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Hulin Wu

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentBiostatistics and Computational Biology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPublic Health Sciences

 
 Awards And Honors
1990     Best First-Year Student Award, Department of Statistics, Florida State University.
1993     First Prize, Student Paper Awards, 1993 Joint Statistical Meetings, Section on Statistics & the Environment, ASA
1994     The ENAR Student Paper Award, the 1994 Spring Meetings, the Eastern North American Region of the Biometrics Society (ENAR)
1994     Ralph A. Bradley Award (for the most outstanding Ph.D graduate), Department of Statistics, Florida State University (FSU).
1995     The Young Investigator Award, the 1995 Joint Statistical Meetings, Epidemiology Section, American Statistical Association.
1997     Young Scientist Scholarship Fund Award, International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication
1998 - 2003The First Independent Research Support & Transition (FIRST) Awards, National Institutes of Health (NIH)
1998     Young Scientist Scholarship Fund Award, the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies
2008     Fellow of the American Statistical Association
2009     The Scientific Advisory Board member, the BMGF-funded (Gate's Foundation) Vaccine Immunology Statistical Center
2011     Long-term Visitor, the Statistical and Applied Mathematical Science Institute (SAMSI)
 
 Overview
My recent research interests include nonparametric regression methods and mixed-effects models for longitudinal data analysis, Bayesian and Monte Carlo filtering approaches for state-space models of biological systems, modeling HIV dynamics and AIDS clinical trials, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and stochastic simulations and modeling of bioterrorist attacks. I am also expanding my research in the area of theoretical immunology.

I received my college education in engineering from the National University of Defense Technology, P.R. China (B.Sc., 1984; M.Sc., 1987). I earned my Ph.D. in statistics from Florida State University in 1994. After two years as a visiting Assistant Professor at the
University of Memphis (TN), I joined Frontier Science & Technology Research Foundation in 1996 as a Senior Statistician to work for Statistical Data Analysis Center (SDAC), currently Center for Biostatistics in AIDS Research (CBAR), Harvard School of Public Health, where I became involved in AIDS clinical trials and HIV dynamic modeling. I served as the Head of Pharmacology/Dynamic Modeling Section at SDAC, Adults AIDS Clinical Trials Group (AACTG) from 1999-2002. I also held an Adjunct Lecturership position at the Department of Biostatistics, Harvard University from 2000-2003. I joined the Department of Biostatistics and Computational Biology, University of Rochester as Professor in 2003.

Since 1998, I have been awarded four research grants to develop statistical methods and mathematical models for HIV dynamics and AIDS clinical trials by NIH. I have advised 9 postdoctoral research fellows from 1998-2005, and most of them obtained academic or research positions at major Universities or Research Institutes after completing their postdoctoral training. I am currently leading a group of faculty and postdoc fellows to work in several NIH-sponsored projects related to modeling of infectious diseases and immune response that include HIV/AIDS and influenza virus.

Recently I received a grant (contract) totaling $10 million over 5 years to establish a Center for Biodefense Immune Modeling (CBIM) where I serve as the Director. I also serve as Chief of the newly established Division of Biomedical Modeling and Informatics (DBMI) in the Department of Biostatistics and Computational Biology.

I received the First Prize Student Paper Award from the Statistics and the Environment Section, American Statistical Association in 1993; the ENAR Student Paper Award from the Eastern North American Region of the Biometrics Society (ENAR) in 1994; the Ralph A. Bradley Award from Department of Statistics, Florida State University in 1994; the Young Investigator Award from the Epidemiology Section, American Statistical Association in 1995; and the Young Scientist Scholarship Fund Award from the International Workshop on HIV Drug Resistance and Treatment Strategies in 1997 and 1998. I served as a grant review member for several AIDS and Related Research sections and special emphasis panels, National Institutes of Health (NIH). I also served as a consultant for other NIH grant review sections and the National Science Foundation (NSF).

 
 Selected Publications
List All   |   Timeline
  1. Wu S, Liu ZP, Qiu X, Wu H. Modeling genome-wide dynamic regulatory network in mouse lungs with influenza infection using high-dimensional ordinary differential equations. PLoS One. 2014; 9(5):e95276.
    View in: PubMed
  2. Henn AD, Wu S, Qiu X, Ruda M, Stover M, Yang H, Liu Z, Welle SL, Holden-Wiltse J, Wu H, Zand MS. High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature. Sci Rep. 2013 Jul 31; 3:2327.
    View in: PubMed
  3. Yang H, Topham DJ, Holden-Wiltse J, Wu H. Statistical Estimation & Inference of Cell Counts from ELISPOT Limiting Dilution Assays. J Biopharm Stat. 2013 Jul 4; 23(4):921-36.
    View in: PubMed
  4. Qiu X, Wu H, Hu R. The impact of quantile and rank normalization procedures on the testing power of gene differential expression analysis. BMC Bioinformatics. 2013; 14:124.
    View in: PubMed
  5. Weaver JM, Yang H, Roumanes D, Lee FE, Wu H, Treanor JJ, Mosmann TR. Increase in IFN?(-)IL-2(+) Cells in Recent Human CD4 T Cell Responses to 2009 Pandemic H1N1 Influenza. PLoS One. 2013; 8(3):e57275.
    View in: PubMed
  6. Wu S, Wu H. More powerful significant testing for time course gene expression data using functional principal component analysis approaches. BMC Bioinformatics. 2013; 14:6.
    View in: PubMed
  7. Li X, Miao H, Henn A, Topham DJ, Wu H, Zand MS, Mosmann TR. Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination. Vaccine. 2012 Jun 29; 30(31):4581-4.
    View in: PubMed
  8. Wu H, Xue H, Kumar A. Numerical discretization-based estimation methods for ordinary differential equation models via penalized spline smoothing with applications in biomedical research. Biometrics. 2012 Jun; 68(2):344-52.
    View in: PubMed
  9. Wu H, Kumar A, Miao H, Holden-Wiltse J, Mosmann TR, Livingstone AM, Belz GT, Perelson AS, Zand MS, Topham DJ. Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors. J Immunol. 2011 Nov 1; 187(9):4474-82.
    View in: PubMed
  10. Wang J, Zhang G, Bambara RA, Li D, Liang H, Wu H, Smith HM, Lowe NR, Demeter LM, Dykes C. Nonnucleoside reverse transcriptase inhibitor-resistant HIV is stimulated by efavirenz during early stages of infection. J Virol. 2011 Oct; 85(20):10861-73.
    View in: PubMed
  11. Miao H, Jin X, Perelson AS, Wu H. Evaluation of multitype mathematical models for CFSE-labeling experiment data. Bull Math Biol. 2012 Feb; 74(2):300-26.
    View in: PubMed
  12. Lee Y, Wu H. Mars approach for global sensitivity analysis of differential equation models with applications to dynamics of influenza infection. Bull Math Biol. 2012 Jan; 74(1):73-90.
    View in: PubMed
  13. Dykes C, Wu H, Sims M, Holden-Wiltse J, Demeter LM. Human immunodeficiency virus type 1 protease inhibitor drug-resistant mutants give discordant results when compared in single-cycle and multiple-cycle fitness assays. J Clin Microbiol. 2010 Nov; 48(11):4035-43.
    View in: PubMed
  14. Ma J, Dykes C, Wu T, Huang Y, Demeter L, Wu H. vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments. BMC Bioinformatics. 2010; 11:261.
    View in: PubMed
  15. Miao H, Hollenbaugh JA, Zand MS, Holden-Wiltse J, Mosmann TR, Perelson AS, Wu H, Topham DJ. Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus. J Virol. 2010 Jul; 84(13):6687-98.
    View in: PubMed
  16. Baer J, Santiago F, Yang H, Wu H, Holden-Wiltse J, Treanor J, Topham DJ. B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Vaccine. 2010 Jan 22; 28(4):907-15.
    View in: PubMed
  17. Lee HY, Topham DJ, Park SY, Hollenbaugh J, Treanor J, Mosmann TR, Jin X, Ward BM, Miao H, Holden-Wiltse J, Perelson AS, Zand M, Wu H. Simulation and prediction of the adaptive immune response to influenza A virus infection. J Virol. 2009 Jul; 83(14):7151-65.
    View in: PubMed
  18. Lee HY, Hawkins E, Zand MS, Mosmann T, Wu H, Hodgkin PD, Perelson AS. Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models. Bull Math Biol. 2009 Oct; 71(7):1649-70.
    View in: PubMed
  19. Miao H, Dykes C, Demeter LM, Cavenaugh J, Park SY, Perelson AS, Wu H. Modeling and estimation of kinetic parameters and replicative fitness of HIV-1 from flow-cytometry-based growth competition experiments. Bull Math Biol. 2008 Aug; 70(6):1749-71.
    View in: PubMed
  20. Miao H, Dykes C, Demeter LM, Wu H. Differential equation modeling of HIV viral fitness experiments: model identification, model selection, and multimodel inference. Biometrics. 2009 Mar; 65(1):292-300.
    View in: PubMed
  21. Wu H, Zhu H, Miao H, Perelson AS. Parameter identifiability and estimation of HIV/AIDS dynamic models. Bull Math Biol. 2008 Apr; 70(3):785-99.
    View in: PubMed
  22. Flanigan RM, Nawoczenski DA, Chen L, Wu H, DiGiovanni BF. The influence of foot position on stretching of the plantar fascia. Foot Ankle Int. 2007 Jul; 28(7):815-22.
    View in: PubMed
  23. Jin X, Wu H, Smith H. APOBEC3G levels predict rates of progression to AIDS. Retrovirology. 2007; 4:20.
    View in: PubMed
  24. Treanor J, Wu H, Liang H, Topham DJ. Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. Vaccine. 2006 Nov 17; 24(47-48):6913-23.
    View in: PubMed
  25. Dykes C, Wang J, Jin X, Planelles V, An DS, Tallo A, Huang Y, Wu H, Demeter LM. Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture. J Clin Microbiol. 2006 Jun; 44(6):1930-43.
    View in: PubMed
  26. Huang Y, Liu D, Wu H. Hierarchical Bayesian methods for estimation of parameters in a longitudinal HIV dynamic system. Biometrics. 2006 Jun; 62(2):413-23.
    View in: PubMed
  27. Liu D, Yu J, Chen H, Reichman R, Wu H, Jin X. Statistical determination of threshold for cellular division in the CFSE-labeling assay. J Immunol Methods. 2006 May 30; 312(1-2):126-36.
    View in: PubMed
  28. Wu H, Huang Y, Acosta EP, Park JG, Yu S, Rosenkranz SL, Kuritzkes DR, Eron JJ, Perelson AS, Gerber JG. Pharmacodynamics of antiretroviral agents in HIV-1 infected patients: using viral dynamic models that incorporate drug susceptibility and adherence. J Pharmacokinet Pharmacodyn. 2006 Aug; 33(4):399-419.
    View in: PubMed
  29. Wu H, Huang Y, Dykes C, Liu D, Ma J, Perelson AS, Demeter LM. Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assay. J Virol. 2006 Mar; 80(5):2380-9.
    View in: PubMed
  30. Wu H, Huang Y, Acosta EP, Rosenkranz SL, Kuritzkes DR, Eron JJ, Perelson AS, Gerber JG. Modeling long-term HIV dynamics and antiretroviral response: effects of drug potency, pharmacokinetics, adherence, and drug resistance. J Acquir Immune Defic Syndr. 2005 Jul 1; 39(3):272-83.
    View in: PubMed
  31. Wu H. Statistical methods for HIV dynamic studies in AIDS clinical trials. Stat Methods Med Res. 2005 Apr; 14(2):171-92.
    View in: PubMed
  32. Ma J, Mosmann T, Wu H. Design considerations for a web-based database system of ELISpot assay in immunological research. AMIA Annu Symp Proc. 2005; 1039.
    View in: PubMed
  33. Acosta EP, Wu H, Hammer SM, Yu S, Kuritzkes DR, Walawander A, Eron JJ, Fichtenbaum CJ, Pettinelli C, Neath D, Ferguson E, Saah AJ, Gerber JG. Comparison of two indinavir/ritonavir regimens in the treatment of HIV-infected individuals. J Acquir Immune Defic Syndr. 2004 Nov 1; 37(3):1358-66.
    View in: PubMed
  34. Wu H, Lathey J, Ruan P, Douglas SD, Spector SA, Lindsey J, Hughes MD, Rudy BJ, Flynn PM. Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to highly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior. J Infect Dis. 2004 Feb 15; 189(4):593-601.
    View in: PubMed
  35. Haas DW, Wu H, Li H, Bosch RJ, Lederman MM, Kuritzkes D, Landay A, Connick E, Benson C, Wilkinson GR, Kessler H, Kim RB. MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. J Acquir Immune Defic Syndr. 2003 Nov 1; 34(3):295-8.
    View in: PubMed
  36. Huang Y, Rosenkranz SL, Wu H. Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity. Math Biosci. 2003 Aug; 184(2):165-86.
    View in: PubMed
  37. DiCenzo R, Forrest A, Squires KE, Hammer SM, Fischl MA, Wu H, Cha R, Morse GD. Indinavir, efavirenz, and abacavir pharmacokinetics in human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother. 2003 Jun; 47(6):1929-35.
    View in: PubMed
  38. Liang H, Wu H, Carroll RJ. The relationship between virologic and immunologic responses in AIDS clinical research using mixed-effects varying-coefficient models with measurement error. Biostatistics. 2003 Apr; 4(2):297-312.
    View in: PubMed
  39. Hamzeh FM, Benson C, Gerber J, Currier J, McCrea J, Deutsch P, Ruan P, Wu H, Lee J, Flexner C. Steady-state pharmacokinetic interaction of modified-dose indinavir and rifabutin. Clin Pharmacol Ther. 2003 Mar; 73(3):159-69.
    View in: PubMed
  40. Wu H, Zhang JT. The study of long-term HIV dynamics using semi-parametric non-linear mixed-effects models. Stat Med. 2002 Dec 15; 21(23):3655-75.
    View in: PubMed
  41. Wu H, Wu L. Identification of significant host factors for HIV dynamics modelled by non-linear mixed-effects models. Stat Med. 2002 Mar 15; 21(5):753-71.
    View in: PubMed
  42. Wu H, Wu L. A multiple imputation method for missing covariates in non-linear mixed-effects models with application to HIV dynamics. Stat Med. 2001 Jun 30; 20(12):1755-69.
    View in: PubMed
  43. Ding AA, Wu H. A comparison study of models and fitting procedures for biphasic viral dynamics in HIV-1 infected patients treated with antiviral therapies. Biometrics. 2000 Mar; 56(1):293-300.
    View in: PubMed
  44. Kuritzkes DR, Sevin A, Young B, Bakhtiari M, Wu H, St Clair M, Connick E, Landay A, Spritzler J, Kessler H, Lederman MM. Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team. J Infect Dis. 2000 Feb; 181(2):491-7.
    View in: PubMed
  45. Spear GT, Olinger G, Sullivan BL, Landay AL, Kessler H, Connick E, Kuritzkes D, St Clair M, Spritzler J, Wu H, Lederman MM. Alteration of complement protein levels after antiretroviral therapy in HIV-infected persons. AIDS Res Hum Retroviruses. 1999 Dec 10; 15(18):1713-5.
    View in: PubMed
  46. Ding AA, Wu H. Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics. Math Biosci. 1999 Aug; 160(1):63-82.
    View in: PubMed
  47. Wu H, Ding AA. Population HIV-1 dynamics in vivo: applicable models and inferential tools for virological data from AIDS clinical trials. Biometrics. 1999 Jun; 55(2):410-8.
    View in: PubMed
  48. Wu H, Kuritzkes DR, McClernon DR, Kessler H, Connick E, Landay A, Spear G, Heath-Chiozzi M, Rousseau F, Fox L, Spritzler J, Leonard JM, Lederman MM. Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. J Infect Dis. 1999 Apr; 179(4):799-807.
    View in: PubMed
  49. Wu H, Ding AA, De Gruttola V. Why are the decay rates in plasma HIV-1 different for different treatments and in different patient populations? AIDS. 1999 Feb 25; 13(3):429-30.
    View in: PubMed
  50. Luzuriaga K, Wu H, McManus M, Britto P, Borkowsky W, Burchett S, Smith B, Mofenson L, Sullivan JL. Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants. J Virol. 1999 Jan; 73(1):362-7.
    View in: PubMed
  51. Wu H. How frequently should viral load be monitored to evaluate antiretroviral therapies in AIDS clinical trials? J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jan 1; 20(1):97-9.
    View in: PubMed
  52. Wu H, Ding AA, De Gruttola V. Estimation of HIV dynamic parameters. Stat Med. 1998 Nov 15; 17(21):2463-85.
    View in: PubMed
  53. Tan WY, Wu H. Stochastic modeling of the dynamics of CD4+ T-cell infection by HIV and some Monte Carlo studies. Math Biosci. 1998 Jan 15; 147(2):173-205.
    View in: PubMed
  54. George EO, Wu H. Testing for treatment related trend with partially exchangeable clustered data. Biometrics. 1997 Jun; 53(2):479-87.
    View in: PubMed

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