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Anna Majewska

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
Other Positions
TitleAssociate Professor
InstitutionUniversity of Rochester, River Campus
DepartmentCenter for Visual Science A&S

 
 Awards And Honors
1997     Columbia University award for summer study at Woods Hole - Methods in Computational Neuroscience
1999     Newberry award  | Biological sciences department, Columbia University
2001 - 2004MIT Whiteman Science Fellowship
2003 - 2008Burroughs-Wellcome Fund career development award in the Biomedical Sciences
2003     Young Scientist Award  | Polish Neuroscience Society
2006     Cajal Club Cortical Explorer Award
2007 - 2009Alfred P. Sloan Fellow
2007 - 2010Whitehall research award
2008     National Academy of Sciences' Kavli Fellow  | National Academy of Sciences
2009     Winter Brain Research Conference Travel Fellow  | Winter Brain Research Conference
 
 Overview
Research: Imaging of synaptic structure and function in the visual system.

My lab uses advanced imaging techniques to study the structure and function of single cells in networks in the intact brain. Although a vast literature describes the development and function of neuronal connectivity, most of this work has been carried out in culture and excised or fixed tissue, where dynamic processes are inferred from static images compared across animals. Little is known about the function of subcellular compartments in the computations carried out by neurons in vivo. The goal of our work is to understand structural and functional changes occurring at synapses during plasticity elicited by sensory stimuli.
My specific interests lie in understanding how visual activity shapes the structure and function of connections between neurons in the visual cortex. During the critical period, closure of one eye leads to a shift in the responses of neurons towards the open eye. My labs current work focuses on the structural basis for this rapid ocular dominance plasticity using in vivo two-photon microscopy to elucidate single cell structure deep in the intact brain. Dendritic spines are the postsynaptic structures of most excitatory synapses in the CNS. Interestingly, spine structure is highly dynamic making the precise morphology of the spine a possible candidate for the coding of synaptic strength. By combining structural two-photon imaging with functional intrinsic signal imaging in the ferret and mouse, we can correlate changes in synaptic structure with changes in response properties of the visual cortex. These experiments have shown increased spine motility as well as increased spine and axon terminal turnover following even one day of monocular deprivation. These synaptic changes occur in the absence of changes in gross dendritic or axonal structure, suggesting that fine scale changes in synaptic connectivity underlie rapid ocular dominance plasticity without an overall remodeling of the pre and postsynaptic scaffold.
My lab is also interested in the mechanisms which underlie structural remodeling at synapses. Imaging carried out in reduced preparations such as the acute brain slice allows us to explore the contributions of different pathways to structural plasticity. Our work has shown that both intracellular pathways and the extracellular matrix are involved in the remodeling of the spine during synaptic plasticity.

Selected peer-reviewed recent publications:

Rittenhouse, C., Majewska, A. (2009) "Synaptic mechanisms of activity-dependent remodeling in visual cortex." J. Exp. Neurosci. 2:23-41.
Kelly, E.A., Tremblay, M-E., McCasland, J., Majewska, A. (2010) "Postsynaptic deregulation in GAP-43 HZ mouse barrel cortex." Cerebral Cortex 20(7):1696-707. PMC 2882825
Tremblay, M-E., Lowery, R. L., Majewska, A. (2010) "Experience-dependent interactions between microglia and synapses in the mouse visual cortex in vivo." PLOS Biology 8(11): e1000527. PMC 2970556
Tropea, D.*, Majewska, A.*, Garcia, R., Sur., M. (2010) "Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex" J Neuroscience 30: 11086-95. *equal contribution PMC 2932955
Bogart, L., Levy, A., Gladstone, M., Allen P.D., Zettel, M., Ison, J.R., Luebke, A., Majewska, A. (2011) "Loss of prestin does not alter the development of auditory cortical dendritic spines" Neural Plasticity. Vol. 2011 Article ID 305621
Jeong, J.K., Tremere, L.A., Burrows, K., Majewska, A.K., Pinaud, R. (2011) The primary visual cortex is a site of production and sensitivity to estrogens. Plos One. 6(5):e20400. PMC 3101258
Tremblay, M.E., Majewska, A. (2011) "A role for microglia in synaptic plasticity?" Communicative and Integrative Biology 4(2). PMC 3104585

 
 Selected Publications
List All   |   Timeline
  1. Majewska AK. Imaging visual cortical structure and function in vivo. J Glaucoma. 2013 Jun-Jul; 22 Suppl 5:S21-3.
    View in: PubMed
  2. Sukhotinsky I, Chan AM, Ahmed OJ, Rao VR, Gradinaru V, Ramakrishnan C, Deisseroth K, Majewska AK, Cash SS. Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model. PLoS One. 2013; 8(4):e62013.
    View in: PubMed
  3. Madden KS, Zettel ML, Majewska AK, Brown EB. Brain tumor imaging: live imaging of glioma by two-photon microscopy. Cold Spring Harb Protoc. 2013; 2013(3).
    View in: PubMed
  4. Madden KS, Zettel ML, Majewska AK, Brown EB. Brain tumor imaging: imaging brain metastasis using a brain-metastasizing breast adenocarcinoma. Cold Spring Harb Protoc. 2013; 2013(3).
    View in: PubMed
  5. Tremblay MÈ, Zettel ML, Ison JR, Allen PD, Majewska AK. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia. 2012 Apr; 60(4):541-58.
    View in: PubMed
  6. Yu H, Majewska AK, Sur M. Rapid experience-dependent plasticity of synapse function and structure in ferret visual cortex in vivo. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21235-40.
    View in: PubMed
  7. Mower AF, Kwok S, Yu H, Majewska AK, Okamoto K, Hayashi Y, Sur M. Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21241-6.
    View in: PubMed
  8. Lu SM, Tremblay MÈ, King IL, Qi J, Reynolds HM, Marker DF, Varrone JJ, Majewska AK, Dewhurst S, Gelbard HA. HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One. 2011; 6(9):e23915.
    View in: PubMed
  9. Jeong JK, Tremere LA, Burrows K, Majewska AK, Pinaud R. The mouse primary visual cortex is a site of production and sensitivity to estrogens. PLoS One. 2011; 6(5):e20400.
    View in: PubMed
  10. Bogart LJ, Levy AD, Gladstone M, Allen PD, Zettel M, Ison JR, Luebke AE, Majewska AK. Loss of prestin does not alter the development of auditory cortical dendritic spines. Neural Plast. 2011; 2011:305621.
    View in: PubMed
  11. Tropea D, Sur M, Majewska AK. Experience-dependent plasticity in visual cortex: Dendritic spines and visual responsiveness. Commun Integr Biol. 2011 Mar; 4(2):216-9.
    View in: PubMed
  12. Tremblay MÈ, Majewska AK. A role for microglia in synaptic plasticity? Commun Integr Biol. 2011 Mar; 4(2):220-2.
    View in: PubMed
  13. Kozai TD, Marzullo TC, Hooi F, Langhals NB, Majewska AK, Brown EB, Kipke DR. Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping. J Neural Eng. 2010 Aug; 7(4):046011.
    View in: PubMed
  14. Majewska AK, Sur M. Plasticity and specificity of cortical processing networks. Trends Neurosci. 2006 Jun; 29(6):323-9.
    View in: PubMed
  15. Majewska AK, Newton JR, Sur M. Remodeling of synaptic structure in sensory cortical areas in vivo. J Neurosci. 2006 Mar 15; 26(11):3021-9.
    View in: PubMed
  16. Oray S, Majewska A, Sur M. Effects of synaptic activity on dendritic spine motility of developing cortical layer v pyramidal neurons. Cereb Cortex. 2006 May; 16(5):730-41.
    View in: PubMed
  17. Hayashi Y, Majewska AK. Dendritic spine geometry: functional implication and regulation. Neuron. 2005 May 19; 46(4):529-32.
    View in: PubMed
  18. Oray S, Majewska A, Sur M. Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation. Neuron. 2004 Dec 16; 44(6):1021-30.
    View in: PubMed
  19. Majewska A, Sur M. Motility of dendritic spines in visual cortex in vivo: changes during the critical period and effects of visual deprivation. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):16024-9.
    View in: PubMed
  20. Yuste R, Majewska A. On the function of dendritic spines. Neuroscientist. 2001 Oct; 7(5):387-95.
    View in: PubMed
  21. Majewska A, Tashiro A, Yuste R. Regulation of spine calcium dynamics by rapid spine motility. J Neurosci. 2000 Nov 15; 20(22):8262-8.
    View in: PubMed
  22. Yuste R, Majewska A, Holthoff K. From form to function: calcium compartmentalization in dendritic spines. Nat Neurosci. 2000 Jul; 3(7):653-9.
    View in: PubMed
  23. Majewska A, Brown E, Ross J, Yuste R. Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalization. J Neurosci. 2000 Mar 1; 20(5):1722-34.
    View in: PubMed
  24. Dunaevsky A, Tashiro A, Majewska A, Mason C, Yuste R. Developmental regulation of spine motility in the mammalian central nervous system. Proc Natl Acad Sci U S A. 1999 Nov 9; 96(23):13438-43.
    View in: PubMed
  25. Smetters D, Majewska A, Yuste R. Detecting action potentials in neuronal populations with calcium imaging. Methods. 1999 Jun; 18(2):215-21.
    View in: PubMed
  26. Yuste R, Majewska A, Cash SS, Denk W. Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis. J Neurosci. 1999 Mar 15; 19(6):1976-87.
    View in: PubMed
  27. Murphy GM, Lee YL, Jia XC, Yu AC, Majewska A, Song Y, Schmidt K, Eng LF. Tumor necrosis factor-alpha and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells. J Neurochem. 1995 Dec; 65(6):2716-24.
    View in: PubMed
  28. Murphy GM, Bitting L, Majewska A, Schmidt K, Song Y, Wood CR. Expression of interleukin-11 and its encoding mRNA by glioblastoma cells. Neurosci Lett. 1995 Aug 25; 196(3):153-6.
    View in: PubMed

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