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Jian Zhu

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester NY 14642
Other Positions
TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentBiochemistry and Biophysics

 
 Awards And Honors
1993     Bronze Medal of National Championship of Applied Physics  | Wuxi
1997 - 2000Annual University Fellowship Award for Excellent Undergraduates  | Peking University
2000     Undergraduate Thesis Presentation Award  | Peking University
2007 - 2009Predoctoral Fellowship Award  | American Heart Association
2011     The 18th Conference on Retroviruses and Opportunistic Infections (CROI)  | Young Investigator Award
2012 - 2013National Research Service Award (NRSA) F32  | NIH/NIAID
 
 Overview
Virus and host are equivalent opponents and have been playing a dynamic and "never-ending" match for a long time. Virus highly depends on host cellular machineries to replicate, while host cells develop multi-layered antiviral mechanisms to control or prevent viral invasion. Short-term acute or long-term chronic viral infection might yield different yet complicated consequences in host cells. Our lab studies the host-virus interactions, particularly for HIV and herpesviruses, by using recently developed, "state-of-the-art", multidisciplinary systematic approaches. We work at the interface of virology, immunology, cellular and molecular biology, proteomics, and functional genomics. The goal is to not only pinpoint key genes that play a role in viral replication or mediate the consequences of viral infection for further dissection of their mechanistic functions using classic cell and/or animal models, but also construct a global landscape of gene network modulating viral infection from the massive data generated by integrative multiple systematic approaches at a higher resolution with the aid of powerful bioinformatic analyses. Currently, one of our major directions is to identify key host factors that regulate viral latency and reactivation for HIV and herpesviruses, by combining the genome-wide RNA interference (RNAi) screening together with various modern proteomic approaches including our recently developed PLATO (ParalleL Analysis of Translated ORFs) synthetic display method. Meanwhile, we're also interested in improving current systematic approaches or developing new ones to facilitate the study of host-virus interactions at various (genetic, biochemical and serological) levels, as well as to improve such study in a more quantitative, dynamic, and in vivo condition. Continuing to improve systematic approaches will increase their reliability and accuracy for better applications reaching a greater scope and depth of current host-virus studies. With more advanced systematic tools we will be led towards a complete understanding of viral pathogenesis, antiviral defense mechanisms, and their consequences in critical diseases such as autoimmunity and cancer.

 
 Selected Publications
List All   |   Timeline
  1. Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nat Biotechnol. 2013 Apr; 31(4):331-4.
    View in: PubMed
  2. Woodard C, Shamay M, Liao G, Zhu J, Ng AN, Li R, Newman R, Rho HS, Hu J, Wan J, Qian J, Zhu H, Hayward SD. Phosphorylation of the chromatin binding domain of KSHV LANA. PLoS Pathog. 2012; 8(10):e1002972.
    View in: PubMed
  3. Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep. 2012 Oct 25; 2(4):807-16.
    View in: PubMed
  4. Shamay M, Liu J, Li R, Liao G, Shen L, Greenway M, Hu S, Zhu J, Xie Z, Ambinder RF, Qian J, Zhu H, Hayward SD. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. J Virol. 2012 May; 86(9):5179-91.
    View in: PubMed
  5. Li R, Zhu J, Xie Z, Liao G, Liu J, Chen MR, Hu S, Woodard C, Lin J, Taverna SD, Desai P, Ambinder RF, Hayward GS, Qian J, Zhu H, Hayward SD. Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe. 2011 Oct 20; 10(4):390-400.
    View in: PubMed
  6. Zhu J, Liao G, Shan L, Zhang J, Chen MR, Hayward GS, Hayward SD, Desai P, Zhu H. Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4. J Virol. 2009 May; 83(10):5219-31.
    View in: PubMed
  7. Chen CS, Korobkova E, Chen H, Zhu J, Jian X, Tao SC, He C, Zhu H. A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli. Nat Methods. 2008 Jan; 5(1):69-74.
    View in: PubMed
  8. Lu JY, Lin YY, Qian J, Tao SC, Zhu J, Pickart C, Zhu H. Functional dissection of a HECT ubiquitin E3 ligase. Mol Cell Proteomics. 2008 Jan; 7(1):35-45.
    View in: PubMed
  9. Zhu J, Gopinath K, Murali A, Yi G, Hayward SD, Zhu H, Kao C. RNA-binding proteins that inhibit RNA virus infection. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3129-34.
    View in: PubMed
  10. Yang Z, Zhu J, Sriadibhatla S, Gebhart C, Alakhov V, Kabanov A. Promoter- and strain-selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85. J Control Release. 2005 Nov 28; 108(2-3):496-512.
    View in: PubMed
  11. Fujimuro M, Liu J, Zhu J, Yokosawa H, Hayward SD. Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen. J Virol. 2005 Aug; 79(16):10429-41.
    View in: PubMed

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