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Juilee Thakar

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box CU420630
Rochester NY 14642
Other Positions
TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentBiostatistics and Computational Biology

 
 Overview
Thakar lab uses systems biology approaches to identify immune signatures that can predict outcome of an immune response to infections or vaccinations. We are particularly interested in understanding dynamics of respiratory infections by single and multiple pathogens. We develop computational tools to model probable trajectories of the immune response which then allows us to identify parameters that can predict future outcomes of the disease. This has direct implications in early diagnosis. The models also reveal the mechanisms of pathogenesis. This work is based on multi-parameter datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.

 
 Selected Publications
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  1. Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. Immune markers associated with host susceptibility to infection with west nile virus. Viral Immunol. 2014 Mar; 27(2):39-47.
    View in: PubMed
  2. Yaari G, Bolen CR, Thakar J, Kleinstein SH. Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations. Nucleic Acids Res. 2013 Oct; 41(18):e170.
    View in: PubMed
  3. Thakar J, Schmid S, Duke JL, García-Sastre A, Kleinstein SH. Overcoming NS1-mediated immune antagonism involves both interferon-dependent and independent mechanisms. J Interferon Cytokine Res. 2013 Nov; 33(11):700-8.
    View in: PubMed
  4. Zaslavsky E, Nudelman G, Marquez S, Hershberg U, Hartmann BM, Thakar J, Sealfon SC, Kleinstein SH. Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection. BMC Bioinformatics. 2013; 14 Suppl 6:S1.
    View in: PubMed
  5. Lass S, Hudson PJ, Thakar J, Saric J, Harvill E, Albert R, Perkins SE. Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth. J R Soc Interface. 2013 Mar 6; 10(80):20120588.
    View in: PubMed
  6. Thakar J, Pathak AK, Murphy L, Albert R, Cattadori IM. Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth. PLoS Comput Biol. 2012 Jan; 8(1):e1002345.
    View in: PubMed
  7. Campbell C, Thakar J, Albert R. Network analysis reveals cross-links of the immune pathways activated by bacteria and allergen. Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Sep; 84(3 Pt 1):031929.
    View in: PubMed
  8. Campbell C, Zhang R, Haley JS, Liu X, Loughran T, Schell TD, Albert R, Thakar J. Why Do CD8+ T Cells become Indifferent to Tumors: A Dynamic Modeling Approach. Front Physiol. 2011; 2:32.
    View in: PubMed
  9. Walsh ER, Thakar J, Stokes K, Huang F, Albert R, August A. Computational and experimental analysis reveals a requirement for eosinophil-derived IL-13 for the development of allergic airway responses in C57BL/6 mice. J Immunol. 2011 Mar 1; 186(5):2936-49.
    View in: PubMed
  10. Thakar J, Poss M, Albert R, Long GH, Zhang R. Dynamic models of immune responses: what is the ideal level of detail? Theor Biol Med Model. 2010; 7:35.
    View in: PubMed
  11. Thakar J, Albert R. Boolean models of within-host immune interactions. Curr Opin Microbiol. 2010 Jun; 13(3):377-81.
    View in: PubMed
  12. Kühnel M, Mayorga LS, Dandekar T, Thakar J, Schwarz R, Anes E, Griffiths G, Reich J. Modelling phagosomal lipid networks that regulate actin assembly. BMC Syst Biol. 2008; 2:107.
    View in: PubMed
  13. Albert I, Thakar J, Li S, Zhang R, Albert R. Boolean network simulations for life scientists. Source Code Biol Med. 2008; 3:16.
    View in: PubMed
  14. Thakar J, Saadatpour-Moghaddam A, Harvill ET, Albert R. Constraint-based network model of pathogen-immune system interactions. J R Soc Interface. 2009 Jul 6; 6(36):599-612.
    View in: PubMed
  15. Thakar J, Pilione M, Kirimanjeswara G, Harvill ET, Albert R. Modeling systems-level regulation of host immune responses. PLoS Comput Biol. 2007 Jun; 3(6):e109.
    View in: PubMed
  16. Thakar J, Schleinkofer K, Borner C, Dandekar T. RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins. 2006 May 15; 63(3):413-23.
    View in: PubMed
  17. Thakar JD, Kunte K, Chauhan AK, Watve AV, Watve MG. Nectarless flowers: ecological correlates and evolutionary stability. Oecologia. 2003 Aug; 136(4):565-70.
    View in: PubMed
  18. Watve M, Thakar J, Kale A, Puntambekar S, Shaikh I, Vaze K, Jog M, Paranjape S. Bee-eaters ( Merops orientalis) respond to what a predator can see. Anim Cogn. 2002 Dec; 5(4):253-9.
    View in: PubMed
  19. Sosinski J, Thakar JH, Germain GS, Harwood FC, Houghton PJ. Proliferation-dependent and -independent cytotoxicity by antitumor diarylsulfonylureas. Indication of multiple mechanisms of drug action. Biochem Pharmacol. 1993 May 25; 45(10):2135-42.
    View in: PubMed

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