Dr. Steven A. Goldman is the Edward and Alma Vollertsen Rykenboer Professor of Neurology. He is Chief of the Department's Division of Cell and Gene Therapy, and Co-Director of Rochester's Center for Translational Neuromedicine. Goldman is Emeritus Chairman of the Department, and holds additional appointments as a Professor of Neurosurgery, and as the Dean Zutes Chair in Biology of the Aging Brain. Goldman moved to Rochester in 2003 from the Weill Medical College of Cornell University, where he was the Nathan Cummings Professor of Neurology, and Attending Neurologist at New York Presbyterian Hospital. A summa cum laude graduate of the University of Pennsylvania, he obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Dr. Goldman interned in Medicine and did his residency in Neurology under Fred Plum at New York Hospital-Cornell, and Jerome Posner at the Memorial Sloan-Kettering Cancer Center, before joining the Cornell faculty. Dr. Goldman is interested in cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. His lab focuses on the use of stem and progenitor cells for the treatment of neurodegenerative disorders such as Huntington's Disease, as well as for the treatment of glial diseases such as the pediatric leukodystrophies and multiple sclerosis He also has a strong interest in the conversion of resident cells into brain cancers, and is board certified in neuro-oncology. He has published over 200 papers in his field, over 100 as first or senior author. Dr. Goldman is a recipient of the Jacob Javits Neuroscience Investigator Award of the NIH, and has been elected to the Association of American Physicians and American Society for Clinical Investigation, as well as the American Neurological Association. Dr. Goldman remains active clinically, with subspecialty interests in stroke, myelin disease and neuro-oncology, and he is the program director for Rochester's neuro-oncology fellowship. He serves on standing committees of the NIH, and is a voting member of the FDA Cellular, Tissue and Gene Therapy Advisory Committee. His work is supported by NIH/NINDS, the Mathers and Adelson Foundations, the Department of Defense, CHDI, the National MS Society, NYSTEM, and Biogen Idec.

• Goldman SA, Nedergaard M, Windrem MS. Glial progenitor cell-based treatment and modeling of neurological disease. Science. 2012 Oct 26; 338(6106):491-5.
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• McClain CR, Sim FJ, Goldman SA. Pleiotrophin Suppression of Receptor Protein Tyrosine Phosphatase-ß/? Maintains the Self-Renewal Competence of Fetal Human Oligodendrocyte Progenitor Cells. J Neurosci. 2012 Oct 24; 32(43):15066-75.
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• Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid ß. Sci Transl Med. 2012 Aug 15; 4(147):147ra111.
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• Oberheim NA, Goldman SA, Nedergaard M. Heterogeneity of astrocytic form and function. Methods Mol Biol. 2012; 814:23-45.
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• Benraiss A, Bruel-Jungerman E, Lu G, Economides AN, Davidson B, Goldman SA. Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF. Gene Ther. 2012 May; 19(5):582.
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• Goldman SA, Chen Z. Perivascular instruction of cell genesis and fate in the adult brain. Nat Neurosci. 2011 Nov; 14(11):1382-9.
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• Benraiss A, Goldman SA. Cellular Therapy and Induced Neuronal Replacement for Huntington's Disease. Neurotherapeutics. 2011 Oct; 8(4):577-90.
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• Goldman SA, Sim FJ. Cell-based therapies for disorders of the brain and spinal cord. Neurotherapeutics. 2011 Oct; 8(4):537-8.
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• Sim FJ, McClain CR, Schanz SJ, Protack TL, Windrem MS, Goldman SA. CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells. Nat Biotechnol. 2011; 29(10):934-41.
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• Benraiss A, Bruel-Jungerman E, Lu G, Economides AN, Davidson B, Goldman SA. Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF. Gene Ther. 2012 May; 19(5):483-93.
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• Eyler CE, Wu Q, Yan K, MacSwords JM, Chandler-Militello D, Misuraca KL, Lathia JD, Forrester MT, Lee J, Stamler JS, Goldman SA, Bredel M, McLendon RE, Sloan AE, Hjelmeland AB, Rich JN. Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell. 2011 Jul 8; 146(1):53-66.
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• Kellar RS, Lancaster JJ, Thai HM, Juneman E, Johnson NM, Byrne HG, Stansifer M, Arsanjani R, Baer M, Bebbington C, Flashner M, Yarranton G, Goldman S. Antibody to granulocyte macrophage colony-stimulating factor reduces the number of activated tissue macrophages and improves left ventricular function after myocardial infarction in a rat coronary artery ligation model. J Cardiovasc Pharmacol. 2011 May; 57(5):568-74.
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• Goldman SA. Progenitor cell-based treatment of the pediatric myelin disorders. Arch Neurol. 2011 Jul; 68(7):848-56.
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• Jakacki RI, Dombi E, Potter DM, Goldman S, Allen JC, Pollack IF, Widemann BC. Phase I trial of pegylated interferon-alpha-2b in young patients with plexiform neurofibromas. Neurology. 2011 Jan 18; 76(3):265-72.
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• Bugiani M, Boor I, van Kollenburg B, Postma N, Polder E, van Berkel C, van Kesteren RE, Windrem MS, Hol EM, Scheper GC, Goldman SA, van der Knaap MS. Defective glial maturation in vanishing white matter disease. J Neuropathol Exp Neurol. 2011 Jan; 70(1):69-82.
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• Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82.
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• Wang S, Chandler-Militello D, Lu G, Roy NS, Zielke A, Auvergne R, Stanwood N, Geschwind D, Coppola G, Nicolis SK, Sim FJ, Goldman SA. Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting. J Neurosci. 2010 Nov 3; 30(44):14635-48.
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• Zhang S, Li B, Lovatt D, Xu J, Song D, Goldman SA, Nedergaard M, Hertz L, Peng L. 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol. 2010 May; 6(2):113-25.
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• Flamez D, Roland I, Berton A, Kutlu B, Dufrane D, Beckers MC, De Waele E, Rooman I, Bouwens L, Clark A, Lonneux M, Jamar JF, Goldman S, Maréchal D, Goodman N, Gianello P, Van Huffel C, Salmon I, Eizirik DL. A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker. Diabetologia. 2010 Jul; 53(7):1372-83.
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• Hertz L, Lovatt D, Goldman SA, Nedergaard M. Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i. Neurochem Int. 2010 Nov; 57(4):411-20.
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• Zakharova L, Mastroeni D, Mutlu N, Molina M, Goldman S, Diethrich E, Gaballa MA. Transplantation of cardiac progenitor cell sheet onto infarcted heart promotes cardiogenesis and improves function. Cardiovasc Res. 2010 Jul 1; 87(1):40-9.
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• Hartog TE, Dittrich F, Pieneman AW, Jansen RF, Frankl-Vilches C, Lessmann V, Lilliehook C, Goldman SA, Gahr M. Brain-derived neurotrophic factor signaling in the HVC is required for testosterone-induced song of female canaries. J Neurosci. 2009 Dec 9; 29(49):15511-9.
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• Sim FJ, Windrem MS, Goldman SA. Fate determination of adult human glial progenitor cells. Neuron Glia Biol. 2009 Nov; 5(3-4):45-55.
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• Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12489-93.
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• Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr; 27(4):806-11.
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• Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M. Uniquely hominid features of adult human astrocytes. J Neurosci. 2009 Mar 11; 29(10):3276-87.
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• Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis Model Mech. 2009 Mar-Apr; 2(3-4):189-95.
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• Thai HM, Juneman E, Lancaster J, Hagerty T, Do R, Castellano L, Kellar R, Williams S, Sethi G, Schmelz M, Gaballa M, Goldman S. Implantation of a three-dimensional fibroblast matrix improves left ventricular function and blood flow after acute myocardial infarction. Cell Transplant. 2009; 18(3):283-95.
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• Ben-Hur T, Goldman SA. Prospects of cell therapy for disorders of myelin. Ann N Y Acad Sci. 2008 Oct; 1142:218-49.
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• Goldman SA. Interview. From canaries to the clinic. Regen Med. 2008 Sep; 3(5):655-9.
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• Goldman SA, Natesan S. A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus. Cell Stem Cell. 2008 Aug 7; 3(2):125-6.
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• Sim FJ, Lang JK, Ali TA, Roy NS, Vates GE, Pilcher WH, Goldman SA. Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation. Glia. 2008 Jul; 56(9):954-62.
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• Windrem MS, Schanz SJ, Guo M, Tian GF, Washco V, Stanwood N, Rasband M, Roy NS, Nedergaard M, Havton LA, Wang S, Goldman SA. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell. 2008 Jun 5; 2(6):553-65.
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• Duncan ID, Goldman S, Macklin WB, Rao M, Weiner LP, Reingold SC. Stem cell therapy in multiple sclerosis: promise and controversy. Mult Scler. 2008 May; 14(4):541-6.
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• Goldman SA, Schanz S, Windrem MS. Stem cell-based strategies for treating pediatric disorders of myelin. Hum Mol Genet. 2008 Apr 15; 17(R1):R76-83.
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• Kim DH, Lilliehook C, Roides B, Chen Z, Chang M, Mobashery S, Goldman SA. Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain. J Neurosci. 2008 Jan 2; 28(1):208-16.
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• Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci. 2007 Nov 7; 27(45):12255-66.
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• Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J Clin Invest. 2007 Oct; 117(10):2889-902.
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• Goldman SA. Disease targets and strategies for the therapeutic modulation of endogenous neural stem and progenitor cells. Clin Pharmacol Ther. 2007 Oct; 82(4):453-60.
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• Ballabh P, Xu H, Hu F, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M. Angiogenic inhibition reduces germinal matrix hemorrhage. Nat Med. 2007 Apr; 13(4):477-85.
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• Goldman SA, Roy NS, Beal MF, Cleren C. Large stem cell grafts could lead to erroneous interpretations of behavioral results? Nat Med. 2007 Feb; 13(2):118-9.
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• Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai J, Xu QX, Davidson BP, Stice SL, Smith AK, Goldman SA, Reubinoff BE, Zhan M, Rao MS, Chesnut JD. Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells. 2007 May; 25(5):1298-306.
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• Kanai R, Tomita H, Hirose Y, Ohba S, Goldman S, Okano H, Kawase T, Yazaki T. Augmented therapeutic efficacy of an oncolytic herpes simplex virus type 1 mutant expressing ICP34.5 under the transcriptional control of musashi1 promoter in the treatment of malignant glioma. Hum Gene Ther. 2007 Jan; 18(1):63-73.
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• Keyoung HM, Goldman SA. Glial progenitor-based repair of demyelinating neurological diseases. Neurosurg Clin N Am. 2007 Jan; 18(1):93-104, x.
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• Roy NS, Chandler-Militello D, Lu G, Wang S, Goldman SA. Retrovirally mediated telomerase immortalization of neural progenitor cells. Nat Protoc. 2007; 2(11):2815-25.
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• Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung HW, Roy NS, Goldman SA. Neurocytoma is a tumor of adult neuronal progenitor cells. J Neurosci. 2006 Nov 29; 26(48):12544-55.
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• Kanai R, Eguchi K, Takahashi M, Goldman S, Okano H, Kawase T, Yazaki T. Enhanced therapeutic efficacy of oncolytic herpes vector G207 against human non-small cell lung cancer--expression of an RNA-binding protein, Musashi1, as a marker for the tailored gene therapy. J Gene Med. 2006 Nov; 8(11):1329-40.
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• Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med. 2006 Nov; 12(11):1259-68.
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• Goldman SA, Windrem MS. Cell replacement therapy in neurological disease. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29; 361(1473):1463-75.
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• Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M. Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev Biol. 2007 Feb 1; 302(1):356-66.
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• Oberheim NA, Wang X, Goldman S, Nedergaard M. Astrocytic complexity distinguishes the human brain. Trends Neurosci. 2006 Oct; 29(10):547-53.
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• Sim FJ, Lang JK, Waldau B, Roy NS, Schwartz TE, Pilcher WH, Chandross KJ, Natesan S, Merrill JE, Goldman SA, Goldmanm SA. Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol. 2006 May; 59(5):763-79.
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• Thai HM, Do BQ, Tran TD, Gaballa MA, Goldman S. Aldosterone antagonism improves endothelial-dependent vasorelaxation in heart failure via upregulation of endothelial nitric oxide synthase production. J Card Fail. 2006 Apr; 12(3):240-5.
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• Goldman SA, Lang J, Roy N, Schanz SJ, Sim FS, Wang S, Washco V, Windrem MS. Progenitor cell-based myelination as a model for cell-based therapy of the central nervous system. Ernst Schering Res Found Workshop. 2006; (60):195-213.
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• Kanai R, Tomita H, Shinoda A, Takahashi M, Goldman S, Okano H, Kawase T, Yazaki T. Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence. Gene Ther. 2006 Jan; 13(2):106-16.
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• Singh Roy N, Nakano T, Xuing L, Kang J, Nedergaard M, Goldman SA. Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol. 2005 Dec; 196(2):224-34.
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• Nakano T, Windrem M, Zappavigna V, Goldman SA. Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons. Dev Biol. 2005 Jul 15; 283(2):474-85.
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• Greene M, Schill K, Takahashi S, Bateman-House A, Beauchamp T, Bok H, Cheney D, Coyle J, Deacon T, Dennett D, Donovan P, Flanagan O, Goldman S, Greely H, Martin L, Miller E, Mueller D, Siegel A, Solter D, Gearhart J, McKhann G, Faden R. Ethics: Moral issues of human-non-human primate neural grafting. Science. 2005 Jul 15; 309(5733):385-6.
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• Goldman S. Stem and progenitor cell-based therapy of the human central nervous system. Nat Biotechnol. 2005 Jul; 23(7):862-71.
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• Goldman SA. Neurology and the stem cell debate. Neurology. 2005 May 24; 64(10):1675-6.
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• Sim FJ, Goldman SA. White matter progenitor cells reside in an oligodendrogenic niche. Ernst Schering Res Found Workshop. 2005; (53):61-81.
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• Goldman SA, Sim F. Neural progenitor cells of the adult brain. Novartis Found Symp. 2005; 265:66-80; discussion 82-97.
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• Goldman SA. Directed mobilization of endogenous neural progenitor cells: the intersection of stem cell biology and gene therapy. Curr Opin Mol Ther. 2004 Oct; 6(5):466-72.
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• Spooner PH, Thai HM, Goldman S, Gaballa MA. Thyroid hormone analog, DITPA, improves endothelial nitric oxide and beta-adrenergic mediated vasorelaxation after myocardial infarction. J Cardiovasc Pharmacol. 2004 Oct; 44(4):453-9.
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• De Tiège X, Goldman S, Laureys S, Verheulpen D, Chiron C, Wetzburger C, Paquier P, Chaigne D, Poznanski N, Jambaqué I, Hirsch E, Dulac O, Van Bogaert P. Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep. Neurology. 2004 Sep 14; 63(5):853-7.
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• Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med. 2004 Aug; 10(8):821-7.
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• Chmielnicki E, Benraiss A, Economides AN, Goldman SA. Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. J Neurosci. 2004 Mar 3; 24(9):2133-42.
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• Roy NS, Nakano T, Keyoung HM, Windrem M, Rashbaum WK, Alonso ML, Kang J, Peng W, Carpenter MK, Lin J, Nedergaard M, Goldman SA. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotechnol. 2004 Mar; 22(3):297-305.
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• Windrem MS, Nunes MC, Rashbaum WK, Schwartz TH, Goodman RA, McKhann G, Roy NS, Goldman SA. Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nat Med. 2004 Jan; 10(1):93-7.
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• Goldman S. Glia as neural progenitor cells. Trends Neurosci. 2003 Nov; 26(11):590-6.
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• Thai H, Wollmuth J, Goldman S, Gaballa M. Angiotensin subtype 1 rReceptor (AT1) blockade improves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor. J Pharmacol Exp Ther. 2003 Dec; 307(3):1171-8.
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• Nedergaard M, Ransom B, Goldman SA. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 2003 Oct; 26(10):523-30.
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• Anderson JL, Krause-Steinrauf H, Goldman S, Clemson BS, Domanski MJ, Hager WD, Murray DR, Mann DL, Massie BM, McNamara DM, Oren R, Rogers WJ. Failure of benefit and early hazard of bucindolol for Class IV heart failure. J Card Fail. 2003 Aug; 9(4):266-77.
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• Packer MA, Stasiv Y, Benraiss A, Chmielnicki E, Grinberg A, Westphal H, Goldman SA, Enikolopov G. Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16):9566-71.
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• Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G, Jiang L, Kang J, Nedergaard M, Goldman SA. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med. 2003 Apr; 9(4):439-47.
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• Windrem MS, Roy NS, Wang J, Nunes M, Benraiss A, Goodman R, McKhann GM, Goldman SA. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain. J Neurosci Res. 2002 Sep 15; 69(6):966-75.
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• Goldman SA, Nedergaard M. Erythropoietin strikes a new cord. Nat Med. 2002 Aug; 8(8):785-7.
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• Bates K, Ruggeroli CE, Goldman S, Gaballa MA. Simvastatin restores endothelial NO-mediated vasorelaxation in large arteries after myocardial infarction. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H768-75.
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• Louissaint A, Rao S, Leventhal C, Goldman SA. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron. 2002 Jun 13; 34(6):945-60.
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• Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M. Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells. J Neurosci. 2002 Jun 1; 22(11):4302-11.
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• Chmielnicki E, Goldman SA. Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain. Prog Brain Res. 2002; 138:451-64.
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• De Witte O, Goldberg I, Wikler D, Rorive S, Damhaut P, Monclus M, Salmon I, Brotchi J, Goldman S. Positron emission tomography with injection of methionine as a prognostic factor in glioma. J Neurosurg. 2001 Nov; 95(5):746-50.
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• Weeks BS, Goldman S, Touma S, Payne M, Cadet P, Stefano GB. Morphine inhibits indolactam V-induced U937 cell adhesion and gelatinase secretion. J Cell Physiol. 2001 Nov; 189(2):179-88.
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• Piper DR, Mujtaba T, Keyoung H, Roy NS, Goldman SA, Rao MS, Lucero MT. Identification and characterization of neuronal precursors and their progeny from human fetal tissue. J Neurosci Res. 2001 Nov 1; 66(3):356-68.
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• Benraiss A, Chmielnicki E, Lerner K, Roh D, Goldman SA. Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J Neurosci. 2001 Sep 1; 21(17):6718-31.
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• Keyoung HM, Roy NS, Benraiss A, Louissaint A, Suzuki A, Hashimoto M, Rashbaum WK, Okano H, Goldman SA. High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nat Biotechnol. 2001 Sep; 19(9):843-50.
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• Sawamoto K, Yamamoto A, Kawaguchi A, Yamaguchi M, Mori K, Goldman SA, Okano H. Direct isolation of committed neuronal progenitor cells from transgenic mice coexpressing spectrally distinct fluorescent proteins regulated by stage-specific neural promoters. J Neurosci Res. 2001 Aug 1; 65(3):220-7.
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• Sawamoto K, Nakao N, Kakishita K, Ogawa Y, Toyama Y, Yamamoto A, Yamaguchi M, Mori K, Goldman SA, Itakura T, Okano H. Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene. J Neurosci. 2001 Jun 1; 21(11):3895-903.
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• Kawaguchi A, Miyata T, Sawamoto K, Takashita N, Murayama A, Akamatsu W, Ogawa M, Okabe M, Tano Y, Goldman SA, Okano H. Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells. Mol Cell Neurosci. 2001 Feb; 17(2):259-73.
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• Levivier M, Wikier D, Goldman S, David P, Metens T, Massager N, Gerosa M, Devriendt D, Desmedt F, Simon S, Van Houtte P, Brotchi J. Integration of the metabolic data of positron emission tomography in the dosimetry planning of radiosurgery with the gamma knife: early experience with brain tumors. Technical note. J Neurosurg. 2000 Dec; 93 Suppl 3:233-8.
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• Massager N, David P, Goldman S, Pirotte B, Wikler D, Salmon I, Nagy N, Brotchi J, Levivier M. Combined magnetic resonance imaging- and positron emission tomography-guided stereotactic biopsy in brainstem mass lesions: diagnostic yield in a series of 30 patients. J Neurosurg. 2000 Dec; 93(6):951-7.
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• Gaballa MA, Goldman S. Gene transfer of endothelial nitric oxide isoform decreases rat hindlimb vascular resistance in vivo. Hum Gene Ther. 2000 Aug 10; 11(12):1637-46.
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• Papadakis V, Dunkel IJ, Cramer LD, Kramer E, Papadopoulos E, Goldman S, Packer RJ, Willoughby M, Baker D, Garvin J, Strandjord S, Coccia P, Kaplan AM, Klemperer M, Finlay JL. High-dose carmustine, thiotepa and etoposide followed by autologous bone marrow rescue for the treatment of high risk central nervous system tumors. Bone Marrow Transplant. 2000 Jul; 26(2):153-60.
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• Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med. 2000 Mar; 6(3):271-7.
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• Roy NS, Benraiss A, Wang S, Fraser RA, Goodman R, Couldwell WT, Nedergaard M, Kawaguchi A, Okano H, Goldman SA. Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J Neurosci Res. 2000 Feb 1; 59(3):321-31.
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• Wang S, Roy NS, Benraiss A, Goldman SA. Promoter-based isolation and fluorescence-activated sorting of mitotic neuronal progenitor cells from the adult mammalian ependymal/subependymal zone. Dev Neurosci. 2000; 22(1-2):167-76.
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• Grafstein B, Liu S, Cotrina ML, Goldman SA, Nedergaard M. Meningeal cells can communicate with astrocytes by calcium signaling. Ann Neurol. 2000 Jan; 47(1):18-25.
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• Roy NS, Wang S, Harrison-Restelli C, Benraiss A, Fraser RA, Gravel M, Braun PE, Goldman SA. Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J Neurosci. 1999 Nov 15; 19(22):9986-95.
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• Simard M, Couldwell WT, Zhang W, Song H, Liu S, Cotrina ML, Goldman S, Nedergaard M. Glucocorticoids-potent modulators of astrocytic calcium signaling. Glia. 1999 Oct; 28(1):1-12.
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• Gaballa MA, Goldman S. Overexpression of endothelium nitric oxide synthase reverses the diminished vasorelaxation in the hindlimb vasculature in ischemic heart failure in vivo. J Mol Cell Cardiol. 1999 Jun; 31(6):1243-52.
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• Leventhal C, Rafii S, Rafii D, Shahar A, Goldman SA. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol Cell Neurosci. 1999 Jun; 13(6):450-64.
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• Williams S, Leventhal C, Lemmon V, Nedergaard M, Goldman SA. Estrogen promotes the initial migration and inception of NgCAM-dependent calcium-signaling by new neurons of the adult songbird brain. Mol Cell Neurosci. 1999 Jan; 13(1):41-55.
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• Kang J, Jiang L, Goldman SA, Nedergaard M. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nat Neurosci. 1998 Dec; 1(8):683-92.
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• Lin JH, Weigel H, Cotrina ML, Liu S, Bueno E, Hansen AJ, Hansen TW, Goldman S, Nedergaard M. Gap-junction-mediated propagation and amplification of cell injury. Nat Neurosci. 1998 Oct; 1(6):494-500.
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• Goldman SA. Adult neurogenesis: from canaries to the clinic. J Neurobiol. 1998 Aug; 36(2):267-86.
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• Jiang J, McMurtry J, Niedzwiecki D, Goldman SA. Insulin-like growth factor-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma. J Neurobiol. 1998 Jul; 36(1):1-15.
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• Pincus DW, Keyoung HM, Harrison-Restelli C, Goodman RR, Fraser RA, Edgar M, Sakakibara S, Okano H, Nedergaard M, Goldman SA. Fibroblast growth factor-2/brain-derived neurotrophic factor-associated maturation of new neurons generated from adult human subependymal cells. Ann Neurol. 1998 May; 43(5):576-85.
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• Pincus DW, Goodman RR, Fraser RA, Nedergaard M, Goldman SA. Neural stem and progenitor cells: a strategy for gene therapy and brain repair. Neurosurgery. 1998 Apr; 42(4):858-67; discussion 867-8.
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• Goldman SA, Luskin MB. Strategies utilized by migrating neurons of the postnatal vertebrate forebrain. Trends Neurosci. 1998 Mar; 21(3):107-14.
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• Wang S, Wu H, Jiang J, Delohery TM, Isdell F, Goldman SA. Isolation of neuronal precursors by sorting embryonic forebrain transfected with GFP regulated by the T alpha 1 tubulin promoter. Nat Biotechnol. 1998 Feb; 16(2):196-201.
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• Goldman SA, Nedergaard M, Crystal RG, Fraser RA, Goodman R, Harrison-Restelli C, Jiang J, Keyoung HM, Leventhal C, Pincus DW, Shahar A, Wang S. Neural precursors and neuronal production in the adult mammalian forebrain. Ann N Y Acad Sci. 1997 Dec 19; 835:30-55.
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• Goldman SA, Kirschenbaum B, Harrison-Restelli C, Thaler HT. Neuronal precursors of the adult rat subependymal zone persist into senescence, with no decline in spatial extent or response to BDNF. J Neurobiol. 1997 Jun 5; 32(6):554-66.
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• Pincus DW, Harrison-Restelli C, Barry J, Goodman RR, Fraser RA, Nedergaard M, Goldman SA. In vitro neurogenesis by adult human epileptic temporal neocortex. Clin Neurosurg. 1997; 44:17-25.
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• Goldman S, Plum F. Compensatory regeneration of the damaged adult human brain: neuroplasticity in a clinical perspective. Adv Neurol. 1997; 73:99-107.
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• De Witte O, Levivier M, Violon P, Salmon I, Damhaut P, Wikler D, Hildebrand J, Brotchi J, Goldman S. Prognostic value positron emission tomography with [18F]fluoro-2-deoxy-D-glucose in the low-grade glioma. Neurosurgery. 1996 Sep; 39(3):470-6; discussion 476-7.
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• Goldman SA, Zukhar A, Barami K, Mikawa T, Niedzwiecki D. Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. J Neurobiol. 1996 Aug; 30(4):505-20.
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• Cool V, Pirotte B, Gérard C, Dargent JL, Baudson N, Levivier M, Goldman S, Hildebrand J, Brotchi J, Velu T. Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. Hum Gene Ther. 1996 Mar 20; 7(5):627-35.
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• Goldman SA, Williams S, Barami K, Lemmon V, Nedergaard M. Transient coupling of Ng-CAM expression to NgCAM-dependent calcium signaling during migration of new neurons in the adult songbird brain. Mol Cell Neurosci. 1996 Jan; 7(1):29-45.
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• Levivier M, Becerra A, De Witte O, Brotchi J, Goldman S. Radiation necrosis or recurrence. J Neurosurg. 1996 Jan; 84(1):148-9.
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• Nedergaard M, Cooper AJ, Goldman SA. Gap junctions are required for the propagation of spreading depression. J Neurobiol. 1995 Dec; 28(4):433-44.
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• Barami K, Iversen K, Furneaux H, Goldman SA. Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J Neurobiol. 1995 Sep; 28(1):82-101.
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• Hidalgo A, Barami K, Iversen K, Goldman SA. Estrogens and non-estrogenic ovarian influences combine to promote the recruitment and decrease the turnover of new neurons in the adult female canary brain. J Neurobiol. 1995 Aug; 27(4):470-87.
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• Gaballa MA, Raya TE, Goldman S. Large artery remodeling after myocardial infarction. Am J Physiol. 1995 May; 268(5 Pt 2):H2092-103.
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• Levivier M, Goldman S, Pirotte B, Brucher JM, Balériaux D, Luxen A, Hildebrand J, Brotchi J. Diagnostic yield of stereotactic brain biopsy guided by positron emission tomography with [18F]fluorodeoxyglucose. J Neurosurg. 1995 Mar; 82(3):445-52.
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• Kirschenbaum B, Goldman SA. Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone. Proc Natl Acad Sci U S A. 1995 Jan 3; 92(1):210-4.
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• Kirschenbaum B, Nedergaard M, Preuss A, Barami K, Fraser RA, Goldman SA. In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cereb Cortex. 1994 Nov-Dec; 4(6):576-89.
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• Barami K, Kirschenbaum B, Lemmon V, Goldman SA. N-cadherin and Ng-CAM/8D9 are involved serially in the migration of newly generated neurons into the adult songbird brain. Neuron. 1994 Sep; 13(3):567-82.
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• Nedergaard M, Goldman SA. Carrier-mediated transport of lactic acid in cultured neurons and astrocytes. Am J Physiol. 1993 Aug; 265(2 Pt 2):R282-9.
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• Goldman SA, Lemmon V, Chin SS. Migration of newly generated neurons upon ependymally derived radial guide cells in explant cultures of the adult songbird forebrain. Glia. 1993 Jul; 8(3):150-60.
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• Goldman SA, Nedergaard M. Newly generated neurons of the adult songbird brain become functionally active in long-term culture. Brain Res Dev Brain Res. 1992 Aug 21; 68(2):217-23.
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• Goldman SA, Zaremba A, Niedzwiecki D. In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. J Neurosci. 1992 Jul; 12(7):2532-41.
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• Nedergaard M, Goldman SA, Desai S, Pulsinelli WA. Acid-induced death in neurons and glia. J Neurosci. 1991 Aug; 11(8):2489-97.
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• Goldman SA. Neuronal development and migration in explant cultures of the adult canary forebrain. J Neurosci. 1990 Sep; 10(9):2931-9.
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• Zaidman GW, Goldman S. A prospective study on the implantation of anterior chamber intraocular lenses during keratoplasty for pseudophakic and aphakic bullous keratopathy. Ophthalmology. 1990 Jun; 97(6):757-62.
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• Goldman SA, Pulsinelli WA, Clarke WY, Kraig RP, Plum F. The effects of extracellular acidosis on neurons and glia in vitro. J Cereb Blood Flow Metab. 1989 Aug; 9(4):471-7.
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• Goldman SA, Gandy SE. Squamous cell carcinoma as a late complication of intracerebroventricular epidermoid cyst. Case report. J Neurosurg. 1987 Apr; 66(4):618-20.
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• Goldman SA, Monahan JW, Schneider BS. The regional and subcellular development of cholecystokinin immunoreactivity in vertebrate brain. Brain Res. 1985 Oct; 354(2):237-46.
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• Vanderhaeghen JJ, Lotstra F, Goldman S, Van Reeth O, Verbanck P, Rossier J. [Colocalization of peptides and classic neurotransmitters in neurons of the central nervous system]. Bull Mem Acad R Med Belg. 1984; 139(1):92-100.
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• Goldman SA, Nottebohm F. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain. Proc Natl Acad Sci U S A. 1983 Apr; 80(8):2390-4.
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• Lorenz DN, Goldman SA. Vagal mediation of the cholecystokinin satiety effect in rats. Physiol Behav. 1982 Oct; 29(4):599-604.
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