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Sally Quataert

TitleResearch Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology in the Center for Vaccine Biology and Immunology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester NY 14642
 
 Overview
The mission of the Human Immunology Center is to provide expertise for applying new cutting edge immunological techniques from basic animal research through development and standardization to human research. Research in the HIC core laboratory supports exploratory clinical research programs by establishing measures for immune status and response across multiple disciplines and programs.
Standard procedures using 18-color multichromatic flow cytometry for cell analysis and 15-color cell sorting, Elispot, fluorispot and lysispot are available for application to clinical trials including lymphoma, autoimmunity, and infectious disease. New techniques provide insight into T, B, dendritic and antigen presenting cell regulation, activation and interactions. Standardized reagent panels for human cell differentiation and activation markers provide the consistency needed to allow interpretation of complex data from analysis of human immune compartments

 
 Selected Publications
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  1. Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S. Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection. Cytometry A. 2012 Nov; 81(11):937-49.
    View in: PubMed
  2. Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH. Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation. Blood. 2011 Sep 29; 118(13):3591-602.
    View in: PubMed
  3. Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell DJ. Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes. 2011 Aug; 60(8):2125-33.
    View in: PubMed
  4. Mace CR, Topham DJ, Mosmann TR, Quataert SA, Treanor JJ, Miller BL. Label-free, arrayed sensing of immune response to influenza antigens. Talanta. 2011 Jan 15; 83(3):1000-5.
    View in: PubMed
  5. Smith ZJ, Wang JC, Quataert SA, Berger AJ. Integrated Raman and angular scattering microscopy reveals chemical and morphological differences between activated and nonactivated CD8+ T lymphocytes. J Biomed Opt. 2010 May-Jun; 15(3):036021.
    View in: PubMed
  6. Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH. Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. J Immunol. 2009 Nov 15; 183(10):6157-66.
    View in: PubMed
  7. Mosmann TR, Kobie JJ, Lee FE, Quataert SA. T helper cytokine patterns: defined subsets, random expression, and external modulation. Immunol Res. 2009 Dec; 45(2-3):173-84.
    View in: PubMed
  8. Wang JC, Kobie JJ, Zhang L, Cochran M, Mosmann TR, Ritchlin CT, Quataert SA. An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform. J Immunol Methods. 2009 Feb 28; 341(1-2):106-16.
    View in: PubMed
  9. Kyu SY, Kobie J, Yang H, Zand MS, Topham DJ, Quataert SA, Sanz I, Lee FE. Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells. J Immunol Methods. 2009 Jan 1; 340(1):42-7.
    View in: PubMed
  10. Hu BT, Yu X, Jones TR, Kirch C, Harris S, Hildreth SW, Madore DV, Quataert SA. Approach to validating an opsonophagocytic assay for Streptococcus pneumoniae. Clin Diagn Lab Immunol. 2005 Feb; 12(2):287-95.
    View in: PubMed
  11. Sikkema DJ, Ziembiec NA, Jones TR, Hildreth SW, Madore DV, Quataert SA. Assignment of weight-based immunoglobulin G1 (IgG1) and IgG2 units in antipneumococcal reference serum lot 89-S(F) for pneumococcal polysaccharide serotypes 1, 4, 5, 7F, 9V, and 18C. Clin Diagn Lab Immunol. 2005 Jan; 12(1):218-23.
    View in: PubMed
  12. Quataert SA, Rittenhouse-Olson K, Kirch CS, Hu B, Secor S, Strong N, Madore DV. Assignment of weight-based antibody units for 13 serotypes to a human antipneumococcal standard reference serum, lot 89-S(f). Clin Diagn Lab Immunol. 2004 Nov; 11(6):1064-9.
    View in: PubMed
  13. Wernette CM, Frasch CE, Madore D, Carlone G, Goldblatt D, Plikaytis B, Benjamin W, Quataert SA, Hildreth S, Sikkema DJ, Käyhty H, Jonsdottir I, Nahm MH. Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides. Clin Diagn Lab Immunol. 2003 Jul; 10(4):514-9.
    View in: PubMed
  14. Quataert S, Martin D, Anderson P, Giebink GS, Henrichsen J, Leinonen M, Granoff DM, Russell H, Siber G, Faden H, Barnes D, Madore DV. A multi-laboratory evaluation of an enzyme-linked immunoassay quantitating human antibodies to Streptococcus pneumoniae polysaccharides. Immunol Invest. 2001 Aug; 30(3):191-207.
    View in: PubMed
  15. Rennels MB, Edwards KM, Keyserling HL, Reisinger K, Blatter MM, Quataert SA, Madore DV, Chang I, Malinoski FJ, Hackell JG, Paradiso PR. Safety and immunogenicity of four doses of Neisseria meningitidis group C vaccine conjugated to CRM197 in United States infants. Pediatr Infect Dis J. 2001 Feb; 20(2):153-9.
    View in: PubMed
  16. English M, MacLennan JM, Bowen-Morris JM, Deeks J, Boardman M, Brown K, Smith S, Buttery J, Clarke J, Quataert S, Lockhart S, Moxon ER. A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. Vaccine. 2000 Dec 8; 19(9-10):1232-8.
    View in: PubMed
  17. Choo S, Seymour L, Morris R, Quataert S, Lockhart S, Cartwright K, Finn A. Immunogenicity and reactogenicity of a pneumococcal conjugate vaccine administered combined with a haemophilus influenzae type B conjugate vaccine in United Kingdom infants. Pediatr Infect Dis J. 2000 Sep; 19(9):854-62.
    View in: PubMed
  18. Sikkema DJ, Friedman KE, Corsaro B, Kimura A, Hildreth SW, Madore DV, Quataert SA. Relationship between serum bactericidal activity and serogroup-specific immunoglobulin G concentration for adults, toddlers, and infants immunized with Neisseria meningitidis serogroup C vaccines. Clin Diagn Lab Immunol. 2000 Sep; 7(5):764-8.
    View in: PubMed
  19. Madore DV, Quataert SA. Interlaboratory reproducibility of an enzyme-linked immunosorbent assay for quantitation of antibodies for Haemophilus influenzae type b polysaccharide. Clin Diagn Lab Immunol. 1999 May; 6(3):446.
    View in: PubMed
  20. Diakun KR, Martin DC, Mininni T, Skuse J, Ziembiec N, Quataert S. Immunoassay of human Neisseria meningitidis serogroup A antibody. Immunol Invest. 1998 Jul-Sep; 27(4-5):203-20.
    View in: PubMed
  21. Diakun KR, Martin DC, Mininni T, Skuse J, Ziembiec N, Quataert S. Immunoassay of human Neisseria meningitidis serogroup A antibody. Immunol Invest. 1997 Aug-Dec; 26(5-7):661-79.
    View in: PubMed
  22. Maslanka SE, Gheesling LL, Libutti DE, Donaldson KB, Harakeh HS, Dykes JK, Arhin FF, Devi SJ, Frasch CE, Huang JC, Kriz-Kuzemenska P, Lemmon RD, Lorange M, Peeters CC, Quataert S, Tai JY, Carlone GM. Standardization and a multilaboratory comparison of Neisseria meningitidis serogroup A and C serum bactericidal assays. The Multilaboratory Study Group. Clin Diagn Lab Immunol. 1997 Mar; 4(2):156-67.
    View in: PubMed
  23. Quataert SA, Kirch CS, Wiedl LJ, Phipps DC, Strohmeyer S, Cimino CO, Skuse J, Madore DV. Assignment of weight-based antibody units to a human antipneumococcal standard reference serum, lot 89-S. Clin Diagn Lab Immunol. 1995 Sep; 2(5):590-7.
    View in: PubMed
  24. Rustici A, Velucchi M, Faggioni R, Sironi M, Ghezzi P, Quataert S, Green B, Porro M. Molecular mapping and detoxification of the lipid A binding site by synthetic peptides. Science. 1993 Jan 15; 259(5093):361-5.
    View in: PubMed
  25. Carlone GM, Frasch CE, Siber GR, Quataert S, Gheesling LL, Turner SH, Plikaytis BD, Helsel LO, DeWitt WE, Bibb WF, et al. Multicenter comparison of levels of antibody to the Neisseria meningitidis group A capsular polysaccharide measured by using an enzyme-linked immunosorbent assay. J Clin Microbiol. 1992 Jan; 30(1):154-9.
    View in: PubMed
  26. Phipps DC, West J, Eby R, Koster M, Madore DV, Quataert SA. An ELISA employing a Haemophilus influenzae type b oligosaccharide-human serum albumin conjugate correlates with the radioantigen binding assay. J Immunol Methods. 1990 Dec 31; 135(1-2):121-8.
    View in: PubMed
  27. Deich RA, Anilionis A, Fulginiti J, Metcalf BJ, Quataert S, Quinn-Dey T, Zlotnick GW, Green BA. Antigenic conservation of the 15,000-dalton outer membrane lipoprotein PCP of Haemophilus influenzae and biologic activity of anti-PCP antisera. Infect Immun. 1990 Oct; 58(10):3388-93.
    View in: PubMed
  28. Green BA, Metcalf BJ, Quinn-Dey T, Kirkley DH, Quataert SA, Deich RA. A recombinant non-fatty acylated form of the Hi-PAL (P6) protein of Haemophilus influenzae elicits biologically active antibody against both nontypeable and type b H. influenzae. Infect Immun. 1990 Oct; 58(10):3272-8.
    View in: PubMed

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