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Julie Ryan

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentDermatology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 704
Rochester NY 14642
Other Positions
TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentRadiation Oncology

 
 Awards And Honors
2001 - 2005Environmental Pathology Training Grant (#T32 ES07017)  | University of North Carolina at Chapel Hill, Dept Path & Lab Med
2002     American Society of Investigative Pathology Travel Award, Experimental Biology Meeting
2004     Transportation Grant Award, Univ of North Carolina at Chapel Hill Graduate School  | 11th Biennial Conf of Internat Assoc Res on Epstein-Barr Virus
2004     Pathobiology of Cancer: The Edward A. Smuckler Memorial Workshop  | American Association of Cancer Research
2005 - 2007National Cancer Institute Cancer Control Research Training Fellowship Award, Dept of Radiation Oncology  | James P. Wilmot Cancer Ctr, Univ of Rochester Sch of Med & Dent
2005 - 2007Rochester Clinical Research Fellow, Dept of Community and Preventative Medicine  | University of Rochester School of Med & Dent
2006 - 2010National Institutes of Health Clinical Loan Repayment Program
2007     Investigation New Drug (IND) #75,444 Curcumin C3 Complex, Food & Drug Administration  | Center for Drug Evaluation and Res, Div of Drug Oncology Prod
 
 Overview
Dr. Ryan performs basic and clinical research combining the fields of cancer control, dermatology, and radiation oncology. Dr. Ryan's research primarily focuses on uncovering the biological mechanisms of radiation-induced skin toxicities and developing a successful intervention to reduce these toxicities and improve the quality of life of cancer patients. Radiation dermatitis occurs in about 95% of patients and can negatively affect a patient's quality of life due to pain and premature interruption of radiation treatment. Management of radiation dermatitis has a broader significance as well; it has great importance in the morbidity and mortality expected in any potential "dirty bomb" attack. Curcumin, a component of turmeric, is a potent antioxidant and anti-inflammatory agent. It has been used for many years to treat skin ailments and is currently being used as an anti-cancer agent. Preclinical studies by our group demonstrated that curcumin (oral administration) reduced radiation skin toxicity by 50% in mice. Currently, Dr Ryan has preclinical laboratory studies and clinical trials examining the role of skin barrier dysfunction and reactive oxygen species (ROS) in the severity of radiation skin injury and testing the efficacy of curcumin (both oral and topical administration) as a mitigator of radiation skin injury. As part of the Center for Medical Countermeasures Against Radiation (U19) Program Grant, Dr Ryan is investigating the hypothesis that radiation-induced skin injury involves altered barrier function, haphazard dendritic cell trafficking, and reactive oxygen species (ROS)-mediated damage resulting in chronic inflammation and impeded wound healing. The clarification of the nature of these defects will provide a foundation for mitigating multi-organ damage from radiation. Furthermore, Dr. Ryan performs preclinical testing on other radioprotective/mitigative agents to reduce tissue injury while enhancing the sensitization of tumors to radiation. Additionally, Dr. Ryan is also interested in elucidating the potential physical and psychosocial factors that influence the frequency and severity of skin problems and pain experienced by cancer patients undergoing radiation treatment. She is currently performing a clinical study to test a new survey instrument designed to assess the skin problems and pain experienced by cancer patients undergoing radiation treatment. Besides radiation-induced skin injury, Dr. Ryan is also involved in studies examining ginger as an intervention for chemotherapy-related nausea. After a successful multisite clinical trial through the URCC Community Clinical Oncology Program (CCOP) demonstrated that ginger supplementation (i.e., capsules) significantly reduced acute chemotherapy-induced nausea in cancer patients receiving standard antiemetics during chemotherapy, Dr. Ryan has designed a pilot clinical trial to determine if ginger-scented nasal strips (Aromainhaler®) will be effective against chemotherapy-induced nausea.

 
 Selected Publications
List All   |   Timeline
  1. Ibrahim SF, Ahronowitz I, McCalmont TH, Hernandez Pampaloni M, Ryan JL, Yu SS. 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Imaging in the Management of Merkel Cell Carcinoma: A Single-Institution Retrospective Study. Dermatol Surg. 2013 Sep; 39(9):1323-33.
    View in: PubMed
  2. Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res. 2013 Jul; 180(1):34-43.
    View in: PubMed
  3. Cummings RJ, Gerber SA, Judge JL, Ryan JL, Pentland AP, Lord EM. Exposure to Ionizing Radiation Induces the Migration of Cutaneous Dendritic Cells by a CCR7-Dependent Mechanism. J Immunol. 2012 Nov 1; 189(9):4247-57.
    View in: PubMed
  4. Fox JK, Masia Warner C, Lerner AB, Ludwig K, Ryan JL, Colognori D, Lucas CP, Brotman LM. Preventive intervention for anxious preschoolers and their parents: strengthening early emotional development. Child Psychiatry Hum Dev. 2012 Aug; 43(4):544-59.
    View in: PubMed
  5. Chandwani KD, Ryan JL, Peppone LJ, Janelsins MM, Sprod LK, Devine K, Trevino L, Gewandter J, Morrow GR, Mustian KM. Cancer-related stress and complementary and alternative medicine: a review. Evid Based Complement Alternat Med. 2012; 2012:979213.
    View in: PubMed
  6. Ryan JL, Shen YJ, Morgan DR, Thorne LB, Kenney SC, Dominguez RL, Gulley ML. Epstein-Barr virus infection is common in inflamed gastrointestinal mucosa. Dig Dis Sci. 2012 Jul; 57(7):1887-98.
    View in: PubMed
  7. Ryan JL. Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):985-93.
    View in: PubMed
  8. Ryan JL, Warner CM. Treating adolescents with social anxiety disorder in schools. Child Adolesc Psychiatr Clin N Am. 2012 Jan; 21(1):105-18, ix.
    View in: PubMed
  9. Ryan JL, Krishnan S, Movsas B, Coleman CN, Vikram B, Yoo SS. Decreasing the adverse effects of cancer therapy: an NCI Workshop on the preclinical development of radiation injury mitigators/protectors. Radiat Res. 2011 Nov; 176(5):688-91.
    View in: PubMed
  10. Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, Hickok JT, Morrow GR. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012 Jul; 20(7):1479-89.
    View in: PubMed
  11. Ryan JL, Jones RJ, Kenney SC, Rivenbark AG, Tang W, Knight ER, Coleman WB, Gulley ML. Epstein-Barr virus-specific methylation of human genes in gastric cancer cells. Infect Agent Cancer. 2010; 5:27.
    View in: PubMed
  12. Fox JK, Halpern LF, Ryan JL, Lowe KA. Stressful life events and the tripartite model: relations to anxiety and depression in adolescent females. J Adolesc. 2010 Feb; 33(1):43-54.
    View in: PubMed
  13. Ryan JL, Jones RJ, Elmore SH, Kenney SC, Miller G, Schroeder JC, Gulley ML. Epstein-Barr virus WZhet DNA can induce lytic replication in epithelial cells in vitro, although WZhet is not detectable in many human tissues in vivo. Intervirology. 2009; 52(1):8-16.
    View in: PubMed
  14. Ryan JL, Morgan DR, Dominguez RL, Thorne LB, Elmore SH, Mino-Kenudson M, Lauwers GY, Booker JK, Gulley ML. High levels of Epstein-Barr virus DNA in latently infected gastric adenocarcinoma. Lab Invest. 2009 Jan; 89(1):80-90.
    View in: PubMed
  15. Hawkins NA, Pollack LA, Leadbetter S, Steele WR, Carroll J, Dolan JG, Ryan EP, Ryan JL, Morrow GR. Informational needs of patients and perceived adequacy of information available before and after treatment of cancer. J Psychosoc Oncol. 2008; 26(2):1-16.
    View in: PubMed
  16. Hickok JT, Roscoe JA, Morrow GR, Ryan JL. A Phase II/III Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Ginger (Zingiber officinale) for Nausea Caused by Chemotherapy for Cancer: A Currently Accruing URCC CCOP Cancer Control Study. Support Cancer Ther. 2007 Sep 1; 4(4):247-50.
    View in: PubMed
  17. Ryan JL, Bole C, Hickok JT, Figueroa-Moseley C, Colman L, Khanna RC, Pentland AP, Morrow GR. Post-treatment skin reactions reported by cancer patients differ by race, not by treatment or expectations. Br J Cancer. 2007 Jul 2; 97(1):14-21.
    View in: PubMed
  18. Figueroa-Moseley C, Jean-Pierre P, Roscoe JA, Ryan JL, Kohli S, Palesh OG, Ryan EP, Carroll J, Morrow GR. Behavioral interventions in treating anticipatory nausea and vomiting. J Natl Compr Canc Netw. 2007 Jan; 5(1):44-50.
    View in: PubMed
  19. Ryan JL, Carroll JK, Ryan EP, Mustian KM, Fiscella K, Morrow GR. Mechanisms of cancer-related fatigue. Oncologist. 2007; 12 Suppl 1:22-34.
    View in: PubMed
  20. Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR. Cancer-related fatigue: the scale of the problem. Oncologist. 2007; 12 Suppl 1:4-10.
    View in: PubMed
  21. Roscoe JA, Kaufman ME, Matteson-Rusby SE, Palesh OG, Ryan JL, Kohli S, Perlis ML, Morrow GR. Cancer-related fatigue and sleep disorders. Oncologist. 2007; 12 Suppl 1:35-42.
    View in: PubMed
  22. Ryan JL, Kaufmann WK, Raab-Traub N, Oglesbee SE, Carey LA, Gulley ML. Clonal evolution of lymphoblastoid cell lines. Lab Invest. 2006 Nov; 86(11):1193-200.
    View in: PubMed
  23. Okunieff P, Xu J, Hu D, Liu W, Zhang L, Morrow G, Pentland A, Ryan JL, Ding I. Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Int J Radiat Oncol Biol Phys. 2006 Jul 1; 65(3):890-8.
    View in: PubMed
  24. Iosifescu DV, Nierenberg AA, Mischoulon D, Perlis RH, Papakostas GI, Ryan JL, Alpert JE, Fava M. An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. J Clin Psychiatry. 2005 Aug; 66(8):1038-42.
    View in: PubMed
  25. Papakostas GI, Petersen T, Lebowitz BD, Mischoulon D, Ryan JL, Nierenberg AA, Bottiglieri T, Alpert JE, Rosenbaum JF, Fava M. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol. 2005 Dec; 8(4):523-8.
    View in: PubMed
  26. Thorne LB, Ryan JL, Elmore SH, Glaser SL, Gulley ML. Real-time PCR measures Epstein-Barr Virus DNA in archival breast adenocarcinomas. Diagn Mol Pathol. 2005 Mar; 14(1):29-33.
    View in: PubMed
  27. Ryan JL, Fan H, Glaser SL, Schichman SA, Raab-Traub N, Gulley ML. Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segments: a novel approach to screen for the virus in paraffin-embedded tissue and plasma. J Mol Diagn. 2004 Nov; 6(4):378-85.
    View in: PubMed
  28. Papakostas GI, Petersen T, Mischoulon D, Ryan JL, Nierenberg AA, Bottiglieri T, Rosenbaum JF, Alpert JE, Fava M. Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression. J Clin Psychiatry. 2004 Aug; 65(8):1090-5.
    View in: PubMed
  29. Ryan JL, Fan H, Swinnen LJ, Schichman SA, Raab-Traub N, Covington M, Elmore S, Gulley ML. Epstein-Barr Virus (EBV) DNA in plasma is not encapsidated in patients with EBV-related malignancies. Diagn Mol Pathol. 2004 Jun; 13(2):61-8.
    View in: PubMed
  30. Hoffman M, Loh KL, Bond VK, Palmieri D, Ryan JL, Church FC. Localization of heparin cofactor II in injured human skin: a potential role in wound healing. Exp Mol Pathol. 2003 Oct; 75(2):109-18.
    View in: PubMed
  31. Furmaga WB, Ryan JL, Coleman WB, Cole SR, Tsongalis GJ. Alu profiling of primary and metastatic nonsmall cell lung cancer. Exp Mol Pathol. 2003 Jun; 74(3):224-9.
    View in: PubMed
  32. Yohe HC, Cuny CL, Macala LJ, Saito M, McMurray WJ, Ryan JL. The presence of sialidase-sensitive sialosylgangliotetraosyl ceramide (GM1b) in stimulated murine macrophages. Deficiency of GM1b in Escherichia coli-activated macrophages from the C3H/HeJ mouse. J Immunol. 1991 Mar 15; 146(6):1900-8.
    View in: PubMed
  33. Coleman DL, Culver KE, Ryan JL. Enhancement of macrophage immune and nonimmune receptor-mediated phagocytosis by a low molecular weight soluble factor from resident thymocytes. J Immunol. 1984 Dec; 133(6):3121-7.
    View in: PubMed
  34. Lovett DH, Ryan JL, Sterzel RB. A thymocyte-activating factor derived from glomerular mesangial cells. J Immunol. 1983 Apr; 130(4):1796-801.
    View in: PubMed

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