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W. Patrick Bernal

TitleClinical Professor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentObstetrics and Gynecology
Address1050 Pittsford-Victor Rd
Pittsford NY 14534
 
 Selected Publications
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  1. Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013 Dec 26; 369(26):2525-34.
    View in: PubMed
  2. Bernal W, Martin-Mateos R, Lipcsey M, Tallis C, Woodsford K, McPhail MJ, Willars C, Auzinger G, Sizer E, Heneghan M, Cottam S, Heaton N, Wendon J. Aerobic capacity during cardiopulmonary exercise testing and survival with and without liver transplantation for patients with chronic liver disease. Liver Transpl. 2014 Jan; 20(1):54-62.
    View in: PubMed
  3. Possamai LA, McPhail MJ, Quaglia A, Zingarelli V, Abeles RD, Tidswell R, Puthucheary Z, Rawal J, Karvellas CJ, Leslie EM, Hughes RD, Ma Y, Jassem W, Shawcross DL, Bernal W, Dharwan A, Heaton ND, Thursz M, Wendon JA, Mitry RR, Antoniades CG. Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*. Crit Care Med. 2013 Nov; 41(11):2543-50.
    View in: PubMed
  4. Higginson IJ, Koffman J, Hopkins P, Prentice W, Burman R, Leonard S, Rumble C, Noble J, Dampier O, Bernal W, Hall S, Morgan M, Shipman C. Development and evaluation of the feasibility and effects on staff, patients, and families of a new tool, the Psychosocial Assessment and Communication Evaluation (PACE), to improve communication and palliative care in intensive care and during clinical uncertainty. BMC Med. 2013; 11:213.
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  5. Slack AJ, Auzinger G, Willars C, Dew T, Musto R, Corsilli D, Sherwood R, Wendon JA, Bernal W. Ammonia clearance with haemofiltration in adults with liver disease. Liver Int. 2014 Jan; 34(1):42-8.
    View in: PubMed
  6. Slack AJ, McPhail MJ, Ostermann M, Bruce M, Sherwood R, Musto R, Dew T, Auzinger G, Bernal W, O'Grady J, Heneghan MA, Moore K, Wendon JA. Predicting the development of acute kidney injury in liver cirrhosis - an analysis of glomerular filtration rate, proteinuria and kidney injury biomarkers. Aliment Pharmacol Ther. 2013 May; 37(10):989-97.
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  7. Bernal W, Hyyrylainen A, Gera A, Audimoolam VK, McPhail MJ, Auzinger G, Rela M, Heaton N, O'Grady JG, Wendon J, Williams R. Lessons from look-back in acute liver failure? A single centre experience of 3300 patients. J Hepatol. 2013 Jul; 59(1):74-80.
    View in: PubMed
  8. Hawton K, Bergen H, Simkin S, Dodd S, Pocock P, Bernal W, Gunnell D, Kapur N. Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses. BMJ. 2013; 346:f403.
    View in: PubMed
  9. Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, Belohradsky BH, Heinz V, Freeman AF, Sullivan KE, Holland SM, Torgerson TR, Al-Herz W, Chou J, Hanson IC, Albert MH, Geha RS, Renner ED, Orange JS. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2013 Mar; 131(3):840-8.
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  10. Gulmez SE, Larrey D, Pageaux GP, Lignot S, Lassalle R, Jové J, Gatta A, McCormick PA, Metselaar HJ, Monteiro E, Thorburn D, Bernal W, Zouboulis-Vafiadis I, de Vries C, Perez-Gutthann S, Sturkenboom M, Bénichou J, Montastruc JL, Horsmans Y, Salvo F, Hamoud F, Micon S, Droz-Perroteau C, Blin P, Moore N. Transplantation for Acute Liver Failure in Patients Exposed to NSAIDs or Paracetamol (Acetaminophen) : The Multinational Case-Population SALT Study. Drug Saf. 2013 Feb; 36(2):135-44.
    View in: PubMed
  11. Walsh S, Diaz-Cano S, Higgins E, Morris-Jones R, Bashir S, Bernal W, Creamer D. Drug reaction with eosinophilia and systemic symptoms: is cutaneous phenotype a prognostic marker for outcome? A review of clinicopathological features of 27 cases. Br J Dermatol. 2013 Feb; 168(2):391-401.
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  12. Taylor NJ, Nishtala A, Manakkat Vijay GK, Abeles RD, Auzinger G, Bernal W, Ma Y, Wendon JA, Shawcross DL. Circulating neutrophil dysfunction in acute liver failure. Hepatology. 2013 Mar; 57(3):1142-52.
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  13. Abeles RD, Taylor NJ, Vijay GK, Ryan J, Tranah TH, Bernal W, Wendon JA, Shawcross DL. Neutrophil CD64 Expression Is Elevated in Acetaminophen-induced Acute Liver Failure. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):1058-9.
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  14. Solís-Muñoz P, López JC, Bernal W, Willars C, Verma A, Heneghan MA, Wendon J, Auzinger G. Voriconazole hepatotoxicity in severe liver dysfunction. J Infect. 2013 Jan; 66(1):80-6.
    View in: PubMed
  15. Antoniades CG, Quaglia A, Taams LS, Mitry RR, Hussain M, Abeles R, Possamai LA, Bruce M, McPhail M, Starling C, Wagner B, Barnardo A, Pomplun S, Auzinger G, Bernal W, Heaton N, Vergani D, Thursz MR, Wendon J. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology. 2012 Aug; 56(2):735-46.
    View in: PubMed
  16. Shawcross DL, Austin MJ, Abeles RD, McPhail MJ, Yeoman AD, Taylor NJ, Portal AJ, Jamil K, Auzinger G, Sizer E, Bernal W, Wendon JA. The impact of organ dysfunction in cirrhosis: survival at a cost? J Hepatol. 2012 May; 56(5):1054-62.
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  17. Daly GM, Bexfield N, Heaney J, Stubbs S, Mayer AP, Palser A, Kellam P, Drou N, Caccamo M, Tiley L, Alexander GJ, Bernal W, Heeney JL. A viral discovery methodology for clinical biopsy samples utilising massively parallel next generation sequencing. PLoS One. 2011; 6(12):e28879.
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  18. Joshi D, Willars C, Bernal W, Wendon J, Auzinger G. Cardiovascular risk assessment of liver transplantation candidates. J Am Coll Cardiol. 2011 Dec 13; 58(25):2700-1; author reply 2701.
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  19. Etogo-Asse FE, Atogo-Asse FE, Vincent RP, Hughes SA, Auzinger G, Le Roux CW, Wendon J, Bernal W. High density lipoprotein in patients with liver failure; relation to sepsis, adrenal function and outcome of illness. Liver Int. 2012 Jan; 32(1):128-36.
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  20. Wendon J, Bernal W, Willars C, Auzinger G. Critical care and cirrhosis: outcome and benefit. Curr Opin Crit Care. 2011 Oct; 17(5):533-7.
    View in: PubMed
  21. Audimoolam VK, Wendon J, Bernal W, Heaton N, O'Grady J, Auzinger G. Iron and acetaminophen a fatal combination? Transpl Int. 2011 Oct; 24(10):e85-8.
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  22. Joshi D, Saha S, Bernal W, Heaton N, Wendon J, Auzinger G. Haemodynamic response to abdominal decompression in acute Budd-Chiari syndrome. Liver Int. 2011 Sep; 31(8):1171-8.
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  23. O'Riordan A, Brummell Z, Sizer E, Auzinger G, Heaton N, O'Grady JG, Bernal W, Hendry BM, Wendon JA. Acute kidney injury in patients admitted to a liver intensive therapy unit with paracetamol-induced hepatotoxicity. Nephrol Dial Transplant. 2011 Nov; 26(11):3501-8.
    View in: PubMed
  24. Bjerring PN, Eefsen M, Larsen FS, Bernal W, Wendon J. Hypermagnesemia does not prevent intracranial hypertension and aggravates cerebral hyperperfusion in a rat model of acute hyperammonemia. Hepatology. 2011 Jun; 53(6):1986-94.
    View in: PubMed
  25. Karvellas CJ, McPhail M, Pink F, Asthana S, Muiesan P, Heaton N, Auzinger G, Bernal W, Eltringham I, Wendon JA. Bloodstream infection after elective liver transplantation is associated with increased mortality in patients with cirrhosis. J Crit Care. 2011 Oct; 26(5):468-74.
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  26. Shawcross DL, Sharifi Y, Canavan JB, Yeoman AD, Abeles RD, Taylor NJ, Auzinger G, Bernal W, Wendon JA. Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis. J Hepatol. 2011 Apr; 54(4):640-9.
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  27. Westbrook RH, Yeoman AD, Joshi D, Heaton ND, Quaglia A, O'Grady JG, Auzinger G, Bernal W, Heneghan MA, Wendon JA. Outcomes of severe pregnancy-related liver disease: refining the role of transplantation. Am J Transplant. 2010 Nov; 10(11):2520-6.
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  28. Donaldson PT, Daly AK, Henderson J, Graham J, Pirmohamed M, Bernal W, Day CP, Aithal GP. Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury. J Hepatol. 2010 Dec; 53(6):1049-53.
    View in: PubMed
  29. Bernal W, Auzinger G, Dhawan A, Wendon J. Acute liver failure. Lancet. 2010 Jul 17; 376(9736):190-201.
    View in: PubMed
  30. McPhail MJ, Wendon JA, Bernal W. Meta-analysis of performance of Kings's College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure. J Hepatol. 2010 Sep; 53(3):492-9.
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  31. Berry PA, Antoniades CG, Hussain MJ, McPhail MJ, Bernal W, Vergani D, Wendon JA. Admission levels and early changes in serum interleukin-10 are predictive of poor outcome in acute liver failure and decompensated cirrhosis. Liver Int. 2010 May; 30(5):733-40.
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  32. Foxton MR, Al-Freah MA, Portal AJ, Sizer E, Bernal W, Auzinger G, Rela M, Wendon JA, Heaton ND, O'Grady JG, Heneghan MA. Increased model for end-stage liver disease score at the time of liver transplant results in prolonged hospitalization and overall intensive care unit costs. Liver Transpl. 2010 May; 16(5):668-77.
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  33. Karvellas CJ, Safinia N, Auzinger G, Heaton N, Muiesan P, O'Grady J, Wendon J, Bernal W. Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study. Liver Int. 2010 Jul; 30(6):826-33.
    View in: PubMed
  34. Bernal W. Lactate is important in determining prognosis in acute liver failure. J Hepatol. 2010 Jul; 53(1):209-10.
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  35. Karvellas CJ, Pink F, McPhail M, Austin M, Auzinger G, Bernal W, Sizer E, Kutsogiannis DJ, Eltringham I, Wendon JA. Bacteremia, acute physiology and chronic health evaluation II and modified end stage liver disease are independent predictors of mortality in critically ill nontransplanted patients with acute on chronic liver failure. Crit Care Med. 2010 Jan; 38(1):121-6.
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  36. Auzinger G, Bernal W, Wendon J. Comment on "Relationship between gas exchange response to prone position and lung recruitability during acute respiratory failure". Intensive Care Med. 2010 Jan; 36(1):177; author reply 178-9.
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  37. Vincent RP, Etogo-Asse FE, Dew T, Bernal W, Alaghband-Zadeh J, le Roux CW. Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairment. Ann Clin Biochem. 2009 Nov; 46(Pt 6):505-7.
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  38. Joshi D, Sizer E, Bernal W, Wendon J, Auzinger G. High values of intrathoracic blood volume in hepatopulmonary syndrome. Crit Care Resusc. 2009 Jun; 11(2):129-31.
    View in: PubMed
  39. Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul; 41(7):816-9.
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  40. Karvellas CJ, Pink F, McPhail M, Cross T, Auzinger G, Bernal W, Sizer E, Kutsogiannis DJ, Eltringham I, Wendon JA. Predictors of bacteraemia and mortality in patients with acute liver failure. Intensive Care Med. 2009 Aug; 35(8):1390-6.
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  41. Bernal W, Cross TJ, Auzinger G, Sizer E, Heneghan MA, Bowles M, Muiesan P, Rela M, Heaton N, Wendon J, O'Grady JG. Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience. J Hepatol. 2009 Feb; 50(2):306-13.
    View in: PubMed
  42. Bernal W, Auzinger G, Wendon J. Prognostic utility of the bilirubin lactate and etiology score. Clin Gastroenterol Hepatol. 2009 Feb; 7(2):249; author reply 249.
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  43. Berry PA, Bernal W, Pagliuca A, Sizer E, Salisbury JR, Wendon JA, Auzinger G. Multiple organ failure and severe bone marrow dysfunction in two 18 year-old Caucasian patients: Epstein-Barr virus and the haemophagocytic syndrome. Anaesthesia. 2008 Nov; 63(11):1249-54.
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  44. Bernal W, Auzinger G, Sizer E, Wendon J. Intensive care management of acute liver failure. Semin Liver Dis. 2008 May; 28(2):188-200.
    View in: PubMed
  45. Al-Chalabi T, Portmann BC, Bernal W, McFarlane IG, Heneghan MA. Autoimmune hepatitis overlap syndromes: an evaluation of treatment response, long-term outcome and survival. Aliment Pharmacol Ther. 2008 Jul; 28(2):209-20.
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  46. Bernal W, Auzinger G, Sizer E, Wendon J. Variation in blood ammonia concentration with site of measurement and evidence of brain and muscle uptake in patients with acute liver failure. Liver Int. 2008 Mar; 28(3):415-7.
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  47. Bernal W, Meda F, Ma Y, Bogdanos DP, Vergani D. Disease-specific autoantibodies in patients with acute liver failure: the King's College London Experience. Hepatology. 2008 Mar; 47(3):1096-7; author reply 1097.
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  48. Bernal W, Hall C, Karvellas CJ, Auzinger G, Sizer E, Wendon J. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology. 2007 Dec; 46(6):1844-52.
    View in: PubMed
  49. Antoniades CG, Berry PA, Bruce M, Cross TJ, Portal AJ, Hussain MJ, Bernal W, Wendon JA, Vergani D. Actin-free Gc globulin: a rapidly assessed biomarker of organ dysfunction in acute liver failure and cirrhosis. Liver Transpl. 2007 Sep; 13(9):1254-61.
    View in: PubMed
  50. Shawcross D, Knighton S, Bernal W, Sizer E, Auzinger G. Old versus new antiepileptic drugs: the SANAD study. Lancet. 2007 Jul 28; 370(9584):314-5; author reply 315-6.
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  51. Bernal W, Ma Y, Smith HM, Portmann B, Wendon J, Vergani D. The significance of autoantibodies and immunoglobulins in acute liver failure: a cohort study. J Hepatol. 2007 Nov; 47(5):664-70.
    View in: PubMed
  52. Karvellas CJ, Bernal W, Wendon J, Auzinger G. Comment on Camus et al.: "Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation". Intensive Care Med. 2007 Jun; 33(6):1102-3; author reply 1104-5.
    View in: PubMed
  53. Auzinger G, O'Callaghan GP, Bernal W, Sizer E, Wendon JA. Percutaneous tracheostomy in patients with severe liver disease and a high incidence of refractory coagulopathy: a prospective trial. Crit Care. 2007; 11(5):R110.
    View in: PubMed
  54. Antoniades CG, Berry PA, Davies ET, Hussain M, Bernal W, Vergani D, Wendon J. Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure. Hepatology. 2006 Jul; 44(1):34-43.
    View in: PubMed
  55. Bernal W, Wendon J. Cell-free artificial liver support: design of appropriate clinical studies. Ther Apher Dial. 2006 Apr; 10(2):175-9.
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  56. Hawton K, Simkin S, Deeks J, Cooper J, Johnston A, Waters K, Arundel M, Bernal W, Gunson B, Hudson M, Suri D, Simpson K. UK legislation on analgesic packs: before and after study of long term effect on poisonings. BMJ. 2004 Nov 6; 329(7474):1076.
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  57. Bernal W, Wendon J. Liver transplantation in adults with acute liver failure. J Hepatol. 2004 Feb; 40(2):192-7.
    View in: PubMed
  58. Bernal W. Intensive care support therapy. Liver Transpl. 2003 Sep; 9(9):S15-7.
    View in: PubMed
  59. Bernal W, Wendon J. More on serum phosphate and prognosis of acute liver failure. Hepatology. 2003 Aug; 38(2):533-4.
    View in: PubMed
  60. Bernal W. Changing patterns of causation and the use of transplantation in the United kingdom. Semin Liver Dis. 2003 Aug; 23(3):227-37.
    View in: PubMed
  61. Bernal W, Donaldson N, Wyncoll D, Wendon J. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Lancet. 2002 Feb 16; 359(9306):558-63.
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  62. Donaldson PT, Norris S, Constantini PK, Bernal W, Harrison P, Williams R. The interleukin-1 and interleukin-10 gene polymorphisms in primary sclerosing cholangitis: no associations with disease susceptibility/resistance. J Hepatol. 2000 Jun; 32(6):882-6.
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  63. Bernal W, Wendon J. Acute liver failure. Curr Opin Anaesthesiol. 2000 Apr; 13(2):113-8.
    View in: PubMed
  64. Cookson S, Constantini PK, Clare M, Underhill JA, Bernal W, Czaja AJ, Donaldson PT. Frequency and nature of cytokine gene polymorphisms in type 1 autoimmune hepatitis. Hepatology. 1999 Oct; 30(4):851-6.
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  65. Bernal W, Wendon J. Acute liver failure; clinical features and management. Eur J Gastroenterol Hepatol. 1999 Sep; 11(9):977-84.
    View in: PubMed
  66. Bernal W, Moloney M, Underhill J, Donaldson PT. Association of tumor necrosis factor polymorphism with primary sclerosing cholangitis. J Hepatol. 1999 Feb; 30(2):237-41.
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  67. Bernal W, Donaldson P, Underhill J, Wendon J, Williams R. Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. J Hepatol. 1998 Jul; 29(1):53-9.
    View in: PubMed
  68. Bernal W, Wendon J, Rela M, Heaton N, Williams R. Use and outcome of liver transplantation in acetaminophen-induced acute liver failure. Hepatology. 1998 Apr; 27(4):1050-5.
    View in: PubMed
  69. Makin AJ, Williams R, Bernal W. Acetaminophen toxicity in an urban county hospital. N Engl J Med. 1998 Feb 19; 338(8):544; author reply 544-5.
    View in: PubMed
  70. Bernal W, Smith HM, Williams R. A community prevalence study of antibodies to hepatitis A and E in inner-city London. J Med Virol. 1996 Jul; 49(3):230-4.
    View in: PubMed

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