Michael Bulger
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics in the Center for Pediatric Biomedical Research |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester NY 14642
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| Title | Associate Professor |
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| Institution | University of Rochester Medical Center |
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| Department | Cancer Center |
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| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biochemistry and Biophysics |
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| 1992 |
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| Excellence in Teaching Award, University of California, San Diego, CA | | 2000 |
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| Burroughs Wellcome Fund Career Award in the Biomedical Sciences | | 2006 |
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| Beckman Young Investigators Award, Arnold and Mabel Beckman Foundation |
Dr. Bulger is interested in the interplay between tissue-specific gene expression and large-scale patterns of chromatin structure, as well as mechanisms by which enhancers and locus control regions (LCRs) mediate gene activation over large genomic distances. He addresses these questions using genes up-regulated or specifically expressed during late erythroid differentiation, including the b-globin genes, as models. Ongoing or planned projects in his lab include:
(1) Modeling the formation of active chromatin domains in different experimental systems, including stably integrated transgenes in cell culture and reconstituted minichromosomes in cell-free extracts, in order to determine the cis-acting sequences and DNA-binding protein factors involved in their establishment and maintenance;
(2) Characterizing non-genic transcription within the b-globin locus, as well as other loci, and investigating the relationship between such transcription and domain-wide gene regulation;
(3) Identifying factors that facilitate enhancer-promoter and/or LCR-promoter communication at the b-globin locus, in order to gain clues as to how such communication occurs;
(4) Identifying factors that bind to 3'HS1 of the b-globin locus, which is the most prominent site of attachment to nuclear matrix at this region, in order to investigate the relationship between nuclear architecture and gene expression;
(5) Investigating the role of serine protease inhibitors (serpins) in chromatin condensation and gene regulation in differentiating erythroid cells.
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Bulger M. Maps for Changing Landscapes: Viewing Epigenomic Signatures through Differentiation. Cell Stem Cell. 2012 Nov 2; 11(5):581-2.
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Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke-Induced Histone Modifications on NF-?B-dependent Genes. PLoS One. 2012; 7(2):e31378.
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Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. NF-?B inducing kinase, NIK mediates cigarette smoke/TNFa-induced histone acetylation and inflammation through differential activation of IKKs. PLoS One. 2011; 6(8):e23488.
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McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. A transient definitive erythroid lineage with unique regulation of the ß-globin locus in the mammalian embryo. Blood. 2011 Apr 28; 117(17):4600-8.
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Fromm G, Cadiz-Rivera B, de Vries C, Getman M, McGrath KE, Kingsley PD, Fields J, Fiering S, Bulger M. An embryonic stage-specific enhancer within the murine ß-globin locus mediates domain-wide histone hyperacetylation. Blood. 2011 May 12; 117(19):5207-14.
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Bulger M, Groudine M. Functional and mechanistic diversity of distal transcription enhancers. Cell. 2011 Feb 4; 144(3):327-39.
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Bulger M, Groudine M. Enhancers: the abundance and function of regulatory sequences beyond promoters. Dev Biol. 2010 Mar 15; 339(2):250-7.
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Fromm G, Bulger M. A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci. Biochem Cell Biol. 2009 Oct; 87(5):781-90.
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Fromm G, de Vries C, Byron R, Fields J, Fiering S, Groudine M, Bender MA, Palis J, Bulger M. Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression. Blood. 2009 Oct 15; 114(16):3479-88.
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Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. Am J Respir Cell Mol Biol. 2009 Feb; 40(2):147-58.
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Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I. IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):689-98.
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Hu X, Eszterhas S, Pallazzi N, Bouhassira EE, Fields J, Tanabe O, Gerber SA, Bulger M, Engel JD, Groudine M, Fiering S. Transcriptional interference among the murine beta-like globin genes. Blood. 2007 Mar 1; 109(5):2210-6.
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Bender MA, Byron R, Ragoczy T, Telling A, Bulger M, Groudine M. Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription. Blood. 2006 Aug 15; 108(4):1395-401.
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Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J. "Maturational" globin switching in primary primitive erythroid cells. Blood. 2006 Feb 15; 107(4):1665-72.
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Hu X, Bulger M, Bender MA, Fields J, Groudine M, Fiering S. Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes. Blood. 2006 Jan 15; 107(2):821-6.
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Yenerel MN, Sundell IB, Weese J, Bulger M, Gilligan DM. Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2. Exp Hematol. 2005 Jul; 33(7):758-66.
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Bulger M. Hyperacetylated chromatin domains: lessons from heterochromatin. J Biol Chem. 2005 Jun 10; 280(23):21689-92.
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Bulger M, Schübeler D, Bender MA, Hamilton J, Farrell CM, Hardison RC, Groudine M. A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol. 2003 Aug; 23(15):5234-44.
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Hu X, Bulger M, Roach JN, Eszterhas SK, Olivier E, Bouhassira EE, Groudine MT, Fiering S. Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A. 2003 Feb 4; 100(3):1111-5.
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Bulger M, Groudine M. TRAPping enhancer function. Nat Genet. 2002 Dec; 32(4):555-6.
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Bulger M, Sawado T, Schübeler D, Groudine M. ChIPs of the beta-globin locus: unraveling gene regulation within an active domain. Curr Opin Genet Dev. 2002 Apr; 12(2):170-7.
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Tyler JK, Collins KA, Prasad-Sinha J, Amiott E, Bulger M, Harte PJ, Kobayashi R, Kadonaga JT. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Mol Cell Biol. 2001 Oct; 21(19):6574-84.
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Nakagawa T, Bulger M, Muramatsu M, Ito T. Multistep chromatin assembly on supercoiled plasmid DNA by nucleosome assembly protein-1 and ATP-utilizing chromatin assembly and remodeling factor. J Biol Chem. 2001 Jul 20; 276(29):27384-91.
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Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14560-5.
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Bender MA, Bulger M, Close J, Groudine M. Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell. 2000 Feb; 5(2):387-93.
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Bulger M, Groudine M. Looping versus linking: toward a model for long-distance gene activation. Genes Dev. 1999 Oct 1; 13(19):2465-77.
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Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5129-34.
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Ito T, Bulger M, Pazin MJ, Kobayashi R, Kadonaga JT. ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Cell. 1997 Jul 11; 90(1):145-55.
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Tyler JK, Bulger M, Kamakaka RT, Kobayashi R, Kadonaga JT. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol Cell Biol. 1996 Nov; 16(11):6149-59.
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Ito T, Tyler JK, Bulger M, Kobayashi R, Kadonaga JT. ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. J Biol Chem. 1996 Oct 4; 271(40):25041-8.
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Ito T, Bulger M, Kobayashi R, Kadonaga JT. Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays. Mol Cell Biol. 1996 Jun; 16(6):3112-24.
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Kamakaka RT, Bulger M, Kaufman PD, Stillman B, Kadonaga JT. Postreplicative chromatin assembly by Drosophila and human chromatin assembly factor 1. Mol Cell Biol. 1996 Mar; 16(3):810-7.
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Bulger M, Ito T, Kamakaka RT, Kadonaga JT. Assembly of regularly spaced nucleosome arrays by Drosophila chromatin assembly factor 1 and a 56-kDa histone-binding protein. Proc Natl Acad Sci U S A. 1995 Dec 5; 92(25):11726-30.
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Kamakaka RT, Bulger M, Kadonaga JT. Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly. Genes Dev. 1993 Sep; 7(9):1779-95.
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