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Bruce Goldman

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
Other Positions
TitleDirector, Autopsy Pathology
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine

 
 Awards And Honors
1974     Phi Beta Kappa Univ. of IL
1977     Alpha Omega Alpha Northwestern U Med Schl
1977     Winton Award in Northwestern U Med Schl Biochemistry
1998     Golden Apple Award Temple University Schl of Med
2001     Golden Apple Award Temple University Schl of Med
2002     Lindback Award for Temple University Distinguished Teaching
2003     Golden Apple Award Temple University Schl of Med.
2004     University Teaching Academy Temple University
2004     Academy of Distinguished Educators in Medicine,Temple University ,Schl of Med
 
 Overview
Most recently, Dr. Goldman completed a study of the resuscitation and transplantation of non-beating donor hearts for the American Heart Association. He is working with Dr. C. Platsoucas in investigating the role of T cell receptor expression in Systemic Sclerosis. They have also studied the role of T cells in Abdominal aortic aneurysm, an antigen driven autoimmune disease, and the immunopathogenesis of chronic cardiac graft rejection. Dr. Goldman's AHA grants have involved the growth and proliferation of human fetal cardiac myocytes, and the role of Insulin-like Growth Factor I in human cardiac cells.

 
 Selected Publications
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  1. Oleksyn D, Pulvino M, Zhao J, Misra R, Vosoughi A, Jenks S, Tipton C, Lund F, Schwartz G, Goldman B, Mohan C, Mehta K, Mehta M, Leitgets M, Sanz I, Chen L. Protein kinase Cß is required for lupus development in Sle mice. Arthritis Rheum. 2013 Apr; 65(4):1022-31.
    View in: PubMed
  2. Ichikawa HT, Conley T, Muchamuel T, Jiang J, Lee S, Owen T, Barnard J, Nevarez S, Goldman BI, Kirk CJ, Looney RJ, Anolik JH. Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells. Arthritis Rheum. 2012 Feb; 64(2):493-503.
    View in: PubMed
  3. Bekar KW, Owen T, Dunn R, Ichikawa T, Wang W, Wang R, Barnard J, Brady S, Nevarez S, Goldman BI, Kehry M, Anolik JH. Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus. Arthritis Rheum. 2010 Aug; 62(8):2443-57.
    View in: PubMed
  4. Wagner D, Bourne PA, Yang Q, Goldman BI, Lewis JS, Xu H. Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. Appl Immunohistochem Mol Morphol. 2008 May; 16(3):301-7.
    View in: PubMed
  5. van Bemmelen PS, Choudry RG, Salvatore MD, Goldenberg M, Goldman BI, Blebea J. Long-term intermittent compression increases arteriographic collaterals in a rabbit model of femoral artery occlusion. Eur J Vasc Endovasc Surg. 2007 Sep; 34(3):340-6.
    View in: PubMed
  6. Goldman BI, Amin KM, Kubo H, Singhal A, Wurzel J. Human myocardial cell lines generated with SV40 temperature-sensitive mutant tsA58. In Vitro Cell Dev Biol Anim. 2006 Nov-Dec; 42(10):324-31.
    View in: PubMed
  7. Tuluc M, Brown D, Goldman B. Lethal vertebral artery dissection in pregnancy: a case report and review of the literature. Arch Pathol Lab Med. 2006 Apr; 130(4):533-5.
    View in: PubMed
  8. Petre RE, Quaile MP, Wendt K, Houser SR, Wald J, Goldman BI, Margulies KB. Regionally heterogeneous tissue mechanics in cardiac amyloidosis. Amyloid. 2005 Dec; 12(4):246-50.
    View in: PubMed
  9. Singhal AK, Abrams JD, Mohara J, Hasz RD, Nathan HM, Fisher CA, Furukawa S, Goldman BI. Potential suitability for transplantation of hearts from human non-heart-beating donors: data review from the Gift of Life Donor Program. J Heart Lung Transplant. 2005 Oct; 24(10):1657-64.
    View in: PubMed
  10. Mohara J, Aguilera I, Goldman BI, Fisher CA, Gaughan JP, Libonati JR, Furukawa S, Singhal AK. Effects of nutrient and hemoglobin enriched cell free perfusates upon ex vivo isolated rat heart preparation. ASAIO J. 2005 May-Jun; 51(3):288-95.
    View in: PubMed
  11. Gupta D, Piacentino V, Macha M, Singhal AK, Gaughan JP, McClurken JB, Goldman BI, Fisher CA, Beltramo D, Monacchio J, Eisen HJ, Furukawa S. Effect of older donor age on risk for mortality after heart transplantation. Ann Thorac Surg. 2004 Sep; 78(3):890-9.
    View in: PubMed
  12. Wurzel J, Goldman BI. Premature coronary disease in systemic lupus. N Engl J Med. 2004 Apr 8; 350(15):1571-5; author reply 1571-5.
    View in: PubMed
  13. Roman MJ, Shanker BA, Davis A, Lockshin MD, Sammaritano L, Simantov R, Crow MK, Schwartz JE, Paget SA, Devereux RB, Salmon JE. Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus. N Engl J Med. 2003 Dec 18; 349(25):2399-406.
    View in: PubMed
  14. Fedalen PA, Piacentino V, Jeevanandam V, Fisher C, Greene J, Margulies KB, Houser SR, Furukawa S, Singhal AK, Goldman BI. Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts. J Heart Lung Transplant. 2003 Nov; 22(11):1234-44.
    View in: PubMed
  15. Xu B, Sakkas LI, Goldman BI, Jeevanandam V, Gaughan J, Oleszak EL, Platsoucas CD. Identical alpha-chain T-cell receptor transcripts are present on T cells infiltrating coronary arteries of human cardiac allografts with chronic rejection. Cell Immunol. 2003 Oct; 225(2):75-90.
    View in: PubMed
  16. Nicolo D, Goldman BI, Monestier M. Reduction of atherosclerosis in low-density lipoprotein receptor-deficient mice by passive administration of antiphospholipid antibody. Arthritis Rheum. 2003 Oct; 48(10):2974-8.
    View in: PubMed
  17. Kashem A, Kashem S, Santamore WP, Crabbe DL, Margulies KB, Melvin DB, Goldman BI. Early and late results of left ventricular reshaping by passive cardiac-support device in canine heart failure. J Heart Lung Transplant. 2003 Sep; 22(9):1046-53.
    View in: PubMed
  18. Kashem A, Santamore WP, Hassan S, Melvin DB, Crabbe DL, Margulies KB, Goldman BI, Llort F, Krieger C, Lesniak J. CardioClasp changes left ventricular shape acutely in enlarged canine heart. J Card Surg. 2003 Jul-Aug; 18 Suppl 2:S49-60.
    View in: PubMed
  19. Leech SH, Rubin S, Eisen HJ, Mather PJ, Goldman BI, McClurken JB, Furukawa S. Cardiac transplantation across a positive prospective lymphocyte cross-match in sensitized recipients. Clin Transplant. 2003; 17 Suppl 9:17-26.
    View in: PubMed
  20. Autieri MV, Kelemen S, Thomas BA, Feller ED, Goldman BI, Eisen HJ. Allograft inflammatory factor-1 expression correlates with cardiac rejection and development of cardiac allograft vasculopathy. Circulation. 2002 Oct 22; 106(17):2218-23.
    View in: PubMed
  21. Chen X, Piacentino V, Furukawa S, Goldman B, Margulies KB, Houser SR. L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circ Res. 2002 Sep 20; 91(6):517-24.
    View in: PubMed
  22. Goldman BI, Wurzel J. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med. 2001 Oct 11; 345(15):1131.
    View in: PubMed
  23. Goldman BI, Wurzel J. Hematopoiesis/erythropoiesis in myocardial infarcts. Mod Pathol. 2001 Jun; 14(6):589-94.
    View in: PubMed
  24. Xu B, Sakkas LI, Slachta CA, Goldman BI, Jeevanandam V, Oleszak EL, Platsoucas CD. Apoptosis in chronic rejection of human cardiac allografts. Transplantation. 2001 Apr 27; 71(8):1137-46.
    View in: PubMed
  25. Jung W, Lu S, Qin P, Afolabi A, Slachta C, Jeevanandam V, Goldman B, Platsoucas CD. Gamma-chain T-cell receptor transcripts are clonally expanded in the coronary arteries of cardiac allografts from patients with chronic rejection. Transplant Proc. 2001 Feb-Mar; 33(1-2):456-8.
    View in: PubMed
  26. Slachta CA, Jeevanandam V, Goldman B, Lin WL, Platsoucas CD. Coronary arteries with chronic rejection contain oligoclonal T cells: persistence of clonally expanded T cell receptor transcripts from the early posttransplantation period through chronic rejection. Transplant Proc. 2001 Feb-Mar; 33(1-2):452-5.
    View in: PubMed
  27. Slachta CA, Jeevanandam V, Goldman B, Lin WL, Platsoucas CD. Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries). J Immunol. 2000 Sep 15; 165(6):3469-83.
    View in: PubMed
  28. Wurzel J, Goldman BI. Angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med. 2000 Jul 13; 343(2):148-9.
    View in: PubMed
  29. Brando C, Marcinkiewicz C, Goldman B, McLane MA, Niewiarowski S. EC3, a heterodimeric disintegrin from Echis carinatus, inhibits human and murine alpha4 integrin and attenuates lymphocyte infiltration of Langerhans islets in pancreas and salivary glands in nonobese diabetic mice. Biochem Biophys Res Commun. 2000 Jan 7; 267(1):413-7.
    View in: PubMed
  30. Slachta CA, Jeevanandam V, Goldman B, Platsoucas CD. T cells infiltrating coronary arteries of cardiac allografts with chronic rejection contain clonally expanded T lymphocytes. Transplant Proc. 1998 Jun; 30(4):1002-4.
    View in: PubMed
  31. Altemose GT, Gritsus V, Jeevanandam V, Goldman B, Margulies KB. Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy. J Heart Lung Transplant. 1997 Jul; 16(7):765-73.
    View in: PubMed
  32. Multhaupt HA, Gåfvels ME, Kariko K, Jin H, Arenas-Elliot C, Goldman BI, Strauss JF, Angelin B, Warhol MJ, McCrae KR. Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry. Am J Pathol. 1996 Jun; 148(6):1985-97.
    View in: PubMed
  33. Goldman BI, Wurzel J. Human fetal cardiocytes in enriched culture. In Vitro Cell Dev Biol Anim. 1995 Nov; 31(10):731-4.
    View in: PubMed
  34. Aldridge SC, Comerota AJ, Katz ML, Wolk JH, Goldman BI, White JV. Popliteal venous aneurysm: report of two cases and review of the world literature. J Vasc Surg. 1993 Oct; 18(4):708-15.
    View in: PubMed
  35. Goldman BI, Wurzel J. Effects of subcultivation and culture medium on differentiation of human fetal cardiac myocytes. In Vitro Cell Dev Biol. 1992 Feb; 28A(2):109-19.
    View in: PubMed
  36. Kohtz DS, Dische NR, Inagami T, Goldman B. Growth and partial differentiation of presumptive human cardiac myoblasts in culture. J Cell Biol. 1989 Mar; 108(3):1067-78.
    View in: PubMed
  37. Weinberger J, Marks SJ, Gaul JJ, Goldman B, Schanzer H, Jacobson J, Dikman S. Atherosclerotic plaque at the carotid artery bifurcation. Correlation of ultrasonographic imaging with morphology. J Ultrasound Med. 1987 Jul; 6(7):363-6.
    View in: PubMed
  38. Goldman B, Blanke H, Wolinsky H. Influence of pressure on permeability of normal and diseased muscular arteries to horseradish peroxidase. A new catheter approach. Atherosclerosis. 1987 Jun; 65(3):215-25.
    View in: PubMed
  39. Goldman BI, Frydman C, Harpaz N, Ryan SF, Loiterman D. Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation. Cancer. 1987 May 15; 59(10):1767-75.
    View in: PubMed
  40. Carone FA, Nakamura S, Goldman B. Urinary loss of glucose, phosphate, and protein by diffusion into proximal straight tubules injured by D-serine and maleic acid. Lab Invest. 1985 Jun; 52(6):605-10.
    View in: PubMed

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