Roman Eliseev
| Title | Research Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics in the Center for Musculoskeletal Research |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester NY 14642
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| 1987 |
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| 1988 | Freshman Competitive Scholarship | Russian State Medical University | | 1993 |
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| 1995 | Moscow Mayor's Honorary Scholarship | Russian State Medical University | | 1998 |
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| Young Investigator Award | Frontiers of Mitochondrial Research | | 2000 |
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| Young Investigator Award | Frontiers in Mitochondrial Research | | 2001 |
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| Graduate Student Society Research Award | University of Rochester SMD | | 2002 |
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| NIH TRavel Scholarship | Keystone Symposia | | 2004 |
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| 2007 | Wilmot Cancer Research Fellowship | Wilmot Foundation | | 2009 |
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| 2011 | CTSI KL2 Career Award | NCRR/NIH |
My research focuses on mechanisms of therapeutic resistance in cancer in general and in bone cancer, in particular. One such mechanism is suppression of programmed cell death or apoptosis. We are studying 1) signaling pathways, such as NF-kB, leading to prevalence of anti-apoptotic factors; and 2) processes leading to specific glycolytic phenotype found in cancer cells.
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Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. Targeting radioresistant osteosarcoma cells with parthenolide. J Cell Biochem. 2012 Apr; 113(4):1282-91.
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Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley KL, Eliseev RA. Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. J Biol Chem. 2011 Jun 24; 286(25):22331-8.
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Shapovalov Y, Benavidez D, Zuch D, Eliseev RA. Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. Int J Cancer. 2010 Jul 1; 127(1):67-76.
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Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. J Biol Chem. 2009 Apr 10; 284(15):9692-9.
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Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. 2008 Jun 5; 27(25):3605-14.
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Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE. Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition. Neurobiol Aging. 2007 Oct; 28(10):1532-42.
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Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. J Cell Biochem. 2005 Dec 15; 96(6):1262-73.
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Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Gunter TE. Determining the oxidation states of manganese in NT2 cells and cultured astrocytes. Neurobiol Aging. 2006 Dec; 27(12):1816-26.
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Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Exp Cell Res. 2006 Jan 1; 312(1):40-50.
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Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Hammond S, Gunter TE. Determining the oxidation states of manganese in PC12 and nerve growth factor-induced PC12 cells. Free Radic Biol Med. 2005 Jul 15; 39(2):164-81.
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Eliseev RA, Vanwinkle B, Rosier RN, Gunter TE. Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB. J Biol Chem. 2004 Nov 5; 279(45):46748-54.
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Eliseev R, Alexandrov A, Gunter T. High-yield expression and purification of p18 form of Bax as an MBP-fusion protein. Protein Expr Purif. 2004 Jun; 35(2):206-9.
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Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD. Calcium and mitochondria. FEBS Lett. 2004 Jun 1; 567(1):96-102.
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Gunter TE, Miller LM, Gavin CE, Eliseev R, Salter J, Buntinas L, Alexandrov A, Hammond S, Gunter KK. Determination of the oxidation states of manganese in brain, liver, and heart mitochondria. J Neurochem. 2004 Jan; 88(2):266-80.
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Eliseev RA, Gunter KK, Gunter TE. Bcl-2 prevents abnormal mitochondrial proliferation during etoposide-induced apoptosis. Exp Cell Res. 2003 Oct 1; 289(2):275-81.
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Eliseev RA, Salter JD, Gunter KK, Gunter TE. Bcl-2 and tBid proteins counter-regulate mitochondrial potassium transport. Biochim Biophys Acta. 2003 Apr 18; 1604(1):1-5.
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Gunter KK, Miller LM, Aschner M, Eliseev R, Depuis D, Gavin CE, Gunte TE. XANES spectroscopy: a promising tool for toxicology: a tutorial. Neurotoxicology. 2002 Jul; 23(2):127-46.
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Eliseev RA, Gunter KK, Gunter TE. Bcl-2 sensitive mitochondrial potassium accumulation and swelling in apoptosis. Mitochondrion. 2002 Feb; 1(4):361-70.
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Pfeiffer DR, Gunter TE, Eliseev R, Broekemeier KM, Gunter KK. Release of Ca2+ from mitochondria via the saturable mechanisms and the permeability transition. IUBMB Life. 2001 Sep-Nov; 52(3-5):205-12.
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Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiat Res. 2001 Jun; 155(6):847-57.
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Klug A. The Human Genome Project. IUBMB Life. 2001 Jan; 51(1):1-4.
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Gunter TE, Buntinas L, Sparagna G, Eliseev R, Gunter K. Mitochondrial calcium transport: mechanisms and functions. Cell Calcium. 2000 Nov-Dec; 28(5-6):285-96.
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Luk'ianova LD, Eliseev RA, Makarenko TN, Matiushin AI. [The effect of various steroid hormones on Ca2+ transport and oxidative metabolism in isolated mitochondria]. Biull Eksp Biol Med. 1994 Dec; 118(12):616-8.
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