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Sundeep Malik

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
 
 Awards And Honors
1991     President's Award for Excellence in teaching by a Graduate Student, SUNY Stony Brook.
 
 Selected Publications
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  1. Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. Phospholipase ce hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 2013 Mar 28; 153(1):216-27.
    View in: PubMed
  2. Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. J Biol Chem. 2011 Jul 1; 286(26):23012-21.
    View in: PubMed
  3. Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in ß-cells of phospholipase C-e knockout mice. J Physiol. 2010 Dec 15; 588(Pt 24):4871-89.
    View in: PubMed
  4. Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. J Biol Chem. 2009 Jan 16; 284(3):1514-22.
    View in: PubMed
  5. Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown JH. Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15543-8.
    View in: PubMed
  6. Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. J Biol Chem. 2007 Feb 23; 282(8):5488-95.
    View in: PubMed
  7. Tesmer JJ. Pharmacology. Hitting the hot spots of cell signaling cascades. Science. 2006 Apr 21; 312(5772):377-8.
    View in: PubMed
  8. Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV. Differential targeting of Gbetagamma-subunit signaling with small molecules. Science. 2006 Apr 21; 312(5772):443-6.
    View in: PubMed
  9. Malik S, Ghosh M, Bonacci TM, Tall GG, Smrcka AV. Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells. Mol Pharmacol. 2005 Jul; 68(1):129-36.
    View in: PubMed
  10. Bonacci TM, Ghosh M, Malik S, Smrcka AV. Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. J Biol Chem. 2005 Mar 18; 280(11):10174-81.
    View in: PubMed
  11. Cameron SJ, Abe J, Malik S, Che W, Yang J. Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation. J Biol Chem. 2004 Jan 9; 279(2):1506-12.
    View in: PubMed
  12. Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. J Biol Chem. 2003 May 30; 278(22):19634-41.
    View in: PubMed
  13. Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J. Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation. J Biol Chem. 2003 May 16; 278(20):18682-8.
    View in: PubMed
  14. Garry MG, Malik S, Yu J, Davis MA, Yang J. Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat. Neuroreport. 2000 Jan 17; 11(1):49-55.
    View in: PubMed
  15. Malik SW, Myers JL, DeRemee RA, Specks U. Lung toxicity associated with cyclophosphamide use. Two distinct patterns. Am J Respir Crit Care Med. 1996 Dec; 154(6 Pt 1):1851-6.
    View in: PubMed
  16. Chiba M, Malik SW, Specks U. Microtiter plate immunoassay for the evaluation of platelet adhesion to fibronectin. J Immunol Methods. 1996 May 10; 191(1):55-63.
    View in: PubMed
  17. Kang EM, Malik SW, Scanlon PD. 39-Year-old man with fever, cough, and dyspnea. Mayo Clin Proc. 1995 Jun; 70(6):587-90.
    View in: PubMed
  18. Malik S, Huang CF, Schmidt J. The role of the CANNTG promoter element (E box) and the myocyte-enhancer-binding-factor-2 (MEF-2) site in the transcriptional regulation of the chick myogenin gene. Eur J Biochem. 1995 May 15; 230(1):88-96.
    View in: PubMed

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