Tzong-jen Sheu
| Title | Research Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics in the Center for Musculoskeletal Research |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester NY 14642
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Mi M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D. Chondrocyte BMP2 signaling plays an essential role in bone fracture healing. Gene. 2013 Jan 10; 512(2):211-8.
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Metz-Estrella D, Jonason JH, Sheu TJ, Mroczek-Johnston RM, Puzas JE. TRIP-1: A regulator of osteoblast function. J Bone Miner Res. 2012 Jul; 27(7):1576-84.
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Mi M, Shi S, Li T, Holz J, Lee YJ, Sheu TJ, Liao Q, Xiao T. TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus. Biochem Biophys Res Commun. 2012 Jun 29; 423(2):366-72.
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Holz JD, Beier E, Sheu TJ, Ubayawardena R, Wang M, Sampson ER, Rosier RN, Zuscik M, Puzas JE. Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-ß signaling. J Orthop Res. 2012 Nov; 30(11):1760-6.
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Ting HJ, Yasmin-Karim S, Yan SJ, Hsu JW, Lin TH, Zeng W, Messing J, Sheu TJ, Bao BY, Li WX, Messing E, Lee YF. A Positive Feedback Signaling Loop between ATM and the Vitamin D Receptor Is Critical for Cancer Chemoprevention by Vitamin D. Cancer Res. 2012 Feb 15; 72(4):958-68.
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Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. J Bone Miner Res. 2011 Apr; 26(4):792-802.
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Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ. Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. Arthritis Rheum. 2010 Aug; 62(8):2359-69.
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Tang DZ, Hou W, Zhou Q, Zhang M, Holz J, Sheu TJ, Li TF, Cheng SD, Shi Q, Harris SE, Chen D, Wang YJ. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun; 25(6):1234-45.
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Tsai CH, Chiu SJ, Liu CC, Sheu TJ, Hsieh CH, Keng PC, Lee YJ. Regulated expression of cofilin and the consequent regulation of p27(kip1) are essential for G(1) phase progression. Cell Cycle. 2009 Aug; 8(15):2365-74.
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Matsuzawa M, Sheu TJ, Lee YJ, Chen M, Li TF, Huang CT, Holz JD, Puzas JE. Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway. J Periodontal Res. 2009 Jun; 44(3):289-96.
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Lee YJ, Tsai CH, Hwang JJ, Chiu SJ, Sheu TJ, Keng PC. Involvement of a p53-independent and post-transcriptional up-regulation for p21WAF/CIP1 following destabilization of the actin cytoskeleton. Int J Oncol. 2009 Feb; 34(2):581-9.
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Zhang M, Zhou Q, Liang QQ, Li CG, Holz JD, Tang D, Sheu TJ, Li TF, Shi Q, Wang YJ. IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways. Osteoarthritis Cartilage. 2009 Jan; 17(1):100-6.
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Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci. 2008 May 1; 121(Pt 9):1455-65.
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Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J Bone Miner Res. 2007 Oct; 22(10):1571-80.
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Holz JD, Sheu TJ, Drissi H, Matsuzawa M, Zuscik MJ, Puzas JE. Environmental agents affect skeletal growth and development. Birth Defects Res C Embryo Today. 2007 Mar; 81(1):41-50.
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Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis. 2007 Jan; 45(1):44-50.
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Brouxhon S, Konger RL, VanBuskirk J, Sheu TJ, Ryan J, Erdle B, Almudevar A, Breyer RM, Scott G, Pentland AP. Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness. J Invest Dermatol. 2007 Feb; 127(2):439-46.
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Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J Biol Chem. 2006 Jul 28; 281(30):21296-304.
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Lee YJ, Sheu TJ, Keng PC. Enhancement of radiosensitivity in H1299 cancer cells by actin-associated protein cofilin. Biochem Biophys Res Commun. 2005 Sep 23; 335(2):286-91.
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Yu HM, Jerchow B, Sheu TJ, Liu B, Costantini F, Puzas JE, Birchmeier W, Hsu W. The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development. 2005 Apr; 132(8):1995-2005.
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Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. J Cell Biochem. 2004 May 15; 92(2):316-31.
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Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem. 2003 Dec 15; 90(6):1287-98.
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Coskunfirat OK, Sheu TJ, Jeng SF, Wei FC. Reconstruction of Achilles tendon and overlying skin with composite groin-fascial free flap: a case report of 14-year follow-up. Plast Reconstr Surg. 2003 Jul; 112(1):215-9.
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Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology. 2003 Jun; 144(6):2514-23.
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Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. A phage display technique identifies a novel regulator of cell differentiation. J Biol Chem. 2003 Jan 3; 278(1):438-43.
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Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):237-41.
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Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. J Bone Miner Res. 2002 May; 17(5):915-22.
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Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Radiat Res. 2002 Jan; 157(1):62-8.
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Liu SH, Sheu TJ. The in vivo effect of lipopolysaccharide on Na+,K(+)-ATPase catalytic (alpha) subunit isoforms in rat sciatic nerve. Neurosci Lett. 1997 Oct 3; 234(2-3):166-8.
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Liu SH, Sheu TJ, Lin RH, Lin-Shiau SY. The in vivo effect of lipopolysaccharide on the spontaneous release of transmitter from motor nerve terminals. Br J Pharmacol. 1995 Sep; 116(2):1757-60.
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Du CL, Kuo ML, Chang HL, Sheu TJ, Wang JD. Changes in lymphocyte single strand breakage and liver function of workers exposed to vinyl chloride monomer. Toxicol Lett. 1995 May; 77(1-3):379-85.
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