Maiken Nedergaard
| Title | Professor |
|---|
| Institution | School of Medicine and Dentistry |
|---|
| Department | Neurosurgery in the Center for Translational Neuromedicine |
|---|
| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester NY 14642
|
|---|
|
|
|
| Title | Co-Director |
|---|
| Institution | University of Rochester Medical Center |
|---|
| Department | Center for Translational Neuromedicine |
|---|
|
|
|---|
| Title | Professor |
|---|
| Institution | School of Medicine and Dentistry |
|---|
| Department | Neurobiology and Anatomy |
|---|
|
|
|---|
| Title | Professor |
|---|
| Institution | School of Medicine and Dentistry |
|---|
| Department | Neurology |
|---|
|
|
|---|
|
| 2008 |
|
| Elected Member of the Royal Danish Academy of Sciences | Royal Danish Academy of Sciences | | 2011 |
|
| Elected Member Royal Academy of Pharmacy of Spain | Royal Academy of Pharmacy of Spain | | 2012 |
|
| Elected Member Academia Europaea | Academia Europaea |
-
Sun W, McConnell E, Pare JF, Xu Q, Chen M, Peng W, Lovatt D, Han X, Smith Y, Nedergaard M. Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science. 2013 Jan 11; 339(6116):197-200.
-
Wang M, Iliff JJ, Liao Y, Chen MJ, Shinseki MS, Venkataraman A, Cheung J, Wang W, Nedergaard M. Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. J Neurosci. 2012 Dec 12; 32(50):17948-60.
-
Iliff JJ, Nedergaard M. A link between glial Ca(2+) signaling and hypoxia in aging? J Cereb Blood Flow Metab. 2013 Feb; 33(2):170.
-
Takano T, Chen X, Luo F, Fujita T, Ren Z, Goldman N, Zhao Y, Markman JD, Nedergaard M. Traditional acupuncture triggers a local increase in adenosine in human subjects. J Pain. 2012 Dec; 13(12):1215-23.
-
Thrane AS, Thrane VR, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA, Nedergaard M. General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18974-9.
-
Goldman SA, Nedergaard M, Windrem MS. Glial progenitor cell-based treatment and modeling of neurological disease. Science. 2012 Oct 26; 338(6106):491-5.
-
Enger R, Gundersen GA, Haj-Yasein NN, Eilert-Olsen M, Thoren AE, Vindedal GF, Petersen PH, Skare O, Nedergaard M, Ottersen OP, Nagelhus EA. Molecular scaffolds underpinning macroglial polarization: An analysis of retinal Müller cells and brain astrocytes in mouse. Glia. 2012 Dec; 60(12):2018-26.
-
Bennett MV, Garré JM, Orellana JA, Bukauskas FF, Nedergaard M, Sáez JC. Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Res. 2012 Dec 3; 1487:3-15.
-
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid ß. Sci Transl Med. 2012 Aug 15; 4(147):147ra111.
-
Bekar LK, Wei HS, Nedergaard M. The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand. J Cereb Blood Flow Metab. 2012 Dec; 32(12):2135-45.
-
Chen MJ, Kress B, Han X, Moll K, Peng W, Ji RR, Nedergaard M. Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia. 2012 Nov; 60(11):1660-70.
-
Cotrina ML, Nedergaard M. Brain connexins in demyelinating diseases: Therapeutic potential of glial targets. Brain Res. 2012 Dec 3; 1487:61-8.
-
O'Donnell J, Zeppenfeld D, McConnell E, Pena S, Nedergaard M. Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance. Neurochem Res. 2012 Nov; 37(11):2496-512.
-
Rangroo Thrane V, Thrane AS, Chanag J, Alleluia V, Nagelhus EA, Nedergaard M. Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy. Neuroscience. 2012 Sep 18; 220:247-55.
-
Wang F, Xu Q, Wang W, Takano T, Nedergaard M. Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7911-6.
-
Messing A, Brenner M, Feany MB, Nedergaard M, Goldman JE. Alexander disease. J Neurosci. 2012 Apr 11; 32(15):5017-23.
-
Verkhratsky A, Sofroniew MV, Messing A, Delanerolle NC, Rempe D, Rodríguez JJ, Nedergaard M. Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro. 2012; 4(3).
-
Wang F, Smith NA, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular k+. Sci Signal. 2012; 5(218):ra26.
-
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6265-70.
-
Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T. Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J Neurosci. 2012 Mar 7; 32(10):3333-8.
-
Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, Nedergaard M. Extracellular Ca2+ acts as a mediator of communication from neurons to glia. Sci Signal. 2012; 5(208):ra8.
-
Nedergaard M, Verkhratsky A. Artifact versus reality-How astrocytes contribute to synaptic events. Glia. 2012 Jul; 60(7):1013-23.
-
Oberheim NA, Goldman SA, Nedergaard M. Heterogeneity of astrocytic form and function. Methods Mol Biol. 2012; 814:23-45.
-
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. Cultured astrocytes do not release adenosine during hypoxic conditions. J Cereb Blood Flow Metab. 2012 Jan; 32(1).
-
Christensen DJ, Nedergaard M. Two-photon in vivo imaging of cells. Pediatr Nephrol. 2011 Sep; 26(9):1483-9.
-
Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):846-51.
-
Rempe DA, Nedergaard M. Targeting glia for treatment of neurological disease. Neurotherapeutics. 2010 Oct; 7(4):335-7.
-
Kimelberg HK, Nedergaard M. Functions of astrocytes and their potential as therapeutic targets. Neurotherapeutics. 2010 Oct; 7(4):338-53.
-
Kasischke KA, Lambert EM, Panepento B, Sun A, Gelbard HA, Burgess RW, Foster TH, Nedergaard M. Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. J Cereb Blood Flow Metab. 2011 Jan; 31(1):68-81.
-
Zhang S, Li B, Lovatt D, Xu J, Song D, Goldman SA, Nedergaard M, Hertz L, Peng L. 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol. 2010 May; 6(2):113-25.
-
Vates GE, Takano T, Zlokovic B, Nedergaard M. Pericyte constriction after stroke: the jury is still out. Nat Med. 2010 Sep; 16(9):959; author reply 960.
-
Kang J, Kang N, Yu Y, Zhang J, Petersen N, Tian GF, Nedergaard M. Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons. Neuroscience. 2010 Sep 15; 169(4):1601-9.
-
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010 Jul; 13(7):883-8.
-
Hertz L, Lovatt D, Goldman SA, Nedergaard M. Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i. Neurochem Int. 2010 Nov; 57(4):411-20.
-
Nedergaard M, Verkhratsky A. Calcium dyshomeostasis and pathological calcium signalling in neurological diseases. Cell Calcium. 2010 Feb; 47(2):101-2.
-
Nedergaard M, Rodríguez JJ, Verkhratsky A. Glial calcium and diseases of the nervous system. Cell Calcium. 2010 Feb; 47(2):140-9.
-
Rempe DA, Takano T, Nedergaard M. TR(I)Pping towards treatment for ischemia. Nat Neurosci. 2009 Oct; 12(10):1215-6.
-
Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12489-93.
-
Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M. Uniquely hominid features of adult human astrocytes. J Neurosci. 2009 Mar 11; 29(10):3276-87.
-
Cotrina ML, Nedergaard M. Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic Signal. 2009 Jun; 5(2):223-32.
-
Hedley-Whyte ET, Goldman JE, Nedergaard M, Friedman A, Han X, Schmidt RE, Powers JM. Hyaline protoplasmic astrocytopathy of neocortex. J Neuropathol Exp Neurol. 2009 Feb; 68(2):136-47.
-
Wang X, Takano T, Nedergaard M. Astrocytic calcium signaling: mechanism and implications for functional brain imaging. Methods Mol Biol. 2009; 489:93-109.
-
Takano T, Nedergaard M. Deciphering migraine. J Clin Invest. 2009 Jan; 119(1):16-9.
-
Takano T, Oberheim N, Cotrina ML, Nedergaard M. Astrocytes and ischemic injury. Stroke. 2009 Mar; 40(3 Suppl):S8-12.
-
Cotrina ML, Lin JH, Nedergaard M. Adhesive properties of connexin hemichannels. Glia. 2008 Dec; 56(16):1791-8.
-
Windrem MS, Schanz SJ, Guo M, Tian GF, Washco V, Stanwood N, Rasband M, Roy NS, Nedergaard M, Havton LA, Wang S, Goldman SA. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell. 2008 Jun 5; 2(6):553-65.
-
Xu H, Hu F, Sado Y, Ninomiya Y, Borza DB, Ungvari Z, Lagamma EF, Csiszar A, Nedergaard M, Ballabh P. Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone. J Neurosci Res. 2008 May 15; 86(7):1482-500.
-
Kang J, Kang N, Lovatt D, Torres A, Zhao Z, Lin J, Nedergaard M. Connexin 43 hemichannels are permeable to ATP. J Neurosci. 2008 Apr 30; 28(18):4702-11.
-
Bekar LK, He W, Nedergaard M. Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo. Cereb Cortex. 2008 Dec; 18(12):2789-95.
-
Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M. Loss of astrocytic domain organization in the epileptic brain. J Neurosci. 2008 Mar 26; 28(13):3264-76.
-
Lin JH, Lou N, Kang N, Takano T, Hu F, Han X, Xu Q, Lovatt D, Torres A, Willecke K, Yang J, Kang J, Nedergaard M. A central role of connexin 43 in hypoxic preconditioning. J Neurosci. 2008 Jan 16; 28(3):681-95.
-
Neuwelt E, Abbott NJ, Abrey L, Banks WA, Blakley B, Davis T, Engelhardt B, Grammas P, Nedergaard M, Nutt J, Pardridge W, Rosenberg GA, Smith Q, Drewes LR. Strategies to advance translational research into brain barriers. Lancet Neurol. 2008 Jan; 7(1):84-96.
-
Bekar L, Libionka W, Tian GF, Xu Q, Torres A, Wang X, Lovatt D, Williams E, Takano T, Schnermann J, Bakos R, Nedergaard M. Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor. Nat Med. 2008 Jan; 14(1):75-80.
-
Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci. 2007 Nov 7; 27(45):12255-66.
-
Iadecola C, Nedergaard M. Glial regulation of the cerebral microvasculature. Nat Neurosci. 2007 Nov; 10(11):1369-76.
-
Braun A, Xu H, Hu F, Kocherlakota P, Siegel D, Chander P, Ungvari Z, Csiszar A, Nedergaard M, Ballabh P. Paucity of pericytes in germinal matrix vasculature of premature infants. J Neurosci. 2007 Oct 31; 27(44):12012-24.
-
Jaiswal JK, Fix M, Takano T, Nedergaard M, Simon SM. Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14151-6.
-
Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M. Cortical spreading depression causes and coincides with tissue hypoxia. Nat Neurosci. 2007 Jun; 10(6):754-62.
-
Ballabh P, Xu H, Hu F, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M. Angiogenic inhibition reduces germinal matrix hemorrhage. Nat Med. 2007 Apr; 13(4):477-85.
-
Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann N Y Acad Sci. 2007 Feb; 1097:40-50.
-
Takano T, Nedergaard M. DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+. Cell Calcium. 2007 May; 41(5):503-4.
-
Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M. Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev Biol. 2007 Feb 1; 302(1):356-66.
-
Oberheim NA, Wang X, Goldman S, Nedergaard M. Astrocytic complexity distinguishes the human brain. Trends Neurosci. 2006 Oct; 29(10):547-53.
-
Tian GF, Takano T, Lin JH, Wang X, Bekar L, Nedergaard M. Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain. Adv Drug Deliv Rev. 2006 Sep 15; 58(7):773-87.
-
Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M. Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo. Nat Neurosci. 2006 Jun; 9(6):816-23.
-
El-Khoury N, Braun A, Hu F, Pandey M, Nedergaard M, Lagamma EF, Ballabh P. Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants. Pediatr Res. 2006 May; 59(5):673-9.
-
Anderson CM, Nedergaard M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends Neurosci. 2006 May; 29(5):257-62.
-
Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M. Astrocyte-mediated control of cerebral blood flow. Nat Neurosci. 2006 Feb; 9(2):260-7.
-
Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M. Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16466-71.
-
Ballabh P, Hu F, Kumarasiri M, Braun A, Nedergaard M. Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter. Pediatr Res. 2005 Oct; 58(4):791-8.
-
Singh Roy N, Nakano T, Xuing L, Kang J, Nedergaard M, Goldman SA. Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol. 2005 Dec; 196(2):224-34.
-
Kang N, Xu J, Xu Q, Nedergaard M, Kang J. Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons. J Neurophysiol. 2005 Dec; 94(6):4121-30.
-
Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M. An astrocytic basis of epilepsy. Nat Med. 2005 Sep; 11(9):973-81.
-
Nedergaard M, Dirnagl U. Role of glial cells in cerebral ischemia. Glia. 2005 Jun; 50(4):281-6.
-
Xu J, Kang N, Jiang L, Nedergaard M, Kang J. Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons. J Neurosci. 2005 Feb 16; 25(7):1750-60.
-
Liu QS, Xu Q, Kang J, Nedergaard M. Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. Neuron Glia Biol. 2004 Nov; 1(4):307-16.
-
Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med. 2004 Aug; 10(8):821-7.
-
Ballabh P, Braun A, Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis. 2004 Jun; 16(1):1-13.
-
Ballabh P, Braun A, Nedergaard M. Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants. Pediatr Res. 2004 Jul; 56(1):117-24.
-
Kang N, Jiang L, He W, Xu J, Nedergaard M, Kang J. Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons. J Neurophysiol. 2004 Aug; 92(2):873-82.
-
Roy NS, Nakano T, Keyoung HM, Windrem M, Rashbaum WK, Alonso ML, Kang J, Peng W, Carpenter MK, Lin J, Nedergaard M, Goldman SA. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotechnol. 2004 Mar; 22(3):297-305.
-
Liu QS, Xu Q, Arcuino G, Kang J, Nedergaard M. Astrocyte-mediated activation of neuronal kainate receptors. Proc Natl Acad Sci U S A. 2004 Mar 2; 101(9):3172-7.
-
Simard M, Nedergaard M. The neurobiology of glia in the context of water and ion homeostasis. Neuroscience. 2004; 129(4):877-96.
-
Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M. Signaling at the gliovascular interface. J Neurosci. 2003 Oct 8; 23(27):9254-62.
-
Ransom B, Behar T, Nedergaard M. New roles for astrocytes (stars at last). Trends Neurosci. 2003 Oct; 26(10):520-2.
-
Nedergaard M, Ransom B, Goldman SA. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 2003 Oct; 26(10):523-30.
-
Anderson CM, Nedergaard M. Astrocyte-mediated control of cerebral microcirculation. Trends Neurosci. 2003 Jul; 26(7):340-4; author reply 344-5.
-
Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G, Jiang L, Kang J, Nedergaard M, Goldman SA. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med. 2003 Apr; 9(4):439-47.
-
Lin JH, Yang J, Liu S, Takano T, Wang X, Gao Q, Willecke K, Nedergaard M. Connexin mediates gap junction-independent resistance to cellular injury. J Neurosci. 2003 Jan 15; 23(2):430-41.
-
Nedergaard M, Takano T, Hansen AJ. Beyond the role of glutamate as a neurotransmitter. Nat Rev Neurosci. 2002 Sep; 3(9):748-55.
-
Goldman SA, Nedergaard M. Erythropoietin strikes a new cord. Nat Med. 2002 Aug; 8(8):785-7.
-
Arcuino G, Lin JH, Takano T, Liu C, Jiang L, Gao Q, Kang J, Nedergaard M. Intercellular calcium signaling mediated by point-source burst release of ATP. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9840-5.
-
Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M. Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells. J Neurosci. 2002 Jun 1; 22(11):4302-11.
-
Cotrina ML, Nedergaard M. Astrocytes in the aging brain. J Neurosci Res. 2002 Jan 1; 67(1):1-10.
-
Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M. Glutamate release promotes growth of malignant gliomas. Nat Med. 2001 Sep; 7(9):1010-5.
-
Cotrina ML, Gao Q, Lin JH, Nedergaard M. Expression and function of astrocytic gap junctions in aging. Brain Res. 2001 May 18; 901(1-2):55-61.
-
Jiang L, Xu J, Nedergaard M, Kang J. A kainate receptor increases the efficacy of GABAergic synapses. Neuron. 2001 May; 30(2):503-13.
-
Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedergaard M. Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. Cancer Res. 2000 Oct 1; 60(19):5395-400.
-
Cotrina ML, Lin JH, López-García JC, Naus CC, Nedergaard M. ATP-mediated glia signaling. J Neurosci. 2000 Apr 15; 20(8):2835-44.
-
Martins-Ferreira H, Nedergaard M, Nicholson C. Perspectives on spreading depression. Brain Res Brain Res Rev. 2000 Apr; 32(1):215-34.
-
Jiang L, Sun S, Nedergaard M, Kang J. Paired-pulse modulation at individual GABAergic synapses in rat hippocampus. J Physiol. 2000 Mar 1; 523 Pt 2:425-39.
-
Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med. 2000 Mar; 6(3):271-7.
-
Roy NS, Benraiss A, Wang S, Fraser RA, Goodman R, Couldwell WT, Nedergaard M, Kawaguchi A, Okano H, Goldman SA. Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J Neurosci Res. 2000 Feb 1; 59(3):321-31.
-
Grafstein B, Liu S, Cotrina ML, Goldman SA, Nedergaard M. Meningeal cells can communicate with astrocytes by calcium signaling. Ann Neurol. 2000 Jan; 47(1):18-25.
-
Simard M, Couldwell WT, Zhang W, Song H, Liu S, Cotrina ML, Goldman S, Nedergaard M. Glucocorticoids-potent modulators of astrocytic calcium signaling. Glia. 1999 Oct; 28(1):1-12.
-
Zhang W, Couldwell WT, Simard MF, Song H, Lin JH, Nedergaard M. Direct gap junction communication between malignant glioma cells and astrocytes. Cancer Res. 1999 Apr 15; 59(8):1994-2003.
-
Williams S, Leventhal C, Lemmon V, Nedergaard M, Goldman SA. Estrogen promotes the initial migration and inception of NgCAM-dependent calcium-signaling by new neurons of the adult songbird brain. Mol Cell Neurosci. 1999 Jan; 13(1):41-55.
-
Cotrina ML, Lin JH, Alves-Rodrigues A, Liu S, Li J, Azmi-Ghadimi H, Kang J, Naus CC, Nedergaard M. Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15735-40.
-
Kang J, Jiang L, Goldman SA, Nedergaard M. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nat Neurosci. 1998 Dec; 1(8):683-92.
-
Cotrina ML, Lin JH, Nedergaard M. Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling. J Neurosci. 1998 Nov 1; 18(21):8794-804.
-
Lin JH, Weigel H, Cotrina ML, Liu S, Bueno E, Hansen AJ, Hansen TW, Goldman S, Nedergaard M. Gap-junction-mediated propagation and amplification of cell injury. Nat Neurosci. 1998 Oct; 1(6):494-500.
-
Pincus DW, Keyoung HM, Harrison-Restelli C, Goodman RR, Fraser RA, Edgar M, Sakakibara S, Okano H, Nedergaard M, Goldman SA. Fibroblast growth factor-2/brain-derived neurotrophic factor-associated maturation of new neurons generated from adult human subependymal cells. Ann Neurol. 1998 May; 43(5):576-85.
-
Cotrina ML, Kang J, Lin JH, Bueno E, Hansen TW, He L, Liu Y, Nedergaard M. Astrocytic gap junctions remain open during ischemic conditions. J Neurosci. 1998 Apr 1; 18(7):2520-37.
-
Pincus DW, Goodman RR, Fraser RA, Nedergaard M, Goldman SA. Neural stem and progenitor cells: a strategy for gene therapy and brain repair. Neurosurgery. 1998 Apr; 42(4):858-67; discussion 867-8.
-
Goldman SA, Nedergaard M, Crystal RG, Fraser RA, Goodman R, Harrison-Restelli C, Jiang J, Keyoung HM, Leventhal C, Pincus DW, Shahar A, Wang S. Neural precursors and neuronal production in the adult mammalian forebrain. Ann N Y Acad Sci. 1997 Dec 19; 835:30-55.
-
Rawanduzy A, Hansen A, Hansen TW, Nedergaard M. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J Neurosurg. 1997 Dec; 87(6):916-20.
-
Wang Z, Tymianski M, Jones OT, Nedergaard M. Impact of cytoplasmic calcium buffering on the spatial and temporal characteristics of intercellular calcium signals in astrocytes. J Neurosci. 1997 Oct 1; 17(19):7359-71.
-
Rawanduzy A, Hansen A, Hansen TW, Nedergaard M. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. Neurosurg Focus. 1997 May 15; 2(5):E1; discussion 1 p following E1.
-
Pincus DW, Harrison-Restelli C, Barry J, Goodman RR, Fraser RA, Nedergaard M, Goldman SA. In vitro neurogenesis by adult human epileptic temporal neocortex. Clin Neurosurg. 1997; 44:17-25.
-
Goldman SA, Williams S, Barami K, Lemmon V, Nedergaard M. Transient coupling of Ng-CAM expression to NgCAM-dependent calcium signaling during migration of new neurons in the adult songbird brain. Mol Cell Neurosci. 1996 Jan; 7(1):29-45.
-
Nedergaard M. Spreading depression as a contributor to ischemic brain damage. Adv Neurol. 1996; 71:75-83; discussion 83-4.
-
Nedergaard M, Cooper AJ, Goldman SA. Gap junctions are required for the propagation of spreading depression. J Neurobiol. 1995 Dec; 28(4):433-44.
-
Nedergaard M. Intracellular Ca2+ transients evoked by lactic acid in cultured mammalian neurons. Am J Physiol. 1995 Feb; 268(2 Pt 2):R506-13.
-
Kirschenbaum B, Nedergaard M, Preuss A, Barami K, Fraser RA, Goldman SA. In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cereb Cortex. 1994 Nov-Dec; 4(6):576-89.
-
Makar TK, Nedergaard M, Preuss A, Hertz L, Cooper AJ. Glutamine transaminase K and omega-amidase activities in primary cultures of astrocytes and neurons and in embryonic chick forebrain: marked induction of brain glutamine transaminase K at time of hatching. J Neurochem. 1994 May; 62(5):1983-8.
-
Nedergaard M. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science. 1994 Mar 25; 263(5154):1768-71.
-
Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ. Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem. 1994 Jan; 62(1):45-53.
-
Nedergaard M, Goldman SA. Carrier-mediated transport of lactic acid in cultured neurons and astrocytes. Am J Physiol. 1993 Aug; 265(2 Pt 2):R282-9.
-
Nedergaard M, Hansen AJ. Characterization of cortical depolarizations evoked in focal cerebral ischemia. J Cereb Blood Flow Metab. 1993 Jul; 13(4):568-74.
-
Goldman SA, Nedergaard M. Newly generated neurons of the adult songbird brain become functionally active in long-term culture. Brain Res Dev Brain Res. 1992 Aug 21; 68(2):217-23.
-
Nedergaard M, Goldman SA, Desai S, Pulsinelli WA. Acid-induced death in neurons and glia. J Neurosci. 1991 Aug; 11(8):2489-97.
-
Nedergaard M, Kraig RP, Tanabe J, Pulsinelli WA. Dynamics of interstitial and intracellular pH in evolving brain infarct. Am J Physiol. 1991 Mar; 260(3 Pt 2):R581-8.
-
Nedergaard M, Desai S, Pulsinelli W. Dicarboxy-dichlorofluorescein: a new fluorescent probe for measuring acidic intracellular pH. Anal Biochem. 1990 May 15; 187(1):109-14.
-
Jakobsen J, Nedergaard M, Aarslew-Jensen M, Diemer NH. Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats. Diabetes. 1990 Apr; 39(4):437-40.
-
Nedergaard M, Diemer NH. Experimental cerebral ischemia: barbiturate resistant increase in regional glucose utilization. J Cereb Blood Flow Metab. 1988 Oct; 8(5):763-6.
-
Hansen AJ, Nedergaard M. Brain ion homeostasis in cerebral ischemia. Neurochem Pathol. 1988 Jul-Dec; 9:195-209.
-
Nedergaard M, Hansen AJ. Spreading depression is not associated with neuronal injury in the normal brain. Brain Res. 1988 May 24; 449(1-2):395-8.
-
Sillesen H, Nedergaard M, Schroeder T, Buchardt Hansen HJ. Middle cerebral artery occlusion in presence of low perfusion pressure increases infarct size in rats. Neurol Res. 1988 Mar; 10(1):61-3.
-
Nedergaard M, Jakobsen J, Diemer NH. Autoradiographic determination of cerebral glucose content, blood flow, and glucose utilization in focal ischemia of the rat brain: influence of the plasma glucose concentration. J Cereb Blood Flow Metab. 1988 Feb; 8(1):100-8.
-
Nedergaard M. Mechanisms of brain damage in focal cerebral ischemia. Acta Neurol Scand. 1988 Feb; 77(2):81-101.
-
Nedergaard M, Gjedde A, Diemer NH. Hyperglycaemia protects against neuronal injury around experimental brain infarcts. Neurol Res. 1987 Dec; 9(4):241-4.
-
Nedergaard M. Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction. Brain Res. 1987 Apr 7; 408(1-2):79-85.
-
Nedergaard M. Neuronal injury in the infarct border: a neuropathological study in the rat. Acta Neuropathol. 1987; 73(3):267-74.
-
Nedergaard M, Diemer NH. Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration. Acta Neuropathol. 1987; 73(2):131-7.
-
Nedergaard M, Vorstrup S, Astrup J. Cell density in the border zone around old small human brain infarcts. Stroke. 1986 Nov-Dec; 17(6):1129-37.
-
Nedergaard M, Astrup J. Infarct rim: effect of hyperglycemia on direct current potential and [14C]2-deoxyglucose phosphorylation. J Cereb Blood Flow Metab. 1986 Oct; 6(5):607-15.
-
Nedergaard M, Gjedde A, Diemer NH. Focal ischemia of the rat brain: autoradiographic determination of cerebral glucose utilization, glucose content, and blood flow. J Cereb Blood Flow Metab. 1986 Aug; 6(4):414-24.
-
Nedergaard M, Astrup J, Klinken L. Cell density and cortex thickness in the border zone surrounding old infarcts in the human brain. Stroke. 1984 Nov-Dec; 15(6):1033-9.
-
Nedergaard M, Klinken L, Paulson OB. Secondary brain stem hemorrhage in stroke. Stroke. 1983 Jul-Aug; 14(4):501-5.
-
Nedergaard M, Egeberg J, Kromann H. Irradiation protects against pancreatic islet degeneration and hyperglycaemia following streptozotocin treatment of mice. Diabetologia. 1983 May; 24(5):382-6.
-
Kromann H, Christy M, Lernmark A, Nedergaard M, Nerup J. The low dose streptozotocin murine model of type 1 (insulin-dependent) diabetes mellitus: studies in vivo and in vitro of the modulating effect of sex hormones. Diabetologia. 1982 Mar; 22(3):194-8.
-
Nedergaard M. [Not Available]. Rev Hist Pharm (Paris). 1977 Sep; 24(234):167-72.
-
Nedergaard M. Health care and hospital pharmacy in Denmark. Am J Hosp Pharm. 1977 Jun; 34(6):595-600.
-
Nedergaard M. Pharmacy in Scandinavia: a corner of the Old World. Hosp Formul. 1975 Jul; 10(7):348, 351, 354-5.
-
Nedergaard M, Norn MS, Sjontoft F. [Single-dose eye drops]. Ugeskr Laeger. 1972 Oct 23; 134(43):2271-3.
-
Mackeprang B, Nedergaard M. [Discussion of a "home-pharmacy"]. Ugeskr Laeger. 1972 Sep 25; 134(39):2038-43.
-
Nedergaard M. Analytical study of L-dopa (substance and tablets). Pharm Acta Helv. 1970 Jun; 45(6):373-8.
-
Nedergaard M, Collado Mdel C. [On the stability of phenoxybenzamine in parental solution. 2]. Pharm Acta Helv. 1969 Sep; 44(9):541-6.
-
Nedergaard M. Colorimetric determination of dienoestrol: quinol-sulphuric acid IV. Boll Chim Farm. 1968 Sep; 107(9):570-3.
-
Collado Mdel C, Nedergaard M. [On the stability of phenoxybenzamine hydrochloride in solution]. Ann Pharm Fr. 1968 May; 26(5):409-12.
-
Nedergaard M. [Hydroquinone-sulfuric acid reagents. 3. Colorimetric determination of diethylstilbestrol]. J Pharm Belg. 1967 Sep-Oct; 22(9):323-8.
-
Nedergaard M. [Investigations on colour reaction between guinol-sulphuric acid and diethylstibestrol and related compounds]. Dan Tidsskr Farm. 1967 Jul; 41(7):125-36.
-
Amdrup E, Bonfils K, Christensen P, Nedergaard M. [The use of karaya-gum powder and aluminum hydroxide gel in cases of external gastrointestinal fistula or stoma]. Nord Med. 1966 May 26; 75(21):598-9.
|
Nedergaard's Networks
Concepts  Derived automatically from this person's publications. _
Co-Authors People in Profiles who have published with this person. _
Similar People People who share similar concepts with this person. _
Same Department
People who are also in this person's primary department.
|
