J. Edward Puzas
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics in the Center for Musculoskeletal Research |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester NY 14642
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| Title | Senior Associate Dean, Basic Research |
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| Institution | School of Medicine and Dentistry |
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| Department | Dean's Office, SMD |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biochemistry and Biophysics |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Engineering |
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Environmental Medicine |
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Metz-Estrella D, Jonason JH, Sheu TJ, Mroczek-Johnston RM, Puzas JE. TRIP-1: A regulator of osteoblast function. J Bone Miner Res. 2012 Jul; 27(7):1576-84.
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Kneiss JA, Houck JR, Bukata SV, Puzas JE. Influence of Upper Extremity Assistance on Lower Extremity Force Application Symmetry in Individuals Post-Hip Fracture During the Sit-to-Stand Task. J Orthop Sports Phys Ther. 2012; 42(5):474-81.
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Holz JD, Beier E, Sheu TJ, Ubayawardena R, Wang M, Sampson ER, Rosier RN, Zuscik M, Puzas JE. Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-ß signaling. J Orthop Res. 2012 Nov; 30(11):1760-6.
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Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med. 2011 Sep 21; 3(101):101ra93.
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Houck J, Kneiss J, Bukata SV, Puzas JE. Analysis of vertical ground reaction force variables during a Sit to Stand task in participants recovering from a hip fracture. Clin Biomech (Bristol, Avon). 2011 Jun; 26(5):470-6.
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Bukata SV, Puzas JE. Orthopedic uses of teriparatide. Curr Osteoporos Rep. 2010 Mar; 8(1):28-33.
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Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D. Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. J Cell Sci. 2009 Oct 1; 122(Pt 19):3566-78.
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Matsuzawa M, Sheu TJ, Lee YJ, Chen M, Li TF, Huang CT, Holz JD, Puzas JE. Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway. J Periodontal Res. 2009 Jun; 44(3):289-96.
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Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res. 2009 Feb; 24(2):251-64.
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Fiorentino PM, Tallents RH, Miller JN, Brouxhon SM, O'Banion MK, Puzas JE, Kyrkanides S. Spinal interleukin-1beta in a mouse model of arthritis and joint pain. Arthritis Rheum. 2008 Oct; 58(10):3100-9.
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Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN. Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum. 2008 Oct; 58(10):3132-44.
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Elfar JC, Jacobson JA, Puzas JE, Rosier RN, Zuscik MJ. Erythropoietin accelerates functional recovery after peripheral nerve injury. J Bone Joint Surg Am. 2008 Aug; 90(8):1644-53.
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Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. J Orthop Res. 2008 Jan; 26(1):96-105.
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Kyrkanides S, Kambylafkas P, Miller JH, Tallents RH, Puzas JE. The cranial base in craniofacial development: a gene therapy study. J Dent Res. 2007 Oct; 86(10):956-61.
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Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J Bone Miner Res. 2007 Oct; 22(10):1571-80.
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Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations. Environ Health Perspect. 2007 Sep; 115(9):1276-82.
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Kyrkanides S, Fiorentino PM, Miller JN, Gan Y, Lai YC, Shaftel SS, Puzas JE, Piancino MG, O'Banion MK, Tallents RH. Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint. Arthritis Rheum. 2007 Jun; 56(6):2038-48.
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Skulan J, Bullen T, Anbar AD, Puzas JE, Shackelford L, LeBlanc A, Smith SM. Natural calcium isotopic composition of urine as a marker of bone mineral balance. Clin Chem. 2007 Jun; 53(6):1155-8.
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Holz JD, Sheu TJ, Drissi H, Matsuzawa M, Zuscik MJ, Puzas JE. Environmental agents affect skeletal growth and development. Birth Defects Res C Embryo Today. 2007 Mar; 81(1):41-50.
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Dai CY, Haqq CM, Puzas JE. Molecular correlates of site-specific metastasis. Semin Radiat Oncol. 2006 Apr; 16(2):102-10.
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Lai YC, Shaftel SS, Miller JN, Tallents RH, Chang Y, Pinkert CA, Olschowka JA, Dickerson IM, Puzas JE, O'Banion MK, Kyrkanides S. Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain. Arthritis Rheum. 2006 Apr; 54(4):1184-97.
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Puzas JE, Houck J, Bukata SV. Accelerated fracture healing. J Am Acad Orthop Surg. 2006; 14(10 Spec No.):S145-51.
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Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival. FEBS Lett. 2005 Dec 19; 579(30):6814-20.
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Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. 2005 Jun; 113(6):749-55.
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Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. Cancer Res. 2005 Apr 15; 65(8):3209-17.
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Yu HM, Jerchow B, Sheu TJ, Liu B, Costantini F, Puzas JE, Birchmeier W, Hsu W. The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development. 2005 Apr; 132(8):1995-2005.
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Campbell JR, Rosier RN, Novotny L, Puzas JE. The association between environmental lead exposure and bone density in children. Environ Health Perspect. 2004 Aug; 112(11):1200-3.
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Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ. Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo. J Orthop Res. 2004 Jul; 22(4):687-96.
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Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. J Cell Biochem. 2004 May 15; 92(2):316-31.
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Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone. 2004 May; 34(5):809-17.
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Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol. 2004 Mar; 198(3):428-40.
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Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. J Orthop Res. 2004 Jan; 22(1):6-12.
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Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem. 2003 Dec 15; 90(6):1287-98.
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Puzas JE. Biology and pathology of the temporomandibular joint: is there an animal model to study this affliction? J Musculoskelet Neuronal Interact. 2003 Dec; 3(4):395-400; discussion 406-7.
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Puzas JE, O'Keefe RJ, Schwarz EM, Zhang X. Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition. J Musculoskelet Neuronal Interact. 2003 Dec; 3(4):308-12; discussion 320-1.
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Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN. The mevalonate synthesis pathway as a therapeutic target in cancer. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S59-66.
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Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S75-85.
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Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003 Sep; 18(9):1593-604.
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Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. J Orthop Res. 2003 Sep; 21(5):908-13.
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Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. Exp Cell Res. 2003 Aug 1; 288(1):198-207.
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Boyan BD, Schwartz Z, Lohmann CH, Sylvia VL, Cochran DL, Dean DD, Puzas JE. Pretreatment of bone with osteoclasts affects phenotypic expression of osteoblast-like cells. J Orthop Res. 2003 Jul; 21(4):638-47.
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Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology. 2003 Jun; 144(6):2514-23.
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Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN. Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB. Cancer Lett. 2003 May 8; 194(1):37-43.
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Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. A phage display technique identifies a novel regulator of cell differentiation. J Biol Chem. 2003 Jan 3; 278(1):438-43.
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Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):237-41.
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Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A. J Orthop Res. 2002 Sep; 20(5):1079-90.
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Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. J Orthop Res. 2002 Jul; 20(4):811-8.
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Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles. J Orthop Res. 2002 Jul; 20(4):714-22.
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Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Exp Cell Res. 2002 Jun 10; 276(2):310-9.
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Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest. 2002 Jun; 109(11):1405-15.
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Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. J Bone Miner Res. 2002 May; 17(5):915-22.
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Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis Rheum. 2002 May; 46(5):1298-308.
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Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN. Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis. Clin Orthop Relat Res. 2002 Apr; (397):228-39.
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Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors. J Surg Oncol. 2002 Mar; 79(3):174-9.
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Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res. 2002 Mar; 20(2):169-73.
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Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res. 2002 Feb; 17(2):192-9.
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Zhang D, Ferguson CM, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. A role for the BMP antagonist chordin in endochondral ossification. J Bone Miner Res. 2002 Feb; 17(2):293-300.
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Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Radiat Res. 2002 Jan; 157(1):62-8.
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Puzas JE, O'Keefe RJ, Lieberman JR. The orthopaedic genome: what does the future hold and are we ready? J Bone Joint Surg Am. 2002 Jan; 84-A(1):133-41.
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Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res. 2002 Jan; 20(1):159-62.
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Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ. PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling. J Cell Physiol. 2001 Sep; 188(3):343-51.
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Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components. J Bone Joint Surg Am. 2001 Jul; 83-A(7):1057-61.
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Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiat Res. 2001 Jun; 155(6):847-57.
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Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res. 2001 Apr; 16(4):660-70.
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Tsingotjidou AS, Zotalis G, Jackson KR, Sawyers C, Puzas JE, Hicks DG, Reiter R, Lieberman JR. Development of an animal model for prostate cancer cell metastasis to adult human bone. Anticancer Res. 2001 Mar-Apr; 21(2A):971-8.
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Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ. PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. J Biol Chem. 2001 Apr 13; 276(15):11639-47.
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Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Schwarz EM, Reynolds PR, Roiser RN, O'Keefe RJ. BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog. J Orthop Res. 2001 Jan; 19(1):18-25.
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Puzas JE, Landeau JM, Tallents R, Albright J, Schwarz EM, Landesberg R. Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity. Cells Tissues Organs. 2001; 169(3):248-56.
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Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation. Endocrinology. 2000 Dec; 141(12):4728-35.
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Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. Cancer Res. 2000 Dec 1; 60(23):6557-62.
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Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN, Puzas JE, Okeefe RJ. Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis. J Orthop Res. 2000 Nov; 18(6):849-55.
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Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR. Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Mol Cell Biol. 2000 Sep; 20(17):6496-507.
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Reynolds SD, Zhang D, Puzas JE, O'Keefe RJ, Rosier RN, Reynolds PR. Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. Gene. 2000 May 2; 248(1-2):233-43.
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Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ. PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes. Exp Cell Res. 2000 May 1; 256(2):555-62.
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Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res. 2000 May; 18(3):472-80.
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Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Reynolds PR, Rosier RN, O'Keefe RJ. BMP-6 is an autocrine stimulator of chondrocyte differentiation. J Bone Miner Res. 1999 Apr; 14(4):475-82.
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Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Genomics. 1999 Mar 15; 56(3):324-36.
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Landesberg R, Takeuchi E, Puzas JE. Differential activation by cytokines of mitogen-activated protein kinases in bovine temporomandibular-joint disc cells. Arch Oral Biol. 1999 Jan; 44(1):41-8.
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Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway. J Orthop Res. 1998 Nov; 16(6):697-704.
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Ishibe M, Ishibashi T, Kaneda K, Koda T, Rosier RN, Puzas JE. Stimulation of bone formation in vivo by insulin-like growth factor-II in rats. Calcif Tissue Int. 1998 Jul; 63(1):36-8.
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Grimsrud CD, Rosier RN, Puzas JE, Reynolds PR, Reynolds SD, Hicks DG, O'Keefe RJ. Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation. J Orthop Res. 1998 Mar; 16(2):247-55.
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Romano PR, Wang J, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation. J Cell Sci. 1998 Mar; 111 ( Pt 6):803-13.
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Blaine TA, Pollice PF, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms. J Bone Joint Surg Am. 1997 Oct; 79(10):1519-28.
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Rosier RN, O'Keefe RJ, Teot LA, Fox EJ, Nester TA, Puzas JE, Reynolds PR, Hicks DG. P-glycoprotein expression in cartilaginous tumors. J Surg Oncol. 1997 Jun; 65(2):95-105.
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Zuscik MJ, Gunter TE, Puzas JE, Rosier RN. Characterization of voltage-sensitive calcium channels in growth plate chondrocytes. Biochem Biophys Res Commun. 1997 May 19; 234(2):432-8.
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O'Keefe RJ, Teot LA, Singh D, Puzas JE, Rosier RN, Hicks DG. Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study. Lab Invest. 1997 Apr; 76(4):457-65.
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O'Keefe RJ, Loveys LS, Hicks DG, Reynolds PR, Crabb ID, Puzas JE, Rosier RN. Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes. J Orthop Res. 1997 Mar; 15(2):162-74.
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Romano PR, Caton JG, Puzas JE. The reversal line may be a key modulator of osteoblast function: observations from an alveolar bone wound-healing model. J Periodontal Res. 1997 Jan; 32(1 Pt 2):143-7.
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Myers MA, Casciani T, Whitbeck MG, Puzas JE. Vertebral body osteopenia associated with posterolateral spine fusion in humans. Spine (Phila Pa 1976). 1996 Oct 15; 21(20):2368-71.
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Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN. Effects of lead on growth plate chondrocyte phenotype. Toxicol Appl Pharmacol. 1996 Sep; 140(1):164-72.
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Landesberg R, Takeuchi E, Puzas JE. Cellular, biochemical and molecular characterization of the bovine temporomandibular joint disc. Arch Oral Biol. 1996 Aug-Sep; 41(8-9):761-7.
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Schwid SR, Goodman AD, Puzas JE, McDermott MP, Mattson DH. Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis. Arch Neurol. 1996 Aug; 53(8):753-7.
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Blaine TA, Rosier RN, Puzas JE, Looney RJ, Reynolds PR, Reynolds SD, O'Keefe RJ. Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles. J Bone Joint Surg Am. 1996 Aug; 78(8):1181-92.
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Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy. Exp Cell Res. 1996 Jul 10; 226(1):197-207.
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Reynolds PR, Reynolds SD, O'Keefe RJ, Puzas JE, Rosier RN. Alternative splicing of a chondrocyte-specific gene. Ann N Y Acad Sci. 1996 Jun 8; 785:321-4.
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Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ. Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages. J Bone Joint Surg Am. 1996 Apr; 78(4):482-96.
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Ishibe M, Nojima T, Ishibashi T, Koda T, Kaneda K, Rosier RN, Puzas JE. 17 beta-estradiol increases the receptor number and modulates the action of 1,25-dihydroxyvitamin D3 in human osteosarcoma-derived osteoblast-like cells. Calcif Tissue Int. 1995 Dec; 57(6):430-5.
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Martinez DA, Zuscik MJ, Ishibe M, Rosier RN, Romano PR, Cushing JE, Puzas JE. Identification of functional insulin-like growth factor-II/mannose-6-phosphate receptors in isolated bone cells. J Cell Biochem. 1995 Oct; 59(2):246-57.
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Ishibe M, Nojima T, Ishibashi T, Koda T, Rosier RN, Puzas JE, Kaneda K. Comparison of the type-2 insulin-like growth factor receptor in normal osteoblasts and osteosarcoma-derived osteoblast-like cells. J Orthop Res. 1995 Sep; 13(5):643-8.
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Hughes SS, Hicks DG, O'Keefe RJ, Hurwitz SR, Crabb ID, Krasinskas AM, Loveys L, Puzas JE, Rosier RN. Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus. J Bone Miner Res. 1995 Apr; 10(4):533-44.
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Rosier RN, Teot LA, Hicks DG, Schwartz C, O'Keefe RJ, Puzas JE. Multiple drug resistance in osteosarcoma. Iowa Orthop J. 1995; 15:66-73.
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Landesberg R, Proctor RL, Rosier RN, Puzas JE. The mandibular condylar growth center: separation and characterization of the cellular elements. Calcif Tissue Int. 1995 Jan; 56(1):71-7.
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Zuscik MJ, Puzas JE, Rosier RN, Gunter KK, Gunter TE. Cyclic-AMP-dependent protein kinase activity is not required by parathyroid hormone to stimulate phosphoinositide signaling in chondrocytes but is required to transduce the hormone's proliferative effect. Arch Biochem Biophys. 1994 Dec; 315(2):352-61.
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O'Keefe RJ, Puzas JE, Loveys L, Hicks DG, Rosier RN. Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture. J Bone Miner Res. 1994 Nov; 9(11):1713-22.
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Zuscik MJ, Gunter TE, Rosier RN, Gunter KK, Puzas JE. Activation of phosphoinositide metabolism by parathyroid hormone in growth plate chondrocytes. Cell Calcium. 1994 Aug; 16(2):112-22.
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Alioto RJ, Rosier RN, Burton RI, Puzas JE. Comparative effects of growth factors on fibroblasts of Dupuytren's tissue and normal palmar fascia. J Hand Surg Am. 1994 May; 19(3):442-52.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I. J Orthop Res. 1994 May; 12(3):299-310.
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Puzas JE, Hicks DG, Reynolds SD, O'Keefe RJ. Regulation of osteoclastic activity in infection. Methods Enzymol. 1994; 236:47-58.
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Ishibe M, Ishibe Y, Ishibashi T, Nojima T, Rosier RN, Puzas JE, Kaneda K. Low content of estrogen receptors in human giant cell tumors of bone. Arch Orthop Trauma Surg. 1994; 113(2):106-9.
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Loveys LS, Gelb D, Hurwitz SR, Puzas JE, Rosier RN. Effects of parathyroid hormone-related peptide on chick growth plate chondrocytes. J Orthop Res. 1993 Nov; 11(6):884-91.
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Kreipe RE, Hicks DG, Rosier RN, Puzas JE. Preliminary findings on the effects of sex hormones on bone metabolism in anorexia nervosa. J Adolesc Health. 1993 Jun; 14(4):319-24.
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Crabb ID, Hughes SS, Hicks DG, Puzas JE, Tsao GJ, Rosier RN. Nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotides. Applications to musculoskeletal tissues. Am J Pathol. 1992 Sep; 141(3):579-89.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes. J Bone Miner Res. 1992 Apr; 7(4):397-404.
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Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes. Calcif Tissue Int. 1992 Jan; 50(1):61-6.
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Puzas JE, Sickel MJ, Felter ME. Osteoblasts and chondrocytes are important target cells for the toxic effects of lead. Neurotoxicology. 1992; 13(4):783-8.
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Ishibe M, Rosier RN, Puzas JE. Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells. J Clin Endocrinol Metab. 1991 Oct; 73(4):785-92.
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Sawyer JR, Myers MA, Rosier RN, Puzas JE. Heterotopic ossification: clinical and cellular aspects. Calcif Tissue Int. 1991 Sep; 49(3):208-15.
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Ishibe M, Rosier RN, Puzas JE. Activation of osteoblast insulin-like growth factor-II/cation-independent mannose-6-phosphate receptors by specific phosphorylated sugars and antibodies induce insulin-like growth factor-II effects. Endocr Res. 1991; 17(3-4):357-66.
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Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes. J Bone Miner Res. 1990 Nov; 5(11):1105-12.
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Gelb DE, Rosier RN, Puzas JE. The production of transforming growth factor-beta by chick growth plate chondrocytes in short term monolayer culture. Endocrinology. 1990 Oct; 127(4):1941-7.
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Gunter TE, Zuscik MJ, Puzas JE, Gunter KK, Rosier RN. Cytosolic free calcium concentrations in avian growth plate chondrocytes. Cell Calcium. 1990 Aug; 11(7):445-57.
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Tallents RH, Macher DJ, Rivoli P, Puzas JE, Scapino RP, Katzberg RW. Animal model for disk displacement. J Craniomandib Disord. 1990; 4(4):233-40.
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Rockwood PR, Horne JG. Heterotopic ossification following uncemented total hip arthroplasty. J Arthroplasty. 1990; 5 Suppl:S43-6.
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O'Keefe RJ, Rosier RN, Puzas JE. Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes. Connect Tissue Res. 1990; 24(1):53-66.
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Puzas JE, Miller MD, Rosier RN. Pathologic bone formation. Clin Orthop Relat Res. 1989 Aug; (245):269-81.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes. J Bone Joint Surg Am. 1989 Apr; 71(4):607-20.
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Rosier RN, O'Keefe RJ, Crabb ID, Puzas JE. Transforming growth factor beta: an autocrine regulator of chondrocytes. Connect Tissue Res. 1989; 20(1-4):295-301.
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O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. Effect of transforming growth factor-beta on DNA synthesis by growth plate chondrocytes: modulation by factors present in serum. Calcif Tissue Int. 1988 Dec; 43(6):352-8.
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O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes. Endocrinology. 1988 Jun; 122(6):2953-61.
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Puzas JE, Turner RT, Howard GA, Brand JS, Baylink DJ. Synthesis of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by calvarial cells. Characterization of the enzyme systems. Biochem J. 1987 Jul 15; 245(2):333-8.
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Puzas JE, Evarts CM, Brand JS. The stimulus for bone formation. Hip. 1987; 25-38.
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Evarts CM, Ayers DC, Puzas JE. Prevention of heterotopic bone formation in high-risk patients by postoperative irradiation. Hip. 1987; 70-83.
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Puzas JE, Brand JS, Jackman KV. Isolation and characterization of bone cells from a patient with osteogenesis imperfecta type 1b. Bone Miner. 1986 Oct; 1(5):373-82.
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Puzas JE, Brand JS. The effect of bone cell stimulatory factors can be measured with thymidine incorporation only under specific conditions. Calcif Tissue Int. 1986 Aug; 39(2):104-8.
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Puzas JE, Brand JS. In vitro use of vitamin D3 metabolites: culture conditions determine cell uptake. Calcif Tissue Int. 1985 Sep; 37(5):474-7.
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Puzas JE, Brand JS. Bone cell phosphotyrosine phosphatase: characterization and regulation by calcitropic hormones. Endocrinology. 1985 Jun; 116(6):2463-8.
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Turner RT, Howard GA, Puzas JE, Baylink DJ, Knapp DR. Calvarial cells synthesize 1 alpha,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Biochemistry. 1983 Mar 1; 22(5):1073-6.
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Howard GA, Turner RT, Puzas JE, Nichols F, Baylink DJ. Bone cells on microcarrier spheres. JAMA. 1983 Jan 14; 249(2):258-9.
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Puzas JE, Turner RT, Howard GA, Baylink DJ. Cells isolated from embryonic intestine synthesize 1,25-dihydroxyvitamin-D3 and 24,25-dihydroxyvitamin-D3 in culture. Endocrinology. 1983 Jan; 112(1):378-80.
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Nefussi JR, Vignery A, Puzas JE, Baron R. Histomorphometry and autoradiography of cultured fetal rat long bones. Anat Rec. 1982 Oct; 204(2):105-12.
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Puzas JE, Jensen JA. Electrophoretically separated bone cell types from the foetal rat calvarium: a histochemical and biochemical study. Histochem J. 1982 Jul; 14(4):561-71.
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Puzas JE, Wilson DE, Treat DE, Brand JS. Adding selected areas of color to black and white slides by color coupling. J Biol Photogr. 1982 Jul; 50(3):69-70.
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Farley JR, Puzas JE, Baylink DJ. Effect of skeletal alkaline phosphatase inhibitors on bone cell proliferation in vitro. Miner Electrolyte Metab. 1982 Jun; 7(6):316-23.
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Baylink D, Farley J, Howard G, Drivdahl R, Puzas E, Masuda T, Ivey J, Gruber H. Coupling factor. Adv Exp Med Biol. 1982; 151:409-21.
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Drivdahl RH, Puzas JE, Howard GA, Baylink DJ. Regulation of DNA synthesis in chick calvaria cells by factors from bone organ culture. Proc Soc Exp Biol Med. 1981 Nov; 168(2):143-50.
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Puzas JE, Drivdahl RH, Howard GA, Baylink DJ. Endogenous inhibitor of bone cell proliferation. Proc Soc Exp Biol Med. 1981 Jan; 166(1):113-22.
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Turner RT, Puzas JE, Forte MD, Lester GE, Gray TK, Howard GA, Baylink DJ. In vitro synthesis of 1 alpha,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by isolated calvarial cells. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):5720-4.
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Puzas JE, Turner RT, Forte MD, Kenny AD, Baylink DJ. Metabolism of 25(OH)D3 to 1,25(OH)2D3 and 24,25(OH)2D3 by chick chorioallantoic cells in culture. Gen Comp Endocrinol. 1980 Sep; 42(1):116-22.
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Puzas JE, Vignery A, Rasmussen H. Isolation of specific bone cell types by free-flow electrophoresis. Calcif Tissue Int. 1979 Jul 3; 27(3):263-8.
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Puzas JE, Brand JS. Parathyroid hormone stimulation of collagenase secretion by isolated bone cells. Endocrinology. 1979 Feb; 104(2):559-62.
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Puzas JE, Goodman DB. A rapid assay for cellular deoxyribonucleic acid. Anal Biochem. 1978 May; 86(1):50-5.
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Puzas JE, Brand JS. Collagenolytic activity from isolated bone cells. Biochim Biophys Acta. 1976 May 13; 429(3):964-74.
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