Haodong Xu
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pathology and Laboratory Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Medicine in the Aab Cardiovascular Research Institute |
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| 1982 |
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| 1987 | Excellent Student Award", Suzhou Medical College | | 1982 |
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| 1987 | Class President, Suzhou Medical College | | 1987 |
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| 1990 | Class President for M.S. | | 1992 |
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| Zhou, Wenxun Scholarship | | 1992 |
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| My thesis was given "Outstanding Youth's Thesis Award" at the Sixth Symposium Cardiac Pacing and Electrophysiology, Wuhan, P.R. China | | 1993 |
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| My thesis was given "Excellent Thesis Award" at the Fourth Symposium on Cardiology, Xian, China. | | 1996 |
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| Applications of patch-clamp techniques", third prize from the National Institute of Health in P.R. China. |
My research is focused on delineating the mechanisms in the regulation of voltage-gated potassium channels underlying the cardiac repolarization. Ongoing studies are focused on defining the functional roles of filamin C, an actin binding protein, in the regulation of both voltage-gated potassium channels and cardiac contraction. In addition, my interests also include molecular mechanisms of lung tumor and fibrosing interstitial pneumonia.
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Denby KS, Briones AJ, Bourne PA, Spaulding BO, Lu D, Fischer-Colbrie R, Qu Z, Wang HL, Xu H. IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver. Appl Immunohistochem Mol Morphol. 2012 Dec; 20(6):573-9.
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Schmidt MT, Himmelfarb EA, Shafi H, Lin F, Xu H, Wang HL. Use of IMP3, S100P, and pVHL immunopanel to aid in the interpretation of bile duct biopsies with atypical histology or suspicious for malignancy. Appl Immunohistochem Mol Morphol. 2012 Oct; 20(5):478-87.
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Biwer LA, Broderick TL, Xu H, Carroll C, Hale TM. Protection against L-NAME-induced reduction in cardiac output persists even after cessation of angiotensin-converting enzyme inhibitor treatment. Acta Physiol (Oxf). 2013 Jan; 207(1):156-65.
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Klunder A, Subik K, Ye B, Xu H, Li F. Intimal sarcoma of the abdominal aorta presenting as a retroperitoneal mass. Pathology. 2012 Aug; 44(5):485-7.
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Thunnissen E, Beasley MB, Borczuk AC, Brambilla E, Chirieac LR, Dacic S, Flieder D, Gazdar A, Geisinger K, Hasleton P, Ishikawa Y, Kerr KM, Lantejoul S, Matsuno Y, Minami Y, Moreira AL, Motoi N, Nicholson AG, Noguchi M, Nonaka D, Pelosi G, Petersen I, Rekhtman N, Roggli V, Travis WD, Tsao MS, Wistuba I, Xu H, Yatabe Y, Zakowski M, Witte B, Kuik DJ. Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study. Mod Pathol. 2012 Dec; 25(12):1574-83.
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Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD. CYLD negatively regulates transforming growth factor-ß-signalling via deubiquitinating Akt. Nat Commun. 2012; 3:771.
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Ye B, Ge Y, Perens G, Hong L, Xu H, Fishbein MC, Li F. Canonical Wnt/ß-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction. Cardiovasc Pathol. 2013 Jan; 22(1):54-7.
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Mao W, You T, Ye B, Li X, Dong HH, Hill JA, Li F, Xu H. Reactive Oxygen Species Suppress Cardiac Na(V)1.5 Expression through Foxo1. PLoS One. 2012; 7(2):e32738.
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Li F, Ye B, Hong L, Xu H, Fishbein MC. Epigenetic modifications of histone h4 in lung neuroendocrine tumors. Appl Immunohistochem Mol Morphol. 2011 Oct; 19(5):389-94.
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Levy M, Trivedi A, Zhang J, Miles L, Mattis AN, Kim GE, Lassman C, Anders RA, Misdraji J, Yerian LM, Xu H, Dhall D, Wang HL. Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver. Hum Pathol. 2012 May; 43(5):695-701.
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Ye J, Findeis-Hosey JJ, Yang Q, McMahon LA, Yao JL, Li F, Xu H. Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung. Appl Immunohistochem Mol Morphol. 2011 Jul; 19(4):313-7.
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Findeis-Hosey JJ, Huang J, Li F, Yang Q, McMahon LA, Xu H. High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not. Hum Pathol. 2011 Jun; 42(6):867-72.
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Lin X, Sime PJ, Xu H, Williams MA, LaRussa L, Georas SN, Guo J. Yin yang 1 is a novel regulator of pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1689-97.
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Li F, Wang X, Xu H, Roggli VL. Small neuroendocrine lesions in intrathoracic lymph nodes of patients with primary lung adenocarcinoma: real metastasis? Am J Surg Pathol. 2010 Nov; 34(11):1701-7.
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Findeis-Hosey JJ, Xu H. The use of insulin like-growth factor II messenger RNA binding protein-3 in diagnostic pathology. Hum Pathol. 2011 Mar; 42(3):303-14.
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Hu Y, Yang Q, McMahon LA, Wang HL, Xu H. Value of D2-40 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumor. Appl Immunohistochem Mol Morphol. 2010 Oct; 18(5):411-3.
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Manganaris C, Wittlin S, Xu H, Gurell M, Sime P, Kottmann RM. Metastatic papillary thyroid carcinoma and severe airflow obstruction. Chest. 2010 Sep; 138(3):738-42.
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Johnson MD, Vito F, Xu H, Xu H. MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain. Appl Immunohistochem Mol Morphol. 2010 May; 18(3):250-3.
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Levy M, Lin F, Xu H, Dhall D, Spaulding BO, Wang HL. S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy. Hum Pathol. 2010 Sep; 41(9):1210-9.
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Ling CH, Ji C, Raymond DP, Bourne PA, Xu HD. Uncommon features of pulmonary Langerhans' cell histiocytosis: analysis of 11 cases and a review of the literature. Chin Med J (Engl). 2010 Feb 20; 123(4):498-501.
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Findeis-Hosey JJ, Yang Q, Spaulding BO, Wang HL, Xu H. IMP3 expression is correlated with histologic grade of lung adenocarcinoma. Hum Pathol. 2010 Apr; 41(4):477-84.
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Hu Y, Mahar TJ, Hicks DG, Raymond D, Jones C, Wandtke JC, Powers JM, Xu H. Malignant solitary fibrous tumor: report of 3 cases with unusual features. Appl Immunohistochem Mol Morphol. 2009 Oct; 17(5):451-7.
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Yu L, Xu H, Wasco MJ, Bourne PA, Ma L. IMP-3 expression in melanocytic lesions. J Cutan Pathol. 2010 Mar; 37(3):316-22.
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Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe J, Yan C. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res. 2009 Nov 6; 105(10):956-64.
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Mentrikoski MJ, Ma L, Pryor JG, McMahon LA, Yang Q, Spaulding BO, Scott GA, Wang HL, Xu H. Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes. Mod Pathol. 2009 Dec; 22(12):1582-7.
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Köbel M, Xu H, Bourne PA, Spaulding BO, Shih IeM, Mao TL, Soslow RA, Ewanowich CA, Kalloger SE, Mehl E, Lee CH, Huntsman D, Gilks CB. IGF2BP3 (IMP3) expression is a marker of unfavorable prognosis in ovarian carcinoma of clear cell subtype. Mod Pathol. 2009 Mar; 22(3):469-75.
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Miyamoto H, Jones CE, Raymond DP, Wandtke JC, Strang JG, Bourne PA, Bonfiglio TA, Xu H. Pulmonary metastases from uterine neoplasms after long tumour-free interval: four cases and review of the literature. Pathology. 2009; 41(3):234-41.
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Fallone E, Bourne PA, Watson TJ, Ghossein RA, Travis WD, Xu H. Ectopic (mediastinal) parathyroid adenoma with prominent lymphocytic infiltration. Appl Immunohistochem Mol Morphol. 2009 Jan; 17(1):82-4.
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Simon RA, di Sant'Agnese PA, Huang LS, Xu H, Yao JL, Yang Q, Liang S, Liu J, Yu R, Cheng L, Oh WK, Palapattu GS, Wei J, Huang J. CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Hum Pathol. 2009 Feb; 40(2):252-8.
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Pryor JG, Simon RA, Bourne PA, Spaulding BO, Scott GA, Xu H. Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas. Hum Pathol. 2009 Feb; 40(2):238-43.
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Lester T, Xu H. Malignant pleural mesothelioma with osseous metastases and pathologic fracture of femoral neck. Appl Immunohistochem Mol Morphol. 2008 Oct; 16(5):507-9.
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Gurell MN, Kottmann RM, Xu H, Sime PJ. Exogenous lipoid pneumonia: an unexpected complication of substance abuse. Ann Intern Med. 2008 Sep 2; 149(5):364-5.
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Xu H. IMP3: a diagnostic and prognostic biomarker in malignant melanoma. Expert Rev Mol Diagn. 2008 Sep; 8(5):557-8.
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Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H. Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity. Circ Res. 2008 Aug 1; 103(3):269-78.
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Li L, Xu H, Spaulding BO, Cheng L, Simon R, Yao JL, di Sant'Agnese PA, Bourne PA, Huang J. Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors. Hum Pathol. 2008 Aug; 39(8):1205-11.
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Wagner D, Bourne PA, Yang Q, Goldman BI, Lewis JS, Xu H. Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. Appl Immunohistochem Mol Morphol. 2008 May; 16(3):301-7.
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Hanley KZ, Facik MS, Bourne PA, Yang Q, Spaulding BO, Bonfiglio TA, Xu H. Utility of anti-L523S antibody in the diagnosis of benign and malignant serous effusions. Cancer. 2008 Feb 25; 114(1):49-56.
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Pryor JG, Bourne PA, Yang Q, Spaulding BO, Scott GA, Xu H. IMP-3 is a novel progression marker in malignant melanoma. Mod Pathol. 2008 Apr; 21(4):431-7.
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LaPoint RJ, Bourne PA, Wang HL, Xu H. Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. Appl Immunohistochem Mol Morphol. 2007 Dec; 15(4):401-6.
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Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, Xu H, Ha UH, Xu H, Li JD. Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. PLoS One. 2007; 2(10):e1032.
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Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA, Li JD. Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity. 2007 Aug; 27(2):349-60.
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Simon R, Bourne PA, Yang Q, Spaulding BO, di Sant'Agnese PA, Wang HL, Xu H. Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not. Hum Pathol. 2007 Aug; 38(8):1178-83.
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Xu H, Bourne PA, Spaulding BO, Wang HL. High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do not. Hum Pathol. 2007 Apr; 38(4):555-63.
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Ishinaga H, Jono H, Lim JH, Kweon SM, Xu H, Ha UH, Xu H, Koga T, Yan C, Feng XH, Chen LF, Li JD. TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J. 2007 Feb 21; 26(4):1150-62.
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Yan C, Ding B, Shishido T, Woo CH, Itoh S, Jeon KI, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, Abe J. Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop. Circ Res. 2007 Mar 2; 100(4):510-9.
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Hameed O, Xu H, Saddeghi S, Maluf H. Hepatoid carcinoma of the pancreas: a case report and literature review of a heterogeneous group of tumors. Am J Surg Pathol. 2007 Jan; 31(1):146-52.
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Wagner D, Joseph J, Huang J, Xu H. Malakoplakia of the prostate on needle core biopsy: a case report and review of the literature. Int J Surg Pathol. 2007 Jan; 15(1):86-9.
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Shah AP, Xu H, Sime PJ, Trawick DR. Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome. Eur Respir J. 2006 Dec; 28(6):1276-9.
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Bhagwat SP, Gigliotti F, Xu H, Wright TW. Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1256-66.
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Guo W, Jung WE, Marionneau C, Aimond F, Xu H, Yamada KA, Schwarz TL, Demolombe S, Nerbonne JM. Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res. 2005 Dec 9; 97(12):1342-50.
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Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14771-6.
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Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res. 2005 Feb 4; 96(2):225-33.
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Xu H, Lu DW, El-Mofty SK, Wang HL. Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expression. Hum Pathol. 2004 Nov; 35(11):1419-22.
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Okamoto RJ, Xu H, Kouchoukos NT, Moon MR, Sundt TM. The influence of mechanical properties on wall stress and distensibility of the dilated ascending aorta. J Thorac Cardiovasc Surg. 2003 Sep; 126(3):842-50.
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Goldstein JA, Beardslee MA, Xu H, Sundt TM, Lasala JM. Infective endocarditis resulting from CardioSEAL closure of a patent foramen ovale. Catheter Cardiovasc Interv. 2002 Feb; 55(2):217-20; discussion 221.
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Sundt TM, Moon MR, Xu H. Reoperation for dilatation of the pulmonary autograft after the Ross procedure. J Thorac Cardiovasc Surg. 2001 Dec; 122(6):1249-52.
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Li H, Guo W, Xu H, Hood R, Benedict AT, Nerbonne JM. Functional expression of a GFP-tagged Kv1.5 alpha-subunit in mouse ventricle. Am J Physiol Heart Circ Physiol. 2001 Nov; 281(5):H1955-67.
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Guo W, Xu H, London B, Nerbonne JM. Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. J Physiol. 1999 Dec 15; 521 Pt 3:587-99.
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Xu H, Barry DM, Li H, Brunet S, Guo W, Nerbonne JM. Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit. Circ Res. 1999 Oct 1; 85(7):623-33.
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Xu H, Li H, Nerbonne JM. Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 alpha subunit. J Physiol. 1999 Aug 15; 519 Pt 1:11-21.
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Xu H, Guo W, Nerbonne JM. Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes. J Gen Physiol. 1999 May; 113(5):661-78.
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Barry DM, Xu H, Schuessler RB, Nerbonne JM. Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res. 1998 Sep 7; 83(5):560-7.
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Xu H, Dixon JE, Barry DM, Trimmer JS, Merlie JP, McKinnon D, Nerbonne JM. Developmental analysis reveals mismatches in the expression of K+ channel alpha subunits and voltage-gated K+ channel currents in rat ventricular myocytes. J Gen Physiol. 1996 Nov; 108(5):405-19.
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Xu HD, Qiu CG, Jiang WP. [Studies on electrophysiology of lysophosphatidylcholine and evaluation of its clinical significance]. Zhonghua Nei Ke Za Zhi. 1994 Aug; 33(8):519-23.
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Huang WQ, Xu HD, Wu X, Xu B, Yu ZM. [Role of the central alpha-receptors in the modulation of carotid sinus reflex of rats]. Sheng Li Xue Bao. 1992 Dec; 44(6):556-61.
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Xu HD, Huang WQ, Zhao WW, Xu B, Yu ZM. [Effect of the central noradrenergic system on carotid sinus reflex in rats]. Sheng Li Xue Bao. 1992 Apr; 44(2):127-32.
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