu J, Xu ZG, Wang XL, Liu SY, Qi YF, Tang PZ. [Surgical treatment of thyroid carcinoma with the upper mediastinal metastasis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Apr; 42(4):277-80.

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Cao WF, Zhang LY, Liu MB, Tang PZ, Liu ZH, Sun BC. Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray. Hum Pathol. 2007 May; 38(5):747-52.

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Tang P, Hajdu SI, Lyman GH. Ductal carcinoma in situ: a review of recent advances. Curr Opin Obstet Gynecol. 2007 Feb; 19(1):63-7.

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Steinman S, Wang J, Bourne P, Yang Q, Tang P. Expression of cytokeratin markers, ER-alpha, PR, HER-2/neu, and EGFR in pure ductal carcinoma in situ (DCIS) and DCIS with co-existing invasive ductal carcinoma (IDC) of the breast. Ann Clin Lab Sci. 2007; 37(2):127-34.

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Uppuluri S, Bhatt S, Tang P, Dogra VS. Clear cell papillary cystadenoma with sonographic and histopathologic correlation. J Ultrasound Med. 2006 Nov; 25(11):1451-3.

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Wang XL, Xu ZG, Tang PZ. [Surgical treatment on primary lesion of advanced pyriform sinus cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Aug; 28(4):534-7.

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Bian X, Tang PZ, Xu ZG, Wen SX, Wang JH. [Role of preoperative ultrasonography in evaluating early cervical metastasis in patients with differentiated thyroid carcinoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Aug; 28(4):530-3.

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Zhang B, Xu ZG, Tang PZ. Elective lateral neck dissection for laryngeal cancer in the clinically negative neck. J Surg Oncol. 2006 May 1; 93(6):464-7.

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Wen SX, Tang PZ, Xu ZG, Qi YF, Li ZJ, Liu WS. [Therapeutic modalities of nasopharyngeal adenoid cystic carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 May; 41(5):359-61.

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Wang XL, Xu ZG, Tang PZ. [Comprehensive treatment of advanced pyriform sinus cancer]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 Feb; 41(2):123-7.

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Tang P, Wang X, Schiffhauer L, Wang J, Bourne P, Yang Q, Quinn A, Hajdu S. Expression patterns of ER-alpha, PR, HER-2/neu, and EGFR in different cell origin subtypes of high grade and non-high grade ductal carcinoma in situ. Ann Clin Lab Sci. 2006; 36(2):137-43.

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Tang P, Wang X, Schiffhauer L, Wang J, Bourne P, Yang Q, Quinn A, Hajdu SI. Relationship between nuclear grade of ductal carcinoma in situ and cell origin markers. Ann Clin Lab Sci. 2006; 36(1):16-22.

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Wang JH, Qi YF, Tang PZ, Wen SX, Zhang ZM, Qin DX. [Clinical analysis of posterior hypopharyngeal wall squamous cell carcinoma: a report of 36 cases]. Ai Zheng. 2005 Sep; 24(9):1106-10.

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Wang JH, Qi YF, Tang PZ, Xu ZG, Wen SX, Liu MB. [Result analysis of perioperative radiotherapy and laryngeal preservation in hypopharyngeal and pyriform sinus squamous cell carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005 Jul; 40(7):528-32.

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Wen SX, Tang PZ, Xu ZG, Qi YF, Zhang ZM, Liu MB, Bian X, Wang JH. [Surgical therapy of subglottic carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005 Jun; 40(6):419-22.

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Wang XL, Xu ZG, Tang PZ, Zhang B. [Selective neck dissection in the management of tongue squamous cell carcinoma with clinically negative nodes]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005 May; 40(5):376-9.

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Zhang ZM, Tang PZ, Xu ZG, Li QH, Hu YH, Xu GZ, Gao L, Tu GY. [Long-term results of different treatment modalities in 464 hypopharyngeal squamous-cell carcinoma patients]. Zhonghua Zhong Liu Za Zhi. 2005 Jan; 27(1):48-51.

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Xu XF, Li ZJ, Wang X, Tang PZ. [The management and prognosis of laryngotracheal invasion by well-differentiated thyroid carcinoma]. Zhonghua Yi Xue Za Zhi. 2004 Nov 17; 84(22):1888-91.

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Liu WS, Tang PZ, Qi YF, Xu ZG, Li ZJ. [Clinical analysis of 57 patients with poorly differentiated carcinomas of the supraglottic larynx]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Sep; 39(9):562-5.

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Liu WS, Qi YF, Tang PZ. [Poorly differentiated thyroid follicular carcinoma - a clinical analysis of 30 cases]. Ai Zheng. 2004 Sep; 23(9):1081-4.

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Liu WS, Tang PZ, Qi YF, Gao L, Li ZJ. [Diagnosis, treatment and prognostic factors of adenoid cystic carcinoma of the palate]. Zhonghua Zhong Liu Za Zhi. 2004 Aug; 26(8):485-9.

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Liu WS, Tang PZ, Xu GZ. [Clinical analysis of 34 cases of esthesioneuroblastoma]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Jun; 39(6):328-32.

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Tang P, McKinley MJ, Sporrer M, Kahn E. Inlet patch: prevalence, histologic type, and association with esophagitis, Barrett esophagus, and antritis. Arch Pathol Lab Med. 2004 Apr; 128(4):444-7.

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Zhang B, Tang PZ, Xu ZG, Qi YF, Wang XL. [Functional evaluation of the selective neck dissection in patients with carcinoma of head and neck]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Jan; 39(1):28-31.

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Wang XL, Qian XL, Zhao QZ, Xu ZG, Tang PZ. [Effects of E1A gene on the growth and chemosensitivity of transplantation tumor of nude mice]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Dec; 38(6):409-12.

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Wang XL, Qian XL, Zhao QZ, Xu ZG, Tang PZ. [Effect of E1A gene on in vitro growth inhibition and radiochemosensitivity of lymph node metastasis cells of human head and neck squamous cell carcinoma]. Ai Zheng. 2003 Nov; 22(11):1140-6.

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Elefteriades J, Lovoulos C, Edwards R, Tittle S, Riley T, Tang P, Rocco E, Kopf G. Novel technique for isolated accessory right heart transplantation for congenital heart disease. J Thorac Cardiovasc Surg. 2003 Jun; 125(6):1283-90.

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Zhang B, Xu ZG, Qi YF, Wang XL, Tang PZ. [Efficacy of selective neck dissection: a review of 123 cases of elective and therapeutic treatment of the neck in squamous cell carcinoma of head and neck]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Apr; 38(2):123-7.

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Tang P, Soukkary S, Kahn E. Mature cystic teratoma of the ovary associated with complete colonic wall and mucinous cystadenoma. Ann Clin Lab Sci. 2003; 33(4):465-70.

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Tang P, Hajdu SI, Conte CC, Filardi DA. Incidental finding of mammary carcinoma in lumpectomy specimens. Ann Clin Lab Sci. 2003; 33(1):23-31.

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Tang P, Vatsia SK, Teichberg S, Kahn E. Pulmonary adenocarcinoma simulating malignant mesothelioma. Arch Pathol Lab Med. 2001 Dec; 125(12):1598-600.

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Tang P, Teichberg S, Roberts B, Hajdu SI. Ultrastructure of the periductal area of comedo carcinoma in situ of the breast. Ann Clin Lab Sci. 2001 Jul; 31(3):284-90.

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Tang P, Jasser SA, Sung JC, Shi Y, Steck PA, Yung WK. Transforming growth factor-alpha antisense vectors can inhibit glioma cell growth. J Neurooncol. 1999 Jun; 43(2):127-35.

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Davies MA, Lu Y, Sano T, Fang X, Tang P, LaPushin R, Koul D, Bookstein R, Stokoe D, Yung WK, Mills GB, Steck PA. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res. 1998 Dec 1; 58(23):5285-90.

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Tang P, Steck PA, Yung WK. The autocrine loop of TGF-alpha/EGFR and brain tumors. J Neurooncol. 1997 Dec; 35(3):303-14.

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Tang P. Human pro-tumor necrosis factor is a homotrimer. Biochemistry. 1996 Jun 25; 35(25):8216-25.

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Tang P. Length of the linking domain of human pro-tumor necrosis factor determines the cleavage processing. Biochemistry. 1996 Jun 25; 35(25):8226-33.

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Utsumi T, Akimaru K, Kawabata Z, Levitan A, Tokunaga T, Tang P, Ide A, Hung MC, Klostergaard J. Human pro-tumor necrosis factor: molecular determinants of membrane translocation, sorting, and maturation. Mol Cell Biol. 1995 Nov; 15(11):6398-405.

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Tang P, Hung MC, Klostergaard J. ADP-ribosylation inhibitors inhibit cellular RNA synthesis but do not affect expression of manganous superoxide dismutase or heat shock protein 70 in tumor necrosis factor alpha-sensitive and -resistant tumor cells. J Interferon Cytokine Res. 1995 Sep; 15(9):791-7.

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Tang P, Hung MC, Klostergaard J. TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation. Lymphokine Cytokine Res. 1994 Apr; 13(2):117-23.

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Bai SH, Xu G, Tang P, Chen XH. [A study of antineoplastic activity of DHAQ on human adenocarcinoma cells of lung hepatoma and gastric cancer cells in vitro]. Hua Xi Yi Ke Da Xue Xue Bao. 1986 Dec; 17(4):284-6.

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Xu G, Bai SH, Chen XH, Tang P, Li GG. [The injury effect of hematoporphyrin disodium salt of the pig and He-Ne laser to human cells in vitro]. Sichuan Yi Xue Yuan Xue Bao. 1985 Dec; 16(4):310-13.

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Xu G, Bai SH, Tang P, Chen XH, Li GG. [Successful induction of transformation of NIH/3T3 cells in vitro by low energy level He-Ne laser]. Sichuan Yi Xue Yuan Xue Bao. 1985 Mar; 16(1):19-23.

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