Kim Tieu
| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurology in the Center for Translational Neuromedicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester NY 14642
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The primary interest of my lab is to study the mechanisms of neurodegeneration induced by genetic mutations, environmental toxicants and gene-environment interactions in Parkinson's disease. Our ultimate goal is to utilize this mechanistic knowledge to develop neuroprotective therapies for Parkinson's disease and perhaps other neurodegenerative disorders as well.
Our experimental approach is to use both genetic and toxicant induced cell culture and animal models of Parkinson's disease. Major techniques that are routinely used in our lab include stereotactic surgery, in vivo microdialysis, HPLC, stereological cell counting, confocal imaging, immunohistochemistry and other standard molecular biology methods such as immunoblotting, RT-PCR, gene cloning and more recently, rAAV mediated gene transfer.
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Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6265-70.
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Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA, Tieu K. Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20766-71.
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Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. Cultured astrocytes do not release adenosine during hypoxic conditions. J Cereb Blood Flow Metab. 2012 Jan; 32(1).
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Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S, Tieu K. D-ß-hydroxybutyrate is protective in mouse models of Huntington's disease. PLoS One. 2011; 6(9):e24620.
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Tieu K. A guide to neurotoxic animal models of Parkinson's disease. Cold Spring Harb Perspect Med. 2011 Sep; 1(1):a009316.
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Rappold PM, Tieu K. Astrocytes and therapeutics for Parkinson's disease. Neurotherapeutics. 2010 Oct; 7(4):413-23.
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Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K, Ballatori N. Neurosteroid transport by the organic solute transporter OSTa-OSTß. J Neurochem. 2010 Oct; 115(1):220-33.
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Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010 Jul; 13(7):883-8.
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Cui M, Tang X, Christian WV, Yoon Y, Tieu K. Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J Biol Chem. 2010 Apr 9; 285(15):11740-52.
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Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrané J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K, Przedborski S. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1):378-83.
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Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S, Tieu K. The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):8043-8.
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Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009 Mar; 390(3):191-214.
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Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z, Xia XG. Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Int J Biol Sci. 2007; 3(4):242-50.
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Perier C, Tieu K, Guégan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S, Vila M. Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19126-31.
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Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW, Przedborski S. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. J Neurosci. 2005 Jul 13; 25(28):6594-600.
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Przedborski S, Tieu K, Perier C, Vila M. MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J Bioenerg Biomembr. 2004 Aug; 36(4):375-9.
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Tieu K, Perier C, Vila M, Caspersen C, Zhang HP, Teismann P, Jackson-Lewis V, Stern DM, Yan SD, Przedborski S. L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease. Ann Neurol. 2004 Jul; 56(1):51-60.
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Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V, Ramasamy R, Przedborski S. D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest. 2003 Sep; 112(6):892-901.
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Tieu K, Ischiropoulos H, Przedborski S. Nitric oxide and reactive oxygen species in Parkinson's disease. IUBMB Life. 2003 Jun; 55(6):329-35.
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Teismann P, Vila M, Choi DK, Tieu K, Wu DC, Jackson-Lewis V, Przedborski S. COX-2 and neurodegeneration in Parkinson's disease. Ann N Y Acad Sci. 2003 Jun; 991:272-7.
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Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6145-50.
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Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S. Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5473-8.
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Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V, Przedborski S. Pathogenic role of glial cells in Parkinson's disease. Mov Disord. 2003 Feb; 18(2):121-9.
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Przedborski S, Jackson-Lewis V, Vila M, Wu DC, Teismann P, Tieu K, Choi DK, Cohen O. Free radical and nitric oxide toxicity in Parkinson's disease. Adv Neurol. 2003; 91:83-94.
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Wu DC, Tieu K, Cohen O, Choi DK, Vila M, Jackson-Lewis V, Teismann P, Przedborski S. Glial cell response: A pathogenic factor in Parkinson's disease. J Neurovirol. 2002 Dec; 8(6):551-8.
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Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R, Hen R. Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14524-9.
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Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci. 2002 Mar 1; 22(5):1763-71.
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Vila M, Jackson-Lewis V, Guégan C, Wu DC, Teismann P, Choi DK, Tieu K, Przedborski S. The role of glial cells in Parkinson's disease. Curr Opin Neurol. 2001 Aug; 14(4):483-9.
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Tieu K, Ashe PC, Zuo DM, Yu PH. Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes. Neuroscience. 2001; 103(1):125-32.
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Tieu K, Zuo DM, Yu PH. Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins. J Neurosci Res. 1999 Nov 1; 58(3):426-35.
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Yu PH, Zhang X, Zuo DM, Lai CT, Tieu K, Davis BA, Boulton AA. Aliphatic N-methylpropargylamines as potential neurorescue agents. Restor Neurol Neurosci. 1998 Jun; 12(2-3):113-8.
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