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Edward Brown

TitleAssociate Professor
InstitutionUniversity of Rochester, River Campus
DepartmentBiomedical Engineering
AddressUniversity of Rochester
500 Joseph C. Wilson Blvd.
Box 270168
Rochester NY 14611
Other Positions
TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy

TitleAssociate Professor
InstitutionUniversity of Rochester Medical Center
DepartmentCancer Center

 
 Awards And Honors
1984 - 1988Reynolds Scholarship (full room, full board, full tuition, stipend)  | Wake Forest University
1992     Phi Beta Kappa  | Wake Forest University
1992     Speas Award for Excellence in Physics  | Wake Forest University
2000     AFLAC-AACR Scholars in Cancer Research Award  | AFLAC
2005 - 2010Era of Hope Scholar Award  | Department of Defense Breast Cancer Research Program
2007 - 2011Pew Scholar in the Biomedical Sciences Award  | Pew Charitable Trusts
2009 - 2014NIH Director's New Innovator Award  | NIH
 
 Selected Publications
List All   |   Timeline
  1. Burke RM, Madden KS, Perry SW, Zettel ML, Brown EB. Tumor-associated macrophages and stromal TNF-a regulate collagen structure in a breast tumor model as visualized by second harmonic generation. J Biomed Opt. 2013 Aug 1; 18(8):86003.
    View in: PubMed
  2. Perry SW, Burke RM, Brown EB. Two-photon and second harmonic microscopy in clinical and translational cancer research. Ann Biomed Eng. 2012 Feb; 40(2):277-91.
    View in: PubMed
  3. Madden KS, Szpunar MJ, Brown EB. ß-Adrenergic receptors (ß-AR) regulate VEGF and IL-6 production by divergent pathways in high ß-AR-expressing breast cancer cell lines. Breast Cancer Res Treat. 2011 Dec; 130(3):747-58.
    View in: PubMed
  4. Kozai TD, Marzullo TC, Hooi F, Langhals NB, Majewska AK, Brown EB, Kipke DR. Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping. J Neural Eng. 2010 Aug; 7(4):046011.
    View in: PubMed
  5. Han X, Brown E. Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective. Opt Express. 2010 May 10; 18(10):10538-50.
    View in: PubMed
  6. Sullivan KD, Brown EB. Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching. J Vis Exp. 2010; (36).
    View in: PubMed
  7. Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophys J. 2009 Jul 8; 97(1):330-6.
    View in: PubMed
  8. Sullivan KD, Sipprell WH, Brown EB, Brown EB. Improved model of fluorescence recovery expands the application of multiphoton fluorescence recovery after photobleaching in vivo. Biophys J. 2009 Jun 17; 96(12):5082-94.
    View in: PubMed
  9. Han X, Burke RM, Zettel ML, Tang P, Brown EB. Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma. Opt Express. 2008 Feb 4; 16(3):1846-59.
    View in: PubMed
  10. Schmidt H, Arendt O, Brown EB, Schwaller B, Eilers J. Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones. J Neurochem. 2007 Feb; 100(3):727-35.
    View in: PubMed
  11. Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B. A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy. Microvasc Res. 2005 Nov; 70(3):165-78.
    View in: PubMed
  12. Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med. 2005 Jun; 11(6):678-82.
    View in: PubMed
  13. Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK. Differential transplantability of tumor-associated stromal cells. Cancer Res. 2004 Sep 1; 64(17):5920-4.
    View in: PubMed
  14. Brown EB, Boucher Y, Nasser S, Jain RK. Measurement of macromolecular diffusion coefficients in human tumors. Microvasc Res. 2004 May; 67(3):231-6.
    View in: PubMed
  15. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 2004 Mar 18; 428(6980):328-32.
    View in: PubMed
  16. Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nat Med. 2004 Feb; 10(2):203-7.
    View in: PubMed
  17. Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y. Irradiation reduces interstitial fluid transport and increases the collagen content in tumors. Clin Cancer Res. 2003 Nov 15; 9(15):5508-13.
    View in: PubMed
  18. Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B. Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series. Microvasc Res. 2003 Sep; 66(2):113-25.
    View in: PubMed
  19. Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med. 2003 Jun; 9(6):796-800.
    View in: PubMed
  20. Schmidt H, Brown EB, Schwaller B, Eilers J. Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching. Biophys J. 2003 Apr; 84(4):2599-608.
    View in: PubMed
  21. Wei X, Henke VG, Strübing C, Brown EB, Clapham DE. Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J. 2003 Feb; 84(2 Pt 1):1317-27.
    View in: PubMed
  22. Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res. 2002 Dec 1; 62(23):6831-6.
    View in: PubMed
  23. Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LL. Red blood cells augment leukocyte rolling in a virtual blood vessel. Biophys J. 2002 Oct; 83(4):1834-41.
    View in: PubMed
  24. Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J. 2002 Sep; 83(3):1650-60.
    View in: PubMed
  25. Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002 Jun 7; 296(5574):1883-6.
    View in: PubMed
  26. Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med. 2001 Jul; 7(7):864-8.
    View in: PubMed
  27. Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4628-33.
    View in: PubMed
  28. Majewska A, Brown E, Ross J, Yuste R. Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalization. J Neurosci. 2000 Mar 1; 20(5):1722-34.
    View in: PubMed
  29. Brown EB, Wu ES, Zipfel W, Webb WW. Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery. Biophys J. 1999 Nov; 77(5):2837-49.
    View in: PubMed
  30. Brown EB, Shear JB, Adams SR, Tsien RY, Webb WW. Photolysis of caged calcium in femtoliter volumes using two-photon excitation. Biophys J. 1999 Jan; 76(1 Pt 1):489-99.
    View in: PubMed
  31. Shear JB, Brown EB, Webb WW. Multiphoton-excited fluorescence of fluorogen-labeled neurotransmitters. Anal Chem. 1996 May 15; 68(10):1778-83.
    View in: PubMed

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