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Lawrence Saubermann

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 667
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
DivisionMedicine - Gastroenterology/Hepatology

 
 Awards And Honors
1987     cum laude Brandeis University
1997     Astra-Merck Advanced Research Training Award American Digestive Health Foundation
1998     Mentored Clinical Scientist Development Award (K08) National Institutes of Health
1998     Physician Post-Doctoral Research Fellowship Award Howard Hughes Medical Institute
1998     Mentored Clinical Scientist Development Award K08  | National Institiute of Health
2001     Appointed Institutional Review Board Committee Member (Panel Green, Active)
2002     Appointed Institutional Review Board Committee Member (Panel Purple, Active)
2002     Appointed Member of New England CCFA Medical Advisory Committee (Active)
2002     Broad Medical Research Program Award Broad Foundation
2003     Senior Research Award Crohn's and Colitis Foundation of America Senior Research Award
2008     Chair of Education, Appointed Member  | CCFA Medical Advisory Committee
2009     Fellowship in American College of Gastroenterology
2010     CCFA Executive Board and CMAC
 
 Overview
Dr. Saubermann is interested in the intestinal mucosal immune system, and how it is involved in Inflammatory Bowel Diseases, such as Crohn's Disease, Ulcerative Colitis, Microscopic/lymphocytic colitis, and Celiac Sprue. He has a number of projects related to inflammatory bowel disease, including clinical research trials with new biologic agents, testing for novel serologic markers of disease activity, and examining the effects of environmental toxins on the mucosal immune system. He is collaborating with other clinical and basic science researchers throughout the university to better understand the mechanisms behind the disease and develop new therapies. In addition, he participates as a co-investigator on a longitudinal countywide database study of inflammatory bowel disease subjects.

 
 Selected Publications
List All   |   Timeline
  1. Stormont JM, Shah AN, Sharma AK, Saubermann LJ, Farmer RG. Colorectal Cancer in IBD Patients. Am J Gastroenterol. 2013 Sep; 108(9):1535.
    View in: PubMed
  2. Roy A, Gaylo A, Cao W, Saubermann LJ, Lawrence BP. Neither direct nor developmental exposure to bisphenol A alters the severity of experimental inflammatory colitis in mice. J Immunotoxicol. 2013 Oct; 10(4):334-40.
    View in: PubMed
  3. Mohanty PH, Sood V, Saubermann LJ. A 16-year-old girl with perianal skin tags. Pediatr Ann. 2012 Jun; 41(6):10-2.
    View in: PubMed
  4. Zhang L, Sun W, Wang J, Zhang M, Yang S, Tian Y, Vidyasagar S, Peña LA, Zhang K, Cao Y, Yin L, Wang W, Zhang L, Schaefer KL, Saubermann LJ, Swarts SG, Fenton BM, Keng PC, Okunieff P. Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. Int J Radiat Oncol Biol Phys. 2010 May 1; 77(1):261-8.
    View in: PubMed
  5. Kobayashi N, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Takahashi H, Yoneda M, Abe Y, Kawamura H, Shimamura T, Kirikoshi H, Kubota K, Sakaguchi T, Saito S, Saubermann LJ, Nakajima A. Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms. J Hepatobiliary Pancreat Surg. 2008; 15(2):169-77.
    View in: PubMed
  6. Kugathasan S, Saubermann LJ, Smith L, Kou D, Itoh J, Binion DG, Levine AD, Blumberg RS, Fiocchi C. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut. 2007 Dec; 56(12):1696-705.
    View in: PubMed
  7. Schaefer KL, Takahashi H, Morales VM, Harris G, Barton S, Osawa E, Nakajima A, Saubermann LJ. PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells. Int J Cancer. 2007 Feb 1; 120(3):702-13.
    View in: PubMed
  8. Probert CS, Saubermann LJ, Balk S, Blumberg RS. Repertoire of the alpha beta T-cell receptor in the intestine. Immunol Rev. 2007 Feb; 215:215-25.
    View in: PubMed
  9. Dendrinos KG, Becker JM, Stucchi AF, Saubermann LJ, LaMorte W, Farraye FA. Anti-Saccharomyces cerevisiae antibodies are associated with the development of postoperative fistulas following ileal pouch-anal anastomosis. J Gastrointest Surg. 2006 Jul-Aug; 10(7):1060-4.
    View in: PubMed
  10. Takahashi H, Fujita K, Fujisawa T, Yonemitsu K, Tomimoto A, Ikeda I, Yoneda M, Masuda T, Schaefer K, Saubermann LJ, Shimamura T, Saitoh S, Tachibana M, Wada K, Nakagama H, Nakajima A. Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties. Cancer Sci. 2006 Sep; 97(9):854-60.
    View in: PubMed
  11. Schaefer KL, Wada K, Takahashi H, Matsuhashi N, Ohnishi S, Wolfe MM, Turner JR, Nakajima A, Borkan SC, Saubermann LJ. Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res. 2005 Mar 15; 65(6):2251-9.
    View in: PubMed
  12. Schaefer KL, Denevich S, Ma C, Cooley SR, Nakajima A, Wada K, Schlezinger J, Sherr D, Saubermann LJ. Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms. Inflamm Bowel Dis. 2005 Mar; 11(3):244-52.
    View in: PubMed
  13. Wada K, Nakajima A, Takahashi H, Yoneda M, Fujisawa N, Ohsawa E, Kadowaki T, Kubota N, Terauchi Y, Matsuhashi N, Saubermann LJ, Nakajima N, Blumberg RS. Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G452-8.
    View in: PubMed
  14. Nakajima A, Wada K, Katayama K, Saubermann L, Osawa E, Nagase H, Ueno N, Matsuhashi N, Aburatani H. Gene expression profile after peroxisome proliferator activator receptor-gamma ligand administration in dextran sodium sulfate mice. J Gastroenterol. 2002 Nov; 37 Suppl 14:62-6.
    View in: PubMed
  15. Saubermann LJ, Nakajima A, Wada K, Zhao S, Terauchi Y, Kadowaki T, Aburatani H, Matsuhashi N, Nagai R, Blumberg RS. Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis. Inflamm Bowel Dis. 2002 Sep; 8(5):330-9.
    View in: PubMed
  16. Probert CS, Chott A, Saubermann LJ, Stevens AC, Balk SP, Blumberg RS. Prevalence of an ulcerative colitis-associated CD8+ T cell receptor beta-chain CDR3-region motif and its association with disease activity. J Clin Immunol. 2001 Mar; 21(2):126-34.
    View in: PubMed
  17. Nakajima A, Wada K, Miki H, Kubota N, Nakajima N, Terauchi Y, Ohnishi S, Saubermann LJ, Kadowaki T, Blumberg RS, Nagai R, Matsuhashi N. Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology. 2001 Feb; 120(2):460-9.
    View in: PubMed
  18. Saubermann LJ. pANCA--is this your final answer? Inflamm Bowel Dis. 2000 Nov; 6(4):332-3.
    View in: PubMed
  19. Mizoguchi A, Mizoguchi E, Saubermann LJ, Higaki K, Blumberg RS, Bhan AK. Limited CD4 T-cell diversity associated with colitis in T-cell receptor alpha mutant mice requires a T helper 2 environment. Gastroenterology. 2000 Oct; 119(4):983-95.
    View in: PubMed
  20. Saubermann LJ, Beck P, De Jong YP, Pitman RS, Ryan MS, Kim HS, Exley M, Snapper S, Balk SP, Hagen SJ, Kanauchi O, Motoki K, Sakai T, Terhorst C, Koezuka Y, Podolsky DK, Blumberg RS. Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 2000 Jul; 119(1):119-28.
    View in: PubMed
  21. Muehlhoefer A, Saubermann LJ, Gu X, Luedtke-Heckenkamp K, Xavier R, Blumberg RS, Podolsky DK, MacDermott RP, Reinecker HC. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol. 2000 Mar 15; 164(6):3368-76.
    View in: PubMed
  22. Blumberg RS, Saubermann LJ, Strober W. Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol. 1999 Dec; 11(6):648-56.
    View in: PubMed
  23. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, Saubermann LJ, Colgan SP. Antigen presentation by intestinal epithelial cells. Immunol Lett. 1999 Jun 15; 69(1):7-11.
    View in: PubMed
  24. Saubermann LJ, Wolf JL. Mesalamine: safe at first look. Inflamm Bowel Dis. 1999 May; 5(2):148-9.
    View in: PubMed
  25. Saubermann LJ, Probert CS, Christ AD, Chott A, Turner JR, Stevens AC, Balk SP, Blumberg RS. Evidence of T cell receptor beta-chain patterns in inflammatory and noninflammatory bowel disease states. Am J Physiol. 1999 Mar; 276(3 Pt 1):G613-21.
    View in: PubMed
  26. Omata F, Itoh T, Shibayama Y, Ide H, Takahashi H, Ueno F, Saubermann LJ, Matsuzaki S. Duodenal variceal bleeding treated with a combination of endoscopic ligation and sclerotherapy. Endoscopy. 1998 Jun; 30(5):S62-3.
    View in: PubMed
  27. Probert CS, Aitken EW, Saubermann LJ, Balk SP, Blumberg RS. T-cell receptor usage in the intestine. Chem Immunol. 1998; 71:27-39.
    View in: PubMed
  28. Probert CS, Christ AD, Saubermann LJ, Turner JR, Chott A, Carr-Locke D, Balk SP, Blumberg RS. Analysis of human common bile duct-associated T cells: evidence for oligoclonality, T cell clonal persistence, and epithelial cell recognition. J Immunol. 1997 Feb 15; 158(4):1941-8.
    View in: PubMed
  29. Probert CS, Chott A, Turner JR, Saubermann LJ, Stevens AC, Bodinaku K, Elson CO, Balk SP, Blumberg RS. Persistent clonal expansions of peripheral blood CD4+ lymphocytes in chronic inflammatory bowel disease. J Immunol. 1996 Oct 1; 157(7):3183-91.
    View in: PubMed

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