Hulin Wu
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biostatistics and Computational Biology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester NY 14642
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| 1990 |
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| Best First-Year Student Award, Department of Statistics, Florida State University. | | 1993 |
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| First Prize, Student Paper Awards, 1993 Joint Statistical Meetings, Section on Statistics & the Environment, ASA | | 1994 |
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| The ENAR Student Paper Award, the 1994 Spring Meetings, the Eastern North American Region of the Biometrics Society (ENAR) | | 1994 |
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| Ralph A. Bradley Award (for the most outstanding Ph.D graduate), Department of Statistics, Florida State University (FSU). | | 1995 |
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| The Young Investigator Award, the 1995 Joint Statistical Meetings, Epidemiology Section, American Statistical Association. | | 1997 |
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| Young Scientist Scholarship Fund Award, International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication | | 1998 |
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| 2003 | The First Independent Research Support & Transition (FIRST) Awards, National Institutes of Health (NIH) | | 1998 |
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| Young Scientist Scholarship Fund Award, the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies | | 2008 |
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| Fellow of the American Statistical Association | | 2009 |
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| The Scientific Advisory Board member, the BMGF-funded (Gate's Foundation) Vaccine Immunology Statistical Center | | 2011 |
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| Long-term Visitor, the Statistical and Applied Mathematical Science Institute (SAMSI) |
My recent research interests include nonparametric regression methods and mixed-effects models for longitudinal data analysis, Bayesian and Monte Carlo filtering approaches for state-space models of biological systems, modeling HIV dynamics and AIDS clinical trials, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and stochastic simulations and modeling of bioterrorist attacks. I am also expanding my research in the area of theoretical immunology.
I received my college education in engineering from the National University of Defense Technology, P.R. China (B.Sc., 1984; M.Sc., 1987). I earned my Ph.D. in statistics from Florida State University in 1994. After two years as a visiting Assistant Professor at the
University of Memphis (TN), I joined Frontier Science & Technology Research Foundation in 1996 as a Senior Statistician to work for Statistical Data Analysis Center (SDAC), currently Center for Biostatistics in AIDS Research (CBAR), Harvard School of Public Health, where I became involved in AIDS clinical trials and HIV dynamic modeling. I served as the Head of Pharmacology/Dynamic Modeling Section at SDAC, Adults AIDS Clinical Trials Group (AACTG) from 1999-2002. I also held an Adjunct Lecturership position at the Department of Biostatistics, Harvard University from 2000-2003. I joined the Department of Biostatistics and Computational Biology, University of Rochester as Professor in 2003.
Since 1998, I have been awarded four research grants to develop statistical methods and mathematical models for HIV dynamics and AIDS clinical trials by NIH. I have advised 9 postdoctoral research fellows from 1998-2005, and most of them obtained academic or research positions at major Universities or Research Institutes after completing their postdoctoral training. I am currently leading a group of faculty and postdoc fellows to work in several NIH-sponsored projects related to modeling of infectious diseases and immune response that include HIV/AIDS and influenza virus.
Recently I received a grant (contract) totaling $10 million over 5 years to establish a Center for Biodefense Immune Modeling (CBIM) where I serve as the Director. I also serve as Chief of the newly established Division of Biomedical Modeling and Informatics (DBMI) in the Department of Biostatistics and Computational Biology.
I received the First Prize Student Paper Award from the Statistics and the Environment Section, American Statistical Association in 1993; the ENAR Student Paper Award from the Eastern North American Region of the Biometrics Society (ENAR) in 1994; the Ralph A. Bradley Award from Department of Statistics, Florida State University in 1994; the Young Investigator Award from the Epidemiology Section, American Statistical Association in 1995; and the Young Scientist Scholarship Fund Award from the International Workshop on HIV Drug Resistance and Treatment Strategies in 1997 and 1998. I served as a grant review member for several AIDS and Related Research sections and special emphasis panels, National Institutes of Health (NIH). I also served as a consultant for other NIH grant review sections and the National Science Foundation (NSF).
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Qiu X, Wu H, Hu R. The impact of quantile and rank normalization procedures on the testing power of gene differential expression analysis. BMC Bioinformatics. 2013; 14:124.
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Weaver JM, Yang H, Roumanes D, Lee FE, Wu H, Treanor JJ, Mosmann TR. Increase in IFN?(-)IL-2(+) Cells in Recent Human CD4 T Cell Responses to 2009 Pandemic H1N1 Influenza. PLoS One. 2013; 8(3):e57275.
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Wu S, Wu H. More powerful significant testing for time course gene expression data using functional principal component analysis approaches. BMC Bioinformatics. 2013; 14:6.
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Li X, Miao H, Henn A, Topham DJ, Wu H, Zand MS, Mosmann TR. Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination. Vaccine. 2012 Jun 29; 30(31):4581-4.
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Wu H, Xue H, Kumar A. Numerical Discretization-Based Estimation Methods for Ordinary Differential Equation Models via Penalized Spline Smoothing with Applications in Biomedical Research. Biometrics. 2012 Jun; 68(2):344-52.
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Wu H, Kumar A, Miao H, Holden-Wiltse J, Mosmann TR, Livingstone AM, Belz GT, Perelson AS, Zand MS, Topham DJ. Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors. J Immunol. 2011 Nov 1; 187(9):4474-82.
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Wang J, Zhang G, Bambara RA, Li D, Liang H, Wu H, Smith HM, Lowe NR, Demeter LM, Dykes C. Nonnucleoside reverse transcriptase inhibitor-resistant HIV is stimulated by efavirenz during early stages of infection. J Virol. 2011 Oct; 85(20):10861-73.
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Miao H, Jin X, Perelson AS, Wu H. Evaluation of Multitype Mathematical Models for CFSE-Labeling Experiment Data. Bull Math Biol. 2012 Feb; 74(2):300-26.
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Lee Y, Wu H. Mars approach for global sensitivity analysis of differential equation models with applications to dynamics of influenza infection. Bull Math Biol. 2012 Jan; 74(1):73-90.
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Dykes C, Wu H, Sims M, Holden-Wiltse J, Demeter LM. Human immunodeficiency virus type 1 protease inhibitor drug-resistant mutants give discordant results when compared in single-cycle and multiple-cycle fitness assays. J Clin Microbiol. 2010 Nov; 48(11):4035-43.
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Ma J, Dykes C, Wu T, Huang Y, Demeter L, Wu H. vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments. BMC Bioinformatics. 2010; 11:261.
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Miao H, Hollenbaugh JA, Zand MS, Holden-Wiltse J, Mosmann TR, Perelson AS, Wu H, Topham DJ. Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus. J Virol. 2010 Jul; 84(13):6687-98.
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Baer J, Santiago F, Yang H, Wu H, Holden-Wiltse J, Treanor J, Topham DJ. B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Vaccine. 2010 Jan 22; 28(4):907-15.
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Lee HY, Topham DJ, Park SY, Hollenbaugh J, Treanor J, Mosmann TR, Jin X, Ward BM, Miao H, Holden-Wiltse J, Perelson AS, Zand M, Wu H. Simulation and prediction of the adaptive immune response to influenza A virus infection. J Virol. 2009 Jul; 83(14):7151-65.
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Lee HY, Hawkins E, Zand MS, Mosmann T, Wu H, Hodgkin PD, Perelson AS. Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models. Bull Math Biol. 2009 Oct; 71(7):1649-70.
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Miao H, Dykes C, Demeter LM, Cavenaugh J, Park SY, Perelson AS, Wu H. Modeling and estimation of kinetic parameters and replicative fitness of HIV-1 from flow-cytometry-based growth competition experiments. Bull Math Biol. 2008 Aug; 70(6):1749-71.
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Miao H, Dykes C, Demeter LM, Wu H. Differential equation modeling of HIV viral fitness experiments: model identification, model selection, and multimodel inference. Biometrics. 2009 Mar; 65(1):292-300.
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Wu H, Zhu H, Miao H, Perelson AS. Parameter identifiability and estimation of HIV/AIDS dynamic models. Bull Math Biol. 2008 Apr; 70(3):785-99.
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Flanigan RM, Nawoczenski DA, Chen L, Wu H, DiGiovanni BF. The influence of foot position on stretching of the plantar fascia. Foot Ankle Int. 2007 Jul; 28(7):815-22.
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Jin X, Wu H, Smith H. APOBEC3G levels predict rates of progression to AIDS. Retrovirology. 2007; 4:20.
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Treanor J, Wu H, Liang H, Topham DJ. Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Vaccine. 2006 Nov 17; 24(47-48):6913-23.
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Dykes C, Wang J, Jin X, Planelles V, An DS, Tallo A, Huang Y, Wu H, Demeter LM. Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture. J Clin Microbiol. 2006 Jun; 44(6):1930-43.
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Huang Y, Liu D, Wu H. Hierarchical Bayesian methods for estimation of parameters in a longitudinal HIV dynamic system. Biometrics. 2006 Jun; 62(2):413-23.
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Liu D, Yu J, Chen H, Reichman R, Wu H, Jin X. Statistical determination of threshold for cellular division in the CFSE-labeling assay. J Immunol Methods. 2006 May 30; 312(1-2):126-36.
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Wu H, Huang Y, Acosta EP, Park JG, Yu S, Rosenkranz SL, Kuritzkes DR, Eron JJ, Perelson AS, Gerber JG. Pharmacodynamics of antiretroviral agents in HIV-1 infected patients: using viral dynamic models that incorporate drug susceptibility and adherence. J Pharmacokinet Pharmacodyn. 2006 Aug; 33(4):399-419.
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Wu H, Huang Y, Dykes C, Liu D, Ma J, Perelson AS, Demeter LM. Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assay. J Virol. 2006 Mar; 80(5):2380-9.
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Wu H, Huang Y, Acosta EP, Rosenkranz SL, Kuritzkes DR, Eron JJ, Perelson AS, Gerber JG. Modeling long-term HIV dynamics and antiretroviral response: effects of drug potency, pharmacokinetics, adherence, and drug resistance. J Acquir Immune Defic Syndr. 2005 Jul 1; 39(3):272-83.
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Wu H. Statistical methods for HIV dynamic studies in AIDS clinical trials. Stat Methods Med Res. 2005 Apr; 14(2):171-92.
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Ma J, Mosmann T, Wu H. Design considerations for a web-based database system of ELISpot assay in immunological research. AMIA Annu Symp Proc. 2005; 1039.
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Acosta EP, Wu H, Hammer SM, Yu S, Kuritzkes DR, Walawander A, Eron JJ, Fichtenbaum CJ, Pettinelli C, Neath D, Ferguson E, Saah AJ, Gerber JG. Comparison of two indinavir/ritonavir regimens in the treatment of HIV-infected individuals. J Acquir Immune Defic Syndr. 2004 Nov 1; 37(3):1358-66.
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Wu H, Lathey J, Ruan P, Douglas SD, Spector SA, Lindsey J, Hughes MD, Rudy BJ, Flynn PM. Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to highly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior. J Infect Dis. 2004 Feb 15; 189(4):593-601.
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Haas DW, Wu H, Li H, Bosch RJ, Lederman MM, Kuritzkes D, Landay A, Connick E, Benson C, Wilkinson GR, Kessler H, Kim RB. MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. J Acquir Immune Defic Syndr. 2003 Nov 1; 34(3):295-8.
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Huang Y, Rosenkranz SL, Wu H. Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity. Math Biosci. 2003 Aug; 184(2):165-86.
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DiCenzo R, Forrest A, Squires KE, Hammer SM, Fischl MA, Wu H, Cha R, Morse GD. Indinavir, efavirenz, and abacavir pharmacokinetics in human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother. 2003 Jun; 47(6):1929-35.
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Liang H, Wu H, Carroll RJ. The relationship between virologic and immunologic responses in AIDS clinical research using mixed-effects varying-coefficient models with measurement error. Biostatistics. 2003 Apr; 4(2):297-312.
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Hamzeh FM, Benson C, Gerber J, Currier J, McCrea J, Deutsch P, Ruan P, Wu H, Lee J, Flexner C. Steady-state pharmacokinetic interaction of modified-dose indinavir and rifabutin. Clin Pharmacol Ther. 2003 Mar; 73(3):159-69.
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Wu H, Zhang JT. The study of long-term HIV dynamics using semi-parametric non-linear mixed-effects models. Stat Med. 2002 Dec 15; 21(23):3655-75.
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Wu H, Wu L. Identification of significant host factors for HIV dynamics modelled by non-linear mixed-effects models. Stat Med. 2002 Mar 15; 21(5):753-71.
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Wu H, Wu L. A multiple imputation method for missing covariates in non-linear mixed-effects models with application to HIV dynamics. Stat Med. 2001 Jun 30; 20(12):1755-69.
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Ding AA, Wu H. A comparison study of models and fitting procedures for biphasic viral dynamics in HIV-1 infected patients treated with antiviral therapies. Biometrics. 2000 Mar; 56(1):293-300.
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Kuritzkes DR, Sevin A, Young B, Bakhtiari M, Wu H, St Clair M, Connick E, Landay A, Spritzler J, Kessler H, Lederman MM. Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team. J Infect Dis. 2000 Feb; 181(2):491-7.
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Spear GT, Olinger G, Sullivan BL, Landay AL, Kessler H, Connick E, Kuritzkes D, St Clair M, Spritzler J, Wu H, Lederman MM. Alteration of complement protein levels after antiretroviral therapy in HIV-infected persons. AIDS Res Hum Retroviruses. 1999 Dec 10; 15(18):1713-5.
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Ding AA, Wu H. Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics. Math Biosci. 1999 Aug; 160(1):63-82.
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Wu H, Ding AA. Population HIV-1 dynamics in vivo: applicable models and inferential tools for virological data from AIDS clinical trials. Biometrics. 1999 Jun; 55(2):410-8.
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Wu H, Kuritzkes DR, McClernon DR, Kessler H, Connick E, Landay A, Spear G, Heath-Chiozzi M, Rousseau F, Fox L, Spritzler J, Leonard JM, Lederman MM. Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. J Infect Dis. 1999 Apr; 179(4):799-807.
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Wu H, Ding AA, De Gruttola V. Why are the decay rates in plasma HIV-1 different for different treatments and in different patient populations? AIDS. 1999 Feb 25; 13(3):429-30.
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Luzuriaga K, Wu H, McManus M, Britto P, Borkowsky W, Burchett S, Smith B, Mofenson L, Sullivan JL. Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants. J Virol. 1999 Jan; 73(1):362-7.
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Wu H. How frequently should viral load be monitored to evaluate antiretroviral therapies in AIDS clinical trials? J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jan 1; 20(1):97-9.
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Wu H, Ding AA, De Gruttola V. Estimation of HIV dynamic parameters. Stat Med. 1998 Nov 15; 17(21):2463-85.
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Tan WY, Wu H. Stochastic modeling of the dynamics of CD4+ T-cell infection by HIV and some Monte Carlo studies. Math Biosci. 1998 Jan 15; 147(2):173-205.
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George EO, Wu H. Testing for treatment related trend with partially exchangeable clustered data. Biometrics. 1997 Jun; 53(2):479-87.
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