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Jorge Yao

Title	Associate Professor
Institution	School of Medicine and Dentistry
Department	Pathology and Laboratory Medicine
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 626 Rochester NY 14642

Awards And Honors

2008

Certificate of Appreciation for Teaching | Urology Residency Program

Overview

I have three major areas of research interests: Genitourinary (GU) Pathology, Tissue Microarrays (TMA), and Fine Needle Aspiration Biopsy (FNA).

During my GU pathology fellowship, I became fascinated by the role of neuroendocrine cells in the benign and neoplastic prostate (see Neuroendocrine website). Subsequently, I decided to study the pathogenesis and characterization of a rare and aggressive form of prostate cancer called small cell carcinoma of the prostate (see Publications below).

At the same time, I was introduced to the construction and use of TMAs for translational and clinical research. Our GU Pathology section has constructed a prostate progression TMA and a kidney tumor prevalence TMA, which have proved very useful in translational research at our institution. We are currently constructing prognostic TMAs for both the prostate and esophagus.

As a cytopathologist, I am involved with improving the efficiency of both superficial palpable lesions and endoscopic ultrasound-guided FNAs of pancreatico-duodenal lesions through the use of novel site-specific antibody panels. Working closely with the Immunocytochemistry laboratory, I am currently evaluating various antibody panels for pancreatic carcinoma from material obtained by endoscopic ultrasound-guided FNA.

Selected Publications

Baran TM, Wilson JD, Mitra S, Yao JL, Messing EM, Waldman DL, Foster TH. Optical property measurements establish the feasibility of photodynamic therapy as a minimally invasive intervention for tumors of the kidney. J Biomed Opt. 2012 Sep 28; 17(9):98002-1.

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Chen H, Sun Y, Wu C, Magyar CE, Li X, Cheng L, Yao JL, Shen S, Osunkoya AO, Liang C, Huang J. Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway. Endocr Relat Cancer. 2012 Jun; 19(3):321-31.

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Izumi K, Li Y, Zheng Y, Gordetsky J, Yao JL, Miyamoto H. Seminal plasma proteins in prostatic carcinoma: increased nuclear semenogelin I expression is a predictor of biochemical recurrence after radical prostatectomy. Hum Pathol. 2012 Nov; 43(11):1991-2000.

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Miyamoto H, Izumi K, Yao JL, Li Y, Yang Q, McMahon LA, Gonzalez-Roibon N, Hicks DG, Tacha D, Netto GJ. GATA binding protein 3 is down-regulated in bladder cancer yet strong expression is an independent predictor of poor prognosis in invasive tumor. Hum Pathol. 2012 Nov; 43(11):2033-40.

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Subik MK, Gordetsky J, Yao JL, di Sant'agnese PA, Miyamoto H. Frozen section assessment in testicular and paratesticular lesions suspicious for malignancy: its role in preventing unnecessary orchiectomy. Hum Pathol. 2012 Sep; 43(9):1514-9.

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Tobis S, Knopf JK, Silvers C, Messing E, Yao J, Rashid H, Wu G, Golijanin D. Robot-assisted and laparoscopic partial nephrectomy with near infrared fluorescence imaging. J Endourol. 2012 Jul; 26(7):797-802.

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Subik MK, Yao JL, di Sant'agnese PA, Miyamoto H. The role of periprostatic and periseminal vesicle lymph node metastasis in the staging and prognosis of prostate cancer. Histopathology. 2012 May; 60(6):1009-10.

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Tobis S, Knopf JK, Silvers CR, Marshall J, Cardin A, Wood RW, Reeder JE, Erturk E, Madeb R, Yao J, Singer EA, Rashid H, Wu G, Messing E, Golijanin D. Near infrared fluorescence imaging after intravenous indocyanine green: initial clinical experience with open partial nephrectomy for renal cortical tumors. Urology. 2012 Apr; 79(4):958-64.

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Miyamoto H, Yao JL, Chaux A, Zheng Y, Hsu I, Izumi K, Chang C, Messing EM, Netto GJ, Yeh S. Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder. BJU Int. 2012 Jun; 109(11):1716-26.

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Onur MR, Wandtke B, Yao JL, Dogra VS. Paratesticular solitary plasmacytoma. J Clin Imaging Sci. 2011; 1:52.

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Gordetsky J, Scosyrev E, Rashid H, Wu G, Silvers C, Golijanin D, Messing EM, Yao JL. Identifying additional lymph nodes in radical cystectomy lymphadenectomy specimens. Mod Pathol. 2012 Jan; 25(1):140-4.

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Gordetsky J, Findeis-Hosey J, Erturk E, Messing EM, Yao JL, Miyamoto H. Role of frozen section analysis of testicular/paratesticular fibrous pseudotumours: a five-case experience. Can Urol Assoc J. 2011 Aug; 5(4):E47-51.

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Zheng Y, Izumi K, Yao JL, Miyamoto H. Dihydrotestosterone upregulates the expression of epidermal growth factor receptor and ERBB2 in androgen receptor-positive bladder cancer cells. Endocr Relat Cancer. 2011; 18(4):451-64.

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Ye J, Findeis-Hosey JJ, Yang Q, McMahon LA, Yao JL, Li F, Xu H. Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung. Appl Immunohistochem Mol Morphol. 2011 Jul; 19(4):313-7.

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Paner GP, McKenney JK, Barkan GA, Yao JL, Frankel WL, Sebo TJ, Shen SS, Jimenez RE. Immunohistochemical analysis in a morphologic spectrum of urachal epithelial neoplasms: diagnostic implications and pitfalls. Am J Surg Pathol. 2011 Jun; 35(6):787-98.

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Tobis S, Knopf J, Silvers C, Yao J, Rashid H, Wu G, Golijanin D. Near infrared fluorescence imaging with robotic assisted laparoscopic partial nephrectomy: initial clinical experience for renal cortical tumors. J Urol. 2011 Jul; 186(1):47-52.

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An L, Mills B, Hah Z, Mao S, Yao J, Joseph J, Rubens DJ, Strang J, Parker KJ. Crawling wave detection of prostate cancer: preliminary in vitro results. Med Phys. 2011 May; 38(5):2563-71.

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Arbini AA, Greco M, Yao JL, Bourne P, Marra E, Hsieh JT, di Sant'agnese PA, Moro L. Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer. Am J Pathol. 2011 May; 178(5):2367-76.

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Williamson SR, Zhang S, Yao JL, Huang J, Lopez-Beltran A, Shen S, Osunkoya AO, MacLennan GT, Montironi R, Cheng L. ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin. Mod Pathol. 2011 Aug; 24(8):1120-7.

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Kohli M, Williams K, Yao JL, Dennis RA, Huang J, Reeder J, Ricke WA. Thrombin expression in prostate: a novel finding. Cancer Invest. 2011 Jan; 29(1):62-7.

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Canacci AM, Izumi K, Zheng Y, Gordetsky J, Yao JL, Miyamoto H. Expression of semenogelins I and II and its prognostic significance in human prostate cancer. Prostate. 2011 Jul; 71(10):1108-14.

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Mir C, Shariat SF, van der Kwast TH, Ashfaq R, Lotan Y, Evans A, Skeldon S, Hanna S, Vajpeyi R, Kuk C, Alkhateeb S, Morote J, van Rhijn BW, Bostrom P, Yao J, Miyamoto H, Jewett M, Fleshner N, Messing E, Zlotta AR. Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi-institutional study. BJU Int. 2011 Jul; 108(1):24-30.

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Samaratunga H, Montironi R, True L, Epstein JI, Griffiths DF, Humphrey PA, van der Kwast T, Wheeler TM, Srigley JR, Delahunt B, Egevad L. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling. Mod Pathol. 2011 Jan; 24(1):6-15.

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Berney DM, Wheeler TM, Grignon DJ, Epstein JI, Griffiths DF, Humphrey PA, van der Kwast T, Montironi R, Delahunt B, Egevad L, Srigley JR. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes. Mod Pathol. 2011 Jan; 24(1):39-47.

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van der Kwast TH, Amin MB, Billis A, Epstein JI, Griffiths D, Humphrey PA, Montironi R, Wheeler TM, Srigley JR, Egevad L, Delahunt B. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume. Mod Pathol. 2011 Jan; 24(1):16-25.

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Magi-Galluzzi C, Evans AJ, Delahunt B, Epstein JI, Griffiths DF, van der Kwast TH, Montironi R, Wheeler TM, Srigley JR, Egevad LL, Humphrey PA. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease. Mod Pathol. 2011 Jan; 24(1):26-38.

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Tan PH, Cheng L, Srigley JR, Griffiths D, Humphrey PA, van der Kwast TH, Montironi R, Wheeler TM, Delahunt B, Egevad L, Epstein JI. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins. Mod Pathol. 2011 Jan; 24(1):48-57.

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Scosyrev E, Yao J, Messing E. Microscopic invasion of perivesical fat by urothelial carcinoma: implications for prognosis and pathology practice. Urology. 2010 Oct; 76(4):908-13; discussion 914.

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Thrall MJ, Russell DK, Facik MS, Yao JL, Warner JN, Bonfiglio TA, Giampoli EJ. High-risk HPV testing in women 30 years or older with negative Papanicolaou tests: initial clinical experience with 18-month follow-up. Am J Clin Pathol. 2010 Jun; 133(6):894-8.

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Yao JL, Ryan CK, Francis CW, Kohli M, Taubman MB, Khorana AA. Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study. Cancer Invest. 2009 May; 27(4):430-4.

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Scosyrev E, Yao J, Messing E. Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? Urology. 2009 Apr; 73(4):822-7.

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Moro L, Arbini AA, Yao JL, di Sant'Agnese PA, Marra E, Greco M. Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2. Cell Death Differ. 2009 Apr; 16(4):571-83.

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Simon RA, di Sant'Agnese PA, Huang LS, Xu H, Yao JL, Yang Q, Liang S, Liu J, Yu R, Cheng L, Oh WK, Palapattu GS, Wei J, Huang J. CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Hum Pathol. 2009 Feb; 40(2):252-8.

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Niu Y, Altuwaijri S, Lai KP, Wu CT, Ricke WA, Messing EM, Yao J, Yeh S, Chang C. Androgen receptor is a tumor suppressor and proliferator in prostate cancer. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12182-7.

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Li L, Xu H, Spaulding BO, Cheng L, Simon R, Yao JL, di Sant'Agnese PA, Bourne PA, Huang J. Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors. Hum Pathol. 2008 Aug; 39(8):1205-11.

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Capello SA, Gordetsky J, Erturk E, Yao J, Joseph JV. Factors associated with ureteral burn injury from an electrified guidewire. J Endourol. 2008 Jun; 22(6):1189-92.

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Johnson AM, O'Connell MJ, Miyamoto H, Huang J, Yao JL, Messing EM, Reeder JE. Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1. BMC Urol. 2008; 8:7.

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Simon RA, di Sant'agnese PA, Palapattu GS, Singer EA, Candelario GD, Huang J, Yao JL. Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid differentiation. Int J Clin Exp Pathol. 2008; 1(2):180-4.

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Li L, Yao JL, di Sant'Agnese PA, Bourne PA, Picken MM, Young AN, Shen SS, Huang J. Expression of claudin-7 in benign kidney and kidney tumors. Int J Clin Exp Pathol. 2008; 1(1):57-64.

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Moro L, Arbini AA, Yao JL, di Sant'Agnese PA, Marra E, Greco M. Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9. Cancer Sci. 2008 Mar; 99(3):553-63.

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Wagner DG, Yao JL, di Sant'Agnese PA, Cheng L, Lopez-Beltran A, Montironi R, Huang J. Soft tissue tumors of the prostate: a review. Anal Quant Cytol Histol. 2007 Dec; 29(6):341-50.

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Huang J, Wu C, di Sant'Agnese PA, Yao JL, Cheng L, Na Y. Function and molecular mechanisms of neuroendocrine cells in prostate cancer. Anal Quant Cytol Histol. 2007 Jun; 29(3):128-38.

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Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao JL, di Sant'Agnese PA, Tsai MY, Chang C. Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. Endocrinology. 2007 Mar; 148(3):1340-9.

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Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, di Sant'Agnese PA, Chang C. Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. Mol Endocrinol. 2007 Feb; 21(2):343-58.

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Huang J, Yao JL, di Sant'Agnese PA, Yang Q, Bourne PA, Na Y. Immunohistochemical characterization of neuroendocrine cells in prostate cancer. Prostate. 2006 Sep 15; 66(13):1399-406.

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Wu CY, Na YQ, Yao JL, di Sant'Agnese PA, Huang JT. [Neuroendocrine differentiation in prostate cancer]. Zhonghua Bing Li Xue Za Zhi. 2006 Sep; 35(9):565-7.

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Wu C, Zhang L, Bourne PA, Reeder JE, di Sant'Agnese PA, Yao JL, Na Y, Huang J. Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer. Prostate. 2006 Aug 1; 66(11):1125-35.

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Zhang Z, Rosen DG, Yao JL, Huang J, Liu J. Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression. Mod Pathol. 2006 Oct; 19(10):1339-43.

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Messing EM, Manola J, Yao J, Kiernan M, Crawford D, Wilding G, di'SantAgnese PA, Trump D. Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy. Lancet Oncol. 2006 Jun; 7(6):472-9.

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Yao JL, Madeb R, Bourne P, Lei J, Yang X, Tickoo S, Liu Z, Tan D, Cheng L, Hatem F, Huang J, Anthony di Sant'Agnese P. Small cell carcinoma of the prostate: an immunohistochemical study. Am J Surg Pathol. 2006 Jun; 30(6):705-12.

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Bao BY, Yao J, Lee YF. 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis. Carcinogenesis. 2006 Sep; 27(9):1883-93.

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Ni J, Wen X, Yao J, Chang HC, Yin Y, Zhang M, Xie S, Chen M, Simons B, Chang P, di Sant'Agnese A, Messing EM, Yeh S. Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway. Cancer Res. 2005 Nov 1; 65(21):9807-16.

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Huang J, Yao JL, Zhang L, Bourne PA, Quinn AM, di Sant'Agnese PA, Reeder JE. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol. 2005 Jun; 166(6):1807-15.

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Li R, Ni J, Bourne PA, Yeh S, Yao J, di Sant'Agnese PA, Huang J. Cell culture block array for immunocytochemical study of protein expression in cultured cells. Appl Immunohistochem Mol Morphol. 2005 Mar; 13(1):85-90.

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Li R, Yao JL, Bourne PA, di Sant'Agnese PA, Huang J. Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma. Arch Pathol Lab Med. 2004 Dec; 128(12):1412-7.

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Liang S, Yao J, Bourne PA, diSant'Agnese PA, Huang J, Lei JY. Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions. Am J Clin Pathol. 2004 Nov; 122(5):747-51.

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Patton KT, Tretiakova MS, Yao JL, Papavero V, Huo L, Adley BP, Wu G, Huang J, Pins MR, Teh BT, Yang XJ. Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. Am J Surg Pathol. 2004 Aug; 28(8):1045-50.

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Yao JL, Bourne PA, Yang Q, Lei J, di Sant'Agnese PA, Huang J. Overexpression of human carcinoma-associated antigen in urothelial carcinoma of the bladder. Arch Pathol Lab Med. 2004 Jul; 128(7):785-7.

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Theise ND, Yao JL, Harada K, Hytiroglou P, Portmann B, Thung SN, Tsui W, Ohta H, Nakanuma Y. Hepatic 'stem cell' malignancies in adults: four cases. Histopathology. 2003 Sep; 43(3):263-71.

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Moreira AL, Yao J, Waisman J, Cangiarella JF. Metastatic "borderline" papillary ovarian tumor in an intramammary lymph node. Breast J. 2002 Sep-Oct; 8(5):309-10.

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Yao JL, Cangiarella JF, Cohen JM, Chhieng DC. Fine-needle aspiration biopsy of peripheral T-cell lymphomas. A cytologic and immunophenotypic study of 33 cases. Cancer. 2001 Apr 25; 93(2):151-9.

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Yao JL, Zhou H, Roche K, Bangaru BS, Ginsburg H, Greco MA. Adenomyoma arising in a meckel diverticulum: case report and review of the literature. Pediatr Dev Pathol. 2000 Sep-Oct; 3(5):497-500.

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Yang GC, Yao JL, Feiner HD, Roses DF, Kumar A, Mulder JE. Lipid-rich follicular carcinoma of the thyroid in a patient with McCune-Albright syndrome. Mod Pathol. 1999 Oct; 12(10):969-73.

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Yao JL, Fasano M, Morotti R, Caprio M, Greco MA. Demonstration of communication between alveolus and interstitium in persistent interstitial pulmonary emphysema: case report. Pediatr Dev Pathol. 1999 Sep-Oct; 2(5):484-7.

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