|Institution||School of Medicine and Dentistry|
|Department||Neurobiology and Anatomy|
|Address||University of Rochester Medical Center|
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
||Excellence in Teaching Award|
||Teacher Appreciation Award|
||Graduate Assistant Award for Outstanding Teaching|
||1995||P.E.O. Scholar Award Educational Grant | Philanthropic Education Organization (P.E.O.)|
||National Hydrocephalus Foundation Award for Presenation of Research at the Pediatric Section Meeting of the AANS | American Association of Neurological Surgeons|
||2001||Ruggles Fellowship in Movement Disorders|
||First Year SMD Teaching Commendation | University of Rochester School of Medicine Class of 2012|
||Manuel D. Goldman Prize for Excellence in Teaching 1st Year Medical Students|
||Manuel D. Goldman Prize for Excellence in Teaching 1st Year Medical Students | University of Rochester School of Medicine Class of 2017|
Sensorimotor Integration in the Basal Ganglia
Many variables influence the decision of whether and when to initiate, suppress, or alter a movement in progress. These decisions, and the movements that follow, are likely orchestrated using basal ganglia circuitry. We postulate that one role of the subthalamic nucleus (STN) is to arrest highly practiced movements or movements that are in progress in order to allow for the evaluation of the need for an adjustment of the movement command. The decision to generate a voluntary movement is preceded by evaluation of the context in which the movement is to occur. Consider the factors that influence our motivation to pet a purring cat, or to suppress the petting of a dog. Prior experiences providing a cumulative record of positive or negative outcomes are likely to be strong influences in these evaluations. For instance, prior experiences with a family cat may have proven to be pleasing, whereas a menacing encounter with an unfamiliar dog may have had adverse consequences. These are simple examples of how past and current context contribute to the ultimate decision to move. If the neural circuitry that is responsible for these evaluations are impaired, inappropriate inhibition or facilitation of movements will occur. Several lines of evidence suggest that STN function is impaired in Parkinson Disease (PD) and that treatment with dopamine agonists (Levadopa) or STN deep brain stimulation (STN-DBS) may further alter STN function, changing the way in which voluntary movement decisions are made. Work in collaboration with Jonathan W. Mink, MD, PhD and Michelle Burack, MD, PhD examines the effects of drug and deep brain stimulation treatments for PD by quantifying limb movement during the performance of tasks that require sensorimotor integration.
Khandwala, V.J., LeBlanc, J.M., Ochocki, B, and Gdowski, M.J. 3-D Motion analysis of planning-related changes in upper limb kinematics resulting from normal aging, Society for Neuroscience Abstracts, 2008.
Suzanne N. Haber and Martha Johnson Gdowski The Basal Ganglia. In: The Human Nervous System, 2nd Edition (George Paxinos and Jurgen K. Mai, eds.). San Diego, Elsevier Science/Academic Press (2004).
Gdowski, M.J., Miller, L.E., Nenonene, E., Parrish, T., Houk, J.C. Context-dependency in the Globus Pallidus Internal Segment During Targeted Arm Movements. Journal of Neurophysiology 85:998-1004, 2001.
Luciano, M.G., Skarupa, D.J., Booth, A.M., Wood, A.S., Brant, C.L., Gdowski, M.J. Cerebrovascular Adaptation in Chronic Hydrocephalus. Journal of Cerebral Blood Flow and Metabolism. 21(3):285-94, 2001.
Johnson, M.J., Ayzman, I., Wood, A.S., Tkach, J.A., Klauschie, J., Skarupa, D.J., McAllister, J.P., and Luciano, M.G. Development and Characterization of an adult model of obstructive hydrocephalus. J. Neurosci. Methods 91(1-2):55-65, 1999.
Mangano, F.T., McAllister, J.P., II, Jones, HC, Johnson, M.J., Kriebel, R.M. The microglial response to progressive hydrocephalus in a model of inherited aqueductal stenosis. Neurological Research 20(8):697-704, 1998.
McAllister, J.P., II, Chovan, P., Steiner, C.P., Johnson, M.J., Ayzman, I., Wood, AS, Tkach, JA, Hahn, J.F. and Luciano, M.G. Differential ventricular expansion in hydrocephalus. European Journal of Pediatric Surgery, Suppl 1:39-42, 1998.
Johnson, M.J. and Alloway, K.D. Cross correlation analysis reveals laminar differences in thalamocortical interactions in the somatosensory system. Journal of Neurophysiology, 75: 1444 57, 1996.
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