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Melanie Wellington

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 690
Rochester NY 14642
 
 Awards And Honors
2005     Young Investigator Award, FEBS Advanced Lecture Course
2006 - 2007Morning Report MVP Award  | Golisano Children's Hospital at Strong
2006 - 2007Strong Children's Research Center Research Development Award  | Golisano Children's Hospital at Strong
2007 - 2008Morning Report MVP Award
2008     Junior Faculty/Post-doctoral Fellow Travel Award  | American Society for Microbiology Conference
 
 Overview
Dr. Wellington's research interests are:
1) Host defense against infection with Candida
2) Fungal infections in children
3) Infections in the immunocompromised host.

Candida is the most common cause of invasive fungal infection. Most individuals are colonized with Candida, but healthy individuals rarely develop disease from the organism. Candida does cause serious disease in patients who are immunocompromised because of malignancies, AIDS, congenital immunodeficiency disorders, or who are receiving medications that inhibit the immune response. Candida disease is extremely difficult to treat and has a high rate of mortality. Therefore, new modalities, such as the use of anti-Candida antibodies are being investigated. However, very little is known about how antibodies function to protect individuals from infection.

The focus of Dr. Wellington's laboratory is to investigate how the immune response to Candida is affected by the presence of anti-Candida antibodies. The major area of investigation is the interaction of phagocytes with Candida. These investigations include characterization of the mechanisms through which antibody enhances the phagocyte response to the organism. In addition to antibody, receptors on the phagocyte surface that recognize pathogen associated molecular patterns may play an important role in activating the anti-Candida response. The ability of phagocytes to respond appropriately to Candida is important for activation of innate and adaptive immune responses to Candida and may lead to protection from the development of Candida disease. We expect these studies to lead to a better understanding of host-fungal interactions, which will allow us to improve the care of patients at risk for Candida disease.

 
 Selected Publications
List All   |   Timeline
  1. Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, Didone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo. MBio. 2014; 5(1).
    View in: PubMed
  2. Wellington M, Koselny K, Sutterwala FS, Krysan DJ. Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages. Eukaryot Cell. 2014 Feb; 13(2):329-40.
    View in: PubMed
  3. Wellington M, Koselny K, Krysan DJ. Candida albicans Morphogenesis Is Not Required for Macrophage Interleukin 1ß Production. MBio. 2012; 4(1).
    View in: PubMed
  4. Butts A, Didone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis. Eukaryot Cell. 2013 Feb; 12(2):278-87.
    View in: PubMed
  5. Kajfasz JK, Mendoza JE, Gaca AO, Miller JH, Koselny KA, Giambiagi-Demarval M, Wellington M, Abranches J, Lemos JA. The Spx regulator modulates stress responses and virulence in Enterococcus faecalis. Infect Immun. 2012 Jul; 80(7):2265-75.
    View in: PubMed
  6. Mitra S, Dolan K, Foster TH, Wellington M. Imaging morphogenesis of Candida albicans during infection in a live animal. J Biomed Opt. 2010 Jan-Feb; 15(1):010504.
    View in: PubMed
  7. Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH. Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa. Infect Immun. 2009 Oct; 77(10):4446-54.
    View in: PubMed
  8. Dolan K, Montgomery S, Buchheit B, Didone L, Wellington M, Krysan DJ. Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization. Antimicrob Agents Chemother. 2009 Aug; 53(8):3337-46.
    View in: PubMed
  9. Wellington M, Dolan K, Krysan DJ. Live Candida albicans suppresses production of reactive oxygen species in phagocytes. Infect Immun. 2009 Jan; 77(1):405-13.
    View in: PubMed
  10. Wellington M, Dolan K, Haidaris CG. Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition. FEMS Immunol Med Microbiol. 2007 Oct; 51(1):70-83.
    View in: PubMed
  11. Wellington M, Kabir MA, Rustchenko E. 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans. Mycologia. 2006 May-Jun; 98(3):393-8.
    View in: PubMed
  12. Wellington MA, Bonnez W. Consultation with the specialist: genital warts. Pediatr Rev. 2005 Dec; 26(12):467-71.
    View in: PubMed
  13. Wellington M, Rustchenko E. 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans. Yeast. 2005 Jan 15; 22(1):57-70.
    View in: PubMed
  14. Wang YK, Das B, Huber DH, Wellington M, Kabir MA, Sherman F, Rustchenko E. Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicans. Yeast. 2004 Jun; 21(8):685-702.
    View in: PubMed
  15. Wellington M, Bliss JM, Haidaris CG. Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infect Immun. 2003 Dec; 71(12):7228-31.
    View in: PubMed
  16. Bliss JM, Wellington M, Gigliotti F. Antifungal pharmacotherapy for neonatal candidiasis. Semin Perinatol. 2003 Oct; 27(5):365-74.
    View in: PubMed
  17. Wellington M, Hall CB. Pacifier as a risk factor for acute otitis media. Pediatrics. 2002 Feb; 109(2):351-2; author reply 353.
    View in: PubMed
  18. Wellington M, Gigliotti F. Update on antifungal agents. Pediatr Infect Dis J. 2001 Oct; 20(10):993-5.
    View in: PubMed

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