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Mireya Felhazy

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentDentistry in the Center for Oral Biology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester NY 14642
 
 Awards And Honors
1981     Certificate of Academic Excellence" School of Dentistry; National Autonomous University of Mexico; Mexico, City
1983     Honorable Mention" (D.D.S. degree); School of Dentistry; National Autonomous University of Mexico; Mexico, City
1989     Honorable Mention" (Master. degree); School of Dentistry; National Autonomous University of Mexico; Mexico, City
1990     Gabino Barreda Medal" for Academic Excellence and Outstanding Achievement in the School of Dentistry, National Autonomous University of Mexico; Mexico, City
1992     Edward H. Hatton Award" Boston MA, U.S.A
1995     Gustavo Baz Prada Award" (2nd place) for Social Service Excellence; School of Dentistry, National Autonomous University of Mexico; Mexico, City
1997     Clausula 90 FAAPA/UAEM Award" for Research Excellence (Health Sciences Area), School of Dentistry, National Autonomous University of the State of Mexico, Toluca, Mexico
1999     Clausula 90 FAAPA/UAEM Award" for Research Excellence (Health Sciences Area), School of Dentistry, National Autonomous University of the State of Mexico, Toluca, Mexico
1999     National Dental Research Award" (1st place), National Dental Research Meeting, University of Veracruz; Xalapa, Veracruz
2000     4Th National Research Award"; Glaxo Wellcome, Mexico, City
2000     II Interstate Heath 2000 Research Award"; ISEM and ISSEMYM (Health Sciences Area), Toluca, Mexico
2001     Clausula 90 FAAPA/UAEM Award" for Research Excellence (Health Sciences Area), School of Dentistry, National Autonomous University of the State of Mexico, Toluca, Mexico
 
 Overview
Saliva is an essential fluid for maintaining not only oral homeostasis, but also for carrying out vital functions such as swallowing, chewing and lubrication. Some systemic diseases such as Sjögren syndrome, and traumatic or iatrogenic events like head and neck radiotherapy, can alter the salivary fluid rate, as well as the salivary composition.

Salivary gland secretion involves the dynamic interaction of the major and minor salivary glands and many other glandular structures which in a coordinated way excrete saliva into the oral cavity. The secretory process is a highly regulated mechanism in which Cl - channels, K + channels, Cl - /HCO 3 - exchangers, aquaporins, Na + /H + exchangers, carbonic anhydrases, Na + /K + /2Cl - co-transporter and the Na + /K + ATPase work in unison to generate saliva. The activation of these proteins on the basolateral and apical membranes of the acinar cells, determines the rate and direction of salt and water secretion, thus producing the primary saliva (isotonic) which is excreted into the lumen. Conversely, activation of the ion transport proteins expressed in ductal cells promotes the excretion of hypotonic saliva, due to the reabsorption of NaCl and the excretion of K + /HCO 3 - .

Within the last five years Proteomics has changed the understanding of molecular biology. Analytical methods and new techniques for proteomics have become available for characterizing thousands of proteins, gathering important information about their physicochemical properties, and studying their role in biological processes and human disease.

The main focus of my current research is to determine the molecular identity of some proteins involved in salivary secretion by MALDI-TOF Mass Spectroscopy in order to gather further understanding about their physiological role in health and disease processes.

 
 Selected Publications
List All   |   Timeline
  1. Romanenko VG, Catalán MA, Brown DA, Putzier I, Hartzell HC, Marmorstein AD, Gonzalez-Begne M, Rock JR, Harfe BD, Melvin JE. Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem. 2010 Apr 23; 285(17):12990-3001.
    View in: PubMed
  2. Catalán MA, Nakamoto T, Gonzalez-Begne M, Camden JM, Wall SM, Clarke LL, Melvin JE. Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J Physiol. 2010 Feb 15; 588(Pt 4):713-24.
    View in: PubMed
  3. Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res. 2009 Mar; 8(3):1304-14.
    View in: PubMed
  4. Nakamoto T, Brown DA, Catalán MA, Gonzalez-Begne M, Romanenko VG, Melvin JE. Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland. J Biol Chem. 2009 Feb 20; 284(8):4815-22.
    View in: PubMed
  5. Romanenko VG, Nakamoto T, Catalán MA, Gonzalez-Begne M, Schwartz GJ, Jaramillo Y, Sepúlveda FV, Figueroa CD, Melvin JE. Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G1058-67.
    View in: PubMed
  6. Reyes JP, Pérez-Cornejo P, Hernández-Carballo CY, Srivastava A, Romanenko VG, Gonzalez-Begne M, Melvin JE, Arreola J. Na+ modulates anion permeation and block of P2X7 receptors from mouse parotid glands. J Membr Biol. 2008 May; 223(2):73-85.
    View in: PubMed
  7. Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 2008 May; 7(5):1994-2006.
    View in: PubMed
  8. Srivastava A, Romanenko VG, Gonzalez-Begne M, Catalán MA, Melvin JE. A variant of the Ca2+-activated Cl channel Best3 is expressed in mouse exocrine glands. J Membr Biol. 2008 Mar; 222(1):43-54.
    View in: PubMed
  9. Taylor SR, Gonzalez-Begne M, Dewhurst S, Chimini G, Higgins CF, Melvin JE, Elliott JI. Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. J Immunol. 2008 Jan 1; 180(1):300-8.
    View in: PubMed
  10. Gonzalez-Begne M, Nakamoto T, Nguyen HV, Stewart AK, Alper SL, Melvin JE. Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem. 2007 Nov 30; 282(48):35125-32.
    View in: PubMed
  11. Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M. Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students. Arch Med Res. 2002 Sep-Oct; 33(5):499-505.
    View in: PubMed
  12. González Begné M, Yslas N, Reyes E, Quiroz V, Santana J, Jimenez G. Clinical effect of a Mexican sanguinaria extract (Polygonum aviculare L.) on gingivitis. J Ethnopharmacol. 2001 Jan; 74(1):45-51.
    View in: PubMed
  13. González M, Banderas JA, Rodríguez V, Castaño VM. Particle-induced X-ray emission and scanning electron microscopic analyses of the effects of CO2 laser irradiation on dentinal structure. J Dent. 1999 Nov; 27(8):595-600.
    View in: PubMed
  14. Gonzalez M, Banderas JA, Baez A, Belmont R. Salivary lead and cadmium in a young population residing in Mexico city. Toxicol Lett. 1997 Sep 19; 93(1):55-64.
    View in: PubMed
  15. Banderas-Tarabay JA, González-Begné M, Sánchez-Garduño M, Millán-Cortéz E, López-Rodríguez A, Vilchis-Velázquez A. [The flow and concentration of proteins in human whole saliva]. Salud Publica Mex. 1997 Sep-Oct; 39(5):433-41.
    View in: PubMed
  16. Banderas Tarabay JA, González Begné M. Genetic salivary protein polymorphism in Mexican population. Bol Estud Med Biol. 1996 Jan-Dec; 44(1-4):19-23.
    View in: PubMed
  17. Banderas JA, González M, Ramírez F, Arroyo A. Bilateral mucous cell containing dentigerous cysts of mandibular third molars: report of an unusual case. Arch Med Res. 1996; 27(3):327-9.
    View in: PubMed
  18. González M, Cabrera R, Grossi SG, Franco F, Aguirre A. Prevalence of dental caries and gingivitis in a population of Mexican schoolchildren. Community Dent Oral Epidemiol. 1993 Feb; 21(1):11-4.
    View in: PubMed
  19. Loomis RE, Gonzalez M, Loomis PM. Investigation of cis/trans proline isomerism in a multiply occurring peptide fragment from human salivary proline-rich glycoprotein. Int J Pept Protein Res. 1991 Nov; 38(5):428-39.
    View in: PubMed

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