Vyacheslav Korshunov
| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Medicine in the Aab Cardiovascular Research Institute |
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| Address | Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta NY 14586
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| 1996 |
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| Honor at the Competition Young Scientists | | 1999 |
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| A Diploma in The Competition Young Scientist (Pharmacist) | | 1999 |
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| 2nd place in the Competition Young Scientist (Pharmacist) | 6th National Russian Congress Man and Medicine | | 2000 |
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| A Travel Award for Young Scientist | | 2001 |
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| Diploma at the II Russian Conference of Young Scientists | | 2003 |
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| Research Recognition Award | American Physiological Society | | 2005 |
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| Finalist of Irvine H. Page Young Investigator Research Award | AHA Council on ATVB | | 2006 |
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| Finalist of the Junior Investigator Award | NAVBO |
Dr. Korshunov's research focuses on vascular biology. First project examines a candidate gene Axl, a receptor tyrosine kinase, in hypertension. Axl is a very promising candidate that regulates both vascular and immune cells in hypertension. Our studies will refine the current concept of the immune response in hypertension. A second project aims to discover causal genes and key pathways of the Glagov phenomenon. Originally described in atherosclerotic patients, Glagov phenomenon is a type of vascular remodeling that preserves the ability of blood to get through the artery. Therapeutic manipulation with vascular remodeling can be crucial for outcomes of cardiovascular diseases, such as heart attacks, strokes and peripheral artery diseases
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Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk BC. Ribosomal Protein L17, RpL17, is an Inhibitor of Vascular Smooth Muscle Growth and Carotid Intima Formation. Circulation. 2012 Nov 13; 126(20):2418-27.
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Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, Leboeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92.
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Smolock EM, Ilyushkina IA, Ghazalpour A, Gerloff J, Murashev AN, Lusis AJ, Korshunov VA. Genetic locus on mouse chromosome 7 controls elevated heart rate. Physiol Genomics. 2012 Jul 3; 44(13):689-98.
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Gerloff J, Korshunov VA. Immune modulation of vascular resident cells by axl orchestrates carotid intima-media thickening. Am J Pathol. 2012 May; 180(5):2134-43.
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Korshunov VA. Axl-dependent signalling: a clinical update. Clin Sci (Lond). 2012 Apr 1; 122(8):361-8.
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Batchu SN, Korshunov VA. Novel tyrosine kinase signaling pathways: implications in vascular remodeling. Curr Opin Nephrol Hypertens. 2012 Mar; 21(2):122-7.
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Smolock EM, Korshunov VA. Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress. Vascul Pharmacol. 2010 Sep-Oct; 53(3-4):185-92.
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Cavet ME, Smolock EM, Menon P, Konishi A, Korshunov VA, Berk BC. Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension. 2010 Jul; 56(1):105-11.
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Zosimovskii VA, Korshunov VA. Return of excitatory waves from field CA1 to the hippocampal formation is facilitated after tetanization of Schäffer collaterals during sleep. Neurosci Behav Physiol. 2010 Mar; 40(3):315-23.
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Chiang HY, Korshunov VA, Serour A, Shi F, Sottile J. Fibronectin is an important regulator of flow-induced vascular remodeling. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1074-9.
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Korshunov VA. A miniature multichannel preamplifier for recording electrophysiological activity in freely moving animals. Neurosci Behav Physiol. 2009 Feb; 39(2):141-5.
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Alexis JD, Wang N, Che W, Lerner-Marmarosh N, Sahni A, Korshunov VA, Zou Y, Ding B, Yan C, Berk BC, Abe J. Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells. Circ Res. 2009 Jan 2; 104(1):69-78.
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Korshunov VA, Berk BC. Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):47-53.
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Korshunov VA, Berk BC. Smooth muscle apoptosis and vascular remodeling. Curr Opin Hematol. 2008 May; 15(3):250-4.
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Zosimovskii VA, Korshunov VA, Markevich VA. Conditions required for the appearance of double responses in hippocampal field CA1 to application of single stimuli to Shäffer collaterals in freely moving rats. Neurosci Behav Physiol. 2008 Mar; 38(3):313-21.
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Korshunov VA, Daul M, Massett MP, Berk BC. Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension. Hypertension. 2007 Dec; 50(6):1057-62.
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Chen C, Korshunov VA, Massett MP, Yan C, Berk BC. Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways. J Vasc Res. 2007; 44(6):504-12.
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Korshunov VA, Schwartz SM, Berk BC. Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1722-8.
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Barker TA, Massett MP, Korshunov VA, Mohan AM, Kennedy AJ, Berk BC. Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade. Hypertension. 2006 Nov; 48(5):942-9.
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Korshunov VA. Microdialysis in freely moving animals with simultaneous recording of electrophysiological processes at the dialysate collection point. Neurosci Behav Physiol. 2006 Jul; 36(6):583-7.
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Korshunov VA, Mohan AM, Georger MA, Berk BC. Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling. Circ Res. 2006 Jun 9; 98(11):1446-52.
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Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C. Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Circ Res. 2006 Mar 31; 98(6):777-84.
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Berk BC, Korshunov VA. Genetic determinants of vascular remodelling. Can J Cardiol. 2006 Feb; 22 Suppl B:6B-11B.
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Plekhanova OS, Solomatina MA, Men'shikov MIu, Bashtrykov PP, Korshunov VA, Berk BS, Tkachuk BA, Parfenova EV. [Plasminogen activators and matrix metalloproteinases during arterial remodeling]. Kardiologiia. 2006; 46(9):47-56.
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Korshunov VA, Nikonenko TA, Tkachuk VA, Brooks A, Berk BC. Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening. Arterioscler Thromb Vasc Biol. 2006 Feb; 26(2):295-300.
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Ezrokhi VL, Korshunov VA, Markevich VA, Voronin LL, Welker E, Zajchenko MI. Stimulation of the lateral hypothalamus provokes the initiation of robust long-term potentiation of the thalamo-cortical input to the barrel field of the adult, freely moving rat. Neurosci Behav Physiol. 2004 Nov; 34(9):919-27.
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Korshunov VA, Solomatina MA, Plekhanova OS, Parfyonova YV, Tkachuk VA, Berk BC. Plasminogen activator expression correlates with genetic differences in vascular remodeling. J Vasc Res. 2004 Nov-Dec; 41(6):481-90.
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Korshunov VA, Berk BC. Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined. Circulation. 2004 Jul 13; 110(2):220-6.
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Konishi A, Aizawa T, Mohan A, Korshunov VA, Berk BC. Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells. J Biol Chem. 2004 Jul 2; 279(27):28766-70.
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Korshunov VA, Massett MP, Carey RM, Berk BC. Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling. J Vasc Res. 2004 Mar-Apr; 41(2):148-56.
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Korshunov VA, Popov VA, Tennova NV, Zosimovskii VA, Markevich VA. [Double evoked responses to the electrical stimulation of Shaffer's collaterals in CA1 hippocampal field]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2004 Mar-Apr; 54(2):183-91.
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Lobanov AV, Rzhevskii DI, Korshunov VA, Murashev AN. Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice. Bull Exp Biol Med. 2004 Feb; 137(2):111-3.
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Korshunov VA, Berk BC. Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening. Arterioscler Thromb Vasc Biol. 2003 Dec; 23(12):2185-91.
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Ezrokhi VL, Korshunov VA, Markevich VA, Voronin LL, Welker E, Zajchenko MI. Stimulation of the lateral hypothalamus provokes the initiation of robust long-term potentiation of the thalamo-cortical input to the barrel field of the adult, freely moving rat. Zh Vyssh Nerv Deiat Im I P Pavlova. 2003 Sep-Oct; 53(5):641-50.
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Murashev AN, Rzhevskii DI, Korshunov VA, Lobanov AV. Arrhythmogenic effects of endothelin-1 under conditions of NO-synthase blockade with L-NAME in NMRI mice. Bull Exp Biol Med. 2003 Apr; 135(4):370-3.
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Korshunov VA. [The problem of adequacy of the methods applying for testing of synaptic plasticity during processes of learning]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2001 Mar-Apr; 51(2):267-78.
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Korshunov VA, Murashev AN, Ivashev MN, Dugin SF, Medvedev OS. [Comparative study of hemodynamic effects of antidepressants (tetrindole and desipramine) during immobilization stress in hypertensive rats]. Eksp Klin Farmakol. 2000 Sep-Oct; 63(5):18-20.
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Korshunov VA, Murashev AN, Ivashev MN, Dugin SF, Medvedev OS. Hemodynamic effects of tetrindol in alert normotensive mice and rats after blockade of nitric oxide synthesis. Bull Exp Biol Med. 2000 Aug; 130(8):777-9.
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Monastyrskaia EA, Murashev AN, Khokhlova ON, Saprunova VB, Korshunov VA, Koshelev VB. [Genetic aspects of arterial hypertension: the role of Y chromosome and mitochondrial DNA]. Ross Fiziol Zh Im I M Sechenova. 2000 Jun; 86(6):671-80.
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Murashev AN, Korshunov VA, Khokhlova ON, Rzhevskii DI, Gmoshinskii IV, Lysikov IuA, Mazo VK. [Quantitative characteristics of the systemic anaphylaxis model in Sprague-Dawley rats]. Ross Fiziol Zh Im I M Sechenova. 2000 Feb; 86(2):190-5.
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Korshunov VA. A micromanipulator for two-channel recording of neuron activity with high-impedance electrodes in freely moving animals. Neurosci Behav Physiol. 1999 Nov-Dec; 29(6):677-80.
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Ezrokhi VL, Zosimovskii VA, Korshunov VA, Markevich VA. Restoration of decaying long-term potentiation in the hippocampal formation by stimulation of neuromodulatory nuclei in freely moving rats. Neuroscience. 1999; 88(3):741-53.
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Markevich VA, Zosimovskii VA, Korshunov VA, Murzina GB, Ezrokhi VL. Identification of a latent state arising in the hippocampus following the cessation of long-term potentiation. Neurosci Behav Physiol. 1994 Sep-Oct; 24(5):394-9.
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